Consulta: subjectFacets:"Anti-inflammatory"
Registros recuperados: 25
Data/hora: 10/06/2024 12:08:53

Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia
Provedor de dados: 5
Autores: Aimond, Axelle; Calabro, Kevin; Audoin, Coralie; Olivier, Elodie; Dutot, Mélody; Buron, Pauline; Rat, Patrice; Laprévote, Olivier; Prado, Soizic; Roulland, Emmanuel; Thomas, Olivier P.; Genta-jouve, Grégory.
This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity.
Tipo: Text
Palavras-chave: Sideritis hyssopifolia; Ent-kaurane; Anti-inflammatory; NMR.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00610/72214/71012.pdf

Improving the Antioxidant Properties of Calophyllum inophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts
Provedor de dados: 5
Autores: Cassien, Mathieu; Mercier, Anne; Thétiot-laurent, Sophie; Culcasi, Marcel; Ricquebourg, Emilie; Asteian, Alice; Herbette, Gaëtan; Bianchini, Jean-pierre; Raharivelomanana, Phila; Pietri, Sylvia.
Tamanu oil from Calophyllum inophyllum L. has long been used in traditional medicine. Ethanol extraction was found the best strategy for recovering bioactive compounds from the resin part of Tamanu oil, yielding two neutral and acidic resins fractions with high phenolics, flavonoids and pyranocoumarins concentrations. A further cascade of LPLC/HPLC separations of neutral and acidic resin fractions allowed identifying fifteen metabolites, and among them, calanolide D and 12-oxocalanolide A (both in neutral fraction) were first identified from a natural source. All these extracts, subfractions and isolated metabolites demonstrated increased free radical scavenging, antioxidant, anti-inflammatory, antimicrobial and antimycobacterial activity compared to...
Tipo: Text
Palavras-chave: Calophyllum inophyllum L; Tamanu oil; Ethanol-soluble resin extracts; Lipophilic antioxidants; Phenolics; Pyranocoumarins; Antimicrobial; Anti-inflammatory; UV protection; EPR spin trapping.
Ano: 2021
URL: https://archimer.ifremer.fr/doc/00677/78918/81283.pdf

Radiation Nephritis: Anti-inflammatory Effect of Dexamethasone in Adult Wistar Rats (Rattus norvegicus)
Provedor de dados: 77
Autores: Owoeye,O; Malomo,A. O; Elumelu,T. N; Salami,A. A; Osuagwu,F. C; Akinlolu,A. A; Adenipekun,A; Shokunbi,M. T.
The anti-inflammatory effect of dexamethasone on the irradiated kidneys of adult Wistar rats (Rattus norvegicus) was studied. Eighteen adult Wistar rats were, after acclimatization, randomly divided into 3 groups of 6 animals per group. The control group had normal saline, receiving neither drugs nor radiation. The second group received normal saline and radiation. The third group received pretreatment with dexamethasone at 1mg/kg body weight/day for 2 days followed by radiation. Radiation was delivered to the animals as a single fraction of 2.5 Gy of gamma rays from Cobalt-60 source, using an AECL Theatron 780-C Teletherapy machine. After exposure to the different interventions, the animals were sacrificed on the 14th post-irradiation day and the kidneys...
Tipo: Journal article
Palavras-chave: Radiation; Nephrons; Glomerulus; Nephritis; Anti-inflammatory; Kidney.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100011

The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement: a systematic review
Provedor de dados: 42
Autores: CORRÊA,ADRIANO S.; ALMEIDA,VINÍCIUS L. DE; LOPES,BEATRIZ M.V.; FRANCO,ADEMIR; MATOS,FELIPE R. DE; QUINTANS-JÚNIOR,LUCINDO J.; RODE,SIGMAR M.; PARANHOS,LUIZ R.
ABSTRACT The present study aimed to perform a systematic literature review to determine if there is a non-steroidal anti-inflammatory drug (NSAID) that interferes less within tooth movement. This research was performed according to the PRISMA statement. Articles were searched in eight electronic databases (PubMed, Scopus, Embase, Web of Science, LILACS, SciELO, Google Scholar, and Open Grey). Only experimental studies on male Wistar rats were selected, which included experiments related to the influence of NSAIDs on orthodontic movement. Studies in animals with pathological conditions, literature review articles, letters to the editor and/or editorials, case reports, abstracts, books, and book chapters were excluded. Each of the steps of this systematic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anti-inflammatory; Drug; Orthodontics; Non-steroidal; Tooth movement.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602851

Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive
Provedor de dados: 42
Autores: WILHELM,ETHEL A.; FERREIRA,ANA TERESINHA; PINZ,MIKAELA P.; REIS,ANGÉLICA S. DOS; VOGT,ANE G.; STEIN,ANDRE L.; ZENI,GILSON; LUCHESE,CRISTIANE.
ABSTRACT The present study investigated the antioxidant effect of a new class of quinoline derivatives (a-d) on assays in vitro. Lipid peroxidation, thiol peroxidase-like and free radical scavenging activities were determined to evaluate antioxidant activity of compounds. Thiol oxidase-like and δ-aminolevulinate dehydratase activities were performed as a toxicological parameter. A second objective of this study was to evaluate the in vivo antinociceptive effect of the compound with better antioxidant effect and without toxic effects in a model of nociception induced by formalin in mice. In liver, at 100 µM, compound a reduced the lipid peroxidation to the control levels, while compounds c and d partially reduced it. In brain, only compound d partially...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antinociceptive; Antiedematogenic; Anti-inflammatory; Antioxidant; Quinoline.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200457

Sambucus australis Modulates Inflammatory Response via Inhibition of Nuclear Factor Kappa B (NF-kB) in vitro
Provedor de dados: 42
Autores: CARNEIRO,NORMA V.Q.; SILVA,HUGO B.F. DA; SILVA,RAIMON R. DA; CARNEIRO,TAMIRES C.B.; COSTA,RYAN S.; PIRES,ANAQUE O.; MARQUES,CINTIA R.; VELOZO,EUDES S.; CONCEIÇÃO,ADILVA S.; SILVA,TANIA M.S. DA; SILVA,TELMA M.G. DA; ALCÂNTARA-NEVES,NEUZA M.; FIGUEIREDO,CAMILA A.
Abstract: Medicinal plants have long been used as an alternative to traditional drugs for the treatment of inflammatory conditions due to the classical side effects and restricted access of various commercially available drugs, such as steroids (GCs) and nonsteroidal anti-inflammatory drugs (NSAIDs). Sambucus australis is a Brazilian herb that is commonly used to treat inflammatory diseases; however, few studies have examined the use of this species in the treatment of inflammatory conditions. The present study aims to evaluate the potential anti-inflammatory activity of S. australis in vitro. We established spleen cell cultures stimulated with pokeweed mitogen (PWM) to evaluate the production of proinflammatory cytokines, such as IL-4, IL-5, IFN-y, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sambucus australis; Elderberry; Anti-inflammatory; NF-kB.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100612

Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models
Provedor de dados: 42
Autores: Santos,Edson N.; Lima,Joaquim C.S.; Noldin,Vânia F.; Cechinel-Filho,Valdir; Rao,Vietla S. N.; Lima,Evangelista F.; Schmeda-Hirschmann,Guillermo; Sousa Jr.,Paulo T.; Martins,Domingos T.O.
Cariniana rubra Miers (Lecythidaceae), popularly known as "jequitibá-vermelho'', is a large Brazilian tree whose bark is used in infusion and decoction for the treatment of inflammatory conditions. This study aims to assess the anti-inflammatory, antinociceptive, and antipyretic effects of Cariniana rubra methanolic stem bark extract (EM Cr) using experimental animals. Anti-inflammatory activity of EM Cr was tested on carrageenan and dextran-induced rat paw edema, carrageenan-induced pleurisy in rats and acetic acid-increase vascular permeability in mice. Antinociceptive and antipyretic activities were evaluated using acetic acid-induced writhing, formalin and hot-plate tests in mice, as well as brewer's yeast-induced pyrexia in rats. The extract...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anti-inflammatory; Antinociceptive; Antipyretic; Cariniana rubra; Lecythidaceae; Triterpenoidal saponins.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200015

