Consulta: subjectFacets:"Bilayer permeation"
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Cholesterol-dependent hemolytic activity of Passiflora quadrangularis leaves
Provedor de dados: 56
Autores: Yuldasheva,L.N.; Carvalho,E.B.; Catanho,M.-T.J.A.; Krasilnikov,O.V.
Plants used in traditional medicine are rich sources of hemolysins and cytolysins, which are potential bactericidal and anticancer drugs. The present study demonstrates for the first time the presence of a hemolysin in the leaves of Passiflora quadrangularis L. This hemolysin is heat stable, resistant to trypsin treatment, has the capacity to froth, and acts very rapidly. The hemolysin activity is dose-dependent, with a slope greater than 1 in a double-logarithmic plot. Polyethylene glycols of high molecular weight were able to reduce the rate of hemolysis, while liposomes containing cholesterol completely inhibited it. In contrast, liposomes containing phosphatidylcholine were ineffective. The Passiflora hemolysin markedly increased the conductance of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Passiflora quadrangularis; Leaf extract; Liposomes; Bilayer permeation; Hemolysin; Membrane cholesterol.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700009