Consulta: subjectFacets:"Cardiovascular disease"
Registros recuperados: 22
Data/hora: 01/06/2024 04:44:33

Association between osteoprotegerin gene polymorphisms and cardiovascular disease in type 2 diabetic patients
Provedor de dados: 74
Autores: Guo,Changlei; Hu,Fudong; Zhang,Shaoli; Wang,Yakun; Liu,Hengdao.
Osteoprotegerin (OPG) gene polymorphisms (T245G, T950C and G1181C) have been associated with osteoporosis and early predictors of cardiovascular disease. The aim of this study was to evaluate whether these polymorphisms contribute to cardiovascular disease (CVD) in type 2 diabetic patients. We performed a case-control study with 178 CVD subjects with diabetes and 312 diabetic patients without CVD to assess the impact of variants of the OPG gene on the risk of CVD. The OPG gene polymorphisms were analyzed by using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). There was no significant association between the T245G and G1181C polymorphisms and CVD in the additive genetic model (OR = 0.96, 95% CI 0.64-1.45, p = 0.79;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiovascular disease; Osteoprotegerin; Polymorphism.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000200006

Effects of gene therapy on cardiovascular symptoms of lysosomal storage diseases
Provedor de dados: 74
Autores: Poletto,Edina; Pasqualim,Gabriela; Giugliani,Roberto; Matte,Ursula; Baldo,Guilherme.
Abstract Lysosomal storage diseases (LSDs) are inherited conditions caused by impaired lysosomal function and consequent substrate storage, leading to a range of clinical manifestations, including cardiovascular disease. This may lead to significant symptoms and even cardiac failure, which is an important cause of death among patients. Currently available treatments do not completely correct cardiac involvement in the LSDs. Gene therapy has been tested as a therapeutic alternative with promising results for the heart disease. In this review, we present the results of different approaches of gene therapy for LSDs, mainly in animal models, and its effects in the heart, focusing on protocols with cardiac functional analysis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lysosomal storage disease; Gene therapy; Cardiovascular disease; Animal models; Heart.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200261

Cohort study of cardiovascular risk in asymptomatic young adults: subclinical atherosclerosis and coronary calcium score
Provedor de dados: 42
Autores: POLETTO,SADI; SCHVARTZMAN,PAULO R.; BRUSCATO,NEIDE M.; MORIGUCHI,EMILIO.
Abstract Coronary artery calcification is an early marker of subclinical atherosclerosis, but little research has been done in asymptomatic individuals under 45 years. In this cohort study with 17 years of follow-up, 155 participants were assessed in 2016 with a coronary calcium score for the association with cardiovascular risk factors. During follow-up, there was a significant increase in anthropometric measurements, cholesterol and fractions, and diastolic pressure. Participants who gained 1 cm in waist circumference had a mean reduction of 0.36 mg/dL in HDL-cholesterol and those who gained 1 kg/m2 in body mass index had a reduction of 0.72 mg/dL in HDL-cholesterol. Married participants had a 4.78 mg/dL reduction in HDL-cholesterol levels compared to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiovascular disease; Coronary calcium score; Subclinical atherosclerosis; Cohort study.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000603129

Microcirculation in obesity: an unexplored domain
Provedor de dados: 42
Autores: Wiernsperger,Nicolas; Nivoit,Pierre; Bouskela,Eliete.
Obesity is traditionally linked to diabetes and cardiovascular diseases. Very recent experimental, clinical and epidemiological, sometimes provocative, data challenge this automaticity by showing that not the amount but the distribution of fat is the important determinant. Moderate abdominal fat accumulation may thus be more harmful than even consequent overweight. In view of the worldwide burden of obesity, factors leading to it in children and young adults must urgently be identified. Since obesity is a very complex cardiometabolic situation, this will require to focus investigations on uncomplicated obese subjects and adequate animal models. The recent discovery of intergenerational transmissions of obesity risk factors and also the key role played by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiovascular disease; Diabetes mellitus; Birth weight; Metabolic syndrome; Leptin.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400005

