Consulta: subjectFacets:"Aging"
Registros recuperados: 83
Data/hora: 06/06/2024 01:15:44

Human aging and somatic point mutations in mtDNA: a comparative study of generational differences (grandparents and grandchildren)
Provedor de dados: 74
Autores: Marinho,Anderson Nonato do Rosário; Moraes,Milene Raiol de; Santos,Sidney; Santos,Ândrea Ribeiro-dos-.
The accumulation of somatic mutations in mtDNA is correlated with aging. In this work, we sought to identify somatic mutations in the HVS-1 region (D-loop) of mtDNA that might be associated with aging. For this, we compared 31 grandmothers (mean age: 63 ± 2.3 years) and their 62 grandchildren (mean age: 15 ± 4.1 years), the offspring of their daughters. Direct DNA sequencing showed that mutations absent in the grandchildren were detected in a presumably homoplasmic state in three grandmothers and in a heteroplasmic state in an additional 13 grandmothers; no mutations were detected in the remaining 15 grandmothers. However, cloning followed by DNA sequencing in 12 grandmothers confirmed homoplasia in only one of the three mutations previously considered to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; MtDNA; Mitochondrial somatic mutations.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100006

Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population
Provedor de dados: 74
Autores: Kim,Hee-Kwon; Jeong,Byung-Hoon.
Abstract The functional variant of the Klotho "KL-VS" stretch, which includes six polymorphisms in linkage disequilibrium, is reportedly associated with healthy aging and longevity in European and American populations. Among Asian populations, this variant has been observed in the Indian population but not in the Iranian population. An association between KL-VS polymorphism and aging has not been reported in Koreans. To investigate whether the KL-VS polymorphism could be associated with healthy aging and longevity in a Korean population, we analyzed genotype and allele frequencies of the KL-VS variant in a large Korean population sample. The KL-VS variant was not found in 874 Korean individuals. Thus, it is not possible to test its association to aging in...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Aging; KLOTHO gene; KL-VS polymorphism; Population genetics.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300370

Influence of water on the short and long term mechanical behaviour of polyamide 6 (nylon) fibres and yarns
Provedor de dados: 5
Autores: Humeau, Corentin; Davies, Peter; Le Gac, Pierre Yves; Jacquemin, Frédéric.
Polyamide fibres are known to be sensitive to water, and this has limited their marine applications. However, their low stiffness and high strength could be attractive for shallow water mooring line ropes, particularly for floating wind turbines. Such applications require the influence of water on mechanical behaviour to be fully understood, and this paper presents results describing how water affects static and creep response of polyamide 6 fibre yarns. First, the effect of water on fibre Tg is quantified, then tensile behaviour is examined. Finally, a model based on Schapery’s non-linear creep analysis is identified for different humidity conditions. The results show that while moisture has a small effect on short-term tensile behaviour, long term...
Tipo: Text
Palavras-chave: Aging; Moisture; Fibre; Creep; Viscoelastic model.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00460/57190/59251.pdf

Influence of Finish Treatment on the Durability of Aramid Fibers Aged Under an Alkaline Environment
Provedor de dados: 5
Autores: Derombise, Guillaume; Van Schoors, Laetitia Vouyovitch; Messou, Marie-fleur; Davies, Peter.
Aramid fibers are high-performance materials which have been used in ropes and protective clothing for many years. They are also now being proposed in geo-textiles for ground reinforcement. The influence of the surface finish composition and content has been studied in the field of cables and textiles, but there is no published data concerning the effect of a finish treatment on the hydrolytic degradation. Aramid fibers with different finish contents have been aged in an alkaline environment. The degradation has been identified by FTIR, viscosimetry, TGA, SEM, and tensile tests. For Technora fibers, the presence of finish appears to limit the tensile strength loss of aramid fibers at pH 11 by limiting abrasion, as well as bulk and surface degradation. For...
Tipo: Text
Palavras-chave: Aramids; Fibers; Aging; Finish; Hydrolysis.
Ano: 2010
URL: http://archimer.ifremer.fr/doc/00006/11702/8987.pdf

Prediction of long term strength of adhesively bonded steel/epoxy joints in sea water
Provedor de dados: 5
Autores: Bordes, Melanie; Davies, Peter; Cognard, J. -y.; Sohier, L.; Sauvant-moynot, V.; Galy, J.
This study is concerned with the development of a tool to predict the long term behaviour of adhesively bonded steel joints aged in sea water. First, diffusion kinetics and the mechanisms governing the degradation of mechanical properties of an epoxy adhesive are described. These two sets of data were used in a Coupled finite element (FE) analysis to determine the stress state in double lap shear (DLS) specimens before and after aging. However, subsequent tests on DLS specimens indicated an adhesive and not cohesive failure mode, so this approach could not be used to predict failure in the present case without introducing an interfacial damage parameter. A second approach was therefore employed, in which modified Arcan samples were designed in order to...
Tipo: Text
Palavras-chave: Coupling; Finite element stress analysis; Aging; Durability.
Ano: 2009
URL: http://archimer.ifremer.fr/doc/2009/publication-6968.pdf

Etude du vieillissement de composites verre resine en milieu marin
Provedor de dados: 5
Autores: Gutierrez, J; Lelay, F; Hoarau, P.
Evolution of glass fibre-resin composites (polyester, epoxy and vinylester) after 30 years in a marine environment has been anticipated by the compilation of the Naval Construction Direction test results. This study showed that 120 degree C epoxy prepreg, in spite of improved initial performance, was more affected by water environment aging than other composites. Post-curing of epoxy and vinylester composites does not significantly improve resistance to water degradation except in the case of high temperature aging (60-70 degree C).
Tipo: Text
Palavras-chave: Ship technology; Age; Aging; Composite materials; Fibre glass; Vieillissement accéléré; Vieillissement naturel; Composite verre résine.
Ano: 1992
URL: http://archimer.ifremer.fr/doc/1992/acte-1056.pdf

Thermoplastic composite cylinders for underwater applications
Provedor de dados: 5
Autores: Davies, Peter; Riou, Luc; Mazeas, Florence; Warnier, Philippe.
A study of thermoplastic matrix composites has been performed to investigate their use in underwater applications such as oceanography, submarine, and sub-sea offshore structures. This article first presents six candidate materials. Results from simple mechanical and seawater aging screening tests on flat specimens are then described. Glass/epoxy and carbon/epoxy composites are used as reference materials. Two materials emerged from this process, glass/PEI and carbon/PEEK. Cylinders of both were manufactured and subjected to hydrostatic pressure tests, and results are compared to those for glass/epoxy and carbon/epoxy cylinders of similar geometry. The carbon/PEEK material appeared most promising. It resisted pressures in excess of 90 MPa and was retained...
Tipo: Text
Palavras-chave: Damage tolerance; Glass/PEI; Carbon/PEEK; Aging; Hydrostatic pressure; Cylinder.
Ano: 2005
URL: http://archimer.ifremer.fr/doc/2005/publication-1037.pdf

Etude du vieillissement de liaisons adhésives en milieu marin pour application offshore
Provedor de dados: 5
Autores: Bordes, Melanie.
This thesis work was performed with a view to offshore applications, and the aim is to improve understanding of the the long term behaviour of adhesive bonding in a marine environment, in order to replace welding by adhesive bonding on offshore platforms. An experimental method has been developed to collect the data required for a numerical model, to predict the life expectancy of adhesively bonded structures. There are several objectives, the first is to understand the mechanisms of failure of adhesively bonded joints and to evaluate the kinetics of their degradation. So, in a first step, the water absorption of bulk adhesives has been studied under different aging conditions, and its influence on the mechanical and physico-chemical properties of the...
Tipo: Text
Palavras-chave: Hydro mechanical modelling; Physico chemical and mechanical properties; Adhesive; Aging; Modélisation hygromécanique; Propriétés physico chimiques et mécaniques; Adhésif; Vieillissement.
Ano: 2009
URL: http://archimer.ifremer.fr/doc/2009/these-6800.pdf

Evaluation of Basalt Fibre Composites for Marine Applications
Provedor de dados: 5
Autores: Davies, Peter; Verbouwe, W.
Basalt fibres offer potential for use in marine structures, but few data exist to evaluate the influence of seawater immersion on their mechanical behaviour. This paper provides the results from a study in which basalt fibre reinforced epoxy composites were aged in natural seawater at different temperatures. Tests were performed under quasi-static and cyclic loading, first in the as-received state then after saturation in natural seawater. Results are compared to those for an E-glass reinforced composite with the same epoxy matrix. They indicate similar mechanical performance for both materials after seawater saturation.
Tipo: Text
Palavras-chave: Seawater; Aging; Fatigue; Basalt fibre; Epoxy; Unidirectional; Flexure.
Ano: 2018
URL: http://archimer.ifremer.fr/doc/00392/50385/51111.pdf

Evolution des propriétés mécaniques de matériaux composites verre/polyester gelcoates en milieu marin
Provedor de dados: 5
Autores: Castaing, P; Tsouvalis, N; Lemoine, Lionel.
Glass-fiber reinforced polyester composites with gelcoat are widely used in nautical construction despite the lack of knowledge concerning their durability when immersed in water. This study deals especially with the influence of the osmotic process of degradation on the evolution of the mechanical properties of orthotropic materials, subjected to accelerated ageing tests. This evolution is experimentally evaluated by performing a non destructive test procedure, the vibrational modal analysis, whose results are additionally confirmed by quasi-static mechanical tests (bending and shear). Although gelcoat blistering has no effect on the mechanical properties of the structure, considerable changes are observed in the elastic moduli and in the ultimate...
Tipo: Text
Palavras-chave: Osmosis; Aging; Mechanical properties; Glass reinforced plastics; Fibre glass; Composite materials; Durabilité; Propriétés mécaniques; Analyse modale; Osmose; Vieillissement; Gelcoat; Polyester; Matériau composite.
Ano: 1992
URL: http://archimer.ifremer.fr/doc/1992/acte-1058.pdf

