Consulta: creatorFacets:"Rocco,Patricia R.M."
Registros recuperados: 3
Data/hora: 02/06/2024 00:57:26

The extracellular matrix of the lung and its role in edema formation
Provedor de dados: 42
Autores: Pelosi,Paolo; Rocco,Patricia R.M.; Negrini,Daniela; Passi,Alberto.
The extracellular matrix is composed of a three-dimensional fiber mesh filled with different macromolecules such as: collagen (mainly type I and III), elastin, glycosaminoglycans, and proteoglycans. In the lung, the extracellular matrix has several functions which provide: 1) mechanical tensile and compressive strength and elasticity, 2) low mechanical tissue compliance contributing to the maintenance of normal interstitial fluid dynamics, 3) low resistive pathway for an effective gas exchange, d) control of cell behavior by the binding of growth factors, chemokines, cytokines and the interaction with cell-surface receptors, and e) tissue repair and remodeling. Fragmentation and disorganization of extracellular matrix components comprises the protective...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Collagen; Glycosaminoglycans; Proteoglycan; Interstitial pressure.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000200010

Understanding the mechanisms of glutamine action in critically ill patients
Provedor de dados: 42
Autores: Oliveira,Gisele P.; Dias,Cristina M.; Pelosi,Paolo; Rocco,Patricia R.M.
Glutamine (Gln) is an important energy source and has been used as a supplementary energy substrate. Furthermore, Gln is an essential component for numerous metabolic functions, including acid-base homeostasis, gluconeogenesis, nitrogen transport and synthesis of proteins and nucleic acids. Therefore, glutamine plays a significant role in cell homeostasis and organ metabolism. This article aims to review the mechanisms of glutamine action during severe illnesses. In critically ill patients, the increase in mortality was associated with a decreased plasma Gln concentration. During catabolic stress, Gln consumption rate exceeds the supply, and both plasma and skeletal muscle pools of free Gln are severely reduced. The dose and route of Gln administration...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heat shock protein; Apoptosis; Cytokines; Glutamine.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000200018

Elastase-induced pulmonary emphysema: insights from experimental models
Provedor de dados: 42
Autores: Antunes,Mariana A.; Rocco,Patricia R.M.
Several distinct stimuli can be used to reproduce histological and functional features of human emphysema, a leading cause of disability and death. Since cigarette smoke is the main cause of emphysema in humans, experimental researches have attempted to reproduce this situation. However, this is an expensive and cumbersome method of emphysema induction, and simpler, more efficacious alternatives have been sought. Among these approaches, elastolytic enzymes have been widely used to reproduce some characteristics of human cigarette smoke-induced disease, such as: augmentation of airspaces, inflammatory cell influx into the lungs, and systemic inflammation. Nevertheless, the use of elastase-induced emphysema models is still controversial, since the disease...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic obstructive pulonary disease; Elastase; Ephysea; Experiental odel; Soke.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000400025