Consulta: subjectFacets:"ACTH"
Registros recuperados: 11
Data/hora: 07/06/2024 08:29:06

Low-dose adrenocorticotropin test in patients with the Acquired Immunodeficiency Syndrome
Provedor de dados: 55
Autores: Wolff,Fernando H.; Nhuch,Claudio; Cadore,Luciana P.; Glitz,Cristina L.; Lhullier,Francisco; Furlanetto,Tania W.
Adrenocortical insufficiency is a serious complication of AIDS. Usually, integrity of the hypothalamo-pituitary-adrenal (HPA) axis in AIDS patients is assessed by measuring basal cortisol levels and cortisol response to 250 mug of ACTH. Recent studies suggest that a lower ACTH dose increases the sensitivity of the procedure. In the present study, we investigated the prevalence of adrenal hypofunction in AIDS patients using a low-dose ACTH test (1 mug), evaluated the clinical characteristics that might suggest this diagnosis, and the diseases and/or drugs that could be associated with it. We prospectively evaluated 63 very ill AIDS patients and 16 normal controls. A standard examination assessed the presence of signs and symptoms of adrenal insufficiency....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Adrenal insufficiency; ACTH; Cortisol.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200002

Atrial natriuretic peptide and feeding activity patterns in rats
Provedor de dados: 56
This review presents historical data about atrial natriuretic peptide (ANP) from its discovery as an atrial natriuretic factor (ANF) to its role as an atrial natriuretic hormone (ANH). As a hormone, ANP can interact with the hypothalamic-pituitary-adrenal axis (HPA-A) and is related to feeding activity patterns in the rat. Food restriction proved to be an interesting model to investigate this relationship. The role of ANP must be understood within a context of peripheral and central interactions involving different peptides and pathways
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Atrial natriuretic peptide; Corticosterone; ACTH; Food restriction.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000400006

Proliferative signaling initiated in ACTH receptors
Provedor de dados: 56
Autores: Lotfi,C.F.P.; Lepique,A.P.; Forti,F.L.; Schwindt,T.T.; Eichler,C.B.; Santos,M.O.; Rebustini,I.T.; Hajj,G.N.M.; Juliano,L.; Armelin,H.A.
This article reviews recent results of studies aiming to elucidate modes of integrating signals initiated in ACTH receptors and FGF2 receptors, within the network system of signal transduction found in Y1 adrenocortical cells. These modes of signal integration should be central to the mechanisms underlying the regulation of the G0-&gt;G1-&gt;S transition in the adrenal cell cycle. FGF2 elicits a strong mitogenic response in G0/G1-arrested Y1 adrenocortical cells, that includes a) rapid and transient activation of extracellular signal-regulated kinases-mitogen-activated protein kinases (ERK-MAPK) (2 to 10 min), b) transcription activation of c-fos, c-jun and c-myc genes (10 to 30 min), c) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ACTH; FGF2; Signal transduction; MAP kinases; Early response genes.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000002

Biosynthesis and metabolism of steroid hormones by human adrenal carcinomas
Provedor de dados: 56
Autores: Brown,J.W.; Fishman,L.M.
Over a 15-year period, our university-based laboratory obtained 125 adrenal tumors, of which 15 (12%) were adrenal cortical carcinomas. Of these, 6 (40% of the carcinomas) occurred in patients with clear clinical manifestations of steroid hormone excess. Adrenal cortical carcinoma cells derived from the surgically resected tumors in 4 of these patients were isolated and established in primary culture. Radiotracer steroid interconversion studies were carried out with these cultures and also on mitochondria isolated from homogenized tissues. Large tumors had the lowest steroidogenic activities per weight, whereas small tumors had more moderately depressed enzyme activities relative to cells from normal glands. In incubations with pregnenolone as substrate, 1...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adrenal carcinoma; Cell culture; Steroids; Metyrapone; Dibutyryl cAMP; ACTH; Krebs cycle intermediates.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000014

Social condition affects hormone secretion and exploratory behavior in rats
Provedor de dados: 56
Autores: Genaro,G.; Schmidek,W.R.; Franci,C.R.
Studies of behavior, endocrinology and physiology have described experiments in which animals housed in groups or in isolation were normally tested individually. The isolation of the animal from its group for testing is perhaps the most common situation used today in experimental procedures, i.e., there is no consideration of the acute stress which occurs when the animal is submitted to a situation different from that it is normally accustomed to, i.e., group living. In the present study, we used 90 male 120-day-old rats (Rattus norvegicus) divided into 5 groups of 18 animals, which were housed 3 per cage, in a total of 6 cages. The animals were tested individually or with their groups for exploratory behavior. Hormones were determined by radioimmunoassay...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Isolation; Group; Stress; Reproduction; ACTH; Luteinizing hormone; Corticosterone; Prolactin.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600008

