Consulta: subjectFacets:"Alloxanthin"
Registros recuperados: 1
Data/hora: 02/06/2024 07:18:32

Carotenoids from Rhodomonas salina Induce Apoptosis and Sensitize A2058 Melanoma Cells to Chemotherapy
Provedor de dados: 5
Autores: De Oliveira-júnior, Raimundo Gonçalves; Nicolau, Elodie; Bonnet, Antoine; Prunier, Grégoire; Beaugeard, Laureen; Joguet, Nicolas; Thiéry, Valérie; Picot, Laurent.
Melanoma is an aggressive tumor with invasive and metastatic potential, frequently exhibiting multidrug resistance mechanisms. In our continuous search for antimelanoma molecules, we have identified some effective marine compounds capable of not only inducing cell death, but also of sensitizing chemoresistant tumor cells to clinically used anticancer drugs. In this report, the cryptophyte Rhodomonas salina (Wislouch) D.R.A.Hill &amp; R.Wetherbee, Pyrenomonadaceae, was chemically investigated in order to identify pigments efficiently inhibiting melanoma cells proliferation. All pharmacological tests were performed on A2058 cells expressing the oncogenic BRAF V600E mutation and resistant to dacarbazine treatment. Flash chromatography of R. salina ethanol...
Tipo: Text
Palavras-chave: Alloxanthin; Chemosensitivity; Crocoxanthin; Cutaneous melanoma; Drug resistance; Microalgae.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00630/74194/73918.pdf