Consulta: creatorFacets:"Zin,W.A."
Registros recuperados: 9
Data/hora: 01/06/2024 08:24:20

Corticosteroids in acute respiratory distress syndrome
Provedor de dados: 56
Autores: Fernandes,A.B.S.; Zin,W.A.; Rocco,P.R.M.
Improving the course and outcome of patients with acute respiratory distress syndrome presents a challenge. By understanding the immune status of a patient, physicians can consider manipulating proinflammatory systems more rationally. In this context, corticosteroids could be a therapeutic tool in the armamentarium against acute respiratory distress syndrome. Corticosteroid therapy has been studied in three situations: prevention in high-risk patients, early treatment with high-dose, short-course therapy, and prolonged therapy in unresolving cases. There are differences between the corticosteroid trials of the past and recent trials: today, treatment starts 2-10 days after disease onset in patients that failed to improve; in the past, the corticosteroid...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute respiratory distress syndrome; Collagen; Cytokine; Methylprednisolone; Experimental models; Clinical trials.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200003

Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test
Provedor de dados: 56
Autores: Valença,A.M.; Nardi,A.E.; Nascimento,I.; Zin,W.A.; Versiani,M.
The aim of the present study was to verify the sensitivity to the carbon dioxide (CO2) challenge test of panic disorder (PD) patients with respiratory and nonrespiratory subtypes of the disorder. Our hypothesis is that the respiratory subtype is more sensitive to 35% CO2. Twenty-seven PD subjects with or without agoraphobia were classified into respiratory and nonrespiratory subtypes on the basis of the presence of respiratory symptoms during their panic attacks. The tests were carried out in a double-blind manner using two mixtures: 1) 35% CO2 and 65% O2, and 2) 100% atmospheric compressed air, 20 min apart. The tests were repeated after 2 weeks during which the participants in the study did not receive any psychotropic drugs. At least 15 of 16 (93.7%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CO2; Anxiety; Breathing; Respiration.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700004

Smoking and psychiatric disorders: a comorbidity survey
Provedor de dados: 56
Autores: Lopes,F.L.; Nascimento,I.; Zin,W.A.; Valença,A.M.; Mezzasalma,M.A.; Figueira,I.; Nardi,A.E.
Epidemiological and clinical studies have shown a positive correlation between smoking and psychiatric disorders. To investigate the prevalence of cigarette smoking, 277 psychiatric outpatients with anxiety or depressive disorders (DSM-IV) answered a self-evaluation questionnaire about smoking behavior and were compared with a group of 68 control subjects. The diagnoses (N = 262) were: 30.2% (N = 79) major depressive disorder, 23.3% (N = 61) panic disorder, 15.6% (N = 41) social anxiety disorder, 7.3% (N = 19) other anxiety disorders, and 23.7% (N = 62) comorbidity disorders. Among them, 26.3% (N = 69) were smokers, 23.7% (N = 62) were former smokers and 50.0% (N = 131) were nonsmokers. The prevalence of nicotine dependence among the smokers was 59.0%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Smoking; Panic disorder; Social anxiety disorder; Depression; Depressive disorder.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000800013

Clinical features of panic patients sensitive to hyperventilation or breath-holding methods for inducing panic attacks
Provedor de dados: 56
Autores: Nardi,A.E.; Valença,A.M.; Lopes,F.L.; Nascimento,I.; Mezzasalma,M.A.; Zin,W.A.
Our aim was to compare the clinical features of panic disorder (PD) patients sensitive to hyperventilation or breath-holding methods of inducing panic attacks. Eighty-five PD patients were submitted to both a hyperventilation challenge test and a breath-holding test. They were asked to hyperventilate (30 breaths/min) for 4 min and a week later to hold their breath for as long as possible, four times with a 2-min interval. Anxiety scales were applied before and after the tests. We selected the patients who responded with a panic attack to just one of the tests, i.e., those who had a panic attack after hyperventilating (HPA, N = 24, 16 females, 8 males, mean age ± SD = 38.5 ± 12.7 years) and those who had a panic attack after breath holding (BHPA, N = 20, 11...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anxiety disorder; Challenge tests; Panic disorder; Hyperventilation; Breath holding.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000200013

Hyperventilation in panic disorder patients and healthy first-degree relatives
Provedor de dados: 56
Autores: Nardi,A.E.; Valença,A.M.; Nascimento,I.; Mezzasalma,M.A.; Lopes,F.L.; Zin,W.A.
Our aim was to observe the induction of panic attacks by a hyperventilation challenge test in panic disorder patients (DSM-IV) and their healthy first-degree relatives. We randomly selected 25 panic disorder patients, 31 healthy first-degree relatives of probands with panic disorder and 26 normal volunteers with no family history of panic disorder. All patients had no psychotropic drugs for at least one week. They were induced to hyperventilate (30 breaths/min) for 4 min and anxiety scales were applied before and after the test. A total of 44.0% (N = 11) panic disorder patients, 16.1% (N = 5) of first-degree relatives and 11.5% (N = 3) of control subjects had a panic attack after hyperventilating (chi² = 8.93, d.f. = 2, P = 0.011). In this challenge test...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Panic attacks; Respiration; Anxiety disorder; Ventilation.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100009

