Consulta: creatorFacets:"Le Pendu, Jacques"
Registros recuperados: 12
Data/hora: 03/06/2024 07:22:57

Sustained fecal-oral human-to-human transmission following a zoonotic event
Provedor de dados: 5
Autores: De Graaf, Miranda; Beck, Relja; Caccio, Simone M.; Duim, Birgitta; Fraaij, Pieter L. A.; Le Guyader, Soizick; Lecuit, Marc; Le Pendu, Jacques; De Wit, Emmie; Schultsz, Constance.
Bacterial, viral and parasitic zoonotic pathogens that transmit via the fecal-oral route have a major impact on global health. However, the mechanisms underlying the emergence of such pathogens from the animal reservoir and their persistence in the human population are poorly understood. Here, we present a framework of human-to-human transmission of zoonotic pathogens that considers the factors relevant for fecal-oral human-to-human transmission route at the levels of host, pathogen, and environment. We discuss current data gaps and propose future research directions.
Tipo: Text
Ano: 2017
URL: http://archimer.ifremer.fr/doc/00358/46959/46873.pdf

Infectivity of GI and GII noroviruses established from oyster related outbreaks
Provedor de dados: 5
Autores: Thebault, Anne; Teunis, Peter F. M.; Le Pendu, Jacques; Le Guyader, Soizick; Denis, Jean-baptiste.
Noroviruses (NoVs) are the major cause of acute epidemic gastroenteritis in industrialized countries. Outbreak strains are predominantly genogroup II (GII) NoV, but genogroup I (GI) strains are regularly found in oyster related outbreaks. The prototype Norwalk virus (GI), has been shown to have high infectivity in a human challenge study. Whether other NoVs are equally infectious via natural exposure remains to be established. Human susceptibility to NoV is partly determined by the secretor status (Se+/-). Data from five published oyster related outbreaks were analyzed in a Bayesian framework. Infectivity estimates where high and consistent with NV(GI) infectivity, for both GII and GI strains. The median and CI95 probability of infection and illness, in...
Tipo: Text
Palavras-chave: Norovirus; Shellfish; Bayesian analysis; Dose-response relationship; Fucosyltransferases.
Ano: 2013
URL: http://archimer.ifremer.fr/doc/00148/25927/24030.pdf

Strain-Dependent Norovirus Bioaccumulation in Oysters
Provedor de dados: 5
Autores: Maalouf, Haifa; Schaeffer, Julien; Parnaudeau, Sylvain; Le Pendu, Jacques; Atmar, Robert L.; Crawford, Sue E.; Le Guyader, Soizick.
Noroviruses (NoVs) are the main agents of gastroenteritis in humans and the primary pathogens of shellfish-related outbreaks. Some NoV strains bind to shellfish tissues by using carbohydrate structures similar to their human ligands, leading to the hypothesis that such ligands may influence bioaccumulation. This study compares the bioaccumulation efficiencies and tissue distributions in oysters (Crassostrea gigas) of three strains from the two principal human norovirus genogroups. Clear differences between strains were observed. The GI.1 strain was the most efficiently concentrated strain. Bioaccumulation specifically occurred in digestive tissues in a dose-dependent manner, and its efficiency paralleled ligand expression, which was highest during the cold...
Tipo: Text
Ano: 2011
URL: http://archimer.ifremer.fr/doc/00036/14753/12087.pdf

COQUENPATH - Rôle de l'environnement marin (en particulier des coquillages) sur la sélection de souches humaines ou animales de norovirus pathogènes pour l'homme
Provedor de dados: 5
Autores: Pommepuy, Monique; Le Guyader, F.s; Le Pendu, Jacques; Poncet, D; Thebault, Anne; Le Saux, Jean-claude.
L'objectif général du projet est de comprendre le rôle du milieu marin, et en particulier des coquillages, sur la sélection des souches de norovirus humaines ou animales et sur leur pathogénicité potentielle pour l'homme. Des évènements récents ont montré l 'importance du potentiel zoonotique des virus, par voie directe, mais aussi au travers d'aliments potentiellement infectés ou contaminés [Yazaki et al., 2003] 1; [Stavrinides et Guttman, 2004]. L'analyse de l'évolution des Caliciviridae montre ainsi que le virus de l'exanthème vésiculeux du porc (VESV) serait apparu via l'alimentation contenant des farines de poissons jnfectés [Etherington et al. , 2006]. L'émergence de pathogènes au travers d'un passage inter - espèce correspond à des évènements rares,...
Tipo: Text
Ano: 2010
URL: http://archimer.ifremer.fr/doc/00044/15550/12937.pdf

