Consulta: subjectFacets:"Brain-derived neurotrophic factor"
Registros recuperados: 2
Data/hora: 09/06/2024 11:54:39

Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis
Provedor de dados: 55
Autores: Cordeiro,Cynthia Azeredo; Vieira,Erica Leandro Marciano; Rocha,Natália Pessoa; Castro,Vinicius Monteiro; Oréfice,Juliana Lambert; Barichello,Tatiana; Costa,Rogerio Alves; Oréfice,Fernando; Young,Lucy; Teixeira,Antonio Lucio.
Abstract Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment.  Methods: Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay.  Results: BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Retinochoroiditis; Toxoplasma gondii; Brain-derived neurotrophic factor.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200176

Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence
Provedor de dados: 56
Autores: Xu,R.; Duan,S.R.; Zhao,J.W.; Wang,C.Y.
Chronic ethanol consumption can produce learning and memory deficits. Brain-derived neurotrophic factor (BDNF) and its receptors affect the pathogenesis of alcoholism. In this study, we examined the expression of BDNF, tropomyosin receptor kinase B (TrkB) and p75 neurotrophin receptor (p75NTR) in the hippocampus of a dog model of chronic alcoholism and abstinence. Twenty domestic dogs (9-10 months old, 15-20 kg; 10 males and 10 females) were obtained from Harbin Medical University. A stable alcoholism model was established through ad libitum feeding, and anti-alcohol drug treatment (Zhong Yao Jie Jiu Ling, the main ingredient was the stems of watermelon; developed in our laboratory), at low- and high-doses, was carried out. The Zhong Yao Jie Jiu Ling was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic alcoholism; Brain-derived neurotrophic factor; Tropomyosin receptor kinase B; P75 Neurotrophin receptor; Immunohistochemistry.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000800703