Consulta: creatorFacets:"Shinde,Ravikumar Bapurao"
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Data/hora: 17/06/2024 15:35:16

Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles
Provedor de dados: 55
Autores: Shinde,Ravikumar Bapurao; Raut,Jayant Shankar; Chauhan,Nitin Mahendra; Karuppayil,Sankunny Mohan.
Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, voriconazole, amphotericin B, and caspofungin, was explored against biofilms of C. albicans. Activity of various concentrations of chloroquine in combination with a particular antifungal drug was analyzed in a checkerboard format. Growth of biofilm in presence of drugs was analyzed by XTT-assay, in terms of relative metabolic activity compared to that of drug free control. Results obtained by XTT-metabolic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antifungal; Biofilm; Candida albicans; Combination; Chloroquine; Drug resistance.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400002