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Serum laminin, type IV collagen and hyaluronan as fibrosis markers in non-alcoholic fatty liver disease
Provedor de dados: 56
Autores: Santos,V.N. dos; Leite-Mór,M.M.B.; Kondo,M.; Martins,J.R.; Nader,H.; Lanzoni,V.P.; Parise,E.R.
Hepatic fibrosis in patients with non-alcoholic fatty liver disease is associated with progression of the disease. In the present study, we analyzed the discriminative ability of serum laminin, type IV collagen and hyaluronan levels to predict the presence of fibrosis in these patients. In this preliminary report, we studied 30 overweight patients divided into two groups according to the absence (group I, N = 19) or presence (group II, N = 11) of fibrosis in a liver biopsy. Triglycerides, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidade, hyaluronan (noncompetitive fluoroassay), type IV collagen, and laminin (ELISA) were determined. Group II presented significantly higher mean laminin, hyaluronan, type IV collagen, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatic fibrosis; Hyaluronan; Laminin; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Type IV collagen.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500012