Consulta: creatorFacets:"Martinelli,Ana de Lourdes Candolo"
Registros recuperados: 3
Data/hora: 16/06/2024 03:31:37

HCV virological response during treatment of chronic hepatitis C is associated with liver histological Improvement in patients with HCV/HIV co-infection
Provedor de dados: 55
Autores: Castro,Gleusa; Ramalho,Leandra Naira Zambelli; Zucoloto,Sérgio; Martinelli,Ana de Lourdes Candolo; Figueiredo,José Fernando de Castro.
Liver histological improvement after treatment for chronic hepatitis C in patients co-infected with human immunodeficiency virus-1 (HIV-1) has been described. Paired liver biopsies in twenty six HCV/HIV co-infected patients were compared to determine factors possibly associated with histological improvement. The patients were submitted to a liver biopsy before treatment for hepatitis C and 25 months after the end of treatment. Fragments of the liver biopsy obtained before and after treatment were compared regarding the following parameters: histological activity index (HAI) and degree of fibrosis (Knodell); intensity of collagen deposits (Sirius Red staining) and degree of stellate cell activation (alpha-smooth muscle actin labeling). The ratios of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis C; Hepatic stellate cell; Histological response; Human immunodeficiency virus; Paired liver biopsies.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300004

Long-term follow-up of patients with chronic hepatitis C with sustained virologic response to interferon
Provedor de dados: 55
Autores: Ferreira,Sandro da Costa; Carneiro,Marcos de Vasconcelos; Souza,Fernanda Fernandes; Teixeira,Andreza Corrêa; Villanova,Marcia Guimarães; Figueiredo,José Fernando de Castro; Passos,Afonso Dinis Costa; Ramalho,Leandra Naira Zambelli; Zucoloto,Sergio; Martinelli,Ana de Lourdes Candolo.
BACKGROUND AND AIM: The durability of the sustained virologic response (SVR) in patients with chronic hepatitis C after treatment and the ideal follow-up time for these patients remains undefined. The objective of the study was to evaluate the durability of the virologic response in patients with chronic hepatitis C followed up for at least 12 months after SVR at HCFMRP-USP. METHODS: The study was conducted on 174 patients with chronic hepatitis C treated with different antiviral regimens who had achieved SVR. Qualitative serum HCV-RNA was determined by the commercial kit (COBAS AMPLICOR HCV, v2.0). RESULTS: There was predominance of male (73%) with a mean age of 45.6 ± 10 years. Liver cirrhosis was present in 16.1% of the study subjects. Mean follow-up...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Interferon; HCV; Follow-up; Hepatocellular carcinoma.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400003

Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration
Provedor de dados: 55
Autores: Chachá,Silvana Gama Florencio; Gomes-Gouvêa,Michele Soares; Malta,Fernanda de Mello; Ferreira,Sandro da Costa; Villanova,Márcia Guimarães; Souza,Fernanda Fernandes; Teixeira,Andreza Correa; Passos,Afonso Dinis da Costa; Pinho,João Renato Rebello; Martinelli,Ana de Lourdes Candolo.
Abstract Hepatitis B virus (HBV) is distributed worldwide, with geographical variations regarding prevalence of the different genotypes. The aim of this study was to determine the HBV genotypes and subgenotypes circulating in Southeast Brazil and compare the genetic sequences found with HBV sequences previously described in the world. Sequences from 166 chronic HBV carriers were analyzed using the fragment constituted by 1306 base pairs comprising surface and polymerase regions of the HBV genome. The sequences obtained were submitted to phylogenetic analysis. HBV subgenotypes A1, A2, D1-D4, F2a, and F4 were found. HBV genotype D was the most frequent, found in 99 patients (58.4%). Within this group, subgenotype D3 was the most prevalent, in 73 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Genotype; Phylogenetics; Intra-familial transmission.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400424