Age Effect in the Morphological Traits Performance for Sex Determination in Human Skulls and Mandibles
Provedor de dados: 77
Autores: Suazo Galdames,Iván; Zavando,Daniela.
In this study we tested the hypothesis that diagnostic performance of the morphological indicators for sexual dimorphism are reduced as they are applied in skull and mandibles of older subjects. We used 275 adult human skulls, 250 of these with mandible, all subjects with sex and age registry. Sixteen classic morphological indicators of sexual dimorphism were evaluated, this information was compared with the registry and results noted in terms of precision. The best general performance of morphological indicators of sexual dimorphism were recorded in the 31 - 40 and 61 - 70 years, age range groups. Lowest precision ws recorded in the group corresponding to subjects between 21 ­ 30 years. Our results do not support the proposed hypothesis and suggest a...
Tipo: Journal article
Palavras-chave: Sexual dimorphism; Sex determination; Aging; Age; Skull.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100053

Use of Anabolic Steroid Altered the Liver Morphology of Rats
Provedor de dados: 77
Autores: Tanasov,Valéria Simões; Neto,Walter Krause; Gonçalves,Leandro; Maifrino,Laura Beatriz Mesiano; de Sousa,Romeu Rodrigues; Gama,Eliane Florencio.
The aim of this research was to investigate the effect of testosterone propionate administration in the liver of rats. The rats were divided in the following groups: Initial control (SC), Aged control (SE) and Anabolic group (SA). Testosterone propionate was administered three times per week during 16 weeks. Using morphoquantitative techniques, we quantified the volume densities of lobular and non-lobular parenchyma, area and number of nuclei of hepatocytes. The data were analyzed statistically using mean and standard deviation, ANOVA one-way and level of significance about p0.05. Our results showed an increase in capillaries, perisinusoidal spaces and biliary ducts in SE group compared to SC. SA group showed a decrease in hepatic cells, non-lobular volume...
Tipo: Journal article
Palavras-chave: Aging; Testosterone proprionate; Hepatic tissue; Animals.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300002

Sagittal Suture of the Human Cranium and the Time of Closing
Provedor de dados: 77
Autores: Alves,Janice Chaim; Wafae,Gabriela Cavallini; Coelho,Daniela de Paula; Wafae,Nader; Coelho,Viviane de Assis; Pereira,Eduardo; Ruiz,Cristiane Regina.
The observation of the stage of ossification of the sagittal suture has been adopted as possible approach of age evaluation in anthropology and legal medicine, as area of cranial pathologies: craniosynostosis and scaphocephaly and as diagnosis resource in tomographies. Regarding it, we found many controversies in the specialized literature, thus we decided to accomplish this research with the following objectives: to examine the ossification of the external surface of the sagittal suture, observing eventual differences due to age, sex and ethnic group. Our material consists of 88 dry craniums of variable ages, both sexes belonging to the ethnic groups: white and black. In that material we observed that: with progression of age, the relation between age and...
Tipo: Journal article
Palavras-chave: Sutures; Synostosis; Anthropology; Aging.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000200026

Report of the second horse mackerel otolith reading workshop
Provedor de dados: 20
Age estimation of commercially exploited fish species in the Benguella region. Stocks of the two species of horse mackerel that occur in the Benguela region, namely Cape (Trachurus trachurus capensis) and Cunene horse mackerel (Trachurus trecae) are being exposed to increasing levels of commercial exploitation, highlighting the requirement for effective management measures to ensure their sustainable utilization. Such measures can only be implemented with confidence if they are based on reliable stock assessment procedures. Sizestructured stock assessment models have been found to be unsuitable for Southern African horse mackerel stocks, and the decision has recently been made to move to an age-structured VPA approach. A fundamental requirement for this...
Tipo: Report
Palavras-chave: Aging; Aging; Http://aims.fao.org/aos/agrovoc/c_192.
Ano: 2001
URL: http://hdl.handle.net/1834/2758

THE IMPACT OF THE YOUNG-OLD AND THE OLD-OLD ON A SMALL RURAL REGION: AN APPLICATION OF THE WISCONSIN ECONOMIC IMPACT MODELING SYSTEM
Provedor de dados: 31
Autores: Stallmann,   Judith I.; Deller,   Steven C.; Shields,   Martin.
The literature on the economic and fiscal impacts of in-migrating retirees on rural communities concentrates on the young, newly-retired.  An issue not systematically addressed are the impacts on the communities as these retirees age.  The Wisconsin Economic Impact Modeling System, a county level conjoined input-output/econometrics simulation model, is used to assess the impact of an aging rural population.  Using data from the US Bureau of Labor Statistics' Consumer Expenditure Survey, profiles of two household types are constructed and used to simulate the economic impact of an additional 500 elderly households into a small rural economy.  Household types vary by age and, as a result, have different income levels and expenditure patterns.  As...
Tipo: Working or Discussion Paper
Palavras-chave: Aging; Economic impacts; Development policy; Community/Rural/Urban Development.
Ano: 1998
URL: http://purl.umn.edu/23987

Demographic Determinants of Savings: Estimating and Interpreting the Aggregate Association in Asia
Provedor de dados: 31
Autores: Schultz,   T. Paul.
Life cycle savings is proposed as one explanation for much of the increase in savings and economic growth in Asia. The association between the age composition of a nation’s population and its savings rate, observed within 16 Asian countries from 1952 to 1992, is reestimated here to be less than a quarter the size reported in a seminal study, which assumed lagged savings is exogenous. Specification tests as well as common sense imply, moreover, that lagged savings is likely to be endogenous, and when estimated accordingly there remains no significant dependence of savings on the age composition, measured in several ways. Research should consider lifetime savings as a substitute for children, and model the causes for the decline in fertility which changes...
Tipo: Working or Discussion Paper
Palavras-chave: Life cycle savings; Aging; Asian growth; Demographic transition; Financial Economics; D91; J11; O11; O53.
Ano: 2004
URL: http://purl.umn.edu/28409

O ENVELHECIMENTO E AS APOSENTADORIAS NO AMBIENTE RURAL: UM ENFOQUE BIBLIOGRÁFICO
Provedor de dados: 31
Autores: Augusto,   Helder dos Anjos; Ribeiro,   Eduardo Magalhaes.
This article analyzes the effect of the aging and the retirements in the Brazilian rural scene, which is a question of most importance for the current days, since the relative participation of the aging group in the total set of the Brazilian population is increasing. Thus, there exists a concern with the future of the Social Security sot that it must pass through reforms. Hence, the objective of this paper is to raise elements for the discussion on the importance of the social security in the agricultural sector, since it passes through significant demographic changes. With a sufficiently fragmented history, since the years of the Empire, the Social Security has been extending several segments of society, being one of the most important forms of inclusion...
Tipo: Journal Article
Palavras-chave: Aging; Social Security; Rural retirements; Brazil.; Community/Rural/Urban Development; Labor and Human Capital.
Ano: 2005
URL: http://purl.umn.edu/43982

Racial inequalities in the socioeconomic, demographic and health conditions of elderly from Maranhão State, Legal Amazon, Brazil: a population-based study
Provedor de dados: 36
Autores: Oliveira,Bruno Luciano Carneiro Alves de; Silva,Alécia Maria da; Silva,Raimundo Antonio da; Thomaz,Erika Barbara Abreu Fonseca.
Aging with quality of life does not occur equally among the racial groups of Brazilian elderly, and few studies have analyzed this issue in the states of the Brazilian Legal Amazon. The objective of this study was to investigate racial inequalities in the socioeconomic, demographic and health conditions of elderly residents of Maranhão state, Brazil. The present work is a cross-sectional study of 450 elders aged 60 years or older included in the 2008 National Household Sample Survey. The prevalence of socioeconomic, demographic, health and habit indicators and of risk factors were estimated in white, brown and black racial categories that were self-reported by the survey participants. The chi-square test was used for comparisons (a=5%). The majority of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Social inequity; Epidemiology; Indicators; Race or ethnic group distribution.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000300006

Blood pressure, heart rate and its autonomic modulation in malnourished rats at different ages
Provedor de dados: 3
Autores: Sant’Helena, Bruna da Rosa Maggi; Brasileiro-Santos, Maria do Socorro; Falcão, Elis Pereira; Duarte, Denia Palmeira Fittipaldi; Pontes Filho, Nicodemos Telles de; Costa, Carlos Peres da.
Malnutrition is responsible for a number of alterations that occur in the organism, including alterations in the cardiovascular system. We hypothesize that long periods of malnutrition occurring after weaning may also be responsible for alterations in the cardiovascular system. Wistar rats were separated into the two following experimental groups: a labina® diet-fed control group (CG) and a malnourished group (MG), fed a multi-deficient diet. Results showed that the mg presented significantly lower body weight (p &lt; 0.001) in rats of all ages, higher heart rate (HR) (p &lt; 0.05) when rats were 3, 4 and 5 months old and lower HR in rats from 6 to 9 months of age, in relation to the CG. Spectral analysis showed a significant increase in the low...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: 2.07.00.00-8; Aging; Multi-deficient diet; Eletrocardiography; Spectral analysis morphology of the ventricles Fisiologa.
Ano: 2014
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/21482

STORING, DISTRIBUTION AND BLENDING OF BIODIESEL
Provedor de dados: 111
Autores: Micic, Radoslav.
Due to nature of biodiesel fuel (B100) as well as biodiesel and fossil diesel oil blends these fuels demands specific conditions of storage, handling, transportation and distribution. Although it is necessary to pay attention to each of the elements in the distribution chain, the most critical operations are related to storing. Tanks for biodiesel storinghave a dominant influence on the maintenance of stable quality, as may occur, issues that directly affect the degradation in quality and problems during distribution, blending and use. In the designing process of the tank space and the installations must be taken into account all specificities of biodiesel also that materials are resistant to the influence of biodiesel and does not affect it contamination....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Transesterification of fatty acid methyl esters (FAME); Aging; Storing; Blending.
Ano: 2020
URL: http://www.cigrjournal.org/index.php/Ejounral/article/view/5583

