Consulta: subjectFacets:"Angiopoietin"
Registros recuperados: 2
Data/hora: 05/06/2024 04:44:41

Relative Changes in mRNA Expression of Angiopoietins and Receptors Tie in Bovine Corpus Luteum during Estrous Cycle and Prostaglandin F2α-induced Luteolysis: A Possible Mechanism for the Initiation of Luteal Regression
Provedor de dados: 19
Autores: TANAKA, Jun; ACOSTA, Tomas J.; BERISHA, Bajram; TETSUKA, Masa; MATSUI, Motozumi; KOBAYASHI, Shuichi; SCHAMS, Dieter; MIYAMOTO, Akio; 松井, 基純; 宮本, 明夫.
Local angiogenesis and angiolysis in the corpus luteum (CL) relate to the luteal function. Recent studies indicate that angiopoietins (ANPT) and their receptors Tie regulate remodeling of microvasculature. We therefore examined 1) the relative changes in the expression of mRNA for ANPT-1, ANPT-2, Tie1 and Tie2 in bovine CL by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) during the estrous cycle and prostaglandin F2α (PGF2α)-induced luteolysis, and 2) the effect of ANPT-2 on progesterone (P4) release from CL at the late stage of the estrous cycle by an in vitro microdialysis system (MDS). The CLs were classified into 4 stages (early: Day 2-5, n=7, mid: Day 8-12, n=15, late: Day 15-17, n=9, regressing: Day &gt;18, n=19). The...
Palavras-chave: Angiopoietin; Angiolysis; Luteolysis; Corpus luteum; Cow.
Ano: 2004
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2977

Stimulated mast cells promote maturation of myocardial microvascular endothelial cell neovessels by modulating the angiopoietin-Tie-2 signaling pathway
Provedor de dados: 56
Autores: Wang,Z.H.; Zhu,W.; Tao,J.P.; Zhang,Q.Y.; Wei,M.
Angiopoietin (Ang)-1 and Ang-2 interact in angiogenesis to activate the Tie-2 receptor, which may be involved in new vessel maturation and regression. Mast cells (MCs) are also involved in formation of new blood vessels and angiogenesis. The present study was designed to test whether MCs can mediate angiogenesis in myocardial microvascular endothelial cells (MMVECs). Using a rat MMVEC and MC co-culture system, we observed that Ang-1 protein levels were very low even though its mRNA levels were increased by MCs. Interestingly, MCs were able to enhance migration, proliferation, and capillary-like tube formation, which were associated with suppressed Ang-2 protein expression, but not Tie-2 expression levels. These MCs induced effects that could be reversed by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Myocardial microvascular endothelial cells; Mast cell; Angiogenesis; Angiopoietin; Tie-2.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001100920