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Data/hora: 11/06/2024 02:35:05

Anticancer and apoptosis-inducing activities of microbial metabolites
Provedor de dados: 69
Autores: Phonnok,Sirinet; Uthaisang-Tanechpongtamb,Wanlaya; Wongsatayanon,Benjamas Thanomsub.
The problems of systemic toxicity and drug resistance in cancer chemotherapy urge the continuing discovery of new anticancer agents. We explored the specific anticancer activity from microbial metabolites to find new lead compound. 394 microbial extracts were evaluated on anti-proliferative activity against 4 cancer cell lines using MTT assay. Of these, 20 samples showed varying degree of cytotoxicity but specifically to the cancer cell lines since the growth of normal cells was not significantly inhibited by 1 mg/ml of each cell extracts. The 4 most potent extracts exhibited strongest growth inhibition to each cancer cell type were selected for further studied. Cell morphological changes such as cell shrinkage, lose of surface contact and blebbing were...
Tipo: Journal article
Palavras-chave: Anticancer; Apoptosis; Bioactive compound; Caspase; Microbial product.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582010000500001