Alcohol, Wine and Platelet Function
Provedor de dados: 48
Autores: RUF,JEAN-CLAUDE.
Epidemiological studies have demonstrated an inverse correlation between moderate wine and alcohol consumption and morbidity and mortality from coronary heart disease. The protective effect has been associated with an increase in the plasma level of HDL cholesterol, as it is well recognized that plasma HDL is inversely correlated with CHD. In addition, it has become evident that blood platelets contribute to the rate of development of atherosclerosis and CHD through several mechanisms. In recent studies it has been shown that the level of HDL cholesterol can explain only 50 % of the protective effect of alcoholic beverages; the other 50 % may be partly related to a decrease in platelet activity. This anti-platelet activity of wine is explained by ethanol...
Tipo: Journal article
Palavras-chave: Alcohol; Cardiovascular disease; Platelet function; Wine.
Ano: 2004
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200006

Effect of Mediterranean and Occidental Diets, and Red Wine, on Plasma Fatty Acids in Humans: An Intervention Study
Provedor de dados: 48
Autores: URQUIAGA,INÉS; GUASCH,VIVIANA; MARSHALL,GUILLERMO; SAN MARTÍN,ALEJANDRA; CASTILLO,ÓSCAR; ROZOWSKI,JAIME; LEIGHTON,FEDERICO.
The type of diet consumed by individuals has been associated with the development of some chronic diseases, including cardiovascular disease (CVD), cancer, diabetes, and others. Populations that consume diets rich in fruits and vegetables and drink wine in moderation, as the Mediterranean, have a higher life expectancy and less chronic diseases than other occidental populations. We carried out an intervention study in humans to evaluate the effect of a Mediterranean diet (MD), an Occidental diet (OD) and their supplementation with red wine, on biochemical, physiological and clinical parameters related to atherosclerosis and other chronic diseases. For 3 months, two groups of 21 male volunteers each, received either a MD or an OD; during the second month,...
Tipo: Journal article
Palavras-chave: Cardiovascular disease; Chronic diseases; Fatty acids; Mediterranean diet; Monounsaturated fatty acids (MUFA); Occidental diet; W-6 fatty acids; W-3 fatty acids; Plasma fatty acids; Polyunsaturated fatty acids (PUFA); Saturated fatty acids (SFA); Wine.
Ano: 2004
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200012

IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction
Provedor de dados: 48
Autores: Ávalos,Ana María; Apablaza,Felipe A; Quiroz,Mariana; Toledo,Viviana; Peña,Juan Pedro; Michea,Luis; Irarrazabal,Carlos E; Carrión,Flavio A; Figueroa,Fernando E.
Th17 cells, a recently described subtype of CD4+ effector lymphocytes, have been linked to cell-mediated autoimmune and inflammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defined. We therefore conducted the present study to evaluate IL-17A and Th17-related cytokine levels in a rat model of myocardial infarction (MI). MI was induced in male Sprague Dawley rats by coronary artery ligation. Controls were sham-operated (Sh) or non-operated (C). Blood and samples from the left ventricle (LV) were collected at weeks 1 and 4 post-MI. At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-&amp;#946; mRNA levels with no apparent change in IL-17 mRNA or protein...
Tipo: Journal article
Palavras-chave: Interleukin-17; Th17; Myocardial infarction; Cardiovascular disease.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000200012

Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease
Provedor de dados: 52
Autores: Fallah,Soudabeh; Moradi,Nariman; Reza,Fadaei; Reza,Ahmadi; Azardokht,Tabatabei; Seifi,Morteza.
ABSTRACT This work aimed to determine whether seropositivity to Helicobacter pylori infection was an independent risk factor for hyperhomocysteinemia patients with cardiovascular disease. The H. pylori IgG, IgA and homocystein levels in 96 patients with cardiovascular disease and 64 participants free of cardiovascular disease as control subjects were determined by ELISA assay. The results showed that seropositivity to H. pylori IgG and IgA levels of coronary artery disease (CAD)patients was significantly higher than the controls and CAD patients with H. pylori IgG and IgA negative antibodies. A significant correlation was found between the seropositivity to H. pylori IgG and homocysteine levels of CAD patients in comparison with the controls and CAD...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiovascular disease; ELISA assay; Homocysteine; Helicobacter pylori.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100304

Comparison of the ACC/AHA and Framingham algorithms to assess cardiovascular risk in HIV-infected patients
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Dias,Fernanda Rezende; Bressan,Flavia Feres; Santos,Carolina Rocio Oliveira.
ABSTRACT The aim of this study was to compare the predictions of Framingham cardiovascular (CV) risk score (FRS) and the American College of Cardiology/American Heart Association (ACC/AHA) risk score in an HIV outpatient clinic in the city of Vitoria, Espirito Santo, Brazil. In a cross-sectional study 341 HIV infected patients over 40 years old consecutively recruited were interviewed. Cohen's kappa coefficient was used to assess agreement between the two algorithms. 61.3% were stratified as low risk by Framingham score, compared with 54% by ACC/AHA score (Spearman correlation 0.845; p &lt; 0.000). Only 26.1% were classified as cardiovascular high risk by Framingham compared to 46% by ACC/AHA score (Kappa = 0.745; p &lt; 0.039). Only one out of eight...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiovascular disease; HIV; Co-morbidities; Non-AIDS events.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600577

Thyrotropin and free thyroxine levels and coronary artery disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Provedor de dados: 56
Autores: de Miranda,E.J.F. Peixoto; Bittencourt,M.S.; Staniak,H.L.; Sharovsky,R.; Pereira,A.C.; Foppa,M.; Santos,I.S.; Lotufo,P.A.; Benseñor,I.M.
Data on the association between subclinical thyroid dysfunction and coronary artery disease (CAD) is scarce. We aimed to analyze the association between thyroid function and CAD using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We included subjects with normal thyroid function (0.4-4.0 mIU/L, and normal free thyroxine, FT4, or 0.8 to 1.9 ng/dL), subclinical hypothyroidism (SCHypo; TSH&gt;4.0 mIU/L and normal FT4), and subclinical hyperthyroidism (SCHyper; TSH&lt;0.4 mIU/L and normal FT4) evaluated by coronary computed tomography angiography. We excluded individuals using medications that interfere in thyroid function or with past medical history of cardiovascular disease. Logistic regression models evaluated the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Thyroid disorders; Thyrotropin levels; Coronary artery disease; Coronary computed tomography angiography; Subclinical atherosclerosis; Cardiovascular disease.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500609

Effect of sildenafil citrate on the cardiovascular system
Provedor de dados: 56
Autores: Shinlapawittayatorn,K.; Chattipakorn,S.; Chattipakorn,N.
Sildenafil citrate is a drug commonly used to manage erectile dysfunction. It is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H -pyrazolo[4,3-d]pyrimidin-5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6O4 S). It is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type 5. In late March through mid-November 1998, the US Food and Drug Administration (FDA) published a report on 130 confirmed deaths among men (mean age, 64 years) who received prescriptions for sildenafil citrate, a period during which &gt;6 million outpatient prescriptions (representing about 50 million tablets) were dispensed. The US FDA recently reported that significant cardiovascular events, including sudden...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sildenafil citrate; Erectile dysfunction; Sudden cardiac death; Cardiovascular disease; Phosphodiesterase inhibitor; Cardioprotection.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900003

