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Parameter Estimation for Dynamic Resource Allocation in Microorganisms: A Bi-level Optimization Problem
Provedor de dados: 5
Autores: Mairet, Francis; Bayen, Térence.
Given their key roles in almost all ecosystems and in several industries, understanding and predicting microorganism growth is of utmost importance. In compliance with evolutionary principles, coarse-grained or genome-scale models of microbial growth can be used to determine optimal resource allocation scheme under dynamic environmental conditions. Resource allocation approaches have given important qualitative results, but it still remains a gap towards quantitiative predictions. The first step in this direction is parameter calibration with experimental data. But fitting these models results in a bi-level optimization problem, whose numerical resolution involves complex optimization issues. As a case study, we present here a coarse-grained model...
Tipo: Text
Palavras-chave: Bi-level optimization; Optimal control; Pontryagin’s principle; Chattering; Microbial growth; Microalgae.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00690/80163/83228.pdf