Consulta: subjectFacets:"Elastic fibers"
Registros recuperados: 4
Data/hora: 01/06/2024 07:49:10

Elastin (ELN) gene point mutation in patients with inguinal hernia
Provedor de dados: 74
Autores: Rodrigues,Consuelo Junqueira; Yoo,Jin Hwan; Rodrigues Junior,Aldo Junqueira.
Groin hernias emerge at the myopectineal orifice of Fruchaud which is closed off by the fascia transversalis. Our previous studies showed structural and quantitative changes of the fascia transversalis elastic fibers of inguinal hernia patients and elderly people. The present study used single-strand conformation polymorphism (SSCP) elastin (analysis to investigate the 34 exons of the ELN gene of 49 inguinal hernia patients (7 females, 42 males aged 58.7 ± 19.82 years) and 75 non-herniated controls (35 females, 40 males aged 46.2 ± 14.32 years). We found that 47 patients and 24 controls had an abnormal exon 20 pattern caused by a g28197A &gt; G missense mutation leading to an S422G amino acid substitution in the elastin hydrophobic domain. The g28197A &gt;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fascia transversalis; Extracellular matrix; Elastic fibers; Elastin gene; Inguinal hernia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100009

The Microfibril-Elastin Fiber System Distribution in Left Atrioventricular Valve of the Rat
Provedor de dados: 77
Autores: Rocha,Vinícius Novaes; Neto-Ferreira,Rodrigo; Mandarim-de-Lacerda,Carlos Alberto; Carvalho,Jorge José de.
The microfibril-elastin fiber system, an important constituent of the extracellular matrix, was studied in the rat left atrioventricular valve to investigate the interrelationship of oxytalan, elaunin and elastic fibers in left atrioventricular valve morphology. The elastin fibers forms continuous bundles observed along the length of the valve in atrial and ventricular layers and oriented parallel to endothelium. The elaunin and oxytalan fibers are distributed in the thickest fiber bundles along the length of the valve. The thinner fibers which radiated towards both the atrial and spongiosa layers, either as isolated or arborescent fiber bundles were identified as oxytalan fibers. With transmission electron microscopy elastic fibers were seen mainly in the...
Tipo: Journal article
Palavras-chave: Elastic fibers; Elaunin fibers; Oxytalan fibers; Left atrioventricular valve.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300040

Structure and Concentration of Elastic System Fibers in the Trachea of the Rat
Provedor de dados: 77
Autores: Andrade,Filipe Moreira de; Judice,Luiz Felippe; Cisne,Rafael; Félix,Bruno; Mourad,Omar Moté Abou; Cardoso,Gilberto Perez; Babinski,Marcio Antonio.
The extracellular matrix is a key element in the tracheal morphology and physiology, both in normal and pathological states, yet little is known regarding its composition and organization. Herein we carried out a detailed study of the morphological organization and volumetric density of elastic system fibers in the trachea of Wistar rats. Six Wistar rats at the age of 45 days were used. The trachea was excised following anesthesia with Thiopental and perfusion through the left ventricle with buffered saline followed by formalin solution. Samples were fixed in formaline, embedded in paraffin, and histologically processed. The elastic system fibers were evaluated at light microscopy by using Weigert's resorcin-fuchsin technique after oxidation with oxone....
Tipo: Journal article
Palavras-chave: Rat; Trachea; Morphology; Elastic fibers; Quantitative evaluation.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100002

Inactivation of capsaicin-sensitive nerves reduces pulmonary remodeling in guinea pigs with chronic allergic pulmonary inflammation
Provedor de dados: 56
Autores: Prado,C.M.; da Rocha,G.Z.; Leick-Maldonado,E.A.; Starling,C.M.; Capelozzi,V.L.; Martins,M.A.; Tibério,I.F.L.C.
Pulmonary remodeling is an important feature of asthma physiopathology that can contribute to irreversible changes in lung function. Although neurokinins influence lung inflammation, their exact role in the extracellular matrix (ECM) remodeling remains to be determined. Our objective was to investigate whether inactivation of capsaicin-sensitive nerves modulates pulmonary ECM remodeling in animals with chronic lung inflammation. After 14 days of capsaicin (50 mg/kg, sc) or vehicle administration, male Hartley guinea pigs weighing 250-300 g were submitted to seven inhalations of increasing doses of ovalbumin (1, 2.5, and 5 mg/mL) or saline for 4 weeks. Seventy-two hours after the seventh inhalation, animals were anesthetized and mechanically ventilated and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Collagen; Elastic fibers; Capsaicin; Chronic lung inflammation.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200007