The anti-inflammatory activity of standard aqueous stem bark extract of Mangifera indica L. as evident in inhibition of Group IA sPLA2
Provedor de dados: 42
Autores: DHANANJAYA,BHADRAPURA LAKKAPPA; SHIVALINGAIAH,SUDHARSHAN.
ABSTRACT The standard aqueous stem bark extract is consumed as herbal drink and used in the pharmaceutical formulations to treat patients suffering from various disease conditions in Cuba. This study was carried out to evaluate the modulatory effect of standard aqueous bark extract of M. indica on Group IA sPLA2. M. indica extract, dose dependently inhibited the GIA sPLA2 (NN-XIa-PLA2) activity with an IC50 value 8.1 µg/ml. M. indica extract effectively inhibited the indirect hemolytic activity up to 98% at ~40 µg/ml concentration and at various concentrations (0-50 µg/ml), it dose dependently inhibited the edema formation. When examined as a function of increased substrate and calcium concentration, there was no relieve of inhibitory effect on the GIA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Secretory phospholipase A2; Anti-inflammatory; Pro-inflammatory; Inhibition; Drug; Plants.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100197

Bioactivities of the ethanol extract from Ageratum fastigiatum branches: antioxidant, antinociceptive and anti-inflammatory
Provedor de dados: 42
Autores: DEL-VECHIO-VIEIRA,GLAUCIEMAR; SANTOS,BRUNA C.S.; ALVES,MARIA SILVANA; ARAÚJO,AÍLSON L.A.; YAMAMOTO,CÉLIA H.; PINTO,MÍRIAM A.O.; KAPLAN,MARIA AUXILIADORA C.; SOUSA,ORLANDO V.
ABSTRACT The present study was designed to investigate the antioxidant, antinociceptive and anti-inflammatory activities of the ethanol extract from Ageratum fastigiatum branches. Phytochemical screening and total phenol and flavonoid contents were determined. The antioxidant activity was assessed by 2,2-diphenyl-1-pycrilhydrazin (DPPH) and iron reducing power methods. The antinociceptive effect was evaluated using the acetic acid-induced writhing, formalin, hot plate and tail immersion assays; while the carrageenan-induced paw edema and pleurisy tests were performed to examine the anti-inflammatory activity against acute inflammation. The extract revealed the presence of flavonoids, tannins, coumarins, terpenes, sterols and saponins. Expressive levels of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ageratum fastigiatum; Analgesic; Anti-inflammatory; Antioxidant; Flavonoids; Total phenols.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401471

Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice
Provedor de dados: 42
Autores: FLORENTINO,IZIARA F.; NASCIMENTO,MARCUS VINÍCIUS M.; GALDINO,PABLINNY M.; BRITO,ADRIANE F. DE; ROCHA,FABIO F. DA; TONUSSI,CARLOS R.; LIMA,THEREZA CHRISTINA M. DE; PAULA,JOSÉ R. DE; COSTA,ELSON A.
The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acariçoba's underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema induced by carrageenan...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acariçoba; Anti-inflammatory; Antinociceptive; Biomedical Sciences; Hydrocotyle umbellata L.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300987

Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats
Provedor de dados: 48
Autores: Morales,Glauco; Paredes,Adrián; Olivares,Alberto; Bravo,Jaime.
BACKGROUND: Algesia and inflammation are related with several pathological conditions. It is known that many drugs available for the treatment of these problems cause unwanted side effects. This study was aimed at evaluating acute toxicity and anti-inflammatory activity of Lampaya medicinalis Phil. (Verbenaceae) widely used in the folk medicine of Northern Chile against rheumatism, arthritis and body joints pain. RESULTS: Oral administration of hydroalcoholic extract (HAE) at the highest dose of 3000 mg/ Kg body weight resulted in no mortalities or evidence of significant behavioral changes. Histological examination revealed normal architecture and no significant adverse effects were observed on the liver, kidney, heart, lung or ovaries and testicles. The...
Tipo: Journal article
Palavras-chave: Lampaya medicinalis; Hydroalcoholic extract; Acute oral toxicity; Histology; Hematology; Anti-inflammatory; Carrageenan.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100006

