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Behavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats
Provedor de dados: 56
Autores: Souza,M.F.; Couto-Pereira,N.S.; Freese,L.; Costa,P.A.; Caletti,G.; Bisognin,K.M.; Nin,M.S.; Gomez,R.; Barros,H.M.T.
Cocaine sensitization is a marker for some facets of addiction, is greater in female rats, and may be influenced by their sex hormones. We compared the modulatory effects of endogenous or exogenous estradiol and progesterone on cocaine-induced behavioral sensitization in 106 female rats. Ovariectomized female rats received progesterone (0.5 mg/mL), estradiol (0.05 mg/mL), progesterone plus estradiol, or the oil vehicle. Sham-operated control females received oil. Control and acute subgroups received injections of saline, while the repeated group received cocaine (15 mg/kg, ip) for 8 days. After 10 days, the acute and repeated groups received a challenge dose of cocaine, after which locomotion and stereotypy were monitored. The estrous cycle phase was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cocaine; Locomotor activity; Female rats; Estradiol; Progesterone; Stereotypic activity.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600505