Consulta: subjectFacets:"Chagas' disease"
Registros recuperados: 25
Data/hora: 05/06/2024 10:11:22

Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review
Provedor de dados: 80
Autores: Oliveira,AP; Mattos,LC; Cavasini,CE.
Duffy gene (FY) codifies the transmembrane glycoprotein Duffy (gp-Fy) of 35 to 43 kDa which is moderately immunogenic. This glycoprotein is polymorphic, and constitutes the antigens of the Duffy histo-blood system which were designated receptors for chemokines and denominated DARC (Duffy antigen/receptor for chemokine). This receptor has an important role in the regulation of chemokine levels in the circulation, as it binds and adsorbs them on the surface of red cells as a reservoir. It plays a "sink" role, which can contribute to homeostasis by removing inflammatory chemokines from circulation as well as maintaining them in plasmatic levels. Chronic Chagas' cardiopathy (CCC) is the most frequent form of the disease. It is an inflammatory disease, in which...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: DARC antigen; Duffy blood-group system; Chagas' disease; Chagas' cardiomyopathy.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300005

Triatominae (Hemiptera: Reduviidae): Systematic questions and some others
Provedor de dados: 82
Autores: Schaefer,Carl W.
The Neotropical Chagas' disease vectors are classified as members of the reduviid subfamily Triatominae. However, this classification has been suggested to be incorrect, and the suggestion has been treated as fact by some authors; the suggestion is that some (all?) groups in Triatominae had different nontriatomine reduviid ancestors. In this article I raise this question explicitly and ask other questions ancillary to it. I do not answer these questions. Of particular interest is the systematic position of Linshcosteus, the only genus of Triatominae all of whose species occur outside the New World (in India). Related to this question is that of the origin(s) of the several species and populations probably derived from the tropicopolitan Triatoma...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Insecta; Chagas' disease; Trypanosoma cruzi; Rhodnius; Linshcosteus; Cladistics.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2003000100001

The metasternal and Brindley's Glands of Triatoma brasiliensis Neiva (Hemiptera: Reduviidae)
Provedor de dados: 82
Autores: Vitta,Ana Cristina R; Serrão,José E; Lima,Eraldo R; Villela,Evaldo F.
Triatoma brasiliensis Neiva is the most important vector of the Chagas' disease in the semiarid zones of North-eastern Brazil. Adult bugs have two main pairs of exocrine glands, the metasternal and the Brindley's glands, which release volatiles possibly with defense, alarm and/or mating functions. To date, anatomical and histological studies of the metasternal and the Brindley's glands in the genus Triatoma are scarce and, considering the relevance of these exocrine glands, the present work aimed at studying their morphology in T. brasiliensis. The metasternal and the Brindley's glands of T. brasiliensis consist of glandular units similar to those described for Rhodnius prolixus Stål and Panstrongylus megistus Burmeister, comprising a secretory apparatus,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas' disease; Triatomine; Morphology.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2009000200010

Evolution of hematophagous habit in Triatominae (Heteroptera: Reduviidae)
Provedor de dados: 97
Autores: Otálora-Luna,Fernando; Pérez-Sánchez,Antonio J; Sandoval,Claudia; Aldana,Elis.
All members of Triatominae subfamily (Heteroptera: Reduviidae), potential vectors of Trypanosoma cruzi etiologic agent of the Chagas disease, feed on blood. Through evolution, these bugs have fixed special morphological, physiological, and behavioral aptations (adaptations and exaptations) adequate to feed on blood. Phylogeny suggests that triatomines evolved from predator reduvids which in turn descended from phytophagous hemipterans. Some pleisiomorphic traits developed by the reduvid ancestors of the triatomines facilitated and modeled hematophagy in these insects. Among them, mouthparts, saliva composition, enzymes, and digestive symbionts are the most noticeable. However, the decisive step that allowed the shift from predation to hematophagy was a...
Tipo: Journal article
Palavras-chave: Latin America; Chagas' disease; Phylogeny; Blood-sucking habit; Triatomines.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2015000100004

