Consulta: subjectFacets:"Glivec"
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Data/hora: 06/06/2024 11:56:52

A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy
Provedor de dados: 60
Autores: Karimi,Maryam; Karimian,Khashayar; Heli,Hossein.
A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Glivec; Nanoemulsion; Anticancer drug; Bioavailability; Breast cancer cell.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100640