Consulta: creatorFacets:"Pinto,Angelo C."
Registros recuperados: 6
Data/hora: 11/06/2024 14:03:37

Absence of mutagenicity in somatic and germ cells of mice submitted to subchronic treatment with an extract of Croton cajucara Benth. (Euphorbiaceae)
Provedor de dados: 74
Autores: Santos,Fabio V.; Mesquita,Suzana F.P.; Faria,Maria José S.S.; Poersh,Aline; Maciel,Maria Aparecida M.; Pinto,Angelo C.; Morimoto,Helena K.; Cólus,Ilce Mara S.
The plant Croton cajucara Benth. (Euphorbiaceae) is a medicinal plant from the Brazilian Amazon where it is commonly known as sacaca. The principal compound isolated from C. cajucara stem-bark extracts is the clerodane-type diterpene trans-dehydrocrotonin (DCTN) which presents several biological activities, including antiulcerogenic, anti-inflammatory, hypoglycemic, antimutagenic and antitumoral activity. However, few studies have been carried out to evaluate the therapeutic potential of raw C. cajucara extracts. We studied mutagenicity and antimutagenicity effects of C. cajucara methanol extract using the micronucleus assay in bone marrow cells and the dominant lethal assay in mice submitted to subchronic treatments. The blood testosterone levels of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimutagenicity; Mutagenicity; Dominant lethal; Micronucleus; Croton cajucara; Medicinal plant.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100029

Constituintes das sementes de Copaifera officinalis L.
Provedor de dados: 36
Autores: Veiga Junior,Valdir F.; Andrade Junior,Martinho A.; Ferraz,Isolde D. K.; Christo,Herick B.; Pinto,Angelo C.
O gênero Copaifera L. é um dos mais importantes economicamente na Região Amazônica devido, principalmente, à produção dos óleos de copaíba, oléo-resinas com diversas propriedades farmacológicas confirmadas. Apesar disso, os estudos fitoquímicos com as sementes das árvores do gênero Copaifera L.são raros. Copaifera officinalis foi a primeira espécie do gênero Copaifera a ser descrita. Este trabalho descreve a composição dos extratos obtidos em hexano e em acetato de etila das sementes de C. officinalis. No extrato obtido em hexano, a análise por cromatografia em fase gasosa utilizando padrões e através de espectrometria de massas permitiu a identificação de: esqualeno, tetradecano, hexadecano, campesterol, estigmasterol e beta-sitosterol; os ácidos graxos...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Copaifera officinalis L.; Cumarina; Ácidos graxos.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000100015

Anthraquinones from the bark of Senna macranthera
Provedor de dados: 42
Autores: Branco,Alexsandro; Pinto,Angelo C.; Schripsema,Jan; Braz-Filho,Raimundo.
2-acetyl physcion (2-acetyl-1,8-dihydroxy-6-methoxy-3-methyl-9,10-anthraquinone, 2), a rare anthraquinone, was isolated from Senna macranthera var. nervosa (Vogel) H.S. Irwin &amp;amp; Barneby (Fabaceae). The chemical structure was elucidated and all ¹H and 13C NMR chemical shifts were assigned by NMR one- (¹HNMR, {¹H}-13CNMR, and APT-13CNMR) and two (COSY, NOESY, HMQC and HMBC) dimensional of this natural compound. Furthermore, the minor anthraquinones chrysophanol (3), chrysophanol-8-methyl ether (4) and physcion (5) were characterized by GC-MS analysis. The occurrence of the anthraquinones 3-5 confirms that S. macranthera is a typical representative of the genus Senna.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anthraquinone; 2-acetyl-physcion; Fabaceae; Senna acranthera.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000400003

Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures
Provedor de dados: 42
Autores: Vieira,Ivo J.C.; Medeiros,Walter L.B.; Monnerat,Cecilia S.; Souza,Jucimar J.; Mathias,Leda; Braz-Filho,Raimundo; Pinto,Angelo C.; Sousa,Priscila M.; Rezende,Claudia M.; Epifanio,Rosângela De A.
The pharmacotherapyfor Alzheimer's disease (AD) includes the use of acetylcholinesterase inhibitors (AChEI). Recent investigations for novel AD therapeutic agents from plants suggested that Tabernaemontana genus is a promising source of novel anticholinesterasic indole alkaloids. In this work two fast screening techniques were combined in order to easily identify novel cholinesterase inhibitors (ChEI). Gas chromatography-mass spectrometry (GC-MS) of the less polar alkaloidic fractions obtained from the acid-base extraction of the stalk of T. laeta revealed thirteen monoindole alkaloids, four of them confirmed by co-injection with previously isolated alkaloids. The others were tentatively identified by mass fragmentation analysis. By gas chromatography with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tabernaemontana; Indole alkaloids; Cholinesterase inhibitor; Thin-layer chromatography assay; Ellman´s method; GC-MS.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000300003

Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives
Provedor de dados: 42
Autores: Camara,Celso A.; Silva,Tania M.S.; da-Silva,Thiago G.; Martins,Rodrigo M.; Barbosa,Ticiano P.; Pinto,Angelo C.; Vargas,Maria D.
The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 µg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biomphalaria glabrata Artemia salina toxicity quinones schistosomiasis molluscicidal activity lawsone 1; 4-naphthoquinone.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200011

Chemical constituents from Vellozia graminifolia (Velloziaceae)
Provedor de dados: 42
Autores: Branco,Alexsandro; Pinto,Angelo C.; Braz Filho,Raimundo.
From the hexane and ethyl acetate extracts obtained from stems, roots and leaf sheaths of Vellozia graminifolia, a mixture of linear hydrocarbons, a mixture of pentacyclic triterpenes, five monoisoprenylated flavonoids and one labdane diterpene, (-)-ent-3beta-hydroxy-8(17)-labden-15-oic acid, were isolated. The linear hydrocarbons and minor triterpenes were identified in their corresponding mixtures by High Resolution Gas Chromatography (HRGC) and HRGC coupled to mass spectrometry. The major pentacyclic triterpenes and the diterpene were characterized by spectral data, including 2D NMR experiments, and chemical transformations.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vellozia graminifolia; Velloziaceae; Triterpenes; Diterpene; Flavonoids.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000300005