Consulta: subjectFacets:"Antigen absorption"
Registros recuperados: 1
Data/hora: 05/06/2024 16:09:23

Coupling of palmitate to ovalbumin inhibits the induction of oral tolerance
Provedor de dados: 56
Autores: Oliveira,F.M.; Silva-Neto,A.F.; Silva,C.A.; Gontijo,C.M.
Oral tolerance is a phenomenon that may occur in animals exposed to protein antigens for the first time by the oral route. They become unable to produce immune responses at the levels normally observed when they are immunized parenterally with antigen in the presence of adjuvants. Lipids have been used as adjuvants for both parenteral and oral immunization. In the present study we coupled ovalbumin with palmitate residues by incubating the protein with the N-hydroxysuccinimide palmitate ester and tested the preparation for its ability to induce oral tolerance. This was performed by giving 20 mg of antigen to mice by the oral route 7 days prior to parenteral immunization in the presence of Al(OH)3. Mice were bled one week after receiving a booster that was...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Oral tolerance; Lipid-protein conjugates; Antigen absorption; Gut mucosa; Ovalbumin.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001100009