In vivo analgesic, antipyretic, and anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic extract from Litsea glutinosaleaves
Provedor de dados: 48
Autores: Bhowmick,Rumpa; Sarwa,Md Shahid; Dewan,Syed Masudur Rahman; Das,Abhijit; Das,Binayok; Uddin,Mir Muhammad Nasir; Islam,Md Siddiqul; Islam,Mohammad Safiqul.
BACKGROUND: The study was conducted to evaluate the in vitro thrombolytic activity, and in vivo analgesic, anti-inflammatory and antipyretic potentials of different hydrocarbon soluble extracts of Litsea glutinosaleaves for the first time widely used in the folkloric treatments in Bangladesh. This work aimed to create new insights on the fundamental mechanisms of the plant extracts involved in these activities. RESULTS: In thrombolytic activity assay, a significant clot disruption was observed at dose of 1 mg/mL for each of the extracts (volume 100 &amp;#956;L) when compared to the standard drug streptokinase. The n-hexane, ethyl acetate, chloroform, and crude methanolic extracts showed 32.23&amp;#8201;±&amp;#8201;0.26, 37.67&amp;#8201;±&amp;#8201;1.31,...
Tipo: Journal article
Palavras-chave: Acetic acid induced writhing; Analgesic; Anti-inflammatory; Antipyretic; Litsea glutinosa; Thrombolytic.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100050

Anti-inflammatory and redox-protective activities of citronellal
Provedor de dados: 48
Autores: Melo,Mônica S; Guimarães,Adriana G; Santana,Michele F; Siqueira,Rosana S; De Lima,Amanda Do Carmo B; Dias,Antonio S; Santos,Márcio Roberto V; Onofre,Alexandre S.C.; Quintans,Jullyana S.S.; De Sousa,Damião P; Almeida,Jackson R.G.S.; Estevam,Charles S; Araujo,Brancilene S; Quintans-Júnior,Lucindo J.
The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p &lt; 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p &lt; 0.05) by i.p. administration of 100 and 200 mg/kg of the compound. When the redox activity was evaluated, CT (200 mg/kg) significantly reduced hepatic lipoperoxidation (p &lt; 0.001), as well as oxidation of plasmatic (p &lt; 0.05) and hepatic (p &lt; 0.01) proteins. The results of the present study support the hypothesis that CT possesses anti-inflammatory and...
Tipo: Journal article
Palavras-chave: Monoterpene; Citronellal; Anti-inflammatory; Redox.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400008

Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation
Provedor de dados: 48
Autores: Raju,Golam Sarwar; Moghal,Md Mizanur Rahman; Hossain,Mohammad Salim; Hassan,Md Mahadi; Billah,Md Mustahsan; Ahamed,Sayed Koushik; Rana,SM Masud.
BACKGROUND: The current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb. RESULTS: The AELS and AEAR extract presented a significant (***p &lt; 0.001) dose dependent increase in reaction time in writhing method and showed inhibition of 63.1% and 57.1% respectively at the doses of 400 mg/kg body weight while standard drug showed (P &lt; 0.001) inhibition of 69.23%. In tail immersion method, AELS and AEAR showed maximum time of tail retention at 30 min in hot water i.e. 6.93 sec and 6.54 sec respectively at highest doses of 400 mg/kg body weight than lower dose while standard pentazocine showed reaction time of 7.62...
Tipo: Journal article
Palavras-chave: Launaea sarmentosa; Aegialitis rotundifolia roxb; Analgesic; Antipyretic; Anti-inflammatory.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100049