Administering ascorbic acid to rats undergoing ageing processes: effects on myosin-V immunoreactive myenteric neurons
Provedor de dados: 42
Autores: Mello,Sônia A.; Marese,Angélica C.M.; Brancalhão,Rose M.C.; Zanoni,Jacqueline N.; Natali,Maria Raquel M.
During the ageing process the enteric nervous system undergoes morphofunctional changes, such as enteric neurodegeneration. Neuronal death can be attributed to increase radicals free, and ascorbic acid (AA), known antioxidant, could minimize damage cause by oxidative stress. The objective of this study is to analyse the behaviour of morphoquantative myenteric neurons in the duodenum of adult Wistar rats with aged 90 (C90), 345 (E345) and 428 (E428) days, as well as animals of the same age who received ascorbic acid supplementation for 120 days (EA345 and EA428). Whole-mount preparations of muscle layer from the duodenum of the animals were immunostained by the method myosin V. 80 microscopic fields were quantified (14.8 mm2/animal) and measured 100...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Antioxidant; Enteric nervous system; Immunohistochemistry.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100337

Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats
Provedor de dados: 42
Autores: PEREIRA,JOICE N.B.; MARI,RENATA B.; STABILLE,SANDRA R.; FARIA,HAROLDO G. DE; MOTA,THAIS F.M.; FERREIRA,WALTER M.
Aging is a biologic process characterized by progressive damage of structures and functions of organic systems. In gastrointestinal tract, it can involve enteric nervous system, which plays an important role in digestion and absorption of nutrients, causing hastening of intestinal transit thus reducing its absorptive function. Caloric restriction has been used in several studies with the intention of delaying deleterious effects of aging. This study aimed to evaluate the effects of caloric restriction on myenteric neurons of ileum by aging in rats. 30 Wistar rats were grouped as follows: GI (animals aged 6 months fed with normal diet), GII (animals aged 18 months fed with normal diet) and GIII (animals aged 18 months subject to 31% of caloric restriction)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Caloric restriction; Myenteric plexus; Small intestine.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301471

Immune System Dysfunction in the Elderly
Provedor de dados: 42
Autores: FUENTES,EDUARDO; FUENTES,MANUEL; ALARCÓN,MARCELO; PALOMO,IVÁN.
ABSTRACT Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Immunosenescence; Adaptive immunity; Innate immunity; Inflammation.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100285

Response of the brain to enrichment
Provedor de dados: 42
Autores: DIAMOND,MARIAN C.
Before 1960, the brain was considered by scientists to be immutable, subject only to genetic control. In the early sixties, however, investigators were seriously speculating that environmental influences might be capable of altering brain structure. By 1964, two research laboratories proved that the morphology and chemistry or physiology of the brain could be experientially altered (Bennett et al. 1964, Hubel and Wiesel 1965). Since then, the capacity of the brain to respond to environmental input, specifically "enrichment,'' has become an accepted fact among neuroscientists, educators and others. In fact, the demonstration that environmental enrichment can modify structural components of the rat brain at any age altered prevailing presumptions about the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enrichment; Cerebral cortex; Hippocampus; Aging; Adult neurogenesis; Dendrites.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000200006

Histological evaluation of the periodontal ligament from aged wistar rats supplemented with ascorbic acid
Provedor de dados: 42
Autores: Zanoni,Jacqueline N.; Lucas,Nathalia M.; Trevizan,Aline R.; Souza,Ivan D.S.
Ascorbic acid (AA) is able to neutralize reactive oxygen species and is essential for collagen synthesis. In aging process oxidative stress is elevated. This study aims to investigate the effects of AA supplementation on the periodontal ligament (PL) of rats during aging. Twenty five rats were used and divided into groups: J90 (90-day-old control), E345 (345-day-old control), E428 (428-day-old control), EA345 (345-day-old supplemented with AA from 90-day-old on) and EA428 (428-day-old supplemented with AA from 90-day-old on). We analyzed the thickness, density of fibroblasts and blood vessels and collagen fibers types in the PL. In group J90 there was predominantly type III collagen fibers (87.64%). In animals supplemented with AA, the area filled by type...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Ascorbic acid; Collagen; Periodontal ligament.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100327

Histomorphological and quantitative immunohistochemical changes in the rat pancreas during aging
Provedor de dados: 47
Autores: Riccillo,F.L.; Bracamonte,M.I.; Cónsole,G.M.; Gómez Dumm,C.L.A.
Although the endocrine pancreas is the purpose of several deep investigations, morphological data referred to the effect of aging on the gland are not homogeneous. The purpose of the current work was to analyze the changes occurring in the pancreas of aged rats, with especial reference to the islet cell populations. Six young (Y), old (O) and senescent (S) male Sprague-Dawley rats were used. The pancreas tails were processed for light microscopy and studied by means of routine stains as well as by immunohistochemical identification of insulin-, glucagon-, somatostatin-, and pancreatic polypeptide- secreting cells (Dako Envision System, DAB as chromogen). A progressive pancreatic histoarchitecture distortion was found among the aged animals. Even when the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Pancreas; Islets; Immunohistochemistry; Morphometry.
Ano: 2004
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452004000200001

Age related interaction of dopamine and serotonin synthesis in striatal synaptosomes
Provedor de dados: 47
Autores: Messripour,Manoochehr; Mesripour,Azadeh.
Tyrosine hydroxylase and tryptophan hydroxylase are key rate limiting enzymes in the biosyn-thesis of dopamine and serotonin, respectively. Since both enzymes are active in striatum, and affected by age, this study was undertaken to investigate interaction between dopamine and serotonin synthesis in brain striatal synaptosomes of aging rat. Male Wistar rats (3 and 30 month old) were killed by decapitation and brain striatal synaptosomes were prepared by discontinuous Ficoll/sucrose gradient technique. Synaptosomes were incubated in the presence of added pargiline (monoamineoxidase inhibitor), dopamine or serotonin synthesized during 25 min was measured by HPLC, employing electrochemical detection. Dopamine synthesis in synaptosomes prepared from young...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Nerve ending; Neurotransmitter; Tyrosine hydroxylase; Tryptophan hydroxylase.
Ano: 2013
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452013000200001

Effect of age on the myosin-V immunoreactive myenteric neurons of rats ileum
Provedor de dados: 47
Autores: Ferreira Schoffen,João Paulo; Marçal Natali,Maria Raquel.
Alterations in the gastrointestinal neuromuscular function related to age have been demonstrated in human and animal models. This study analyzes the effects of the aging process on the area of the neuronal cell bodies of the myenteric plexus in the antimesenteric and intermediate regions of the ileal circumference of Wistar, 12 month-old in comparison 3 month-old animals. The ileum was removed and whole-mount preparations immunostained by the antibody anti-myosin-V were processed. The morphometric analyses were performed using a computerized image analysis system, with a subsequent distribution of neurons by size in intervals of 100 &amp;#956;m². The cellular body morphometry revealed a significant increase in the size of the myosin-V- immunoreactive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Ileum; Myenteric plexus; Myosin-V; Neuronal plasticity.
Ano: 2007
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452007000100004

T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells
Provedor de dados: 48
Autores: LEIVA-SALCEDO,ELIAS; PEREZ,VIVIANA; ACUÑA-CASTILLO,CLAUDIO; WALTER,ROBIN; SIERRA,FELIPE.
Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as inhibition of the ERK signaling pathway. T-kininogen is a potent inhibitor of cysteine proteinases, and we have described that the inhibition of ERK activity occurs, at least in part, via stabilization of the MAP kinase phosphatase, MKP-1. Since fibroblasts are not a physiological target of T-kininogen, we have now purified the protein from rat serum, and used it to assess the effect of T-kininogen on endothelial cells. Adding purified T-kininogen to EAhy 926 hybridoma cells resulted in inhibition of basal ERK activity levels, as estimated...
Tipo: Journal article
Palavras-chave: Aging; Endothelial cells; ERK pathway; Kininogen; Kinins.
Ano: 2002
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200020

Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans
Provedor de dados: 48
Autores: Park,Seul-Ki; Park,Sang-Kyu.
Electrolyzed-reduced water (ERW) scavenges reactive oxygen species and is a powerful anti-oxidant. A positive correlation between oxidative stress and aging has been proved in many model organisms. In Caenorhabditis elegans, many long-lived mutants showed reduced fertility as a trade off against longevity phenotype. We aimed to study the effect of ERW on oxidative stress, fertility and lifespan of C. elegans. We also investigated the genetic pathway involved in the effect of ERW on resistance to oxidative stress and lifespan. We compared lifespan and fertility of worms in media prepared with distilled water and ERW. ERW significantly extended lifespan and increased the number of progeny produced. Then the effect of ERW on resistance to oxidative stress and...
Tipo: Journal article
Palavras-chave: Electrolyzed-reduced water; Aging; Daf-16; Fertility; Lifespan.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200005

On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae)
Provedor de dados: 48
Autores: Rivera,Daniela S.; Inestrosa,Nibaldo C.; Bozinovic,Francisco.
Cognitive ecologist posits that the more efficiently an animal uses information from the biotic and abiotic environment, the more adaptive are its cognitive abilities. Nevertheless, this approach does not test for natural neurodegenerative processes under field or experimental conditions, which may recover animals information processing and decision making and may explain, mechanistically, maladaptive behaviors. Here, we call for integrative approaches to explain the relationship between ultimate and proximate mechanisms behind social behavior. We highlight the importance of using the endemic caviomorph rodent Octodon degus as a valuable natural model for mechanistic studies of social behavior and to explain how physical environments can shape social...
Tipo: Journal article
Palavras-chave: Cognitive ecology; Octodon degus; Social behavior; Stress; Aging; Alzheimer's disease.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100010

Free radical chemistry in biological systems
Provedor de dados: 48
Autores: VALDEZ,LAURA B; LORES ARNAIZ,SILVIA; BUSTAMANTE,JUANITA; ALVAREZ,SILVIA; COSTA,LIDIA E; BOVERIS,ALBERTO.
Mitochondria are an active source of the free radical superoxide (O2-) and nitric oxide (NO), whose production accounts for about 2% and 0.5% respectively, of mitochondrial O2 uptake under physiological conditions. Superoxide is produced by the auto-oxidation of the semiquinones of ubiquinol and the NADH dehydrogenase flavin and NO by the enzymatic action of the nitric oxide synthase of the inner mitochondrial membrane (mtNOS). Nitric oxide reversibly inhibits cytochrome oxidase activity in competition with O2. The balance between NO production and its utilization results in a NO intramitochondrial steady-state concentration of 20-50 nM, which regulates mitochondrial O2 uptake and energy supply. The regulation of cellular respiration and energy production...
Tipo: Journal article
Palavras-chave: Superoxide radical; Nitric oxide; Peroxynitrite; Mitochondria; Apoptosis; Aging.
Ano: 2000
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200005