Psychiatric disorders and cardiac anxiety in exercising and sedentary coronary artery disease patients: a case-control study
Provedor de dados: 56
Autores: Sardinha,A.; Araújo,C.G.S.; Nardi,A.E.
Regular physical exercise has been shown to favorably influence mood and anxiety; however, there are few studies regarding psychiatric aspects of physically active patients with coronary artery disease (CAD). The objective of the present study was to compare the prevalence of psychiatric disorders and cardiac anxiety in sedentary and exercising CAD patients. A total sample of 119 CAD patients (74 men) were enrolled in a case-control study. The subjects were interviewed to identify psychiatric disorders and responded to the Cardiac Anxiety Questionnaire. In the exercise group (N = 60), there was a lower prevalence (45 vs 81%; P &lt; 0.001) of at least one psychiatric diagnosis, as well as multiple comorbidities, when compared to the sedentary group (N =...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Exercise training; Mental health; Depression; Cardiovascular disease; Cardiac rehabilitation.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200031

Estrogen replacement therapy and cardioprotection: mechanisms and controversies
Provedor de dados: 56
Autores: Subbiah,M.T.R.
Epidemiological and case-controlled studies suggest that estrogen replacement therapy might be beneficial in terms of primary prevention of coronary heart disease (CHD). This beneficial effect of estrogens was initially considered to be due to the reduction of low density lipoproteins (LDL) and to increases in high density lipoproteins (HDL). Recent studies have shown that estrogens protect against oxidative stress and decrease LDL oxidation. Estrogens have direct effects on the arterial tissue and modulate vascular reactivity through nitric oxide and prostaglandin synthesis. While many of the effects of estrogen on vascular tissue are believed to be mediated by estrogen receptors alpha and ß, there is evidence for `immediate non-genomic' effects. The role...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Estrogen therapy; Postmenopausal women; Cardiovascular disease; Plasma lipoproteins; Lipoprotein oxidation; Estrogen receptors; Thrombosis; Nitric oxide synthesis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300001

Acute electrophysiologic consequences of pyridostigmine inhibition of cholinesterase in humans
Provedor de dados: 56
Autores: Zimerman,L.I.; Liberman,A.; Castro,R.R.T.; Ribeiro,J.P.; Nóbrega,A.C.L.
The cardiovascular electrophysiologic basis for the action of pyridostigmine, an acetylcholinesterase inhibitor, has not been investigated. The objective of the present study was to determine the cardiac electrophysiologic effects of a single dose of pyridostigmine bromide in an open-label, quasi-experimental protocol. Fifteen patients who had been indicated for diagnostic cardiac electrophysiologic study underwent two studies just before and 90-120 min after the oral administration of pyridostigmine (45 mg). Pyridostigmine was well tolerated by all patients. Wenckebach nodal anterograde atrioventricular point and basic cycle were not altered by pyridostigmine. Sinus recovery time (ms) was shorter during a 500-ms cycle stimulation (pre: 326 ± 45 vs post:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiac electrophysiology; Parasympathetic nervous system; Cholinesterase inhibitors; Cardiovascular disease; Pyridostigmine bromide; Autonomic nervous system.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000200013

Atherogenic lipid profile of Brazilian near-term newborns
Provedor de dados: 56
Autores: Pardo,I.M.C.G.; Geloneze,B.; Tambascia,M.A.; Barros-Filho,A.A.
Cardiovascular disease is the primary cause of death in Brazil. Recent studies have shown that low birth weight and preterm birth are linked to a higher prevalence of cardiovascular disease. The aim of the present study was to compare the levels of lipids and apolipoproteins and atherogenic indexes between term and near-term newborn infants. A sample of umbilical cord blood was obtained from 135 newborns (66 males) divided into two groups: 25 near-term neonates (35-36.6 weeks of gestational age) and 110 term neonates (37-42 weeks of gestational age). The total cholesterol concentrations were higher in the near-term neonates than in the term group (94.04 ± 8.02 vs 70.42 ± 1.63 mg/dl, P &lt; 0.01), due to an increase in the LDL-cholesterol fraction in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lipids; Apolipoproteins; Cholesterol; Cord blood; Cardiovascular disease; Newborns.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500013