Understanding the mechanisms of lung mechanical stress
Provedor de dados: 56
Autores: Garcia,C.S.N.B.; Prota,L.F.M.; Morales,M.M.; Romero,P.V.; Zin,W.A.; Rocco,P.R.M.
Physical forces affect both the function and phenotype of cells in the lung. Bronchial, alveolar, and other parenchymal cells, as well as fibroblasts and macrophages, are normally subjected to a variety of passive and active mechanical forces associated with lung inflation and vascular perfusion as a result of the dynamic nature of lung function. These forces include changes in stress (force per unit area) or strain (any forced change in length in relation to the initial length) and shear stress (the stress component parallel to a given surface). The responses of cells to mechanical forces are the result of the cell's ability to sense and transduce these stimuli into intracellular signaling pathways able to communicate the information to its interior. This...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mechanical forces; Mechanosensors; Mechanotransduction; Cell-cell interactions; Cytokines; Extracellular matrix.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600001

Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats
Provedor de dados: 56
Autores: Alves-Neto,O.; Tavares,P.; Rocco,P.R.M.; Zin,W.A.
Ketamine is believed to reduce airway and pulmonary tissue resistance. The aim of the present study was to determine the effects of ketamine on the resistive, elastic and viscoelastic/inhomogeneous mechanical properties of the respiratory system, lungs and chest wall, and to relate the mechanical data to findings from histological lung analysis in normal animals. Fifteen adult male Wistar rats were assigned randomly to two groups: control (N = 7) and ketamine (N = 8). All animals were sedated (diazepam, 5 mg, ip) and anesthetized with pentobarbital sodium (20 mg/kg, ip) or ketamine (30 mg/kg, ip). The rats were paralyzed and ventilated mechanically. Ketamine increased lung viscoelastic/inhomogeneous pressure (26%) compared to the control group. Dynamic and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ketamine; Elastance; Lung tissue; Resistive pressure; Viscoelasticity; Rat.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000900016

Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma
Provedor de dados: 56
Autores: Campos,H.S.; Xisto,D.G.; Oliveira,M.B.G.; Teixeira,I.; Negri,E.M.; Mauad,T.; Carnielli,D.; Lima,L.M.; Barreiro,E.J.; Faffe,D.S.; Zin,W.A.; Lapa e Silva,J.R.; Rocco,P.R.M.
The aim of the present study was to compare the efficacy of a novel phosphodiesterase 4 and 5 inhibitor, LASSBio596, with that of dexamethasone in a murine model of chronic asthma. Lung mechanics (airway resistance, viscoelastic pressure, and static elastance), histology, and airway and lung parenchyma remodeling (quantitative analysis of collagen and elastic fiber) were analyzed. Thirty-three BALB/c mice were randomly assigned to four groups. In the asthma group (N = 9), mice were immunized with 10 µg ovalbumin (OVA, ip) on 7 alternate days, and after day 40 they were challenged with three intratracheal instillations of 20 µg OVA at 3-day intervals. Control mice (N = 8) received saline under the same protocol. In the dexamethasone (N = 8) and LASSBio596...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Asthma; Lung function; Steroid; Phosphodiesterase inhibitors; BALB/c mice.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200016

Toxicity of a cyanobacterial extract containing microcystins to mouse lungs
Provedor de dados: 56
Autores: Picanço,M.R.; Soares,R.M.; Cagido,V.R.; Azevedo,S.M.F.O.; Rocco,P.R.M.; Zin,W.A.
Toxic cyanobacteria in drinking water supplies can cause serious public health problems. In the present study we analyzed the time course of changes in lung histology in young and adult male Swiss mice injected intraperitoneally (ip) with a cyanobacterial extract containing the hepatotoxic microcystins. Microcystins are cyclical heptapeptides quantified by ELISA method. Ninety mice were divided into two groups. Group C received an injection of saline (300 µl, ip) and group Ci received a sublethal dose of microcystins (48.2 µg/kg, ip). Mice of the Ci group were further divided into young (4 weeks old) and adult (12 weeks old) animals. At 2 and 8 h and at 1, 2, 3, and 4 days after the injection of the toxic cyanobacterial extract, the mice were anesthetized...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Microcystins; Lung; Inflammation; Alveolar collapse.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800013