Consulta: subjectFacets:"Case-control study"
Registros recuperados: 12
Data/hora: 13/06/2024 01:27:37

A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population
Provedor de dados: 74
Autores: Brincas,Heloisa Magagnin; Augusto,Danillo G.; Mathias,Carolina; Cavalli,Iglenir João; Lima,Rubens Silveira de; Kuroda,Flávia; Urban,Cícero de Andrade; Gradia,Daniela Fiori; de Oliveira,Jaqueline; de Almeida,Rodrigo Coutinho; Ribeiro,Enilze Maria de Souza Fonseca.
Abstract MicroRNAs (miRNAs) play an essential role in gene expression and affect the development of tumours, including breast cancer (BC). Polymorphisms in miRNA genes can affect the interaction of miRNAs with their target messenger RNA by interfering, creating or disrupting target sites. The single nucleotide polymorphism (SNP) rs2910164, located in the seed region of miR146a, was shown to be associated with BC among different populations. In the present study, we investigated whether rs2910164 is associated with BC in 326 patients and 411 controls from a Brazilian population of predominantly European ancestry. The presence of the allele rs2910164*C was associated with an increased risk of BC (OR=1.4, 95% CI=1.03-1.85, p = 0.03). We also analysed publicly...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MiRNA polymorphism; MiR146a; Rs2910164; Breast cancer; Case-control study.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000500103

Association of T174M polymorphism of angiotensinogen gene with essential hypertension: a meta-analysis
Provedor de dados: 74
Autores: Liao,Xiaoyang; Yang,Zhiyi; Peng,Daqing; Dai,Hua; Lei,Yi; Zhao,Qian; Han,Yanbing; Wang,Weiwen.
The association between T174M polymorphism of angiotensinogen gene and essential hypertension risk remains controversial. We herein performed a meta-analysis to achieve a reliable estimation of their relationship. All the studies published up to May 2013 on the association between T174M polymorphism and essential hypertension risk were identified by searching the electronic repositories PubMed, MEDLINE and EMBASE, Springer, Elsevier Science Direct, Cochrane Library and Google Scholar. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. Ultimately, nine eligible studies, including 2188 essential hypertension cases and 2459 controls, were enrolled in this meta-analysis. No significant associations were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Essential hypertension; Case-control study; T174M; Polymorphism; Meta-analysis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000400001

Genetic association of single nucleotide polymorphisms in dystrobrevin binding protein 1 gene with schizophrenia in a Malaysian population
Provedor de dados: 74
Autores: Tan,Grace Kang Ning; Tee,Shiau Foon; Tang,Pek Yee.
Dystrobrevin binding protein 1 (DTNBP1) gene is pivotal in regulating the glutamatergic system. Genetic variants of the DTNBP1 affect cognition and thus may be particularly relevant to schizophrenia. We therefore evaluated the association of six single nucleotide polymorphisms (SNPs) with schizophrenia in a Malaysian population (171 cases; 171 controls). Associations between these six SNPs and schizophrenia were tested in two stages. Association signals with p &lt; 0.05 and minor allele frequency &gt; 0.05 in stage 1 were followed by genotyping the SNPs in a replication phase (stage 2). Genotyping was performed with sequenced specific primer (PCR-SSP) and restriction fragment length polymorphism (PCR-RFLP). In our sample, we found significant associations...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Case-control study; DTNBP1; Schizophrenia; Single nucleotide polymorphism.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000200138

The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
Provedor de dados: 74
Autores: Cimponeriu,Danut; Apostol,Pompilia; Radu,Irina; Craciun,Anne Marie; Serafinceanu,Cristian; Toma,Mihai; Panaite,Cristian; Cheta,Dan.
The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p &lt; 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p &lt; 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Insulin -23Hph; Insulin-like growth factor 2 Apa; Diabetes; Obesity; Case-control study.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400003