Inositol metabolism in Trypanosoma cruzi: potential target for chemotherapy against Chagas' disease
Provedor de dados: 42
Autores: OLIVEIRA,MECIA M.; EINICKER-LAMAS,MARCELO.
Chagas' disease is a debilitating and often fatal disease caused by the protozoan parasite Trypanosoma cruzi. The great majority of surface molecules in trypanosomes are either inositol-containing phospholipids or glycoproteins that are anchored into the plasma membrane by glycosylphosphatidylinositol anchors. The polyalcohol myo-inositol is the precursor for the biosynthesis of these molecules. In this brief review, recent findings on some aspects of the molecular and cellular fate of inositol in T. cruzi life cycle are discussed and identified some points that could be targets for the development of parasite-specific therapeutic agents.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inositol; Trypanosoma cruzi; Chagas' disease; Chemotherapy.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300015

The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet
Provedor de dados: 42
Autores: SOARES,MILENA B. P.; PONTES-DE-CARVALHO,LAIN; RIBEIRO-DOS-SANTOS,RICARDO.
Chagas' disease is a major health problem in Latin America, where it constitutes one of the leading causes of heart failure. About one fourth of Trypanosoma cruzi-infected individuals develop chronic chagasic cardiomyopathy (CChC), the most severe form of the disease. CChC is histologically characterized by the presence of multifocal inflammatory infiltrates in the heart, composed mainly by mononuclear cells, usually adhered to myocytes and leading to myocytolysis, and frequently by interstitial fibrosis. The pathogenesis of CChC is still unclear, despite intense investigations both in human beings and in animal models of the disease. Although tissue parasitism is rare in the chronic phase of infection, an immune response targeted to persistent parasites...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas' disease; Myocarditis; Autoimmunity; Trypanosoma cruzi; Delayed-type hypersensitivity.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000400008

Effect of tranquilization and anesthesia on high-resolution electrocardiographic indices of dogs in the chronic chagasic myocardiopathy
Provedor de dados: 45
Autores: Ferreira,W.L.; Paula,D.P.; Nunes,N.; Camacho,A.A.
The effect of tranquilization and anesthesia on high-resolution electrocardiography (HRECG) indices of dogs in the undetermined chronic phase of Chagas' disease was studied. Eight adult female mongrel dogs were submitted to six protocols: group 1: animals not submitted to tranquilization or anesthesia; group 2: tranquilization with acepromazine; group 3: tranquilization with a combination of acepromazine and buprenorphine; group 4: general inhalatory anesthesia with isoflurane; group 5: general inhalatory anesthesia with sevoflurane; group 6: anesthesia with propofol. The animals were submitted to all protocols at an interval of 15 days between assessments. HRECG was performed in the time domain. Regarding the electrocardiographic parameters analyzed, no...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dog; Chagas' disease; High-resolution electrocardiography; Anesthesia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352006000600015

Conventional serological performance in diagnosis of Chagas' disease in southern Brazil
Provedor de dados: 55
Autores: Araújo,Anelise Bergmann; Berne,Maria Elisabeth Aires.
Results of Chagas' disease diagnosis show disagreement. The aim of this study was to compare commercial tests for Chagas' disease serodiagnosis in southern Brazil. A total of 161 samples were evaluated. Three enzyme-linked immunosorbent assays, one indirect hemagglutination and one indirect immunofluorescence were assessed. Trypomastigote excreted-secreted antigen-blot was a confirmatory method. From 161 samples, 65.84% were positive in all tests, while 34.16% presents mismatch result in at least one of the tests. All techniques tested presented false-positive and/or false-negative results as follows: Enzyme-linked immunosorbent assay 1 had more false-positive results (lower specificity), indirect immunofluorescence had the highest rate of false-negative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Chagas' disease; Serodiagnosis; Immunoassays.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200010

Reactivation of Chagas' disease leading to the diagnosis of acquired immunodeficiency syndrome
Provedor de dados: 55
Autores: Santos,Eder de Oliveira; Canela,João dos Reis; Monção,Henry Carlos Gomes; Roque,Mauro José Guedes.
Reactivation of chronic Chagas' disease is a rare condition and occurs only in immunosuppressed patients. We report a case of a patient with a rapid and fatal reactivation of Chagas' disease, manifested by meningoencephalitis, which lead to a diagnosis of acquired immunodeficiency syndrome (AIDS). We believe there is sufficient evidence to include the reactivation of Chagas' disease among the diagnostic criteria of AIDS in Human Immunodeficiency Virus (HIV) infection.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Chagas' disease; Trypanosoma cruzi; Acquired immunodeficiency syndrome; Human immunodeficiency virus; Meningoencephalitis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600009

Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection
Provedor de dados: 56
Autores: Costa,F.; Pereira-Chioccola,V.L.; Ribeirão,M.; Schenkman,S.; Rodrigues,M.M.
Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface. Here, we review studies that characterize the immune response to the catalytic domain of the enzyme in humans during Chagas' disease or in mice following immunization with the TS gene. In both cases, there are antibodies that strongly inhibit the enzymatic activity and generation of interferon-&lt;FONT FACE="Symbol"&gt;g&lt;/FONT&gt;-producing T cells.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: DNA vaccination; Trans-sialidase; Chagas' disease.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200013

Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: identification of a B13-driven human T cell clone that recognizes cardiac myosin
Provedor de dados: 56
Autores: Abel,L.C.J.; Kalil,J.; Cunha-Neto,E.
Previous reports from our group have demonstrated the association of molecular mimicry between cardiac myosin and the immunodominant Trypanosoma cruzi protein B13 with chronic Chagas' disease cardiomyopathy at both the antibody and heart-infiltrating T cell level. At the peripheral blood level, we observed no difference in primary proliferative responses to T. cruzi B13 protein between chronic Chagas' cardiopathy patients, asymptomatic chagasics and normal individuals. In the present study, we investigated whether T cells sensitized by T. cruzi B13 protein respond to cardiac myosin. T cell clones generated from a B13-stimulated T cell line obtained from peripheral blood of a B13-responsive normal donor were tested for proliferation against B13 protein and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Molecular mimicry; Crossreactive T cells; Cardiac myosin; Trypanosoma cruzi; Chagas' disease.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100007

Mechanical cardiac remodeling and new-onset atrial fibrillation in long-term follow-up of subjects with chronic Chagas' disease
Provedor de dados: 56
Autores: Benchimol-Barbosa,P.R.; Barbosa-Filho,J.
Atrial fibrillation (AF) affects subjects with Chagas' disease and is an indicator of poor prognosis. We investigated clinical, echocardiographic and electrocardiographic variables of Chagas' disease in a long-term longitudinal study as predictors of a new-onset AF episode lasting &gt;24 h, nonfatal embolic stroke and cardiac death. Fifty adult outpatients (34 to 74 years old, 62% females) staged according to the Los Andes classification were enrolled. During a follow-up of (mean ± SD) 84.2 ± 39.0 months, 9 subjects developed AF (incidence: 3.3 ± 1.0%/year), 5 had nonfatal stroke (incidence: 1.3 ± 1.0%/year), and nine died (mortality rate: 2.3 ± 0.8%/year). The progression rate of left ventricular mass and left ventricular ejection fraction was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas' disease; Cardiomyopathy; Atrial fibrillation; Cardiac death; Embolic stroke; Prognosis.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300006

Immunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas' disease?
Provedor de dados: 56
Autores: Rodrigues,M.M.; Alencar,B.C.G. de; Claser,C.; Tzelepis,F.
Intense immune responses are observed during human or experimental infection with the digenetic protozoan parasite Trypanosoma cruzi. The reasons why such immune responses are unable to completely eliminate the parasites are unknown. The survival of the parasite leads to a parasite-host equilibrium found during the chronic phase of chagasic infection in most individuals. Parasite persistence is recognized as the most likely cause of the chagasic chronic pathologies. Therefore, a key question in Chagas' disease is to understand how this equilibrium is established and maintained for a long period. Understanding the basis for this equilibrium may lead to new approaches to interventions that could help millions of individuals at risk for infection or who are...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Chagas' disease; Trypanosoma cruzi; Immunodominance; Major histocompatibility complex.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300001

