Consulta: creatorFacets:"Webster, Bonnie L."
Registros recuperados: 2
Data/hora: 06/06/2024 13:06:49

Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages
Provedor de dados: 5
Autores: Rey, Olivier; Toulza, Eve; Chaparro, Cristian; Allienne, Jean-françois; Kincaid-smith, Julien; Mathieu-begné, Eglantine; Allan, Fiona; Rollinson, David; Webster, Bonnie L.; Boissier, Jérôme.
Hybridization is a fascinating evolutionary phenomenon that raises the question of how species maintain their integrity. Inter-species hybridization occurs between certain Schistosoma species that can cause important public health and veterinary issues. In particular hybrids between Schistosoma haematobium and S. bovis associated with humans and animals respectively are frequently identified in Africa. Recent genomic evidence indicates that some S. haematobium populations show signatures of genomic introgression from S. bovis. Here, we conducted a genomic comparative study and investigated the genomic relationships between S. haematobium, S. bovis and their hybrids using 19 isolates originating from a wide geographical range over Africa, including samples...
Tipo: Text
Ano: 2021
URL: https://archimer.ifremer.fr/doc/00678/79020/81421.pdf

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment
Provedor de dados: 5
Autores: Chevalier, Frederic D.; Le Clec'H, Winka; Mcdew-white, Marina; Menon, Vinay; Guzman, Meghan A.; Holloway, Stephen P.; Cao, Xiaohang; Taylor, Alexander B.; Kinung'Hi, Safari; Gouvras, Anouk N.; Webster, Bonnie L.; Webster, Joanne P.; Emery, Aidan M.; Rollinson, David; Garba Djirmay, Amadou; Al Mashikhi, Khalid M.; Al Yafae, Salem; Idris, Mohamed A.; Mone, Helene; Mouahid, Gabriel; Hart, P. John; Loverde, Philip T.; Anderson, Timothy J. C.
Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution of drug resistance. We provide evidence that alleles conferring resistance to oxamniquine (OXA), an antischistosomal drug, are widespread in natural parasite populations under minimal drug pressure and predate OXA deployment. OXA has been used since the 1970s to treat Schistosoma mansoni infections in the New World where S. mansoni established during the slave trade. Recessive loss-of-function mutations within a parasite sulfotransferase (SmSULT-OR) underlie resistance, and several verified resistance...
Tipo: Text
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00659/77118/78534.pdf