Consulta: subjectFacets:"Cefepime"
Registros recuperados: 5
Data/hora: 10/06/2024 07:45:22

Farmacocinética y penetración en líquido tisular de cefepime administrado en conejos hipertérmicos
Provedor de dados: 38
Autores: Rule,Roberto; Vita,Mariangeles; Baschar,Hugo; Farina,Osvaldo Hugo.
La farmacocinética sérica y tisular de cefepime administrado por vía endovenosa (20 mg/kg de peso) fue determinada en conejos sanos, con hipertermia producida por lipopolisacáridos de E. coli e implantados en tejido subcutáneo con cajas para recolección de líquido tisular. Diez conejos adultos fueron utilizados en dos experiencias (E1 y E2). Las concentraciones de cefepime en suero (S) y líquido tisular (LT) fueron determinadas por método biológico. Para el análisis cinético se utilizó un modelo no compartimental. Los resultados farmacocinéticos (medias ± error estándar) fueron: tiempo medio de eliminación [t1\2 (E1 S)=1,5±0,2 y (E2 S)=2,0±0,2 h] (p&lt;0,05), área bajo la curva [ABC (E1 S)=181,6±17,5 y (E2 S)=192,3±18,5 (µg/mL/h]; Volumen de distribución...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cinética; Cefepime; Lipolisacáridos; Líquido tisular; Conejos.
Ano: 2008
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572008000200007

Evaluation of cefepime kinetic variables and milk production volume in goats
Provedor de dados: 45
Autores: Rule,R.; Lacchini,R.; Mordujovich,P.; Antonini,A.
Avaliaram-se as variáveis cinéticas da cefepime e a produção de leite de cabras após a administração parenteral (intravenosa e intramuscular) de cefepime, com e sem reação inflamatória na região implantada. Dez cabras em lactação, implantadas com caixas de material sem reação imunológica para colher o fluido de tecido (FT) foram usadas em dois experimentos. No primeiro a aplicação de cefepime foi feita na primeira semana após a implantação e no segundo na oitava semana. Na primeira semana após a implantação observou-se elevação dos níveis de proteína no fluido do tecido após uma simples dose de 20mg/kg de cefepime via endovenosa ou intramuscular. Amostras do sangue e do leite foram obtidas e as variáveis cinéticas foram avaliadas.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cefepime; Goat; Kinetic; Milk; Production.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000100018

Cefepime restriction improves gram-negative overall resistance patterns in neonatal intensive care unit
Provedor de dados: 55
Autores: Araujo,Orlei Ribeiro de; Silva,Dafne Cardoso Bourguignon da; Diegues,Ana Regina; Arkader,Ronaldo; Cabral,Eloíza Aparecida Ferreira; Afonso,Marta Rodriguez; Louzada,Maria Eduarda; Albertoni,Andréa de Cássia Stéfano.
Antibiotic restriction can be useful in maintaining bacterial susceptibility. The objective of this study was verify if restriction of cefepime, the most frequently used cephalosporin in our neonatal intensive care unit (NICU), would ameliorate broad-spectrum susceptibility of Gram-negative isolates. Nine hundred and ninety-five premature and term newborns were divided into 3 cohorts, according to the prevalence of cefepime use in the unit: Group 1 (n=396) comprised patients admitted from January 2002 to December 2003, period in which cefepime was the most used broad-spectrum antibiotic. Patients in Group 2 (n=349) were admitted when piperacillin/tazobactam replaced cefepime (January to December 2004) and in Group 3 (n=250) when cefepime was reintroduced...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Drug resistance; Infection control; Cefepime; Bacterial.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200022

Rapid diagnosis of community-acquired pneumonia using the Bac T/ alert 3D system
Provedor de dados: 55
Autores: Capoor,Malini R.; Nair,Deepthi; Aggarwal,Pushpa; Gupta,B.
We compared BacT/Alert 3D with conventional culture for the diagnosis of community-acquired pneumonia (CAP). Antimicrobial susceptibility testing of the isolates was performed with the disk diffusion method, and the minimum inhibitory concentration (MIC) was calculated. Automation was superior in terms of recovery and time to detect pathogens. The bacterial spectrum in CAP was Streptococcus pneumoniae (35.3%) Staphylococcus aureus (23.5%), Klebsiella pneumoniae (20.5%) and Haemophilus influenzae (8.8%). Three of the 12 S. pneumoniae isolates showed penicillin resistance on MIC and two showed erythromycin resistance. There were two H. influenzae strains resistant to penicillin; these were beta lactamase producers. One-fourth of the S. aureus were oxacillin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Community-acquired pneumonia; Streptococcus pneumoniae; Cefepime.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500010

A multicenter comparative study of cefepime versus broad-spectrum antibacterial therapy in moderate and severe bacterial infections
Provedor de dados: 55
Autores: Badaró,Roberto; Molinar,Fernando; Seas,Carlos; Stamboulian,Daniel; Mendonça,João; Massud,João; Nascimento,Luiz Olympio.
The safety and efficacy of cefepime empiric monotherapy compared with standard broad-spectrum combination therapy for hospitalized adult patients with moderate to severe community-acquired bacterial infections were evaluated. In an open-label, multicenter study, 317 patients with an Acute Physiology and Chronic Health Evaluation (APACHE II) score ranging from &gt;5 to =19 were enrolled with documented pneumonia (n=196), urinary tract infection (n=65), intra-abdominal infection (n=38), or sepsis (n=18). Patients were randomly assigned 1:1 to receive cefepime 1 to 2 g IV twice daily or three times a day or IV ampicillin, cephalothin, or ceftriaxone ± aminoglycoside therapy for 3 to 21 days. For both treatment groups, metronidazole, vancomycin, or macrolide...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cefepime; Ampicillin; Caphalotin; Ceftriaxone; Aminoglycoside; Urinary tract infections; Intra-abdominal infections; Sepsis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500001