Consulta: creatorFacets:"Ramos,E.R.P."
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Data/hora: 05/06/2024 19:01:03

4-Aminopyridine inhibits the neuromuscular effects of nitric oxide and 8-Br-cGMP
Provedor de dados: 56
Autores: Queiroz,R.N.; Ramos,E.R.P.; Alves-Do-Prado,W.
The effects induced by nitric oxide (NO) in different tissues depend on direct and/or indirect interactions with K+ channels. The indirect interaction of NO is produced by activation of guanylyl cyclase which increases the intracellular cGMP. Since NO, cGMP and 4-aminopyridine alone induce tetanic fade and increase amplitude of muscular contractions in isolated rat neuromuscular preparations, the present study was undertaken to determine whether or not the neuromuscular effects of NO and 8-Br-cGMP can be modified by 4-aminopyridine. Using the phrenic nerve and diaphragm muscle isolated from male Wistar rats (200-250 g), we observed that L-arginine (4.7 mM) and 8-Br-cGMP (18 µM), in contrast to D-arginine, induced an increase in the amplitude of muscle...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: L-arginine; Nitric oxide; CGMP; Skeletal muscle; Tetanic fade; K+ channel.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700016