Esophageal striated muscle contractions in patients with Chagas' disease and idiopathic achalasia
Provedor de dados: 56
Autores: Dantas,R.O.; Aprile,L.R.O.; Aben-Athar,C.G.; Miranda,A.L.M.
Chagas' disease causes degeneration and reduction of the number of intrinsic neurons of the esophageal myenteric plexus, with consequent absent or partial lower esophageal sphincter relaxation and loss of peristalsis in the esophageal body. The impairment of esophageal motility is seen mainly in the distal smooth muscle region. There is no study about esophageal striated muscle contractions in the disease. In 81 patients with heartburn (44 with esophagitis) taken as controls, 51 patients with Chagas' disease (21 with esophageal dilatation) and 18 patients with idiopathic achalasia (11 with esophageal dilatation) we studied the amplitude, duration and area under the curve of esophageal proximal contractions. Using the manometric method and a continuous...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Esophageal contractions; Chagas' disease; Idiopathic achalasia; Esophageal striated muscle.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600007

Protein 3-nitrotyrosine formation during Trypanosoma cruzi infection in mice
Provedor de dados: 56
Autores: Naviliat,M.; Gualco,G.; Cayota,A.; Radi,R.
Nitric oxide (·NO) is a diffusible messenger implicated in Trypanosoma cruzi resistance. Excess production of ·NO and oxidants leads to the generation of nitrogen dioxide (·NO2), a strong nitrating agent. Tyrosine nitration is a post-translational modification resulting from the addition of a nitro (-NO2) group to the ortho-position of tyrosine residues. Detection of protein 3-nitrotyrosine is regarded as a marker of nitro-oxidative stress and is observed in inflammatory processes. The formation and role of nitrating species in the control and myocardiopathy of T. cruzi infection remain to be studied. We investigated the levels of ·NO and protein 3-nitrotyrosine in the plasma of C3H and BALB/c mice and pharmacologically modulated their production during...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Peroxynitrite; Nitric oxide; Nitrotyrosine; Free radicals; Trypanosoma cruzi; Chagas' disease.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200011

Minor segmental wall motion abnormalities detected in patients with Chagas' disease have adverse prognostic implications
Provedor de dados: 56
Autores: Pazin-Filho,A.; Romano,M.M.D.; Almeida-Filho,O.C.; Furuta,M.S.; Viviani,L.F.; Schmidt,A.; Marin-Neto,J.A.; Maciel,B.C.
Recent data from our laboratory have shown that patients with the indeterminate form of Chagas' disease can have impairment of left ventricular contractility, as evaluated by the slope of the left ventricle end-systolic pressure-dimension relationship. We also showed that Chagas' disease patients with minimal baseline wall motion abnormalities detected by two-dimensional echocardiography have more intense contractility impairment when compared to patients with the indeterminate form of the disease without this abnormality. The prognostic implications of these findings have not been established. We evaluated 59 patients (37-76 years, mean = 55 years) with different clinical forms of Chagas' disease, who had normal left ventricular global systolic function...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Echocardiography; Chagas' disease; Left ventricular function; Indeterminate form of Chagas' disease.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400008

Noninvasive prognostic markers for cardiac death and ventricular arrhythmia in long-term follow-up of subjects with chronic Chagas' disease
Provedor de dados: 56
Autores: Benchimol-Barbosa,P.R.
The objective of the present study was to investigate clinical, echocardiographic and electrocardiographic (12-lead resting ECG, 24-h ambulatory ECG monitoring and signal-averaged ECG (SAECG)) parameters in subjects with chronic Chagas' disease in a long-term follow-up as prognostic markers for adverse outcomes. Fifty adult outpatients (34 to 74 years old, 31 females) staged according to Los Andes class I, II or III and complaining of palpitation were enrolled in a longitudinal study. SAECG was analyzed in time and frequency domains and the endpoint was a composite of cardiac death and ventricular tachycardia. During a follow-up of 84.2 ± 39.0 months, 34.0% of the patients developed adverse outcomes (9 cardiac deaths and 11 episodes of ventricular...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas' disease; Cardiomyopathy; Noninvasive prognostic assessment; Long-term follow-up study; Echocardiography; Electrocardiography.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000200003

