Consulta: subjectFacets:"Coumarin"
Registros recuperados: 10
Data/hora: 05/06/2024 16:59:54

Activities and Novel Applications of Secondary Metabolite Coumarins
Provedor de dados: 87
Autores: HUSSAIN,M.I.; QAMAR ABBAS,S.; REIGOSA,M.J.
ABSTRACT: This review covers biological activity of secondary metabolites, coumarin and their derivatives on different organisms (pests, pathogens, weeds), as well as their applications in agriculture as eco-friendly pesticides and weed control agents. Naturally occurring coumarins have shown biological and allelopathic potential on a broad range of organisms. Coumarin inhibits seed germination, root growth, morphology, histology, water uptake, respiration, photosynthesis, cell elongation, cell división and differentiation. Coumarin demonstrate excellent insecticidal potential against eggs, larvae and adult insects. Coumarin showed antifeedent responses in a wide range of memebers from invertebrates to vertebrates. The information provided in this review...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coumarin; Secondary metabolites; Multifunctionality; Herbivory; Allelopathy; Phytotoxicity; Weed control.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582018000100220

Obtention of dry extract from aqueous extracts of Justicia pectoralis Jacq. (tilo)
Provedor de dados: 98
Autores: Rodríguez Chanfrau,Jorge Enrique; López Hernández,Orestes Dario; Núñez Figueredo,Yanier; Rodríguez Ferrada,Carlos; Nogueira Mendoza,Antonio.
Introduction: Justicia pectoralis Jacq. (Acanthaceae), is a medicinal species native to the American tropics. In Cuba it is used in folk medicine in the treatment of nervous disorders. The Cuban Pharmaceutical Industry is working on the development of technological processes for the obtention of pharmaceutical quality raw materials from natural products. Objectives: develop a technological process to obtain dry extract from aqueous extracts of J. pectoralis. Methods: a process to obtain dry extract by spray drying from aqueous extract of J. pectoralis was developed. The influence of solid-liquid r ratio and extraction time on coumarin content was evaluated by applying a response surface methodology (RSM). The drying process and later pharmacological...
Tipo: Journal article
Palavras-chave: Aqueous extract; Coumarin; Justicia pectoralis Jacq.; Response surface methodology; Pharmacological evaluation; Sedative activity; Spray drying.
Ano: 2013
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962013000400006

Effects of some phenolic compounds on soybean seed germination and on seed-borne fungi
Provedor de dados: 52
Autores: Colpas,Flávia Tavares; Ono,Elizabeth Orika; Rodrigues,João Domingos; Passos,José Raimundo de Souza.
Studies were carried out on the effects of coumarin, ferulic acid and naringenin on soybean seed germination and on the growth of seed-borne fungi at concentrations of 50 and 100 mg.L-1. The compounds showed good inhibition of seed germination, especially at 50 mg.L-1, but little fungistatic activity. Possible mechanisms of action are discussed.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Glycine max; Soybean; Phenolics; Coumarin; Ferulic acid; Naringenin.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000200003

Current status of rodenticide intoxication in Brazil: a preliminary survey from 2009 to 2011
Provedor de dados: 52
Autores: Papini,Solange; Nakagawa,Lia Emi.
The chemical control of rodents with anticoagulant products, especially derivatives of the coumarin chemical group, is legally authorised in Brazil. These products provide effective control and are safe for humans. However, the use of illegal 'rodenticides' has increased in many Brazilian cities recently, accompanied by increased numbers of suicides, homicides, and intoxications. The National Toxicology Information System (Sinitox) registers the number of rodenticide intoxications, including suicides, but does not differentiate between the legal and illegal rodenticides. Intoxications by rodenticides outnumber those by illicit drugs and pesticides. A survey of data from 2005-2011 revealed an average of about 3,800 intoxications per year, about 60% of which...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coumarin; Aldicarb; Paraffin block; Pellet; Powder; 'Chumbinho'.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000500685

Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
Provedor de dados: 56
Autores: Weng,K.-G.; Yuan,Y.-L.
Series of novel coumarin derivatives [I (a–d) and II (a–d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coumarin; X-ray; Lung cancer.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100603

Aurapten, a coumarin with growth inhibition against Leishmania major promastigotes
Provedor de dados: 56
Autores: Napolitano,H.B.; Silva,M.; Ellena,J.; Rodrigues,B.D.G.; Almeida,A.L.C.; Vieira,P.C.; Oliva,G.; Thiemann,O.H.
Several natural compounds have been identified for the treatment of leishmaniasis. Among them are some alkaloids, chalcones, lactones, tetralones, and saponins. The new compound reported here, 7-geranyloxycoumarin, called aurapten, belongs to the chemical class of the coumarins and has a molecular weight of 298.37. The compund was extracted from the Rutaceae species Esenbeckia febrifuga and was purified from a hexane extract starting from 407.7 g of dried leaves and followed by four silica gel chromatographic fractionation steps using different solvents as the mobile phase. The resulting compound (47 mg) of shows significant growth inhibition with an LD50 of 30 µM against the tropical parasite Leishmania major, which causes severe clinical manifestations...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coumarin; Aurapten (7-geranyloxycoumarin); X-rays; Leishmania; Inhibitor.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200010