Superoxide dismutase and catalase: tissue activities and relation with age in the long-lived species Margaritifera margaritifera
Provedor de dados: 48
Autores: FERNÁNDEZ,CARLOS; SAN MIGUEL,EDUARDO; FERNÁNDEZ-BRIERA,ALMUDENA.
Free radicals are extremely reactive and produce damage and modify cell functions. Furthermore, superoxide dismutase and catalase are believed to play a key role in the enzymatic defence of the cells. Indeed, some authors have argued that reduced free-radical damage could explain increased longevity. Margaritifera margaritifera is one of the longest-lived animals in the world (up to 100-200 years). Furthermore, this organism may serve as a useful model for gerontologists interested in exploring the mechanisms that promote long life and the slowing of senescence. The present study estimated for the first time individual enzymatic activity for superoxide dismutase isozymes (Cu,Zn-SOD and Mn-SOD) and catalase in tissue preparations of gills, digestive glands...
Tipo: Journal article
Palavras-chave: Margaritifera margaritifera; Free radicals; Aging; Superoxide dismutase; Catalase.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100006

Long lasting structural changes in primary motor cortex after motor skill learning: a behavioural and stereological study
Provedor de dados: 48
Autores: MORALES,PAOLA.
Many motor skills, once acquired, are stored over a long time period, probably sustained by permanent neuronal changes. Thus, in this paper we have investigated with quantitative stereology the generation and persistence of neuronal density changes in primary motor cortex (MI) following motor skill learning (skilled reaching task). Rats were trained a lateralised reaching task during an "early" (22-31 days oíd) or "late" (362-371 days oíd) postnatal period. The trained and corresponding control rats were sacrificed at day 372, immediately after the behavioural testing. The "early" trained group preserved the learned skilled reaching task when tested at day 372, without requiring any additional training. The "late" trained group showed a similar capacity to...
Tipo: Journal article
Palavras-chave: Motor cortex; Plasticity; Persistence of structural changes; Aging; Motor skill learning (skilled reaching task); Stereology; Rat.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000400005

Isolation, Culturing, Characterization and Aging of Adipose Tissue-derived Mesenchymal Stem Cells: A Brief Overview
Provedor de dados: 52
Autores: Fathi,Ezzatollah; Farahzadi,Raheleh.
ABSTRACT The aim of this review was to describe the current state-of-the-art regarding isolation, characterization and aging of adipose tissue-derived mesenchymal stem cells (ADSCs). Mesenchymal stem cells (MSCs) have recently received widespread attention because of their potential use in tissue-engineering applications. Various studies have indicated that MSCs with a fibroblast-like morphology migrate to the sites of injury and help to regenerate damaged tissue. Over the past few years, it has been recognized that fat is not only an energy supply, but also a rich source of multipotent stem cells that can be easily harvested, isolated and selected as compared with other tissues. ADSCs are particularly interesting because of their rapid proliferation and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adipose tissue-derived mesenchymal stem cells; Adipose tissue; Isolation; Aging; Differentiation potential.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100302

Diet, Epidemiological Factors and Cognitive Impairment: A Cross-Sectional Study in the Elderly Population
Provedor de dados: 52
Autores: França,Vivian Francielle; Azzolini,Thairine; Pissaia,Ediane; Bortoloti,Durcelina Schiavoni; Signorini,Taise; Costa,Lediana Dalla; Souza,Marília Moraes Queiroz; Lívero,Francislaine Aparecida dos Reis; Lovato,Evellyn Claudia Wietzikoski.
ABSTRACT Purpose Population aging is one of the great achievements of humanity. However, with aging, the incidence of chronic diseases and those related to cognition deficits increase. In this way, strategies aimed at preventing or delaying cognitive deficit are extremely necessary. Thus, this study investigates the relationship between cognitive deficits, schooling and eating habits in a Brazilian elderly population. Methods The dietary habits of 400 older adults were investigated through structured questionnaires. Unhealthy eating habits such as low consumption of fruits, vegetables and beans, consumption of fatty meats and whole milk, adjusted for other variables, were evaluated. Cognitive function was assessed by the Mini Mental State Examination...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Cognitive; Diet; Fruits; Schooling; Vegetable.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100327

Cellular aging: theories and technological influence
Provedor de dados: 52
Autores: Mercado-Sáenz,Silvia; Ruiz-Gómez,Miguel J.; Morales-Moreno,Francisco; Martínez-Morillo,Manuel.
The aim of this article was to review the factors that influence the aging, relationship of aging with the biological rhythms and new technologies as well as the main theories to explain the aging, and to analysis the causes of aging. The theories to explain the aging could be put into two groups: those based on a program that controlled the regression of the organism and those that postulated that the deterioration was due to mutations. It was concluded that aging was a multifactorial process. Genetic factors indicated the maximum longevity of the individual and environmental factors responsible for the real longevity of the individual. It would be necessary to guarantee from early age the conservation of a natural life rhythm.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Longevity; Biological rhythms; Caloric restriction; Telomerase; Free radical.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600008

Age-related Changes in DNA Methylation Status of hTERT Gene Promoter of Oral Epithelial Cells
Provedor de dados: 52
Autores: Bezerra,Stephane Flaviane de Oliveira; Costa,Ludimila de Araújo; Freitas,Priscylla Alves Nascimento de; Oliveira,Naila Francis Paulo de.
The purpose of this study was to investigate the effect of aging on the DNA methylation status of two genes involved in tumorigenesis (telomerase gene hTERT and DNA repair gene- MLH1) and one in metabolism (methylenetetrahydrofolate reductase gene- MTHFR) in oral epithelial cells. DNA methylation analysis was performed by Methylation Sensitive Restriction Enzymes (MSRE) of healthy oral epithelial cells of child (6-10 years, n=21), young (20-25 years, n=19) and elderly (over 60 years, n=25). The results for the hTERT gene showed significant variation in the methylation frequency at CpG dinucleotides among the groups (p=0.0001), with the methylated condition more frequently in children and young people. In relation to MLH1 and MTHFR, no differences were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epigenetic; DNA methylation; Aging; DNA repair; Telomerase; MTHFR.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000100082

Aging, neurocognitive impairment and adherence to antiretroviral therapy in human immunodeficiency virus-infected individuals
Provedor de dados: 55
Autores: Pinheiro,Cezar Arthur Tavares; Souza,Luciano Dias de Mattos; Motta,Janaína Vieira dos Santos; Kelbert,Evelin Franco; Martins,Clarissa de Souza Ribeiro; Souza,Marília Silva de; Pinheiro,Karen Amaral Tavares; Coelho,Fábio Monteiro da Cunha; Pinheiro,Ricardo Tavares.
ABSTRACT  Background/objective: There is an increasing number of older patients with human immunodeficiency virus infection due to the success of antiretroviral therapy, the improved prognosis and life expectancy of patients, and the higher number of new infections among older individuals. The main objective of the present study was to compare the characteristics of older human immunodeficiency virus patients with those of younger patients.  Materials and methods: We conducted a cross-sectional study with human immunodeficiency virus-infected patients who were treated at the Specialized Care Service (Serviço de Assistência Especializada) for human immunodeficiency virus/AIDS in the city of Pelotas, South Brazil. Sociodemographic information as well as data...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; HIV; Neurocognitive impairment; Adherence.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600599

Aging with HIV: an overview of an urban cohort in Rio de Janeiro (Brazil) across decades of life
Provedor de dados: 55
Autores: Torres,Thiago Silva; Cardoso,Sandra Wagner; Velasque,Luciane de Souza; Marins,Luana Monteiro Spindola; Oliveira,Marília Santini de; Veloso,Valdilea Gonçalves; Grinsztejn,Beatriz.
The introduction of highly active antiretroviral therapy during the 1990s was crucial to the decline in the rates of morbidity and death related to the acquired immunodeficiency syndrome (AIDS) and turned human immunodeficiency virus (HIV) infection into a chronic condition. Consequently, the HIV/AIDS population is becoming older. The aim of this study was to describe the immunological, clinical and comorbidity profile of an urban cohort of patients with HIV/AIDS followed up at Instituto de Pesquisa Clinica Evandro Chagas, Oswaldo Cruz Foundation in Rio de Janeiro, Brazil. Retrospective data from 2307 patients during January 1st, 2008 and December 31st, 2008 were collected. For continuous variables, Cuzick's non-parametric test was used. For categorical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Aging; Elderly; Brazil; Comorbidity; HAART.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300004

Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age
Provedor de dados: 55
Autores: Torres,Thiago Silva; Cardoso,Sandra Wagner; Velasque,Luciane S.; Veloso,Valdilea G.; Grinsztejn,Beatriz.
Toxicity is the most frequently reported reason for modifying or discontinuing the first combined antiretroviral therapy regimens, and it can cause significant morbidity, poor quality of life and also can be an important barrier to adherence, ultimately resulting in treatment failure and viral resistance. Elderly patients with HIV/AIDS (≥50 years) may have a different profile in terms of treatment modification due to higher incidence of comorbidities and polypharmacy. The aim of this study was to describe the incidence of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity (TOX-MOD) during the first year of treatment at the IPEC – FIOCRUZ HIV/AIDS cohort, Rio de Janeiro, Brazil, stratified by age. Demographic, clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Toxicity; Aging; Antiretroviral.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100034