Improving early detection of exotic or emergent oyster diseases in France: identifying factors associated with shellfish farmer reporting behaviour of oyster mortality
Provedor de dados: 5
Autores: Lupo, Coralie; Osta-amigo, Axel; Mandard, Yann-vari; Peroz, Carole; Renault, Tristan.
Farmers’ vigilance is essential for the detection of epidemics, including potential emerging diseases, in marine shellfish. A field study was conducted to investigate oyster farmers’ reporting practices and behaviour, and to identify factors influencing the reporting process of oyster mortality, with the ultimate aim of improving early detection of unexplained oyster mortality outbreaks.  A retrospective case-control study of oyster farmers from Charente-Maritime (France) was designed, based on interviews with 27 non-reporting and 89 reporting farmers, further split into 40 formerly-reporting and 49 currently-reporting farmers. Information about farmer and farm characteristics, farming practices, farm health history and related financial compensation on...
Tipo: Text
Palavras-chave: Case-control study; Ordinal logistic regression; Surveillance; Notification; Shellfish diseases.
Ano: 2014
URL: http://archimer.ifremer.fr/doc/00190/30132/28594.pdf

Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk
Provedor de dados: 5
Autores: Zidane, Monia; Ren, Yen; Xhaard, Constance; Leufroy, Axelle; Côte, Suzanne; Dewailly, Eric; Noël, Laurent; Guérin, Thierry; Bouisset, Patrick; Bernagout, Solène; Paaoafaite, John; Iltis, Jacques; Taquet, Marc; Suhas, Eric; Rachédi, Frédérique; Boissin, Jean Louis; Sebbag, Joseph; Shan, Larrys; Bost-bezeaud, Frédérique; Petitdidier, Patrice; Rubino, Carole; Gardon, Jacques; De Vathaire, Florent.
Background: In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer. Objective: The present study aims to provide quantitative information on food contamination by mercury (Hg), lead (Pb), arsenic (As) and cadmium (Cd) in French Polynesia and its potential correlation with measurements performed in fingernails of Polynesians, and then to investigate the potential association between these nETE and different thyroid cancer risks. Methods: The study population included 229 interviewed cases and 373 interviewed controls We performed a descriptive analysis of Polynesian food and examined the association...
Tipo: Text
Palavras-chave: Thyroid cancer; NETE; Diet; Fingernail; Case-control study.
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00660/77190/78617.pdf

Prognostic indicators in bacterial meningitis: a case-control study
Provedor de dados: 55
Autores: Mendizabal,Maria de Fátima Magalhães Acioly; Bezerra,Phelipe Cunha; Guedes,Diego Lins; Cabral,Diogo Buarque Cordeiro; Miranda-Filho,Demócrito de Barros.
This was a case-control study to identify prognostic indicators of bacterial meningitis in a reference hospital in Pernambuco/Brazil. The data were collected from charts of 294 patients with bacterial meningitis between January 2000 and December 2004. Variables were grouped in biological, clinical, laboratory and etiologic agent/treatment. Variables selected in each step were grouped and adjusted for age. Two models were created: one containing clinical variables (clinical model) and other containing laboratory variables (laboratory model). In the clinical model the variables associated with death due to bacterial meningitis were dyspnea (p = 0.006), evidence of shock (p = 0.051), evidence of altered mental state (p = 0.000), absence of headache (p =...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacterial meningitis; Prognostic indicators; Case-control study.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500005

Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment
Provedor de dados: 55
Autores: Pinheiro,Millena R.S.; Lacerda,Heloisa R.; Melo,Renata G.L.; Maciel,Mª Amélia.
A retrospective case-control study was conducted to investigate the risk factors for death among intensive care unit patients with Pseudomonas aeruginosa infection. Out of 131 patients investigated, 67 (51.1%) died within 30 days of being diagnosed with this infection. The mean duration of hospital stay before this diagnosis was 28.5 ± 26.5 days. No association was found between bacterial resistance and death in this study (multiresistant p= 0.26; panresistant p= 0.42), but the adequacy of the initial treatment was inversely proportional to the degree of resistance. There was a tendency towards greater mortality among patients who received combination therapy (empirical p= 0.09; definitive p= 0.08), despite the greater frequency of appropriate treatment in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Risk factors; Case-control study; Pseudomonas aeruginosa; Death.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600013