Percent body fat is a better predictor of cardiovascular risk factors than body mass index
Provedor de dados: 56
Autores: Zeng,Qiang; Dong,Sheng-Yong; Sun,Xiao-Nan; Xie,Jing; Cui,Yi.
The objective of the present study was to evaluate the predictive values of percent body fat (PBF) and body mass index (BMI) for cardiovascular risk factors, especially when PBF and BMI are conflicting. BMI was calculated by the standard formula and PBF was determined by bioelectrical impedance analysis. A total of 3859 ambulatory adult Han Chinese subjects (2173 males and 1686 females, age range: 18-85 years) without a history of cardiovascular diseases were recruited from February to September 2009. Based on BMI and PBF, they were classified into group 1 (normal BMI and PBF, N = 1961), group 2 (normal BMI, but abnormal PBF, N = 381), group 3 (abnormal BMI, but normal PBF, N = 681), and group 4 (abnormal BMI and PBF, N = 836). When age, gender, lifestyle,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Obesity; Body composition; Body mass index; Cardiovascular disease; Risk factor; Percent body fat; Bioelectrical impedance.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000700005

Protective effect of yerba mate intake on the cardiovascular system: a post hoc analysis study in postmenopausal women
Provedor de dados: 56
Autores: da Veiga,D.T.A.; Bringhenti,R.; Copes,R.; Tatsch,E.; Moresco,R.N.; Comim,F.V.; Premaor,M.O.
The prevalence of cardiovascular and metabolic diseases is increased in postmenopausal women, which contributes to the burden of illnesses in this period of life. Yerba mate (Ilex paraguariensis) is a native bush from Southern South America. Its leaves are rich in phenolic components, which may have antioxidant, vasodilating, hypocholesterolemic, and hypoglycemic proprieties. This post hoc analysis of the case-control study nested in the Obesity and Bone Fracture Cohort evaluated the consumption of yerba mate and the prevalence of hypertension, dyslipidemia, and coronary diseases in postmenopausal women. Ninety-five postmenopausal women were included in this analysis. A questionnaire was applied to evaluate the risk factors and diagnosis of cardiovascular...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Yerba mate; Ilex paraguariensis; Postmenopausal women; Diabetes mellitus; Hypertension; Cardiovascular disease.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600607

Association between the -174 G/C promoter polymorphism of the interleukin-6 gene and cardiovascular disease risk factors in Brazilian older women
Provedor de dados: 56
Autores: Tonet,A.C; Karnikowski,M; Moraes,C.F; Gomes,L; Karnikowski,M.G.O; Córdova,C; Nóbrega,O.T.
In worldwide studies, interleukin-6 (IL-6) is implicated in age-related disturbances. The aim of the present report was to determine the possible association of IL-6 -174 C/G promoter polymorphism with the cytokine profile as well as with the presence of selected cardiovascular risk features. This was a cross-sectional study on Brazilian women aged 60 years or older. A sample of 193 subjects was investigated for impaired glucose regulation, diabetes, hypertension, and dyslipidemia. Genotyping was done by direct sequencing of PCR products. IL-6 and C-reactive protein were quantified by high-sensitivity assays. General linear regression models or the Student t-test were used to compare continuous variables among genotypes, followed by adjustments for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytokine; Interleukin-6; Genetics; Elderly; Cardiovascular disease; Brazil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100008

A time series analysis of meteorological factors and hospital outpatient admissions for cardiovascular disease in the Northern district of Guizhou Province, China
Provedor de dados: 56
Autores: Jie,Y.; Houjin,H.; Mengxue,Y.; Wei,Q.; Jie,X.
Findings on the effects of weather on health, especially the effects of ambient temperature on overall morbidity, remain inconsistent. We conducted a time series study to examine the acute effects of meteorological factors (mainly air temperature) on daily hospital outpatient admissions for cardiovascular disease (CVD) in Zunyi City, China, from January 1, 2007 to November 30, 2009. We used the generalized additive model with penalized splines to analyze hospital outpatient admissions, climatic parameters, and covariate data. Results show that, in Zunyi, air temperature was associated with hospital outpatient admission for CVD. When air temperature was less than 10°C, hospital outpatient admissions for CVD increased 1.07-fold with each increase of 1°C, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Temperature; Cardiovascular disease; Hospital outpatient admission.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000800689