Aging with HIV: a practical review
Provedor de dados: 55
Autores: Cardoso,Sandra Wagner; Torres,Thiago Silva; Santini-Oliveira,Marilia; Marins,Luana Monteiro Spindola; Veloso,Valdiléa Gonçalves; Grinsztejn,Beatriz.
The worldwide elderly population is expected to grow by an additional 694 million people by 2025. By that time, there will be approximately two billion elderly people in the world, most of whom (80%) will be living in developing countries. Based on recent estimates, this population will number over 40 million in 2030 in Brazil and a consequent increase in governmental spending for this population can be expected. Since highly active antiretroviral therapy became available in the mid-1990s, the life expectancy of people living with HIV has increased significantly. Approximately 12 million life years were added to the world between 1996 and 2008 as a consequence of wider access to highly active antiretroviral therapy. In Brazil, the incidence of AIDS among...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Aging; Elderly; Brazil; Comorbidity; HAART.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400013

Testosterone therapy delays cardiomyocyte aging via an androgen receptor-independent pathway
Provedor de dados: 56
Autores: Zhang,L.; Wu,S.Z.; Ruan,Y.J.; Hong,L.; Xing,X.W.; Lai,W.Y.
The testicular feminized (Tfm) mouse carries a nonfunctional androgen receptor (AR) and reduced circulating testosterone levels. We used Tfm and castrated mice to determine whether testosterone modulates markers of aging in cardiomyocytes via its classic AR-dependent pathway or conversion to estradiol. Male littermates and Tfm mice were divided into 6 experimental groups. Castrated littermates (group 1) and sham-operated Tfm mice (group 2, N = 8 each) received testosterone. Sham-operated Tfm mice received testosterone in combination with the aromatase inhibitor anastrazole (group 3, N = 7). Castrated littermates (group 4) and sham-operated untreated Tfm mice (group 5) were used as controls (N = 8 and 7, respectively). An additional control group (group 6)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Testosterone; Cardiomyocyte; Androgen receptor; Estradiol; Tfm mice.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100007

Chronic converting enzyme inhibition normalizes QT interval in aging rats
Provedor de dados: 56
Autores: Silva,V.J. Dias da; Ferreira Neto,E.; Salgado,H.C.; Fazan Júnior,R.
The aim of the present study was to investigate the effects of converting enzyme inhibition by captopril on ECG parameters in aged rats. Four-month-old male rats received captopril dissolved in tap water (0.5 mg/l) or tap water for 2 or 20 months. At the end of treatment, under anesthesia, RR and PR interval, P wave and QRS duration, QT and corrected QT interval were measured in all animals. On the following day, chronic ECG (lead II) recordings were performed to quantify supraventricular (SVPB) or ventricular premature beats (VPB). After sacrifice, the hearts were removed and weighed. RR interval was similar in young and untreated aged rats, but significantly larger in aged rats treated with captopril. P wave and QRS length did not differ among groups. PR...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Electrocardiogram; Captopril; Rats.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900003

Aging and immunoglobulin isotype patterns in oral tolerance
Provedor de dados: 56
Autores: Faria,A.M.C.; Ficker,S.M.; Speziali,E.; Menezes,J.S.; Stransky,B.; Verdolin,B.A.; Lahmann,W.M.; Rodrigues,V.S.; Vaz,N.M.
In the present review we address oral tolerance as an important biological phenomenon and discuss how it is affected by aging. Other factors such as frequency of feeding and previous digestion of the antigen also seem to influence the establishment of oral tolerance. We also analyze immunoglobulin isotypes of specific antibodies formed by tolerant and immunized animals of different ages submitted to different conditions of oral antigen administration. Isotypic patterns were studied as a parameter for assessing the pathways of B and T cell interactions leading to antibody production
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Oral tolerance; Aging; Isotypes; Gut; Mucosa.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100005

The nucleolus: a paradigm for cell proliferation and aging
Provedor de dados: 56
Autores: Comai,L.
The nucleolus is the cellular site of ribosome biosynthesis. At this site, active ribosomal DNA (rDNA) genes are rapidly transcribed by RNA polymerase I (pol I) molecules. Recent advances in our understanding of the pol I transcription system have indicated that regulation of ribosomal RNA (rRNA) synthesis is a critical factor in cell growth. Importantly, the same signaling networks that control cell growth and proliferation and are deregulated in cancer appear to control pol I transcription. Therefore, the study of the biochemical basis for growth regulation of pol I transcription can provide basic information about the nuclear signaling network. Hopefully, this information may facilitate the search for drugs that can inhibit the growth of tumor cells by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nucleolus; RNA pol I; Aging; Transcription; Werner syndrome.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200004

Peripubertal orchidectomy transitorily affects age-associated thymic involution in rats
Provedor de dados: 56
Autores: Pesic,V.; Radojevic,K.; Kosec,D.; Plecas-Solarovic,B.; Perisic,M.; Pilipovic,I.; Leposavic,G.
The role of gonadal hormones in induction and, particularly, maintenance/progression of rat thymic involution, which normally starts around puberty, was reassessed by examining the effects of peripubertal orchidectomy on thymic weight and morphometric parameters at different times up to the age of 10 months. Up to 6 months post-castration both thymic weight and cellularity in orchidectomized (Cx) rats were greater than in age-matched control rats, sham Cx (Sx). The increase in thymic cellularity reflected an increase in thymocyte proliferation rate (the proportion of proliferating cells was 18.6 ± 0.7% in 2-month-old Cx (N = 5) vs 13.4 ± 0.3% (N = 5) in age-matched Sx rats) followed by reduced sensitivity to apoptotic signals (apoptotic thymocytes were 9.8...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rat thymus; Aging; Orchidectomy; Stereological analysis; Thymocyte proliferation; Thymocyte apoptosis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100009

Identification of sarcopenic obesity in postmenopausal women: a cutoff proposal
Provedor de dados: 56
Autores: Oliveira,R.J.; Bottaro,M.; Júnior,J.T.; Farinatti,P.T.V.; Bezerra,L.A.; Lima,R.M.
Sarcopenic obesity is the combination of reduced fat-free mass (FFM) and increased fat mass (FM) with advancing age but there is lack of clear criteria for its identification. The purposes of the present investigation were: 1) to determine the prevalence of postmenopausal women with reduced FFM relative to their FM and height, and 2) to examine whether there are associations between the proposed classification and health-related variables. A total of 607 women were included in this cross-sectional study and were separated into two subsets: 258 older women with a mean age of 66.8 ± 5.6 years and 349 young women aged 18-40 years (mean age, 29.0 ± 7.5 years). All volunteers underwent body composition assessment by dual-energy X-ray absorptiometry. The FFM...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fat-free mass; Sarcopenia; Aging; Muscle strength.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100014

Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses
Provedor de dados: 56
Autores: Scandalios,J.G.
Molecular oxygen (O2) is the premier biological electron acceptor that serves vital roles in fundamental cellular functions. However, with the beneficial properties of O2 comes the inadvertent formation of reactive oxygen species (ROS) such as superoxide (O2&lt;FONT FACE=Symbol&gt;·-&lt;/FONT&gt;), hydrogen peroxide, and hydroxyl radical (OH&lt;FONT FACE=Symbol&gt;·&lt;/FONT&gt;). If unabated, ROS pose a serious threat to or cause the death of aerobic cells. To minimize the damaging effects of ROS, aerobic organisms evolved non-enzymatic and enzymatic antioxidant defenses. The latter include catalases, peroxidases, superoxide dismutases, and glutathione S-transferases (GST). Cellular ROS-sensing mechanisms are not well understood, but a number of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Catalase; Aging; Telomeres; Gene regulation; Superoxide dismutase; Genomics.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700003

Effects of dietary lipids on renal function of aged rats
Provedor de dados: 56
Autores: Valente Gamba,C.; Zeraib Caraviello,A.; Matsushita,A.; Alves,G.M.; Nunes da Silva,L.; Nascimento Gomes,G.; Zaladek Gil,F.
Normal aging is accompanied by renal functional and morphological deterioration and dietetic manipulation has been used to delay this age-related decline. We examined the effects of chronic administration of diets containing 5% lipid-enriched diet (LD, w/w) on renal function of rats at different ages. Three types of LD were tested: canola oil, fish oil and butter. Mean systemic tail-cuff blood pressure and glycemia remained within the normal range whatever the age and the diet of the animals. Proteinuria began to rise from the 8th month in the groups ingesting LD, while in the control group it increased significantly (above 10 mg/24 h) only after the 10th month. With age, a significant and progressive decline in glomerular filtration rate (GFR) and renal...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Aging; Lipids; Proteinuria; Renal function; Acid excretion; Canola oil; Fish oil.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200016

Mechanisms involved in anti-aging effects of guarana (Paullinia cupana) in Caenorhabditis elegans
Provedor de dados: 56
Autores: Arantes,L.P.; Machado,M.L.; Zamberlan,D.C.; da Silveira,T.L.; da Silva,T.C.; da Cruz,I.B.M.; Ribeiro,E.E.; Aschner,M.; Soares,F.A.A.
Guarana (Paullinia cupana) is habitually ingested by people in the Amazon region and is a key ingredient in various energy drinks consumed worldwide. Extension in longevity and low prevalence of chronic age-related diseases have been associated to habitual intake of guarana. Anti-aging potential of guarana was also demonstrated in Caenorhabditis elegans; however, the mechanisms involved in its effects are not clear. Herein, we investigated the putative pathways that regulate the effects of guarana ethanolic extract (GEE) on lifespan using C. elegans. The major known longevity pathways were analyzed through mutant worms and RT-qPCR assay (DAF-2, DAF-16, SKN-1, SIR-2.1, HSF-1). The possible involvement of purinergic signaling was also investigated. This...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Antioxidant; Guarana; Lifespan; Natural products; Xanthines.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900602

Sleep, ageing and night work
Provedor de dados: 56
Autores: Pires,M.L.N.; Teixeira,C.W.; Esteves,A.M.; Bittencourt,L.R.A.; Silva,R.S.; Santos,R.F.; Tufik,S.; Mello,M.T.
Studies have shown that the frequency or worsening of sleep disorders tends to increase with age and that the ability to perform circadian adjustments tends to decrease in individuals who work the night shift. This condition can cause consequences such as excessive sleepiness, which are often a factor in accidents that occur at work. The present study investigated the effects of age on the daytime and nighttime sleep patterns using polysomnography (PSG) of long-haul bus drivers working fixed night or day shifts. A total of 124 drivers, free of sleep disorders and grouped according to age (&lt;45 years, N = 85, and ≥45 years, N = 39) and PSG timing (daytime (D) PSG, N = 60; nighttime (N) PSG, N = 64) participated in the study. We observed a significant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep; Shift work; Night work; Aging; Polysomnography; REM; Slow wave sleep (SWS).
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000900011

