Consulta: creatorFacets:"de la Fuente-Juárez,Graciela"
Registros recuperados: 3
Data/hora: 02/06/2024 05:06:58

Morphological Alterations in Mouse Placenta Induced by Diazepam
Provedor de dados: 77
Autores: Márquez-Orozco,María Cristina; Gasca-Ramírez,María Verónica; de la Fuente-Juárez,Graciela; Márquez-Orozco,Amalia.
Diazepam (DZ) is a benzodiazepine that belongs to the group of minor tranquilizers with myo-relaxing and anticonvulsant properties. DZ and its metabolites cross the placental barrier in human, monkey, hamster, and mouse, and accumulate in the placenta. Our aim was to investigate, through histological techniques, and semifine sections if DZ induces morphological changes in the placenta. Twenty female mice of the ICR strain were distributed randomly in two groups. One group (DZ) was treated from days 6 to 17 of gestation with a single daily subcutaneous (sc) dose of DZ of 2.7 mg/kg/ (bw); the second, control group (C) was treated with saline solution. All females (10 DZ and 10 C) were killed by decapitation. Placentas were extracted and fixed in...
Tipo: Journal article
Palavras-chave: Benzodiazepine; Diazepam; Mouse; Placenta; Histology.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200007

Histological Changes of the Ovary of Adult Mice Exposed Prenatally to Flunitrazepam
Provedor de dados: 77
Autores: Aguirre -Samudio,Ana Julia; de la Fuente-Juárez,Graciela; Márquez-Orozco,Amalia; Márquez-Orozco,María Cristina.
Flunitrazepam (FNZ) is a minor tranquillizer involving allosteric modulation of the GABA receptor complex. It is a ligand of the peripheral benzodiazepine receptor (PBR) that participates in cholesterol transport in steroidogenic organs. The purpose was to investigate whether a single oral dose of FNZ of 2.5 mg/kg of body weight (bw), administered on day 6 of gestation, alters the structure of the adult ovary of mouse offsprings at 2 months of age. The mouse offsprings of the in utero FNZ-treated group and those of the control group (C) were killed. Ovaries were obtained in early estrous, fixed in Zenker solution, and processed by routine histological techniques. Serial sections were observed under light microscopy to determine the characteristics and...
Tipo: Journal article
Palavras-chave: Benzodiazepine; Flunitrazepam; Atretic follicles; Corpus luteum; Prenatal exposure.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500022

Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to Diazepam
Provedor de dados: 77
Autores: Márquez-Orozco,María Cristina; de la Fuente-Juárez,Graciela; Márquez-Orozco,Amalia.
Previous research has shown that fetal mice hepatic cells from females treated with diazepam (Valium) during pregnancy depict cytoplasmic and nuclear modifications when observed with photonic microscope. The purpose of this work is to investigate if diazepam administered subcutaneously (SC) to pregnant mice females induces ultraestructural alterations in the cytoplasmic organelles and nucleus to fetal hepatocytes. Transmission electron microscopy observations of fetal hepatocytes from pregnant females treated with a single daily dose of diazepam 2.7 mg/kg/bw/SC administered from 6th to 15th days of gestation revealed that they frequently presented disorganized and dilated rough endoplasmic reticulum cisterns, membranous elements, abundant Golgi complex and...
Tipo: Journal article
Palavras-chave: Benzodiazepines; Diazepam; Fetal hepatocytes; Ultrastructure.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400040