Shellfish contamination by norovirus : strain selection based on ligand expression?
Provedor de dados: 5
Autores: Le Guyader, Soizick; Atmar, Robert; Maalouf, Haifa; Le Pendu, Jacques.
Shellfish can be a vector for human pathogens. Despite regulation based on enteric bacteria, shellfish are still implicated in viral outbreaks. Oysters are the most common shellfish associated with outbreaks, and noroviruses, which cause acute gastroenteritis, are the most frequently identified pathogen in these outbreaks. Analysis of shellfish-related outbreak data worldwide shows an unexpected high proportion of NoV GI strains. Recent studies performed in vitro, in vivo and in the environment indicate that oysters are not just a passive filter, but can selectively accumulate norovirus strains based on virus carbohydrate ligands shared with humans. These observations may help explain the GI/GII bias observed in shellfish-related outbreaks compared to...
Tipo: Text
Palavras-chave: Shellfish; Noroviruses; Oyster contamination; Pathogen.
Ano: 2013
URL: http://archimer.ifremer.fr/doc/00150/26093/24313.pdf

Huîtres et norovirus : une affinité particulière?
Provedor de dados: 5
Autores: Le Guyader, Soizick; Maalouf, Haifa; Le Pendu, Jacques.
Shellfish can be a vector for human pathogens. Despite regulation based on enteric bacteria, shellfish are still implicated in viral outbreaks. Oysters are the most common shellfish associated with outbreaks, and noroviruses, which cause acute gastroenteritis, are the most frequently identified pathogen in these outbreaks. Analysis of shellfish-related outbreak data worldwide shows an unexpected high proportion of genogroup I strains. Recent studies performed in vitro, in vivo and in the environment indicate that oysters are not just a passive filter, but can selectively accumulate norovirus strains based on virus carbohydrate ligands shared with humans. These observations may help explain the GI/GII bias observed in shellfish-related outbreaks compared to...
Tipo: Text
Palavras-chave: Huîtres; Norovirus; Ligand; Sélection de souches; Oysters; Norovirus; Ligand; Strain selection.
Ano: 2013
URL: http://archimer.ifremer.fr/doc/00152/26357/24514.pdf

Comprehensive Analysis of a Norovirus-Associated Gastroenteritis Outbreak, from the Environment to the Consumer
Provedor de dados: 5
Autores: Le Guyader, Soizick; Krol, Joanna; Ambert-balay, Katia; Ruvoen-clouet, Nathalie; Desaubliaux, Benedicte; Parnaudeau, Sylvain; Le Saux, Jean-claude; Ponge, Agnes; Pothier, Pierre; Atmar, Robert L.; Le Pendu, Jacques.
Noroviruses have been recognized to be the predominant agents of nonbacterial gastroenteritis outbreaks in humans, and their transmission via contaminated shellfish consumption has been demonstrated. Norovirus laboratory experiments, volunteer challenge studies, and community gastroenteritis outbreak investigations have identified human genetic susceptibility factors related to histo-blood group antigen expression. Following a banquet in Brittany, France, in February 2008, gastroenteritis cases were linked to oyster consumption. This study identified an association of the norovirus illnesses with histo-blood group expression, and oyster contamination with norovirus was confirmed by qualitative and quantitative analyses. The secretor phenotype was...
Tipo: Text
Ano: 2010
URL: http://archimer.ifremer.fr/doc/00002/11309/8050.pdf

Transmission of viruses through shellfish: when specific ligands come into play
Provedor de dados: 5
Autores: Le Guyader, Soizick; Atmar, Robert L.; Le Pendu, Jacques.
Shellfish are known as vectors for human pathogens and despite regulation based on enteric bacteria they are still implicated in viral outbreaks. Among shellfish, oysters are the most common vector of contamination, and the pathogens most frequently involved in these outbreaks are noroviruses, responsible for acute gastroenteritis in humans. Analysis of shellfish-related outbreak data worldwide show an unexpected high proportion of NoV GI strains. Recent studies performed in vitro, in vivo and in the environment indicate that oysters are not just passive filters, but can selectively accumulate norovirus strains based on viral carbohydrate ligands shared with humans. These observations contribute to explain the GI bias observed in shellfish-related...
Tipo: Text
Ano: 2012
URL: http://archimer.ifremer.fr/doc/00114/22516/20238.pdf

