Consulta: creatorFacets:"Sapienza,Marcelo Tatit"
Registros recuperados: 1
Data/hora: 06/06/2024 01:02:33

Preparation and evaluation of modified composition for lyophilized kits of [Cu(MIBI)4]BF4 for [99mTc] technetium labeling
Provedor de dados: 52
Autores: Lima,Marisa de Jesus de C.; Marques,Fabio Luiz Navarro; Okamoto,Miriam Roseli Yoshie; Garcez,Alexandre Tales; Sapienza,Marcelo Tatit; Buchpiguel,Carlos Alberto.
The [Cu(MIBI)4]BF4 complex was synthesized and different formulations for lyophilized kits that could be cost-effectively used with different routines in nuclear medicine laboratories were investigated. In one preparation the kit components were kept similar to the Cardiolite® , except that the SnCl2.2H2O concentration was increased to 0.150 mg. In a second formulation, component concentrations were reduced to 1/5 of the original value and the SnCl2.2H2O concentration was adjusted to 0.04 mg. These products were labeled with maximum activities of 55.5 GBq and 8.14 GBq, respectively, and have shown an average radiochemical purity of 95 %. Biodistribution of the products was assessed by dissection in mice and in rabbits, and did not show any statistical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: [99mTc]technetium; [[99mTc](MIBI)6]+; Radiopharmaceutical; Biodistribution.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700001