Consulta: subjectFacets:"Crohn's disease"
Registros recuperados: 5
Data/hora: 01/06/2024 04:55:51

Classical and recent advances in the treatment of inflammatory bowel diseases
Provedor de dados: 56
Autores: Sales-Campos,H.; Basso,P.J.; Alves,V.B.F.; Fonseca,M.T.C.; Bonfá,G.; Nardini,V.; Cardoso,C.R.B.
Crohn's disease (CD) and ulcerative colitis (UC) are intestinal disorders that comprise the inflammatory bowel diseases (IBD). These disorders have a significant effect on the quality of life of affected patients and the increasing number of IBD cases worldwide is a growing concern. Because of the overall burden of IBD and its multifactorial etiology, efforts have been made to improve the medical management of these inflammatory conditions. The classical therapeutic strategies aim to control the exacerbated host immune response with aminosalicylates, antibiotics, corticosteroids, thiopurines, methotrexate and anti-tumor necrosis factor (TNF) biological agents. Although successful in the treatment of several CD or UC conditions, these drugs have limited...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Treatment; Immune modulation; Cellular therapy.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000200096

Fluorescent quantitative PCR of Mycobacterium tuberculosis for differentiating intestinal tuberculosis from Crohn's disease
Provedor de dados: 56
Autores: Fei,B.Y.; Lv,H.X.; Zheng,W.H.
Intestinal tuberculosis (ITB) and Crohn's disease (CD) are granulomatous disorders with similar clinical manifestations and pathological features that are often difficult to differentiate. This study evaluated the value of fluorescent quantitative polymerase chain reaction (FQ-PCR) for Mycobacterium tuberculosis (MTB) in fecal samples and biopsy specimens to differentiate ITB from CD. From June 2010 to March 2013, 86 consecutive patients (38 females and 48 males, median age 31.3 years) with provisional diagnoses of ITB and CD were recruited for the study. The patients' clinical, endoscopic, and histological features were monitored until the final definite diagnoses were made. DNA was extracted from 250 mg fecal samples and biopsy tissues from each patient....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Intestinal tuberculosis; Crohn's disease; Diagnosis; Fluorescent quantitative PCR; Mycobacterium tuberculosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000200166

Bronchial hyperresponsiveness and analysis of induced sputum cells in Crohn's disease
Provedor de dados: 56
Autores: Bartholo,R.M.; Zaltman,C.; Elia,C.; Cardoso,A.P.; Flores,V.; Lago,P.; Cassabian,L.; Carvalho Dorileo,F.; Lapa-e-Silva,J.R.
With the aim of investigating the presence of latent inflammatory process in the lungs of patients with Crohn's disease, 15 patients with Crohn's disease were evaluated by spirometry, the methacholine challenge test, induced sputum, and skin tests for inhaled antigens. Serum IgE, erythrocyte sedimentation rate and hematocrit were also determined. The patients were compared with 20 healthy controls by the Mann-Whitney and Fisher exact tests. Their respiratory physical examination was normal. None had a personal or family history of clinical atopy. None had a previous history of pulmonary disease, smoking or toxic bronchopulmonary exposure. None had sinusitis, migraine, diabetes mellitus, or cardiac failure. Four (26.6%) of the patients with Crohn's disease...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inflammatory bowel disease; Crohn's disease; Bronchial hyperresponsiveness; Lymphocytosis.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200007

Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects
Provedor de dados: 56
Autores: Vilela,E.G.; Torres,H.O.G.; Ferrari,M.L.A.; Lima,A.S.; Cunha,A.S.
The gut barrier monitors and protects the gastrointestinal tract from challenges such as microorganisms, toxins and proteins that could act as antigens. There is evidence that gut barrier dysfunction may act as a primary disease mechanism in intestinal disorders. The aim of the present study was to evaluate the barrier function towards sugars after the appropriate treatment of celiac disease and Crohn's disease patients and compare the results with those obtained with healthy subjects. Fifteen healthy volunteers, 22 celiac disease patients after 1 year of a gluten-free diet, and 31 Crohn's disease patients in remission were submitted to an intestinal permeability test with 6.0 g lactulose and 3.0 g mannitol. Six-hour urinary lactulose excretion in Crohn's...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Intestinal permeability; Celiac disease; Crohn's disease; Mannitol; Lactulose.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200010

Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease
Provedor de dados: 56
Autores: Basso,P.J.; Fonseca,M.T.C.; Bonfá,G.; Alves,V.B.F.; Sales-Campos,H.; Nardini,V.; Cardoso,C.R.B.
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic disorder that affects thousands of people around the world. These diseases are characterized by exacerbated uncontrolled intestinal inflammation that leads to poor quality of life in affected patients. Although the exact cause of IBD still remains unknown, compelling evidence suggests that the interplay among immune deregulation, environmental factors, and genetic polymorphisms contributes to the multifactorial nature of the disease. Therefore, in this review we present classical and novel findings regarding IBD etiopathogenesis. Considering the genetic causes of the diseases, alterations in about 100 genes or allelic variants, most of them in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Immune response; Etiology; Microbiota.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000900727