A comparative study of aging of the elastic fiber system of the diaphragm and the rectus abdominis muscles in rats
Provedor de dados: 56
Autores: Rodrigues,C.J.; Rodrigues Junior,A.J.
In the present study the age-related changes of the striated muscle elastic fiber system were investigated in the diaphragm and rectus abdominis muscles of 1-, 4-, 8- and 18-month-old rats. The activation patterns of these muscles differ in that the diaphragm is regularly mobilized tens of times every minute during the entire life of the animal whereas the rectus abdominis, although mobilized in respiration, is much less and more irregularly activated. The elastic fibers were stained by the Verhoeff technique for mature elastic fibers. Weigert stain was used to stain mature and elaunin elastic fibers, and Weigert-oxone to stain mature, elaunin and oxytalan elastic fibers. The density of mature and elaunin elastic fibers showed a progressive increase with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Elastin; Extracellular matrix; Diaphragm; Rectus abdominis.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001200008

Comparison of endoplasmic reticulum stress and mitochondrial biogenesis responses after 12 weeks of treadmill running and ladder climbing exercises in the cardiac muscle of middle-aged obese rats
Provedor de dados: 56
Autores: Kim,Kijin; Ahn,Nayoung; Jung,Suryun.
The purpose of the present study was to compare the influence of aerobic exercise (AE) lasting 12 weeks to that of resistance exercise (RE) of the same duration on endoplasmic reticulum (ER) stress and mitochondrial biogenesis in the cardiac muscle of middle-aged obese rats. Obesity was induced in thirty 50-week-old male Sprague Dawley rats over 6 weeks by administration of a high-fat diet. The rats were then subjected to treadmill-running (AE) and ladder-climbing (RE) exercises 3 times per week for 12 weeks. Rats in the AE group showed significantly lower increases in body weight and intraperitoneal fat than those in the sedentary control (SC) group (P&lt;0.05). The 12-week exercise regimes resulted in a significant increase in expression of mitochondrial...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Exercise training; Mitochondrial biogenesis; Endoplasmic reticulum stress; Obesity; Cardiac muscle; Aging.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000604

Assessing negative priming by attended distractors in a paper-and-pencil task
Provedor de dados: 56
Autores: Rosin,F.M.
The paper-and-pencil digit-comparison task for assessing negative priming (NP) was introduced, using a referent-size-selection procedure that was demonstrated to enhance the effect. NP is indicated by slower responses to recently ignored items, and proposed within the clinical-experimental framework as a major cognitive index of active suppression of distracting information, critical to executive functioning. The digit-comparison task requires circling digits of a list with digit-asterisk pairs (a baseline measure for digit-selection), and the larger of two digits in each pair of the unrelated (with different digits in successive digit-pairs) and related lists (in which the smaller digit subsequently became a target). A total of 56 students (18-38 years)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Negative priming; Selective attention; Paper-and-pencil tasks; Aging; Executive function.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800004

Effect of Walker 256 tumor growth on intestinal absorption of leucine, methionine and glucose in newly weaned and mature rats
Provedor de dados: 56
Autores: Gomes-Marcondes,M.C.C.; Honma,H.N.; Areas,M.A.; Cury,L.
In tumor-bearing rats, most of the serum amino acids are used for synthesis and oxidation processes by the neoplastic tissue. In the present study, the effect of Walker 256 carcinoma growth on the intestinal absorption of leucine, methionine and glucose was investigated in newly weaned and mature rats. Food intake and carcass weight were decreased in newly weaned (NT) and mature (MT) rats bearing Walker 256 tumor in comparison with control animals (NC and MC). The tumor/carcass weight ratio was higher in NT than in MT rats, whereas nitrogen balance was significantly decreased in both as compared to control animals. Glucose absorption was significantly reduced in MT rats (MT = 47.3 ± 4.9 vs MC = 99.8 ± 5.3 nmol min-1 cm-1, Kruskal-Wallis test,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Walker 256 tumor; Intestinal absorption; Amino acids; Glucose; Aging.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001000017

Cognitive performance of young and elderly subjects on the free word recall memory test: effect of presentation order on recall order
Provedor de dados: 56
Autores: Santos-Galduróz,R.F.; Oliveira,F.G.; Galduróz,J.C.F.; Bueno,O.F.A.
The influence of aging on memory has been extensively studied, but the importance of short-term memory and recall sequence has not. The objective of the current study was to examine the recall order of words presented on lists and to determine if age affects recall sequence. Physically and psychologically healthy male subjects were divided into two groups according to age, i.e., 23 young subjects (20 to 30 years) and 50 elderly subjects (60 to 70 years) submitted to the Wechsler Adult Intelligence Scale-Revised and the free word recall test. The order of word presentation significantly affected the 3rd and 4th words recalled (P &lt; 0.01; F = 14.6). In addition, there was interaction between the presentation order and the type of list presented (P &lt;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Recall order; Aging; Memory; Presentation order.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001000019

Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
Provedor de dados: 56
Autores: Santos-Galduróz,R.F.; Galduróz,J.C.F.; Facco,R.L.; Hachul,H.; Tufik,S.
Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Isoflavone; Cognitive disorders; Aging; Information integration; Memory; Menopause.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100016

Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men
Provedor de dados: 56
Autores: Zembron-Lacny,A.; Dziubek,W.; Rynkiewicz,M.; Morawin,B.; Woźniewski,M.
Regular exercise plays an important preventive and therapeutic role in heart and vascular diseases, and beneficially affects brain function. In blood, the effects of exercise appear to be very complex and could include protection of vascular endothelial cells via neurotrophic factors and decreased oxidative stress. The purpose of this study was to identify the age-related changes in peripheral brain-derived neurotrophic factor (BDNF) and its relationship to oxidative damage and conventional cardiovascular disease (CVD) biomarkers, such as atherogenic index, C-reactive protein (hsCRP) and oxidized LDL (oxLDL), in active and inactive men. Seventeen elderly males (61-80 years) and 17 young males (20-24 years) participated in this study. According to the 6-min...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neurotrophins; Lipoproteins; Oxidative damage; Aging; Cardiorespiratory fitness.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000700603

Egocentric and allocentric spatial memory in healthy aging: performance on real-world tasks
Provedor de dados: 56
Autores: Fernandez-Baizan,C.; Diaz-Caceres,E.; Arias,J.L.; Mendez,M.
Although normal aging has been related to several cognitive difficulties, other processes have been studied less, such as spatial memory. Our aim was to compare egocentric and allocentric memory in an elderly population using ecological tasks. Twenty-eight cognitively unimpaired participants performed Egocentric and Allocentric Spatial Memory Tasks, as well as Spatial Span from CANTAB, Benton's Judge of Line Orientation test (JoLO), and Montreal Cognitive Assessment test (MoCA). The results revealed that younger participants showed better performance than older participants on both the Egocentric and Allocentric Spatial Memory Tasks, although only the Egocentric test was able to discriminate between younger, middle, and older elderly participants. Learning...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Egocentric spatial memory; Allocentric spatial memory; Aging; Spatial learning; Spatial strategies.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400611

Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians
Provedor de dados: 56
Autores: Souza,D.R.S.; De Godoy,M.R.; Hotta,J.; Tajara,E.H.; Brandão,A.C.; Pinheiro Júnior,S.; Tognola,W.A.; Dos Santos,J.E.
The genetic basis for dementias is complex. A common polymorphism in the apolipoprotein E (APOE) gene is considered to be the major risk factor in families with sporadic and late-onset Alzheimer's disease as well as in the general population. The distribution of alleles and genotypes of the APOE gene in late-onset Alzheimer's disease (N = 68), other late-life dementias (N = 39), and in cognitively normal controls (N = 58) was determined, as also was the risk for Alzheimer's disease associated with the epsilon4 allele. Peripheral blood samples were obtained from a total of 165 individuals living in Brazil aged 65-82 years. Genomic DNA was amplified by the polymerase chain reaction and the products were digested with HhaI restriction enzyme. APOE epsilon2...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Alzheimer's disease; Vascular dementia; Dementia; Apolipoprotein E; Aging; Genetic polymorphisms.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700013

Alternative mitochondrial functions in cell physiopathology: beyond ATP production
Provedor de dados: 56
Autores: Kowaltowski,A.J.
It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mitochondrial permeability transition; Uncoupling proteins; Alternative oxidase; Cardioprotection; Free radicals; Aging.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200014

Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man
Provedor de dados: 56
Autores: Ueno,L.M.; Miyachi,M.; Matsui,T.; Takahashi,K.; Yamazaki,K.; Hayashi,K.; Onodera,S.; Moritani,T.
To examine the possible age-related blood pressure (BP) deregulation in response to central hypervolemia, we measured spontaneous baroreflex sensitivity (SBRS), carotid arterial compliance (CC), and R-R interval coefficient of variation (RRICV) during basal and thermoneutral resting head-out-of-water immersion (HOWI) in 7 young (YG = 24.0 ± 0.8 years) and 6 middle-aged/older (OL = 59.3 ± 1.3 years) healthy men. Compared with basal conditions (YG = 19.6 ± 4.0 vs OL = 6.1 ± 1.5 ms/mmHg, P &lt; 0.05), SBRS remained higher in YG than OL during rest HOWI (YG = 23.6 ± 6.6 vs OL = 9.3 ± 2.1 ms/mmHg, P &lt; 0.05). The RRICV was significantly different between groups (YG = 6.5 ± 1.4 vs OL = 2.8 ± 0.4%, P &lt; 0.05) under HOWI. The OL group had no increase in CC,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Baroreflex sensitivity; Carotid compliance; Water immersion; Hypertension; Vascular stiffness.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400018

