Consulta: creatorFacets:"Soares,F.A."
Registros recuperados: 6
Data/hora: 01/06/2024 00:45:00

Índice gonadossomático e correlações entre dimensões e peso testiculares na codorna japonesa (Coturnix coturnix japonica) aos 60 dias de idade
Provedor de dados: 45
Autores: Lanna,L.L.; Soares,F.A.; Santos,T.M.; Oliveira,J.N.; Marques-Júnior,A.P.
As dimensões e o peso testicular foram avaliados em 25 machos adultos de codornas japonesas (Coturnix coturnix japonica) e correlacionados entre si, a fim de se buscar obter informações que possibilitem a criação de um parâmetro preditivo da capacidade de produção espermática. As aves foram abatidas e os testículos removidos para mensuração e pesagem. As dimensões e o peso entre os testículos esquerdo e direito foram comparados. Os parâmetros testiculares foram correlacionados entre si por meio da determinação do coeficiente de correlação linear. O índice gonadossomático também foi determinado, indicando alocação de 3,68% do peso corporal em testículos nos machos avaliados, resultado maior do que os descritos na literatura. Apesar da diferença de formato...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dimensões testiculares; Peso testicular; Índice gonadossomático; Codorna japonesa.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352013000400003

Role of the extracellular matrix in variations of invasive pathways in lung cancers
Provedor de dados: 56
Autores: de Sá,V.K.; Carvalho,L.; Gomes,A.; Alarcão,A.; Silva,M.R.; Couceiro,P.; Sousa,V.; Soares,F.A.; Capelozzi,V.L.
Among the most common features of highly invasive tumors, such as lung adenocarcinomas (AD) and squamous cell carcinomas (SqCC), is the massive degradation of the extracellular matrix. The remarkable qualitative and quantitative modifications of hyaluronidases (HAases), hyaluronan synthases (HAS), E-cadherin adhesion molecules, and the transforming growth factor β (TGF-β) may favor invasion, cellular motility, and proliferation. We examined HAase proteins (Hyal), HAS, E-cadherin, and TGF-β profiles in lung AD subtypes and SqCC obtained from smokers and non-smokers. Fifty-six patients, median age 64 years, who underwent lobectomy for AD (N = 31) and SqCC (N = 25) were included in the study. HAS-1, -2 and -3, and Hyal-1 and -3 were significantly more...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lung cancer E-cadherin TGF-β HAS-1; HAS-2 and HAS-3 Hyal-1 and Hyal-3 Immunohistochemistry Prognosis and morphometry.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000100021

Sentinel node biopsy in breast cancer: results in a large series
Provedor de dados: 56
Autores: Carvalho,S.M.T.; Mourão Netto,M.; Lima,E.N.P.; Pimentel,A.M.; Makdissi,F.B.; Osório,C.A.B.T.; Maciel,M.S.; Iyeyasu,H.; Collins,J.B.; Fontes,C.M.; Perina,A.L.; Soares,F.A.
Sentinel lymph node biopsy (SLNB) is an appropriate method for the evaluation of axillary status in cases of early breast cancer. We report our experience in treating cases evaluated using SLNB. We analyzed a total of 1192 cases assessed by means of SLNB from July 1999 to December 2007. SLNB processing was successfully completed in 1154 cases with the use of blue dye or radiolabeled 99mTc-Dextran-500, or both. Of these 1154 patients, 857 were N0(i-) (no regional lymph node metastasis, negative immunohistochemistry, IHC), 96 were N0(i+) (no regional lymph node metastasis histologically, positive IHC, no IHC cluster greater than 0.2 mm) and 201 were N1mi (greater than 0.2 mm, none greater than 2.0 mm). Most of the tumors (70%) were invasive ductal carcinomas...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Breast neoplasms; Sentinel lymph node; Sentinel lymph node biopsy; Completion axillary dissection.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000600011

Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis
Provedor de dados: 56
Autores: Sá,V.K. de; Rocha,T.P.; Moreira,AL.; Soares,F.A.; Takagaki,T.; Carvalho,L.; Nicholson,A.G.; Capelozzi,V.L.
We collected a series of 136 lung/bronchial and 56 matched lung parenchyma tissue samples from patients who underwent lung/bronchial biopsies and presented invasive carcinoma after lung surgery. The lung/bronchial samples included basal cell hyperplasia, squamous metaplasia, moderate dysplasia, adenomatous hyperplasia, severe dysplasia, squamous cell carcinoma and adenocarcinoma. Matched lung parenchyma tissue samples included 25 squamous cell carcinomas and 31 adenocarcinomas. Immunohistochemistry was performed to analyze for the distribution of hyaluronidase (Hyal)-1 and −3, and hyaluronan synthases (HAS)-1, −2, and −3. Hyal-1 showed significantly higher expression in basal cell hyperplasia than in moderate dysplasia (P=0.01), atypical adenomatous...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hyaluronidases and hyaluronan synthases; Lung cancer; Pre-neoplastic lung/bronchial lesions; Immunohistochemistry; Morphometry; Prognosis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001101039

p16 (INK4a) has clinicopathological and prognostic impact on oropharynx and larynx squamous cell carcinoma
Provedor de dados: 56
Autores: Silva,S.D.; Nonogaki,S.; Soares,F.A.; Kowalski,L.P.
CDKN2A encodes proteins such as p16 (INK4a), which negatively regulate the cell-cycle. Molecular genetic studies have revealed that deletions in CDKN2A occur frequently in cancer. Although p16 (INK4a) may be involved in tumor progression, the clinical impact and prognostic implications in head and neck squamous cell carcinoma (HNSCC) are controversial. The objective of this study was to evaluate the frequency of the immunohistochemical expression of p16 (INK4a) in 40 oropharynx and 35 larynx from HNSCC patients treated in a single institution and followed-up at least for 10 years in order to explore potential associations with clinicopathological outcomes and prognostic implications. Forty cases (53.3%) were positive for p16 (INK4a) and this expression was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Head and neck cancer; Squamous cell carcinoma; Prognostic value; P16.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200032

p53 immunostaining is correlated with reduced survival and is not correlated with gene mutations in resected pulmonary large cell carcinomas
Provedor de dados: 56
Autores: Massoni Neto,L.M.; Bianchi,C.P.; Ab'Saber,A.M.; Parra,E.R.; Takagaki,T.; Pereira,J.C.; Soares,F.A.; Leite,K.; Capelozzi,V.L.
Malignancy of pulmonary large cell carcinomas (LCC) increases from classic LCC through LCC with neuroendocrine morphology (LCCNM) to large cell neuroendocrine carcinomas (LCNEC). However, the histological classification has sometimes proved to be difficult. Because the malignancy of LCC is highly dependent on proteins with functions in the cell cycle, DNA repair, and apoptosis, p53 has been targeted as a potentially useful biological marker. p53 mutations in lung cancers have been shown to result in expression and protein expression also occurs in the absence of mutations. To validate the importance of both p53 protein expression (by immunostaining) and p53 gene mutations in lung LCC (by PCR-single strand conformational polymorphism analysis of exons 5, 6,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Large cell carcinoma; P53; Genetics; Molecular biology; Lung cancer; Mutation analysis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800004