A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp.
Provedor de dados: 58
Autores: Guerra,Felipe Q.S.; Araújo,Rodrigo S.A.; Sousa,Janiere P.; Silva,Viviane A.; Pereira,Fillipe O.; Mendonça-Junior,Francisco J.B.; Barbosa-Filho,José M.; Pereira,Julio Abrantes; Lima,Edeltrudes O.
Abstract Fungal infections have become a concern for health professionals, and the emergence of resistant strains has been reported for all known classes of antifungal drugs. Among the fungi causing disease, we highlight those that belong to the genus Aspergillus. For these reasons, the search for new antifungals is important. This study examines the effects of a coumarin derivative, 4-acetatecoumarin (Cou-UMB16) both alone and together with antifungal drugs, and its mode of action against Aspergillus spp. Cou-UMB16 was tested to evaluate its effects on mycelia growth, and germination of Aspergillus spp. fungal conidia. We investigated its possible action on cell walls, on the cell membrane, and also the capacity of this coumarin derivative to enhance the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coumarin; Antifungal activity; A. flavus; A. fumigatus; Mode of action.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200407

Synthesis of some novel pyrimidine, thiophene, coumarin, pyridine and pyrrole derivatives and their biological evaluation as analgesic, antipyretic and anti-inflammatory agents
Provedor de dados: 60
Autores: El-Sharkawy,Karam Ahmed; AlBratty,Mohammed Mofreh; Alhazmi,Hassan Ahmad.
Pyrimidine derivative 3 was afforded through the reaction of compound (1) with 5-ureidohydantion (2). Product 3 underwent a cyclization to produce fused pyrimidine derivative 7, although the latter product 7 was synthesized through one step via the reaction of compound (1) with 5-ureidohydantion (2) using another catalyst. Compound 3 was oriented to react with cyclic ketones 8a,b in the presence of elemental sulfur, salicylaldehyde (10), aryldiazonium chlorides 12a,b and ω-bromo-4-methoxy- acetophenone (14), which afforded, fused thiophene derivatives 9a,b, coumarin derivative 11, arylhdrazono derivatives 13a,b and 4-methoxyphenyl butenyl derivative 15, respectively. The latter product 15 was reacted with either potassium cyanide (16a) or potassium...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pyrimidine derivative; Thiophene; Coumarin; Pyridine; Pyrrole; Analgesic; Antipyretic and anti-inflammatory agents.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400603

Stability of hydroalcoholic extracts of two species of guaco; Mikania glomerata SPRENG. and Mikania laevigata SCHULTZ. (Asteraceae), by UHPLC-MS
Provedor de dados: 60
Autores: Melo,Lucilia Vilela de; Sawaya,Alexandra Christine Helena Frankland.
It is important to study the stability of plant extracts used as active ingredients in phytotherapic medicine, as degradation of the active principles directly affects the efficacy and safety of these products. Therefore, a stability study of the hydroalcoholic extract of the species: Mikania glomerata and Mikania laevigata was conducted in order to determine the speed of degradation and shelf life of these extracts, which are incorporated in cough syrup in Brazil. Leaves of both species were dried in an oven or by lyophilization (freeze-dried). Hydroalcoholic extracts underwent both accelerated stability study of six months and long-term stability study for 12 months. Samples were stored at different temperatures and every three months were analysed by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mikania glomerata Spreng.; Mikania laevigata Sch; Bip ex Baker; Guaco; Ultra-high performance liquid chromatography-mass spectrometry; Stability test; Coumarin; Chlorogenic acid.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100584

8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects
Provedor de dados: 60
Autores: Olaya,María del Pilar; Vergel,Nadezdha Esperanza; López,Jose Luis; Viña,Dolores; Guerrero,Mario Francisco.
Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new synthetic coumarin, were evaluated. To do this, we used the reserpine model of Parkinson’s disease, an assay of levodopa/carbidopa potentiation, the catalepsy model of haloperidol, and an in vitro assay against monoamine oxidase (MAO) activity. Additionally, lipid peroxidation and protein carbonyl group quantification was performed in mice brain homogenates previously treated with haloperidol. FCS303 inhibited monoamine oxidase B (MAO-B) with an IC50 of 5.46 ± 0.36 µM; however, there was no effect on monoamine oxidase A (MAO-A). The oral...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Parkinson’s disease; Monoamine oxidase B; Coumarin; Mice; Reserpine; Levodopa; Carbidopa.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100508