Consulta: creatorFacets:"Li,Zhen-Lin"
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Data/hora: 09/06/2024 17:27:32

Effect of branched-chain amino acids, valine, isoleucine and leucine on the biosythesis of bitespiramycin 4"-O-acylspiramycins
Provedor de dados: 58
Autores: Li,Zhen-Lin; Wang,Yong-Hong; Chu,Ju; Zhuang,Ying-Ping; Zhang,Si-Liang.
Bitespiramycin, a group of 4"-O-acylated spiramycins with 4"-O-isovalerylspiramycins as the major components, was produced by recombinantspiramycin-producing strain Streptomyces spiramyceticus harboring a 4"-O-acyltransferase gene. The experiment was initially performed in synthetic medium with 0.5 g l-1 Valine, Isoleucine or Leucine feeding at 36 h cultivation. When valine was fed, the biological titer of bitespiramycin was 45.3% higher than that of the control group, but the relative content of total isovalerylspiramycin components decreased by 22.5%. In the case of ilecine, the biological titer of bitespiramycin and the total isovalerylspiramycins alone were 85% and 72.1% of the control group, respectively. In contrast, the relative content of other...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bitespiramycin; Valine; Leucine; Isoleucine; Biosynthesis.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000400003