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Olfactory deficit as a result of clozapine withdrawal syndrome in an animal model of schizophrenia: preliminary results
Provedor de dados: 42
Autores: PACHECO,FELIPE D.; SILVA,MAURICIO L. DA; BATISTA,GRAZIELA; SANTOS,WITÓRIA; CASTRO,ADALBERTO A. DE; CANEVER,LARA; ZUGNO,ALEXANDRA I.
ABSTRACT Clozapine is an antipsychotic that produces serious withdrawal effects in schizophrenic patients. Olfactory deficits are well known as part of negative symptoms, but it is not known whether antipsychotic use and/or withdrawal are implicated. Then, we tested clozapine withdrawal in association with two widely used schizophrenia models: Neonatal immune challenge by Polycitidilic-polyinosinic acid (polyI:C) and ketamine. PolyI:C (or saline) was injected subcutaneously in neonatal period, dose of 5 mg/kg from 2 to 6 Post Natal Days, and ketamine or saline at the dose 25mg/kg intraperitoneally (i.p.), daily for 7 days from 53 to 60 post natal day. Clozapine 10mg/kg (or saline) was administered i.p. from 46 to 60 post natal day. Olfactory discrimination...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Olfactory deficit; Clozapine; Schizophrenia; Animal model.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000401659