In vivo antipyretic, antiemetic, in vitro membrane stabilization, antimicrobial, and cytotoxic activities of different extracts from Spilanthes paniculata leaves
Provedor de dados: 48
Autores: Hossain,Mohammad Mobarak; Ahamed,Sayed Koushik; Dewan,Syed Masudur Rahman; Hassan,Md Mahadi; Istiaq,Arif; Islam,Mohammad Safiqul; Moghal,Md Mizanur Rahman.
BACKGROUND: The study was conducted to evaluate the in vitro antimicrobial activity, cytotoxic, and membrane stabilization activities, and in vivo antiemetic and antipyretic potentials of ethanolic extract, n-hexane and ethyl acetate soluble fractions of Spilanthes paniculata leaves for the first time widely used in the traditional treatments in Bangladesh. RESULTS: In antipyretic activity assay, a significant reduction (P &lt; 0.05) was observed in the temperature in the mice tested. At dose 400 mg/kg-body weight, the n-hexane soluble fraction showed the effect (36.7 ± 0.63°C ) as like as the standard (dose 150 mg/kg-body weight) after 5 h of administration. Extracts showed significant (P &lt; 0.001) potential when tested for the antiemetic activity...
Tipo: Journal article
Palavras-chave: Antiemetic; Anti-inflammatory; Antimicrobial activity; Brine shrimp lethality bioassay; Cytotoxic; Membrane stabilization; Spilanthes paniculata.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100045

Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model
Provedor de dados: 48
Autores: Hwan-Hee,Jang; Su-Yeon,Cho; Mi-Ju,Kim; Jung-Bong,Kim; Sung-Hyen,Lee; Mee-Young,Lee; Young-Min,Lee.
BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-&amp;#945; and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an...
Tipo: Journal article
Palavras-chave: Anti-inflammatory; Asthma; Salvia plebeia.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100041

Nephroprotective and anti-inflammatory effects of aqueous extract of Melissa officinalis L. on acetaminophen-induced and pleurisy-induced lesions in rats
Provedor de dados: 52
Autores: Müzell,Denise Pereira; Lunardelli,Adroaldo; Leite,Carlos Eduardo; Fagundes,Rodrigo Medeiros; Saciura,Vasyl Custódio; Reichel,Carlos Luiz; Oliveira,Jarbas Rodrigues de; Astarita,Leandro Vieira.
This study assessed the bioactive properties of an aqueous extract of M. officinalis for its anti-inflammatory activity and its protection against hepatic and renal lesions induced by acetaminophen (APAP). Animals pre-treated with the crude extract in pleurisy induced by carrageenan showed a reduction in the amounts of exudate, in the numbers of leukocytes and polymorphonuclear cells. Intragastric administration of the extract for seven days prior to the APAP-induced lesion showed no protective effect on the liver. The treatment with the extract induced an increase of serum aspartate aminotransferase, indicating a rise of toxicity. Contrarily, the same treatment reduced the APAP induced lesion in kidney, with respect to ν-glutamyltransferase. The results...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acetaminophen; Melissa officinalis; Pleurisy; Anti-inflammatory; Kidney; Liver.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300006

Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC
Provedor de dados: 56
Autores: Bayeux,M.C.; Fernandes,A.T.; Foglio,M.A.; Carvalho,J.E.
The species Cordia curassavica (Boraginaceae), known popularly as "erva baleeira", is used in folk medicine for the treatment of several inflammatory processes and as a healing agent. The objective of the present study was to evaluate the antiedematogenic activity of crude dichloromethane extracts of Cordia curassavica and of the artemetin-enriched fraction. The crude extract and artemetin fraction were tested in the model of carrageenin-induced paw edema in male Swiss mice (25-30 g). The crude dichloromethane extract (300 and 1000 mg/kg, po, N = 6) showed significant antiedematogenic activity, reducing the edema by 42, 57 and 45% and 46, 62 and 69%, 3, 4 and 5 h after carrageenin administration, respectively. Indomethacin (10 mg/kg, po, N = 6) reduced the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cordia curassavica; Cordia verbenaceae; Antiedematogenic; Anti-inflammatory; Medicinal plants.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000017