Food and the circadian activity of the hypothalamic-pituitary-adrenal axis
Provedor de dados: 56
Autores: Leal,A.M.O.; Moreira,A.C.
Temporal organization is an important feature of biological systems and its main function is to facilitate adaptation of the organism to the environment. The daily variation of biological variables arises from an internal time-keeping system. The major action of the environment is to synchronize the internal clock to a period of exactly 24 h. The light-dark cycle, food ingestion, barometric pressure, acoustic stimuli, scents and social cues have been mentioned as synchronizers or" zeitgebers". The circadian rhythmicity of plasma corticosteroids has been well characterized in man and in rats and evidence has been accumulated showing daily rhythmicity at every level of the hypothalamic-pituitary-adrenal (HPA) axis. Studies of restricted feeding in rats are...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Feeding; Glucocorticoids; CRH; ACTH; Circadian rhythm.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200003

Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
Provedor de dados: 56
Autores: Armelin,H.A.; Lotfi,C.F.P.
FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adrenocortical cell cycle; ACTH; FGF2; ERK-MAPK; C-fos proto-oncogene.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700007

Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection
Provedor de dados: 56
Autores: McCann,S.M.; Antunes-Rodrigues,J.; Franci,C.R.; Anselmo-Franci,J.A.; Karanth,S.; Rettori,V.
The release of adrenocorticotropin (ACTH) from the corticotrophs is controlled principally by vasopressin and corticotropin-releasing hormone (CRH). Oxytocin may augment the release of ACTH under certain conditions, whereas atrial natriuretic peptide acts as a corticotropin release-inhibiting factor to inhibit ACTH release by direct action on the pituitary. Glucocorticoids act on their receptors within the hypothalamus and anterior pituitary gland to suppress the release of vasopressin and CRH and the release of ACTH in response to these neuropeptides. CRH neurons in the paraventricular nucleus also project to the cerebral cortex and subcortical regions and to the locus ceruleus (LC) in the brain stem. Cortical influences via the limbic system and possibly...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Corticotropin-releasing hormone (CRH); Vasopressin; Oxytocin; Atrial natriuretic peptide (ANP); ACTH; Cortisol; Norepinephrine; Acetyl choline; Nitric oxide.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000001

Aversive stimulation during the stress-hyporesponsive period does not affect the number of corticotroph cells in neonatal male rats
Provedor de dados: 56
Autores: Aguiar,C.E.; Cadore,L.P.; Padoin,M.J.; Barbosa-Coutinho,L.M.; Lucion,A.B.
Immunohistochemistry was used to evaluate the effects of neonatal handling and aversive stimulation during the first 10 days of life on the number of corticotrophs in the anterior lobe of the pituitary of 11-day-old male Wistar rats. Since adult rats handled during infancy respond with reduced corticosterone secretion in response to stressors and with less behavior inhibition in novel environments, we assumed that neonatal stimulation could affect pituitary morphology during this critical period of cell differentiation. Three groups of animals were studied: intact (no manipulation, N = 5), handled (N = 5) and stimulated (submitted to 3 different aversive stimuli, N = 5). The percentage of ACTH-immunoreactive cells in the anterior lobe of the pituitary...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ACTH; Immunohistochemistry; Pituitary; Neonatal handling; Stress.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200013

Release of plasma atrial natriuretic peptide after volume expansion is not related to pituitary-adrenal axis diurnal variation in normal subjects
Provedor de dados: 56
The existence of a circadian rhythm of atrial natriuretic peptide (ANP) in humans is controversial. We studied the plasma ANP response to isotonic blood volume expansion in the morning and in the afternoon and its relationship with adrenocorticotropic hormone (ACTH)-cortisol diurnal variation in seven normal subjects. Basal plasma ANP level was similar in the morning (19.6 ± 2.4 pg/ml) and in the afternoon (21.8 ± 4.8 pg/ml). The ANP peak obtained with saline infusion (0.9% NaCl, 12 ml/kg) in the morning (49.4 ± 8 pg/ml) did not differ from that obtained in the afternoon (60.3 ± 10.1 pg/ml). There was no correlation between the individual mean cortisol and ACTH levels and the ANP peak obtained with saline infusion. These data indicate no diurnal variation...
Palavras-chave: ANP; Diurnal variation; ACTH; Cortisol.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000500008

Características endócrinas, metabólicas e indicadoras da qualidade da carne em bovinos Nelore castrados e não castrados
Provedor de dados: 65
Autores: Silva,Bárbara; Poleti,Mirele Daiana; Moncau,Cristina Tschorny; Rosa,Alessandra Fernandes; Silva,Saulo da Luz e; Balieiro,Júlio César de Carvalho.
O objetivo deste estudo foi avaliar características endócrinas (ACTH e cortisol plasmático), metabólicas (glicogênio e lactato muscular) e indicadoras de qualidade da carne em bovinos Nelore castrados e não castrados. Foram abatidos 130 animais (78 castrados e 52 não castrados), entre os anos de 2009 e 2011. Amostras de sangue foram coletadas, in vivo e post mortem (IV e PM), para mensurações endócrinas. Para os metabólitos, foram coletadas amostras do músculo Longissimus dorsi (LD). Para as análises físico-químicas, três bifes do músculo LD (entre a 10ª e 12ª costelas) foram maturados por um, sete e 14 dias. O pH e a temperatura dos animais foram mensurados a uma e 24 horas PM. As análises estatísticas foram realizadas por meio do procedimento de modelos...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: ACTH; Bovinos de corte; Cortisol; Glicogênio; Lactato.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000500023