Consulta: creatorFacets:"Paiva,Jacqueline Boldrin de"
Registros recuperados: 2
Data/hora: 11/06/2024 07:31:19

Requirement for cobalamin by Salmonella enterica serovars Typhimurium, Pullorum, Gallinarum and Enteritidis during infection in chickens
Provedor de dados: 58
Autores: Paiva,Jacqueline Boldrin de; Penha Filho,Rafael Antonio Casarin; Berchieri Junior,Angelo; Lemos,Manoel Victor Franco.
Salmonella enterica serovar Typhimurium synthesizes cobalamin (vitamin B12) only during anaerobiosis. Two percent of the S. Typhimurium genome is devoted to the synthesis and uptake of vitamin B12 and to B12-dependent reactions. To understand the requirement for cobalamin synthesis better, we constructed mutants of Salmonella serovars Enteritidis and Pullorum that are double-defective in cobalamin biosynthesis (ΔcobSΔcbiA). We compared the virulence of these mutants to that of their respective wild type strains and found no impairment in their ability to cause disease in chickens. We then assessed B12 production in these mutants and their respective wild type strains, as well as in S. Typhimurium ΔcobSΔcbiA, Salmonella Gallinarum ΔcobSΔcbiA, and their...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Salmonella; Cobalamin; Gene deletion; Chickens.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000400024

A defective mutant of Salmonella enterica Serovar Gallinarum in cobalamin biosynthesis is avirulent in chickens
Provedor de dados: 58
Autores: Paiva,Jacqueline Boldrin de; Penha Filho,Rafael Antonio Casarin; Arguello,Yuli Melisa Sierra; Berchieri Junior,Ângelo; Lemos,Manuel Victor Franco; Barrow,Paul A.
Salmonella enterica serovar Gallinarum (SG) is a fowl typhoid agent in chickens and is a severe disease with worldwide economic impact as its mortality may reach up to 80%. It is one of a small group of serovars that typically produces typhoid-like infections in a narrow range of host species and which therefore represents a good model for human typhoid. The survival mechanisms are not considered to be virulent mechanisms but are essential for the life of the bacterium. Mutants of Salmonella Gallinarum containing defective genes, related to cobalamin biosynthesis and which Salmonella spp. has to be produced to survive when it is in an anaerobic environment, were produced in this study. Salmonella Gallinarum is an intracellular parasite. Therefore, this...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Salmonella Gallinarum; Cobalamin biosynthesis; Attenuated strain; CbiA and cobS genes; CbiA; CobS.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000300012