Tracheal instillation of urban PM2.5 suspension promotes acute cardiac polarization changes in rats
Provedor de dados: 56
Autores: Maatz,L.F.; Wood,G.J.A.; Rivero,D.H.R.F.; Saldiva,P.H.N.
The mechanisms by which PM2.5 increases cardiovascular mortality are not fully identified. Autonomic alterations are the current main hypotheses. Our objective was to determine if PM2.5 induces acute cardiac polarization alterations in healthy Wistar rats. PM2.5 samples were collected on polycarbonate filters. Solutions containing 10, 20, and 50 µg PM2.5 were administered by tracheal instillation. P wave duration decreased significantly at 20 µg (0.99 ± 0.06, 0.95 ± 0.06, and 0.96 ± 0.07; P &lt; 0.001), and 50 µg (0.98 ± 0.06, 0.98 ± 0.07, and 0.96 ± 0.08; 60, 90 and 120 min, respectively) compared to blank filter solution (P &lt; 0.001). PR interval duration decreased significantly at 20 µg (0.99 ± 0.06, 0.98 ± 0.07, and 0.97 ± 0.08) and 50 µg (0.99 ±...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ECG alterations; Particulate matter; PM2.5; Wave segments; Tracheal instillation; Cardiovascular disease.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200009

MicroRNA profiling identifies miR-7-5p and miR-26b-5p as differentially expressed in hypertensive patients with left ventricular hypertrophy
Provedor de dados: 56
Autores: Kaneto,C.M.; Nascimento,J.S.; Moreira,M.C.R.; Ludovico,N.D.; Santana,A.P.; Silva,R.A.A.; Silva-Jardim,I.; Santos,J.L.; Sousa,S.M.B.; Lima,P.S.P.
Recent evidence suggests that cell-derived circulating miRNAs may serve as biomarkers of cardiovascular diseases. However, a few studies have investigated the potential of circulating miRNAs as biomarkers for left ventricular hypertrophy (LVH). In this study, we aimed to characterize the miRNA profiles that could distinguish hypertensive patients with LHV, hypertensive patients without LVH and control subjects, and identify potential miRNAs as biomarkers of LVH. LVH was defined by left ventricular mass indexed to body surface area &gt;125 g/m2 in men and &gt;110 g/m2 in women and patients were classified as hypertensive when presenting a systolic blood pressure of 140 mmHg or more, or a diastolic blood pressure of 90 mmHg or more. We employed miRNA PCR...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiovascular disease; Hypertension; Left ventricular hypertrophy; MicroRNAs.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200605

Clinacanthus nutans: Its potential against diabetic vascular diseases
Provedor de dados: 60
Autores: Azemi,Ahmad Khusairi; Mokhtar,Siti Safiah; Rasool,Aida Hanum Ghulam.
Diabetes is an independent risk factor for the development of cardiovascular disease, with approximately 80% of cardiovascular mortality and morbidity linked to vascular complications such as atherosclerosis. It has been estimated that up to one-third of patients with diabetes mellitus use some form of complementary and/or alternative medicine. One plant that has received attention from diabetic patients for its perceived antidiabetic properties is Clinacanthus nutans, a member of the Acanthaceae family that is known as snake grass. Ethnomedical applications of this herb have been identified for the treatment of certain conditions, including fever, diabetes, skin rashes, and insect bites. This review aims to assess the potential of C. nutans to be used in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: C. nutans; Diabetes; Inflammation; Cardiovascular disease.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100635