Consulta: subjectFacets:"Fractional clearance rate"
Registros recuperados: 1
Data/hora: 06/06/2024 00:22:43

Plasma clearance and biodistribution of oxidatively modified 99mTc-ß-VLDL in rabbits
Provedor de dados: 56
The biodistribution and removal from plasma (measured as fractional clearance rate, FCR, per hour) of native and oxidatively modified 99mtechnetium-labeled ß-very low density lipoprotein (99mTc-ß-VLDL) were investigated in hypercholesterolemic (HC) and control (C) three-month old New Zealand rabbits. The intracellular accumulation of ß-VLDL labeled with 99mTc was studied in vitro in THP-1 cells and monocyte-derived macrophages isolated from rabbits. After intravenous injection into C rabbits, copper-oxidized ß-VLDL (99mTc-ox-ß-VLDL) was cleared from the circulation faster (0.362 ± 0.070/h) than native ß-VLDL (99mTc-nat-ß-VLDL, 0.241 ± 0.070/h). In contrast, the FCR of 99mTc-ox-ß-VLDL in HC rabbits was lower (0.100 ± 0.048/h) than that of 99mTc-nat-ß-VLDL...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: SS-very low density lipoprotein; Copper-mediated oxidation; Biodistribution; Fractional clearance rate; Atherosclerosis; Hypercholesterolemia; Cholesterol feeding; Rabbit.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000600002