In vitro anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A, a chalcone isolated from Boesenbergia rotunda (L.) (fingerroot)
Provedor de dados: 56
Autores: Isa,N.M.; Abdelwahab,S.I.; Mohan,S.; Abdul,A.B.; Sukari,M.A.; Taha,M.M.E.; Syam,S.; Narrima,P.; Cheah,S.Ch.; Ahmad,S.; Mustafa,M.R.
The current in vitro study was designed to investigate the anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A (BA), a chalcone derivative of known structure isolated from Boesenbergia rotunda. Human hepatocellular carcinoma (HepG2), colon adenocarcinoma (HT-29), non-small cell lung cancer (A549), prostate adenocarcinoma (PC3), and normal hepatic cells (WRL-68) were used to evaluate the cytotoxicity of BA using the MTT assay. The antioxidant activity of BA was assessed by the ORAC assay and compared to quercetin as a standard reference antioxidant. ORAC results are reported as the equivalent concentration of Trolox that produces the same level of antioxidant activity as the sample tested at 20 µg/mL. The toxic effect of BA on...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Boesenbergia rotunda; Boesenbergin A; Cytotoxicity; Antioxidation; Anti-inflammatory.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600008

Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications
Provedor de dados: 56
Autores: Guidoni,M.; de Christo Scherer,M.M.; Figueira,M.M.; Schmitt,E.F.P.; de Almeida,L.C.; Scherer,R.; Bogusz,S.; Fronza,M.
Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264.7 cells by investigating the release of nitric oxide (NO), superoxide anion generation (O2-), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6). ABTS cation radical scavenging capacity assay, ferric reducing antioxidant potential (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and NO free radical scavenging assays were used to evaluate the antioxidant activity. VOB was tested...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vegetable oil blend; Skin care; Fatty acids; Anti-inflammatory; Nitric oxide; Scratch assay.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000200609

Evaluation of antiarthritic activity of ginkgolic acid against Freund’s adjuvant induced arthritic rat model
Provedor de dados: 60
Autores: Zhang,Ziqiang; Wang,Xiaogang; Li,Pengshan; Bai,Minghua; Qi,Wenbing.
This study aimed to analyze the antiarthritic activity of ginkgolic acid against the Complete Freund’s Adjuvant (CFA)-induced arthritis in rats. Arthritis was induced through an intradermal injection of CFA (0.1 mL) at the right hind footpad of adult Wistar Albino rats. Ginkgolic acid was administered orally at doses of 25 mg/kg and 50 mg/kg, respectively, once daily via gavage for 25 days upon inducing arthritis. Indomethacin was administered orally at a dose of 3 mg/kg twice in a week which served as positive control group. The animals were sacrificed and subjected to biochemical and histopathological analysis upon completion of treatment. Ginkgolic acid was able to reverse the arthritic effect (p &lt; 0.01) induced by CFA in a dose dependent manner....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ginkgolic acid; Complete Freund’s Adjuvant (CFA); Osteoarthritis; Antioxidant; Anti-inflammatory; Histopathology.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100617

Anti-inflammatory activity and identification of the Verbena litoralis Kunth crude extract constituents
Provedor de dados: 60
Autores: Lima,Rachel de; Brondani,Juliana Calil; Dornelles,Rafaela Castro; Lhamas,Cibele Lima; Faccin,Henrique; Silva,Carine Viana; Dalmora,Sérgio Luiz; Manfron,Melânia Palermo.
Verbena litoralis is a plant popularly known as “gervãozinho-do-campo” in Portuguese. It is traditionally used for stomach, liver and gallbladder problems, and as an anti-inflammatory and anthelmintic. The goal of this study was to determine the chemical composition of the crude extract obtained from the aerial parts of V. litoralis by Ultra High Performance Liquid chromatography coupled with Mass Spectrometry in Tandem (UHPLC-MS/MS); assess the anti-inflammatory activity of ethyl acetate fraction and of crude extract; and verify liver, kidney and pancreas damage. In this study, the chemical composition of the extract was identified via UHPLC/MS/MS, assessing the anti-inflammatory activity of the crude extract and the acetate fraction in an induction model...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Verbena litoralis; UHPLC/MS; Flavonoids; Anti-inflammatory.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100540

