Consulta: subjectFacets:"Anticoagulant"
Registros recuperados: 4
Data/hora: 09/06/2024 13:47:30

Characterization and biological properties of sulfated polysaccharides of Corallina officinalis and Pterocladia capillacea
Provedor de dados: 39
Autores: Ismail,Mona Mohamed; Amer,Mohamed Saleh.
ABSTRACT Red seaweed possess various sulfated polysaccharides (SPs) that could potentially be exploited as bioactive agents for medical and industrial applications. Crude polysaccharides from the red algae Corallina officinalis (SP1) and Pterocladia capillacea (SP2) were extracted and characterized according to their chemical content and their antioxidant, anti-inflammatory, anticoagulant, antibacterial, antifungal, and antifouling activities. The isolated polysaccharides contained low levels of protein and high levels of carbohydrate and sulfate. The extracted SPs were characterized by Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectral data and revealed that SP1 is composed of carrageenan, while SP2 is composed of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anticoagulant; Antifouling; Antimicrobial; Antioxidant; Polysaccharides; Red seaweed.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062020000400623

Structure and anticoagulant properties of sulfated glycosaminoglycans from primitive Chordates
Provedor de dados: 42
Autores: PAVÃO,MAURO S. G.
Dermatan sulfates and heparin, similar to the mammalian glycosaminoglycans, but with differences in the degree and position of sulfation were previously isolated from the body of the ascidian Styela plicata and Ascidia nigra. These differences produce profound effects on their anticoagulant properties. S. plicata dermatan sulfate composed by 2-O-sulfatedalpha-L-iduronic acid and 4-O-sulfated N-acetyl-beta-D-galactosamine residues is a potent anticoagulant due to a high heparin cofactor II activity. Surprisingly, it has a lower potency to prevent thrombus formation on an experimental model and a lower bleeding effect in rats than the mammalian dermatan sulfate. In contrast, A. nigra dermatan sulfate, also enriched in 2-O-sulfated alpha-L-iduronic acid, but...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ascidian; Heparin; Dermatan sulfate; Heparin cofactor II; Anticoagulant; Antithrombotic.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000100007

Reversal of the anticoagulant and anti-hemostatic effect of low molecular weight heparin by direct prothrombin activation
Provedor de dados: 56
Autores: Andrade,S.A.; Carrijo-Carvalho,L.C.; Peceguini,L.A.M.; Wlian,L.; Sato,A.C.; Luchiari,C.; Silva,E.D.; Maffei,F.H.A.; Chudzinski-Tavassi,A.M.
Lopap, found in the bristles of Lonomia obliqua caterpillar, is the first exogenous prothrombin activator that shows serine protease-like activity, independent of prothrombinase components and unique lipocalin reported to interfere with hemostasis mechanisms. To assess the action of an exogenous prothrombin activator reversing the anticoagulant and antihemostatic effect induced by low molecular weight heparin (LMWH), male New Zealand rabbits (N = 20, weighing 3.8-4.0 kg) allocated to 4 groups were anticoagulated with 1800 IU/kg LMWH (iv) over 2 min, followed by iv administration of saline (SG) or recombinant Lopap (rLopap) at 1 µg/kg (LG1) or 10 µg/kg (LG10), 10 min after the injection of LMWH, in a blind manner. Control animals (CG) were treated only with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Prothrombin activation; Procoagulant; Exogenous hemostatic factor; RLopap; Bleeding; Anticoagulant.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001000007

Antithrombotic effect of Lonomia obliqua caterpillar bristle extract on experimental venous thrombosis
Provedor de dados: 56
Autores: Prezoto,B.C.; Maffei,F.H.A.; Mattar,L.; Chudzinski-Tavassi,A.M.; Curi,P.R.
The venom of Lonomia obliqua caterpillar may induce a hemorrhagic syndrome in humans, and blood incoagulability by afibrinogenemia when intravenously injected in laboratory animals. The possible antithrombotic and thrombolytic activities of L. obliqua caterpillar bristle extract (LOCBE) were evaluated in this study. The minimal intravenous dose of the extract necessary to induce afibrinogenemia and anticoagulation was 3.0 and 10.0 µg protein/kg body weight for rabbits and rats, respectively. In rabbits, this dose induced total blood incoagulability for at least 10 h and did not reduce the weight of preformed venous thrombi, in contrast to streptokinase (30,000 IU/kg). In rats, pretreatment with 5.0 and 10.0 µg/kg LOCBE prevented the formation of thrombi...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Thrombosis; Fibrinolysis; Anticoagulant; Venom; Lonomia obliqua caterpillar.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600011