Mycobacterium tuberculosis complex bacteremia among HIV and non-HIV patients in a Mexican tertiary care center
Provedor de dados: 55
Autores: Tamez-Torres,Karla Maria; Torres-Gonzalez,Pedro; Cervera-Hernandez,Miguel E.; Chavez-Mazari,Barbara; Barrientos-Flores,Corazon de Jesus; Bobadilla-del-Valle,Miriam; Ponce-de-Leon,Alfredo; Sifuentes-Osornio,Jose.
ABSTRACT  Objectives: To determine the factors associated with Mycobacterium tuberculosis complex-positive blood culture.  Methods: Case-control study. Sociodemographic, clinical and laboratory data were collected from 2000 to 2015.  Results: We reviewed medical records of 533 patients with culture-proven tuberculosis, of whom 27.2% (145/533) had blood culture available. Patients with mycobacteremia presented more frequently with abdominal tuberculosis, body mass index &lt;18 kg/m2, and had lower hemoglobin and albumin levels. No differences were observed regarding HIV status.  Conclusions: Few studies have reported on the characteristics associated with Mycobacterium tuberculosis complex bacteremia, especially among Human Immunodeficiency Virus-negative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; Human immunodeficiency virus; Bloodstream infection; Mycobacteremia; Case-control study.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500387

Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients
Provedor de dados: 56
Autores: Brunoni,A.R.; Lotufo,P.A.; Sabbag,C.; Goulart,A.C.; Santos,I.S.; Benseñor,I.M.
Brain-derived neurotrophic factor (BDNF) is associated with neuroplasticity and synaptic strength, and is decreased in conditions associated with chronic stress. Nevertheless, BDNF has not yet been investigated in psoriasis, a chronic inflammatory systemic disease that is exacerbated by stress. Therefore, our aim was to determine BDNF plasma levels in psoriasis patients and healthy controls. Adult patients (n=94) presenting with psoriasis for at least 1 year were enrolled, and age- and gender-matched with healthy controls (n=307) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Participants had neither a previous history of coronary artery disease nor current episode of major depression. BDNF plasma levels were determined using the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brain derived neurotrophic factor; Psoriasis; Neurotrophins; Psychological stress; Case-control study.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000800711

The rs878081 polymorphism of AIRE gene increases the risk of rheumatoid arthritis in a Chinese Han population: a case-control study
Provedor de dados: 56
Autores: Yang,Haoyu; Li,Jin; Jiang,Lifeng; Jiang,Xijia; Zhou,Xindie; Xu,Nanwei.
The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid arthritis (RA) in different populations have yielded conflicting findings. Thus, this case-control study involving 300 RA cases and 300 controls was aimed to identify whether such association existed in a Chinese Han population from East China. The rs878081 polymorphism of the AIRE gene was genotyped. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using the chi-squared test, genetic model analysis, and stratification analysis. Genetic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIRE; Single-nucleotide polymorphism; Rheumatoid arthritis; Case-control study.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200612

Protective effect of the APOE-e3 allele in Alzheimer’s disease
Provedor de dados: 56
Autores: de-Almada,B.V.P.; de-Almeida,L.D.; Camporez,D.; de-Moraes,M.V.D.; Morelato,R.L.; Perrone,A.M.S.; Belcavello,L.; Louro,I.D.; de-Paula,F.
Although several alleles of susceptibility to Alzheimer’s disease (AD) have been studied in the last decades, few polymorphisms have been considered as risk factors for the disease. Among them, the APOE-e4 allele appears to be the major genetic risk factor for the onset of the disease. However, it is important to confirm the potential susceptibility of these genetic variants in different populations in order to establish a genetic profile for the disease in specific communities. This study analyzed the APOE polymorphisms regarding susceptibility to AD in a sample of 264 individuals (primarily Caucasians; 82 cases and 182 controls) in the population from Vitória, ES, Brazil, by PCR restriction fragment length polymorphism (PCR-RFLP) methods. The patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alzheimer’s disease; APOE-e3 allele; APOE-e4 allele; Brazilian population; Case-control study.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100002