Consulta: subjectFacets:"B lymphocytes"
Registros recuperados: 2
Data/hora: 01/06/2024 06:39:43

IgE expression on the surface of B1 and B2 lymphocytes in experimental murine schistosomiasis
Provedor de dados: 56
Autores: Oliveira,F.L.; Aguiar,A.M.; Borojevic,R.; El-Cheikh,M.C.
In a previous study we monitored the distribution and phenotype expression of B1 cells during the evolution of experimental murine schistosomiasis mansoni and we proposed that the B1 cells were heterogeneous: a fraction which originated in the spleen and followed the migratory pathway to mesenteric ganglia, while the other was the resident peritoneal B1-cell pool. In the present study, we have addressed the question of whether these two B1-lymphocyte populations are involved in the production of the late Ig isotype IgE, which is present in high levels in schistosomal infection. Lymphocyte expression of surface markers and immunoglobulins were monitored by immunofluorescence flow cytometry. Both in the spleen and mesenteric ganglia, the B1 and B2 cells were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Schistosomiasis; B lymphocytes; Immunoglobulin switch.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700006

Modulation of B lymphocyte function by an aqueous fraction of the ethanol extract of Cissampelos sympodialis Eichl (Menispermaceae)
Provedor de dados: 56
Autores: Alexandre-Moreira,M.S.; Piuvezam,M.R.; Pecanha,L.M.T.
Cissampelos sympodialis Eichl species are used in folk medicine for the treatment of asthma, arthritis and rheumatism. In the present study, we investigated the immunomodulatory effect of an aqueous fraction of a 70% (v/v) ethanol extract of C. sympodialis leaves on B lymphocyte function. The hydroalcoholic extract inhibited the in vitro proliferative response of resting B cells induced by LPS (IC50 = 17.2 µg/ml), anti-delta-dextran (IC50 = 13.9 µg/ml) and anti-IgM (IC50 = 24.3 µg/ml) but did not affect the anti-MHC class II antibody-stimulated proliferative response of B cell blasts obtained by stimulation with IL-4 and anti-IgM. Incubation with the hydroalcoholic extract used at 50 µg/ml induced a 700% increase in intracellular cAMP levels. IgM secretion...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: B lymphocytes; Cissampelos sympodialis; Natural products; Trypanosoma cruzi; Immunoglobulin.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001100010