Consulta: creatorFacets:"Silva,Roseane Pereira da"
Registros recuperados: 2
Data/hora: 05/06/2024 11:09:51

Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats
Provedor de dados: 52
Autores: Barbosa,Vanessa Santos de Arruda; Holanda,Maria de Carvalho Xavier; Silva,Roseane Pereira da; Oliveira,Daniel Pereira de; Silva Júnior,Maurício Ferreira da; Oliveira,Elias Herculano de; Spyrides,Maria Helena Constantino; Medeiros,Aldo Cunha.
Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiparasite; Radiopharmaceutical; Technetium-99m; Benznidazole; Biodistribution; Trypanosoma cruzi.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700028

Effect of medicinal plants on the parasitemia of Trypanosoma cruzi and on the biodistribution of sodium pertechnetate (Na99mTcO4)
Provedor de dados: 52
Autores: Silva,Roseane Pereira da; Holanda,Cecília Maria de Carvalho Xavier; Barbosa,Vanessa Santos de Arruda; Oliveira,Daniel Pereira de; Lima,Natália Alves; Câmara,Antônia Cláudia Jácome da; Medeiros,Aldo da Cunha; Constantino,Maria Helena Spyrides.
Artemisia vulgaris (AV) is an antihelmintic and antimalarial drug; Aloe vera(babosa) acts as antidiabetic, laxative and anti-inflammatory;Benznidazole (BZ) is a trypanocidal of Trypanosoma cruzi (TC). Technetium-99m (99mTc) has been used in nuclear medicine to obtain diagnostic images. This study evaluated the plant effects in TC parasitemia and on the biodistribution of 99mTc in mice. Twenty mice were infected by TC. At the peak of parasitemia, 5 mice received babosa; 5 received AV and 5 received BZ. The parasitemia was determined at 0, 2, 4 and 6 h of drugs administration. Five infected mice without drugs, 5 mice without TC and the group treated with AV, received 99mTc. The radioactivity was calculated. Infected mice that received babosa reduced...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aloe vera; Artemisia vulgaris; Technetium-99m; Trypanosoma cruzi; Parasitemia; Biodistribution.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700034