Upper esophageal sphincter pressure in patients with Chagas' disease and primary achalasia
Provedor de dados: 56
Autores: Dantas,R.O.
The most important component of the upper esophageal sphincter (UES) is the cricopharyngeal muscle. During the measurement of sphincter pressure the catheter passed through the sphincter affects the pressure value. In Chagas' disease and primary achalasia there is an esophageal myenteric plexus denervation which may affect UES pressure. We measured the UES pressure of 115 patients with Chagas' disease, 28 patients with primary achalasia and 40 healthy volunteers. We used a round manometric catheter with continuous perfusion and the rapid pull-through method, performed in triplicate during apnea. Pressures were measured in four directions, and the direction with the highest pressure (anterior/posterior) and the average of the four directions were measured....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Upper esophageal sphincter; Megaesophagus; Achalasia; Chagas' disease.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500009

Proteomic inventory of myocardial proteins from patients with chronic Chagas' cardiomyopathy
Provedor de dados: 56
Autores: Teixeira,P.C.; Iwai,L.K.; Kuramoto,A.C.K.; Honorato,R.; Fiorelli,A.; Stolf,N.; Kalil,J.; Cunha-Neto,E.
Chronic Chagas' disease cardiomyopathy (CCC) is an often fatal outcome of Trypanosoma cruzi infection, with a poorer prognosis than other cardiomyopathies. CCC is refractory to heart failure treatments, and is the major indication of heart transplantation in Latin America. A diffuse myocarditis, plus intense myocardial hypertrophy, damage and fibrosis, in the presence of very few T. cruzi forms, are the histopathological hallmarks of CCC. To gain a better understanding of the pathophysiology of CCC, we analyzed the protein profile in the affected CCC myocardium. Homogenates from left ventricular myocardial samples of end-stage CCC hearts explanted during heart transplantation were subjected to two-dimensional electrophoresis with Coomassie blue staining;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas' disease; Cardiomyopathy; Proteomic analysis; Two-dimensional electrophoresis; MALDI-ToF.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200005

Presence of autoantibodies against HeLa small nuclear ribonucleoproteins in chagasic and non-chagasic cardiac patients
Provedor de dados: 56
Autores: Bosetto,M.C.; Peixoto,M.S.; Castro,L.I.R. de; Cicarelli,R.M.B.
We detected anti-human small nuclear ribonucleoprotein (snRNP) autoantibodies in chagasic patients by different immunological methods using HeLa snRNPs. ELISA with Trypanosoma cruzi total lysate antigen or HeLa human U small nuclear ribonucleoproteins (UsnRNPs) followed by incubation with sera from chronic chagasic and non-chagasic cardiac patients was used to screen and compare serum reactivity. Western blot analysis using a T. cruzi total cell extract was also performed in order to select some sera for Western blot and immunoprecipitation assays with HeLa nuclear extract. ELISA showed that 73 and 95% of chronic chagasic sera reacted with HeLa UsnRNPs and T. cruzi antigens, respectively. The Western blot assay demonstrated that non-chagasic cardiac sera...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas' disease; Autoantibodies; Small nuclear ribonucleoprotein; Trypanosoma cruzi; HeLa cells; Cross-reactivity.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100006

Leptin levels in different forms of Chagas' disease
Provedor de dados: 56
Autores: Fernandes,F.; Dantas,S.; Ianni,B.M.; Ramires,F.J.A.; Buck,P.; Salemi,V.M.C.; Lopes,H.F.; Mady,C.
Leptin is produced primarily by adipocytes. Although originally associated with the central regulation of satiety and energy metabolism, increasing evidence indicates that leptin may be an important mediator in cardiovascular pathophysiology. The aim of the present study was to investigate plasma leptin levels in patient with Chagas' heart disease and their relation to different forms of the disease. We studied 52 chagasic patients and 30 controls matched for age and body mass index. All subjects underwent anthropometric, leptin and N-terminal pro-brain natriuretic peptide (NT-proBNP) measurements and were evaluated by echocardiography, 12-lead electrocardiogram (ECG), and chest X-ray. All patients had fasting blood samples taken between 8:00 and 9:00 am....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas' disease; Leptin; Heart failure; Left ventricular failure.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001200006

