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4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
Provedor de dados: 80
Autores: Rodrigues,Carina Agostinho; Santos,Paloma Freire dos; Costa,Marcela Oliveira Legramanti da; Pavani,Thais Fernanda Amorim; Xander,Patrícia; Geraldo,Mariana Marques; Mengarda,Ana; Moraes,Josué de; Rando,Daniela Gonçales Galasse.
Abstract  Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological screening of eight 4-phenyl-1,3-thiazol-2-amines assayed against Leishmania amazonensis. Herein we propose that these compounds are good starting points for the search of new antileishmanial drugs by demonstrating some of the structural aspects which could interfere with the observed activity, as well as suggesting potential macromolecular targets.  Methods: The compounds were easily synthesized by the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: 2-aminothiazoles; Antikinetoplastids; Antileishmanial; Cutaneous; Target fishing.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100317