Consulta: creatorFacets:"Lefranc,Marie-Paule"
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Data/hora: 03/06/2024 18:11:20

A 37-kb restriction map of the human immunoglobulin lambda variable locus, VB cluster, harboring four functional genes and two non-coding Vl sequences
Provedor de dados: 54
Autores: Passos Jr.,Geraldo A.S.; Lefranc,Marie-Paule.
The human immunoglobulin lambda variable locus (IGLV) is mapped at chromosome 22 band q11.1-q11.2. The 30 functional germline v-lambda genes sequenced untill now have been subgrouped into 10 families (V&lt;FONT FACE="Symbol"&gt;l&lt;/font&gt;1 to V&lt;FONT FACE="Symbol"&gt;l&lt;/font&gt;10). The number of V&lt;FONT FACE="Symbol"&gt;l&lt;/font&gt; genes has been estimated at approximately 70. This locus is formed by three gene clusters (VA, VB and VC) that encompass the variable coding genes (V) responsible for the synthesis of lambda-type Ig light chains, and the J&lt;FONT FACE="Symbol"&gt;l&lt;/font&gt;-C&lt;FONT FACE="Symbol"&gt;l&lt;/font&gt; cluster with the joining segments and the constant genes. Recently the entire variable lambda gene locus was...
Tipo: Info:eu-repo/semantics/article
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000400027