Distribution in Tissue and Seasonal Variation of Norovirus Genogroup I and II Ligands in Oysters
Provedor de dados: 5
Autores: Maalouf, Haifa; Zakhour, Maha; Le Pendu, Jacques; Le Saux, Jean-claude; Atmar, Robert L.; Le Guyader, Francoise S.
Bivalve molluscan shellfish, such as oysters, filter large volumes of water as part of their feeding activities and are able to accumulate and concentrate different types of pathogens, particularly noroviruses, from fecal human pollution. Based on our previous observation of a specific binding of the Norwalk strain (prototype norovirus genogroup I) to the oyster digestive tract through an A-like carbohydrate structure indistinguishable from human blood group A antigen and on the large diversity between strains in terms of carbohydrate-binding specificities, we evaluated the different ligands implicated in attachment to oysters tissues of strains representative of two main genogroups of human norovirus. The GI.1 and GII.4 strains differed in that the latter...
Tipo: Text
Ano: 2010
URL: http://archimer.ifremer.fr/doc/00011/12215/9045.pdf

Tulane Virus as a Potential Surrogate To Mimic Norovirus Behavior in Oysters
Provedor de dados: 5
Autores: Drouaz, Najoua; Schaeffer, Julien; Farkas, Tibor; Le Pendu, Jacques; Le Guyader, Soizick.
Oyster contamination by noroviruses is an important health and economic problem. The present study aimed to compare the behaviors of Norwalk virus (the prototype genogroup I norovirus) and two culturable viruses: Tulane virus and mengovirus. After bioaccumulation, tissue distributions were quite similar for Norwalk virus and Tulane virus, with the majority of viral particles detected in digestive tissues, while mengovirus was detected in large amounts in the gills and mantle as well as in digestive tissues. The levels of persistence of all three viruses over 8 days were comparable, but clear differences were observed over longer periods, with Norwalk and Tulane viruses displaying rather similar half-lives, unlike mengovirus, which was cleared more rapidly....
Tipo: Text
Ano: 2015
URL: https://archimer.ifremer.fr/doc/00275/38633/37163.pdf

Bovine Norovirus: Carbohydrate Ligand, Environmental Contamination, and Potential Cross-Species Transmission via Oysters
Provedor de dados: 5
Autores: Zakhour, Maha; Maalouf, Haifa; Di Bartolo, Ilaria; Haugarreau, Larissa; Le Guyader, Francoise; Ruvoen-clouet, Nathalie; Le Saux, Jean-claude; Ruggeri, Franco Maria; Pommepuy, Monique; Le Pendu, Jacques.
Noroviruses (NoV) are major agents of acute gastroenteritis in humans and the primary pathogens of shellfish-related outbreaks. Previous studies showed that some human strains bind to oyster tissues through carbohydrate ligands that are similar to their human receptors. Thus, based on presentation of shared norovirus carbohydrate ligands, oysters could selectively concentrate animal strains with increased ability to overcome species barriers. In comparison with human GI and GII strains, bovine GIII NoV strains, although frequently detected in bovine feces and waters of two estuaries of Brittany, were seldom detected in oysters grown in these estuaries. Characterization of the carbohydrate ligand from a new GIII strain indicated recognition of the...
Tipo: Text
Ano: 2010
URL: http://archimer.ifremer.fr/doc/00014/12534/9527.pdf

Bioaccumulation Efficiency, Tissue Distribution, and Environmental Occurrence of Hepatitis E Virus in Bivalve Shellfish from France
Provedor de dados: 5
Autores: Grodzki, Marco; Schaeffer, Julien; Piquet, Jean-come; Le Saux, Jean-claude; Cheve, Julien; Ollivier, Joanna; Le Pendu, Jacques; Le Guyader, Soizick.
Hepatitis E virus (HEV), an enteric pathogen of both humans and animals, is excreted by infected individuals and is therefore present in wastewaters and coastal waters. As bivalve molluscan shellfish are known to concentrate viral particles during the process of filter feeding, they may accumulate this virus. The bioaccumulation efficiencies of oysters (Crassostrea gigas), flat oysters (Ostrea edulis), mussels (Mytilus edulis), and clams (Ruditapes philippinarum) were compared at different time points during the year. Tissue distribution analysis showed that most of the viruses were concentrated in the digestive tissues of the four species. Mussels and clams were found to be more sensitive to sporadic contamination events, as demonstrated by rapid...
Tipo: Text
Ano: 2014
URL: http://archimer.ifremer.fr/doc/00204/31501/29905.pdf