Mitochondrial DNA synthesis studied autoradiographically in various cell types in vivo
Provedor de dados: 56
Autores: Korr,H.; Kurz,C.; Seidler,T.O.; Sommer,D.; Schmitz,C.
It is generally accepted that mitochondria are able to proliferate even in postmitotic cells due to their natural turnover and also to satisfy increased cell energy requirements. However, no detailed studies are available, particularly with respect to specific cell types. Since [3H]-thymidine is incorporated not only into nuclear (n) DNA but also into the DNA of cytoplasmic mitochondria, an autoradiographic approach was developed at the light microscopy level in order to study basic questions of mitochondrial (mt) proliferation in organs of rodents in situ via the cytoplasmic incorporation of [3H]-thymidine injected into the animals 1 h before sacrifice. Experiments carried out on mice after X-irradiation showed that cytoplasmic labeling was not due to a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Autoradiography; Mitochondrial DNA synthesis; Turnover of mitochondria; Unscheduled DNA synthesis.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000200012

Acute exercise performed close to the anaerobic threshold improves cognitive performance in elderly females
Provedor de dados: 56
Autores: Córdova,C.; Silva,V.C.; Moraes,C.F.; Simões,H.G.; Nóbrega,O.T.
The objective of the present study was to compare the effect of acute exercise performed at different intensities in relation to the anaerobic threshold (AT) on abilities requiring control of executive functions or alertness in physically active elderly females. Forty-eight physically active elderly females (63.8 ± 4.6 years old) were assigned to one of four groups by drawing lots: control group without exercise or trial groups with exercise performed at 60, 90, or 110% of AT (watts) and submitted to 5 cognitive tests before and after exercise. Following cognitive pretesting, an incremental cycle ergometer test was conducted to determine AT using a fixed blood lactate concentration of 3.5 mmol/L as cutoff. Acute exercise executed at 90% of AT resulted in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Alert; Anaerobic threshold; Exercise; Executive functions; Response time test.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000500010

Autonomic modulation of heart rate of young and postmenopausal women undergoing estrogen therapy
Provedor de dados: 56
Autores: Neves,V.F.C.; Silva de Sá,M.F.; Gallo Jr.,L.; Catai,A.M.; Martins,L.E.B.; Crescêncio,J.C.; Perpétuo,N.M.; Silva,E.
The aim of the present study was to determine whether estrogen therapy (ET) reduces alterations of the autonomic control of heart rate (HR) due to hypoestrogenism and aging. Thirteen young (24 ± 2.6 years), 10 postmenopausal (53 ± 4.6 years) undergoing ET (PM-ET), and 14 postmenopausal (56 ± 2.6 years) women not undergoing ET (PM) were studied. ET consisted of 0.625 mg/day conjugated equine estrogen. HR was recorded continuously for 8 min at rest in the supine and sitting positions. HR variability (HRV) was analyzed by time (SDNN and rMSSD indices) and frequency domain methods. Power spectral components are reported as normalized units (nu) at low (LF) and high (HF) frequencies, and as LF/HF ratio. Intergroup comparisons: SDNN index was higher in young...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heart rate variability; Aging; Menopause; Estrogen therapy.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400007

Presence of age- and sex-related differences in heart rate variability despite the maintenance of a suitable level of accelerometer-based physical activity
Provedor de dados: 56
Autores: Spina,G.D.; Gonze,B.B.; Barbosa,A.C.B.; Sperandio,E.F.; Dourado,V.Z.
There is currently a lack of information adjacent on the influence of sex and age in heart rate variability (HRV), adjusted according to accelerometer-based physical activity (PADL). We hypothesized that the effect of sex and age on the HRV should be reduced or absent in individuals with a suitable PADL level. We aim to evaluate the influence of sex and age on HRV, adjusted for the confounding effects of the PADL level. A total of 485 age-stratified subjects (18–39, 40–59, and ≥60 years) underwent HRV analyses at rest and 7-day assessments of accelerometer-based PADL. Multivariate analyses of covariance were done using log-transformed HRV indices as outcomes, age and sex as fixed factors, and PADL, cardiovascular risk, fat body mass, and heart rate (HR) at...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Autonomic balance; HRV; Aging.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000800605

Baroreflex sensitivity in frailty syndrome
Provedor de dados: 56
Autores: Buto,M.S.S.; Catai,A.M.; Vassimon-Barroso,V.; Gois,M.O.; Porta,A.; Takahashi,A.C.M.
Frailty is related to a decrease in the physiological reserves, which causes difficulties in maintaining homeostasis. An example of physiological mechanisms for cardiovascular homeostasis is the baroreflex. The aim of this study was to compare baroreflex among frail, prefrail, and nonfrail individuals, in supine and orthostatic positions. Community-dwelling older adults were evaluated and categorized into frail, prefrail, or nonfrail groups, according to frailty phenotype. The RR interval (RRi) and systolic blood pressure (SBP) series were recorded for 15 min in the supine and 15 min in the orthostatic positions. Mean and variance of RRi and SBP, and baroreflex evaluated by phase, gain (α), and coherence (K2) were determined. A two-way repeated measures...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Baroreflex; Autonomic nervous system; Aging; Frailty.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400602

Aging reduces the primary humoral response and the in vitro cytokine production in mice
Provedor de dados: 56
Autores: Simioni,P.U.; Costa,E.H.; Tamashiro,W.M.S.C.
Aging is accompanied by a decrease in several physiological functions that make older individuals less responsive to environmental challenges. In the present study, we analyzed the immune response of female BALB/c mice (N = 6) of different ages (from 2 to 96 weeks) and identified significant age-related alterations. Immunization with hapten-protein (trinitrophenyl-bovine serum albumin) conjugates resulted in lower antibody levels in the primary and secondary responses of old mice (72 weeks old). Moreover, young mice (2, 16, and 32 weeks old) maintained specific antibodies in their sera for longer periods after primary immunization than did old mice. However, a secondary challenge efficiently induced memory in old mice, as shown by the increased antibody...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Cytokines; Antibody; Proliferation; T cell response; T cell subsets.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800012

Longitudinal brain volumetric changes during one year in non-elderly healthy adults: a voxel-based morphometry study
Provedor de dados: 56
Autores: Guimarães,R.M.; Schaufelberger,M.S.; Santos,L.C.; Duran,F.L.S.; Menezes,P.R.; Scazufca,M.; Gouvea,M.T.V; Busatto,G.F.
Previous cross-sectional magnetic resonance imaging (MRI) studies of healthy aging in young adults have indicated the presence of significant inverse correlations between age and gray matter volumes, although not homogeneously across all brain regions. However, such cross-sectional studies have important limitations and there is a scarcity of detailed longitudinal MRI studies with repeated measures obtained in the same individuals in order to investigate regional gray matter changes during short periods of time in non-elderly healthy adults. In the present study, 52 healthy young adults aged 18 to 50 years (27 males and 25 females) were followed with repeated MRI acquisitions over approximately 15 months. Gray matter volumes were compared between the two...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gray matter; Aging; Voxel-based morphometry; Magnetic resonance imaging; Prefrontal cortex; Hippocampus.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600007

Effect of age on upper and lower eyelid saccades
Provedor de dados: 56
Autores: Leite,L.V.O.; Cruz,A.A.V.; Messias,A.; Malbouisson,J.M.C.
To study the effect of age on the metrics of upper and lower eyelid saccades, eyelid movement of two groups of 30 subjects each were measured using computed image analysis. The patients were divided on the basis of age into a younger group (20-30 years) and an older group (60-91 years). Eyelid saccade functions were fitted by the damped harmonic oscillator model. Amplitude and peak velocity were used to compare the effect of age on the saccades of the upper and lower eyelid. There was no statistically significant difference in saccade amplitude between groups for the upper eyelid (mean ± SEM; upward, young = 9.18 ± 0.32 mm, older = 8.93 ± 0.31 mm, t = 0.56, P = 0.58; downward, young = 9.11 ± 0.27 mm, older = 8.86 ± 0.32 mm, t = 0.58, P = 0.56) However,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Upper eyelid saccade; Lower eyelid saccade; Aging; Digital image processing.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200017

Effect of medroxyprogesterone acetate on thyrotropin secretion in adult and old female rats
Provedor de dados: 56
Autores: Moreira,R.M.; Borges,P.P.; Lisboa,P.C.; Curty,F.H.; Moura,E.G.; Pazos-Moura,C.C.
Steroid hormones have been implicated in the modulation of TSH secretion; however, there are few and controversial data regarding the effect of progesterone (Pg) on TSH secretion. Medroxyprogesterone acetate (MPA) is a synthetic alpha-hydroxyprogesterone analog that has been extensively employed in therapeutics for its Pg-like actions, but that also has some glucocorticoid and androgen activity. Both hormones have been shown to interfere with TSH secretion. The objective of the present study was to investigate the effects of MPA or Pg administration to ovariectomized (OVX) rats on in vivo and in vitro TSH release and pituitary TSH content. The treatment of adult OVX rats with MPA (0.25 mg/100 g body weight, sc, daily for 9 days) induced a significant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Medroxyprogesterone acetate; Progesterone; Thyrotropin; Aging; Ovariectomy; Thyrotropin-releasing hormone.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900020

Effect of aging and oral tolerance on dendritic cell function
Provedor de dados: 56
Autores: Simioni,P.U.; Fernandes,L.G.R.; Gabriel,D.L.; Tamashiro,W.M.S.C.
Oral tolerance can be induced in some mouse strains by gavage or spontaneous ingestion of dietary antigens. In the present study, we determined the influence of aging and oral tolerance on the secretion of co-stimulatory molecules by dendritic cells (DC), and on the ability of DC to induce proliferation and cytokine secretion by naive T cells from BALB/c and OVA transgenic (DO11.10) mice. We observed that oral tolerance could be induced in BALB/c mice (N = 5 in each group) of all ages (8, 20, 40, 60, and 80 weeks old), although a decline in specific antibody levels was observed in the sera of both tolerized and immunized mice with advancing age (40 to 80 weeks old). DC obtained from young, adult and middle-aged (8, 20, and 40 weeks old) tolerized mice were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Oral tolerance; Dendritic cell; Antibody; Proliferation; Cytokine secretion.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000100010

