Consulta: creatorFacets:"Wu,Jianhua"
Registros recuperados: 2
Data/hora: 05/06/2024 18:15:50

Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China
Provedor de dados: 55
Autores: Zhao,Youyun; Wu,Jianhua; Sun,Lijun; Liu,Guangzhong; Li,Bo; Zheng,Yi; Li,Xiaodong; Tao,Junxiu.
Abstract  Objective There are a lot of disagreements in the studies on hepatitis B virus (HBV) DNA polymerase mutation rate associated with nucleos(t)ide analogues (NAs) in treatment-naive chronic hepatitis B (CHB) patients. This is the first study aimed to investigate the prevalence of spontaneous HBV resistance mutations in Central China.  Methods This study included treatment-naive patients with CHB from June 2012 to May 2015 receiving care at the Institute of Liver Disease in Central China. All patients completed a questionnaire covering different aspects, such as family medical history, course of liver disease, medication history, alcohol use, among others. Mutations in HBV DNA polymerase associated with NAs resistance were detected using INNO-LiPA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Chronic hepatitis B; Viral resistance mutations.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200173

2-Methyl 2-butanol suppresses human retinoblastoma cells through cell cycle arrest and autophagy
Provedor de dados: 56
Autores: Li,Xiangyun; Zhu,Xiangxiang; Xu,Chong; Wu,Jianhua.
2-Methyl-2-butanol (MBT) is a chemical compound from the group of alcohols more specifically pentanols, which has shown an excellent anti-cancer activity in our previous study. However, its mechanism of action remains unclear. The present study was designed to investigate the anti-cancer effect of MBT on human retinoblastoma cells. The results showed that the use of MBT leads to HXO-RB44 cell death but is cytotoxic to normal cells at higher concentrations. It showed a dose- as well as a time-dependent inhibition of HXO-RB44 cells. P27 is a cell cycle inhibitory protein, which plays an important role in cell cycle regulation whereas cyclin-B1 is a regulatory protein involved in mitosis. MBT increased the cell cycle arrest in a dose-dependent manner by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: 2-methyl-2-butanol; Retinoblastoma; Cell cycle arrest; Autophagy; Phosphoinositide 3-kinase (PI3K)/Akt.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500605