The in vitro and in vivo investigation of biological activities and phenolic analysis of Helichrysum plicatum subsp. plicatum
Provedor de dados: 60
Autores: Taşkın,Turgut; Gezmiş,Tuğba; Çam,Muhammet Emin; Taşkın,Duygu; Çelik,Berna Özbek; Şenkardeş,İsmail; Süzgeç-Selçuk,Sevda.
In Turkey, Helichrysum genus is represented by 26 taxa belonging to 20 species in Turkish flora of which 14 ones are endemic to Turkey. The aerial parts of Helichrysum plicatum subsp. plicatum are used kidney stones, kidney and stomach ailments. The extraction procedures and solvents are important step in processing of bioactive constituents from the plant materials. Therefore, the aim of this study was to evaluate in vitro antioxidant, antimicrobial, anti-urease, anticholinesterase and in vivo anti-inflammatory activities of Helichrysum plicatum subsp. plicatum different extracts. In addition, the phenolic characterization of the Soxhlet and maceration methanol extracts which showed significant antioxidant, anti-urease, antimicrobial, anti-inflammatory...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helichrysum plicatum subsp; Plicatum; Anti-inflammatory; Anti-urease; Anticholinesterase; HPLC-DAD-MS.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100554

Antioxidant and anti-inflammatory activities of winery wastes seeds of Vitis labrusca
Provedor de dados: 65
Autores: Scola,Gustavo; Kappel,Virginia Demarchi; Moreira,José Claudio Fonseca; Dal-Pizzol,Felipe; Salvador,Mirian.
There are many studies about the biological activities of Vitis vinifera grape seeds, which are rich in phenolic compounds, known by their several health beneficial effects. However, until now there is no data about biological activities of the seeds of V. labrusca, specie found in South and North America. Every year, the global wine production (around 260 million hL) generates about 19.5 million ton of wastes, which are usually discarded in the environment. The aim of this research was to evaluate the antioxidant and anti-inflammatory activities of aqueous extracts of seeds from wine wastes of Vitis labrusca (cv. 'Bordo' and 'Isabella'). Both extracts showed significant antioxidant and anti-inflammatory activities, which are positively correlated with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: V. labrusca; Winery wastes; Antioxidant; Anti-inflammatory.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782011000700020

Systemic and neurotoxic effects of epidural meloxicam in rabbits
Provedor de dados: 65
Autores: Felipe,Gracineide da Costa; Henrique,Fernanda Vieira; Rego,Renato Otaviano do; Alves,Alane Pereira; Oliveira,Kalyne Danielly Silva de; Firmino,Millena de Oliveira; Medeiros,Lylian Karlla Gomes de; Silva,Gustavo de Assis; Batista,Luanna Figueirêdo; Dantas,Antônio Flávio Medeiros; Souza,Bonifácio Benicio de; Nóbrega Neto,Pedro Isidro da.
ABSTRACT: The aim of this study was to assess systemic and neurotoxic changes following an epidural administration of meloxicamin to rabbits. Twelve adult rabbits four males and eight females; average mass, 1.9 ± 0.1kg were randomly divided into two groups: a control group (GC), which received a single dose of 0.9% NaCl epidurally in a volume of 0.3mL kg-1and a meloxicam group (GM), which received 0.2mg kg-1 meloxicam epidurally along with 0.9% NaCl in a total volume of 0.3mL kg-1. Heart rate, respiratory rate, body temperature, and neurological abnormalities were assessed prior to administration of anesthesia (H0), 1, 2, 3, 6, 12, and 24h following epidural puncture (H1, H2, H3, H6, H12, and H24, respectively), and every 24h afterward for 10 days after...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anti-inflammatory; Leporids; Spinal cord; Neurotoxicity.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000500602