Relative influence of age, resting heart rate and sedentary life style in short-term analysis of heart rate variability
Provedor de dados: 56
Autores: Migliaro,E.R.; Contreras,P.; Bech,S.; Etxagibel,A.; Castro,M.; Ricca,R.; Vicente,K.
In order to assess the relative influence of age, resting heart rate (HR) and sedentary life style, heart rate variability (HRV) was studied in two different groups. The young group (YG) consisted of 9 sedentary subjects aged 15 to 20 years (YG-S) and of 9 nonsedentary volunteers (YG-NS) also aged 15 to 20. The elderly sedentary group (ESG) consisted of 16 sedentary subjects aged 39 to 82 years. HRV was assessed using a short-term procedure (5 min). R-R variability was calculated in the time-domain by means of the root mean square successive differences. Frequency-domain HRV was evaluated by power spectrum analysis considering high frequency and low frequency bands. In the YG the effort tolerance was ranked in a bicycle stress test. HR was similar for both...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heart rate variability; Short-term analysis; Autonomic nervous system; Aging; Sedentary life style.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400009

Differential effects of aging on spatial contrast sensitivity to linear and polar sine-wave gratings
Provedor de dados: 56
Autores: Costa,T.L.; Nogueira,R.M.T.B.L.; Pereira,A.G.F.; Santos,N.A.
Changes in visual function beyond high-contrast acuity are known to take place during normal aging. We determined whether sensitivity to linear sine-wave gratings and to an elementary stimulus preferentially processed in extrastriate areas could be distinctively affected by aging. We measured spatial contrast sensitivity twice for concentric polar (Bessel) and vertical linear gratings of 0.6, 2.5, 5, and 20 cycles per degree (cpd) in two age groups (20-30 and 60-70 years). All participants were free of identifiable ocular disease and had normal or corrected-to-normal visual acuity. Participants were more sensitive to Cartesian than to polar gratings in all frequencies tested, and the younger adult group was more sensitive to all stimuli tested. Significant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Contrast sensitivity; Circular gratings; Linear gratings; Aging; Spatial vision.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000855

Myosin Va is developmentally regulated and expressed in the human cerebellum from birth to old age
Provedor de dados: 56
Autores: Souza,C.C.R.; Dombroski,T.C.D.; Machado,H.R.; Oliveira,R.S.; Rocha,L.B.; Rodrigues,A.R.A.; Neder,L.; Chimelli,L.; Corrêa,V.M.A.; Larson,R.E.; Martins,A.R.
Myosin Va functions as a processive, actin-based motor molecule highly enriched in the nervous system, which transports and/or tethers organelles, vesicles, and mRNA and protein translation machinery. Mutation of myosin Va leads to Griscelli disease that is associated with severe neurological deficits and a short life span. Despite playing a critical role in development, the expression of myosin Va in the central nervous system throughout the human life span has not been reported. To address this issue, the cerebellar expression of myosin Va from newborns to elderly humans was studied by immunohistochemistry using an affinity-purified anti-myosin Va antibody. Myosin Va was expressed at all ages from the 10th postnatal day to the 98th year of life, in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Myosin Va; Human cerebellum; Postnatal development; Aging; Immunohistochemical expression.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200164

Muscle strength but not functional capacity is associated with plasma interleukin-6 levels of community-dwelling elderly women
Provedor de dados: 56
Autores: Oliveira,D.M.G.; Narciso,F.M.S.; Santos,M.L.A.S.; Pereira,D.S.; Coelho,F.M.; Dias,J.M.D.; Pereira,L.S.M.
The association of plasma interleukin-6 (IL-6) levels, muscle strength and functional capacity was investigated in a cross-sectional study of community-dwelling elderly women from Belo Horizonte, Brazil. Elderly people who present controlled chronic diseases with no negative impact on physical, psychosocial and mental functionality are considered to be community-dwelling. Psychological and social stress due to unsuccessfully aging can represent a risk for immune system disfunctions. IL-6 levels, isokinetic muscle strength of knee flexion/extension, and functional tests to determine time required to rise from a chair and gait velocity were measured in 57 participants (71.21 ± 7.38 years). Serum levels of IL-6 were measured in duplicate and were performed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Muscle strength; Interleukin-6; Elderly women; Sarcopenia; Aging; IL-6.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200017

Gender-dependent effects of aging on the kidney
Provedor de dados: 56
Autores: Gava,A.L.; Freitas,F.P.S.; Meyrelles,S.S.; Silva,I.V.; Graceli,J.B.
It is well known that the kidney plays an important role in the development of cardiovascular diseases such as hypertension. The normal aging process leads to changes in kidney morphology, hemodynamics and function, which increase the incidence of cardiovascular events in the elderly population. These disturbances are influenced by several factors, including gender. In general, females are protected by the effects of estrogens on the cardiorenal system. Several studies have demonstrated the beneficial effects of estrogens on renal function in the elderly; however, the relationships between androgens and kidney health during one’s lifetime are not well understood. Sex steroids have many complex actions, and the decline in their levels during aging clearly...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sexual dimorphism; Renal function; Aging; Cardiovascular disorders; Sex hormones.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900012

Aging alters the production of iNOS, arginase and cytokines in murine macrophages
Provedor de dados: 56
Autores: Cecílio,C.A.; Costa,E.H.; Simioni,P.U.; Gabriel,D.L.; Tamashiro,W.M.S.C.
The limited amount of information on the primary age-related deficiencies in the innate immune system led us to study the production of inducible nitric oxide synthase (iNOS), arginase, and cytokines in macrophages of young (8 weeks old) and old (72 weeks old) female BALB/c mice. We first evaluated iNOS and arginase inducers on peritoneal (PMΦ) and bone marrow-derived (BMMΦ) macrophages of young BALB/c and C57BL/6 mice, and then investigated their effects on macrophages of old mice. Upon stimulation with lipopolysaccharide (LPS), resident and thioglycolate-elicited PMΦ from young mice presented higher iNOS activity than those from old mice (54.4%). However, LPS-stimulated BMMΦ from old mice showed the highest NO levels (50.1%). Identical NO levels were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; INOS; Arginase; Cytokines; Murine macrophages; Inflammatory stimuli.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700010

Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
Provedor de dados: 56
Autores: Zamberlan,D.C.; Amaral,G.P.; Arantes,L.P.; Machado,M.L.; Mizdal,C.R.; Campos,M.M.A.; Soares,F.A.A.
Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptionally rich source of bioactive compounds with pharmacological properties. In the present study, we explored the effects of the ethanolic extract of R. officinalis (eeRo) on stress resistance and longevity using the non-parasitic nematode Caenorhabditis elegans as a model. We report for the first time that eeRo increased resistance against oxidative and thermal stress and extended C. elegans longevity in an insulin/IGF signaling pathway-dependent manner. These data...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Caenorhabditis elegans; Natural compounds; Rosemary; Daf-2; Stress resistance; Aging.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000900601

Effects of strain and age on ear wound healing and regeneration in mice
Provedor de dados: 56
Autores: Costa,R.A.; Ruiz-de-Souza,V.; Azevedo Jr.,G.M.; Vaz,N.M.; Carvalho,C.R.
Round holes in the ears of MRL mice tend to close with characteristics of regeneration believed to be absent in other mouse strains (e.g., C57BL/6). We evaluated the kinetics and the histopathology of ear wound closure in young (8 weeks old) C57BL/6 and BALB/c mice. We also used middle-aged (40 weeks old) C57BL/6 mice to evaluate the influence of aging on this process. A circular through-and-through hole was made in the ear, photographs were taken at different times after injury and wound area was measured with digital analysis software. The percentages of closed area measured on day 100 were: 23.57 ± 8.66% for young BALB/c mice, 56.47 ± 7.39% for young C57BL/6 mice, and 75.31 ± 23.65% for middle-aged C57BL/6 mice. Mice were sacrificed on days 1, 3, 5, 25,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Wound healing; Regeneration; Scar; Aging; C57BL/6 mice; BALB/c mice.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200004

Diagnosing dementia and normal aging: clinical relevance of brain ratios and cognitive performance in a Brazilian sample
Provedor de dados: 56
Autores: Chaves,M.L.F.; Ilha,D.; Maia,A.L.G.; Motta,E.; Lehmen,R.; Oliveira,L.M.
The main objective of the present study was to evaluate the diagnostic value (clinical application) of brain measures and cognitive function. Alzheimer and multiinfarct patients (N = 30) and normal subjects over the age of 50 (N = 40) were submitted to a medical, neurological and cognitive investigation. The cognitive tests applied were Mini-Mental, word span, digit span, logical memory, spatial recognition span, Boston naming test, praxis, and calculation tests. The brain ratios calculated were the ventricle-brain, bifrontal, bicaudate, third ventricle, and suprasellar cistern measures. These data were obtained from a brain computer tomography scan, and the cutoff values from receiver operating characteristic curves. We analyzed the diagnostic parameters...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brain ratios; Aging; Dementia; Cognition.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900013

Strength and power training did not modify cardiovascular responses to aerobic exercise in elderly subjects
Provedor de dados: 56
Autores: Queiroz,A.C.C.; Chehuen,M.R.; Costa,L.A.R.; Wallerstein,L.F.; Mello,M.T.; Ugrinowitsch,C.; Forjaz,C.L.M.
Resistance training increases muscle strength in older adults, decreasing the effort necessary for executing physical tasks, and reducing cardiovascular load during exercise. This hypothesis has been confirmed during strength-based activities, but not during aerobic-based activities. This study determined whether different resistance training regimens, strength training (ST, constant movement velocity) or power training (PT, concentric phase performed as fast as possible) can blunt the increase in cardiovascular load during an aerobic stimulus. Older adults (63.9 ± 0.7 years) were randomly allocated to: control (N = 11), ST (N = 13, twice a week, 70-90% 1-RM) and PT (N = 15, twice a week, 30-50% 1-RM) groups. Before and after 16 weeks, oxygen uptake (VO2),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Resistance training; Maximal exercise test; Aerobic exercise.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900006