Induction of chagasic-like arrhythmias in the isolated beating hearts of healthy rats perfused with Trypanosoma cruzi-conditioned medium
Provedor de dados: 56
Autores: Rodríguez-Angulo,H.; Toro-Mendoza,J.; Marques,J.; Bonfante-Cabarcas,R.; Mijares,A.
Chagas' myocardiopathy, caused by the intracellular protozoan Trypanosoma cruzi, is characterized by microvascular alterations, heart failure and arrhythmias. Ischemia and arrythmogenesis have been attributed to proteins shed by the parasite, although this has not been fully demonstrated. The aim of the present investigation was to study the effect of substances shed by T. cruzi on ischemia/reperfusion-induced arrhythmias. We performed a triple ischemia-reperfusion (I/R) protocol whereby the isolated beating rat hearts were perfused with either Vero-control or Vero T. cruzi-infected conditioned medium during the different stages of ischemia and subsequently reperfused with Tyrode's solution. ECG and heart rate were recorded during the entire experiment. We...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas' disease; Arrhythmias; Ischemia.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000100058

Breathing disorders in congestive heart failure: gender, etiology and mortality
Provedor de dados: 56
Autores: Silva,R.S.; Figueiredo,A.C.; Mady,C.; Lorenzi-Filho,G.
We investigated the relationship between sleep-disordered breathing (SDB) and Cheyne-Stokes respiration (CSR) while awake as well as mortality. Eighty-nine consecutive outpatients (29 females) with congestive heart failure (CHF; left ventricular ejection fraction, LVEF &lt;45%) were prospectively evaluated. The presence of SDB and of CSR while awake before sleep onset was investigated by polysomnography. SDB prevalence was 81 and 56%, using apnea-hypopnea index cutoffs &gt;5 and &gt;15, respectively. CHF etiologies were similar according to the prevalence of SDB and sleep pattern. Males and females were similar in age, body mass index, and LVEF. Males presented more SDB (P = 0.01), higher apnea-hypopnea index (P = 0.04), more light sleep (stages 1 and 2; P...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep apnea; Cheyne-Stokes respiration; Congestive heart failure; Gender; Chagas' disease.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300007

Sera from chronic chagasic patients depress cardiac electrogenesis and conduction
Provedor de dados: 56
Autores: Costa,P.C.S.; Fortes,F.S.A.; Machado,A.B.; Almeida,N.A.C.; Olivares,E.L.; Cabral,P.R.; Pedrosa,R.C.; Goldenberg,R.C.; Campos-de-Carvalho,A.C.; Masuda,M.O.
We report results obtained with sera from 58 chronic chagasic patients that were evaluated for effects on heart rate and atrioventricular (AV) conduction in isolated rabbit hearts and screened for the presence of muscarinic and beta-adrenergic activity. We show that sera from 26 patients decreased heart rate, while 10 increased it and 22 had no effect. Additionally, sera from 20 of the 58 patients blocked AV conduction. Muscarinic activation seems to be involved in both effects, but is not the only mechanism, since atropine did not antagonize the decrease in heart rate in 23% of sera or AV block in 40%. Sera from patients with complex arrhythmias were significantly more effective in depressing both heart rate and AV conduction. Sera that induce increases...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas' disease; Antibodies; Muscarinic activation; Beta-adrenergic activation; Gap junction; Mammalian heart.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400010

Leishmania infantum heat shock protein 83 for the serodiagnosis of tegumentary leishmaniasis
Provedor de dados: 56
Autores: Celeste,B.J.; Angel,S.O.; Castro,L.G.M.; Gidlund,M.; Goto,H.
The serologic assay is an important tool in the diagnosis of leishmaniasis. One of the most commonly used tests is enzyme-linked immunosorbent assay (ELISA). Since total Leishmania promastigotes are used as antigen in the routine assay, false-positive reactions are frequent due to cross-reaction with sera from other diseases, mainly Chagas' disease. Therefore, an antigen that determines less cross-reactivity has been pursued for the serodiagnosis of leishmaniasis. In the present study we analyzed the use of recombinant Leishmania infantum heat shock protein (Hsp) 83 in ELISA for the serodiagnosis of cutaneous (N = 12) and mucocutaneous leishmaniasis (N = 14) and we observed the presence of anti-L. infantum Hsp 83 antibodies in all samples as well as...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Leishmania infantum; Sp 83; ELISA; Serodiagnosis; Tegumentary leishmaniasis; Chagas' disease.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001100001