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On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses
Provedor de dados: 5
Autores: Lerat, Emmanuelle; Casacuberta, Josep; Chaparro, Cristian; Vieira, Cristina.
Eukaryotic genomes comprise a large proportion of repeated sequences, an important fraction of which are transposable elements (TEs). TEs are mobile elements that have a significant impact on genome evolution and on gene functioning. Although some TE insertions could provide adaptive advantages to species, transposition is a highly mutagenic event that has to be tightly controlled to ensure its viability. Genomes have evolved sophisticated mechanisms to control TE activity, the most important being epigenetic silencing. However, the epigenetic control of TEs can also affect genes located nearby that can become epigenetically regulated. It has been proposed that the combination of TE mobilization and the induced changes in the epigenetic landscape could...
Tipo: Text
Palavras-chave: Transposable element; Epigenomics; Bioinformatic tools.
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00487/59900/63082.pdf