Consulta: creatorFacets:"Resende,Jarbas Magalhães"
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Data/hora: 15/06/2024 17:22:04

Synthesis and antimicrobial evaluation of two peptide LyeTx I derivatives modified with the chelating agent HYNIC for radiolabeling with technetium-99m
Provedor de dados: 80
Autores: Fuscaldi,Leonardo Lima; Santos,Daniel Moreira dos; Pinheiro,Natália Gabriela Silva; Araújo,Raquel Silva; Barros,André Luís Branco de; Resende,Jarbas Magalhães; Fernandes,Simone Odília Antunes; Lima,Maria Elena de; Cardoso,Valbert Nascimento.
Abstract  Background  Current diagnostic methods and imaging techniques are not able to differentiate septic and aseptic inflammation. Thus, reliable methods are sought to provide this distinction and scintigraphic imaging is an interesting option, since it is based on physiological changes. In this context, radiolabeled antimicrobial peptides have been investigated as they accumulate in infectious sites instead of aseptic inflammation. The peptide LyeTx I, from the venom of Lycosa erythrognatha, has potent antimicrobial activity. Therefore, this study aimed to synthesize LyeTx I derivatives with the chelating compound HYNIC, to evaluate their antimicrobial activity and to radiolabel them with 99mTc.  Methods  Two LyeTx I derivatives, HYNIC-LyeTx I...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Septic and aseptic inflammation; Differential diagnosis; Antimicrobial peptides LyeTx I derivatives; MALDI-ToF-MS RP-HPLC; Technetium-99m; HYNIC EDDA Tricine.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100312