Consulta: subjectFacets:"Growth hormone"
Registros recuperados: 26
Data/hora: 13/06/2024 04:22:03

Growth Hormone insensitivity (Laron syndrome): Report of a new family and review of Brazilian patients
Provedor de dados: 74
Autores: Villela,Thais R.; Freire,Bruna L.; Braga,Nathalia T. P.; Arantes,Rodrigo R.; Funari,Mariana F. A.; Alexander,Jorge A L; Silva,Ivani N.
Abstract Laron’s syndrome (LS) is a rare genetic disorder characterized by insensitivity to growth hormone (GH). Up to the present time, over 70 mutations of GH receptor (GHR) gene have been identified leading to GH/insulin-like growth factor type 1 (IGF1) signaling pathway defect. The number of LS patients worldwide is unknown, as many are probably undiagnosed. We report two sibs from a consanguineous family from Minas Gerais, southeastern Brazil. The parents have three children. The older, a 4-years-old girl was 80.2 cm tall (-5.7 SDS height/age), and the youngest sister, aged 3 years, was 73.2 cm tall (-5.82 SDS height/age). Their clinical and biochemical features are typical of LS patients, such as high serum level of GH and low IGF1 concentrations. A...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Laron Syndrome; Growth hormone; Growth hormone receptor; Genetics.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000500102

A growth hormone-based phylogenetic analysis of euteleostean fishes including a representative species of the Atheriniformes Order, Odontesthes argentinensis
Provedor de dados: 74
Autores: Marins,Luis F.; Levy,Jose A.; Folch,Josep M.; Sanchez,Armand.
The GH (growth hormone) cDNA sequence of the marine silverside fish Odontesthes argentinensis was obtained using the RACE protocol (Rapid Amplification of cDNA Ends). The marine silverside GH cDNA sequence is 928 nucleotides long and was found to encode a polypeptide of 204 amino acids, including a signal peptide of 17 amino acids. The 5' and 3' untranslated regions of the messenger are 109 and 204 nucleotides long, respectively. The deduced GH amino acid sequence was used to infer a phylogenetic tree with GH amino acid sequences from representative species belonging to the Euteleostei Subdivision using the maximum parsimony method. The topology found is according to the major phylogenetic grouping of euteleosts. The results corroborate the hypothesis that...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Growth hormone; CDNA; RACE (Rapid Amplification of cDNA Ends); Phylogeny.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300013

Simultaneous overexpression of GH and STAT5b genes inhibits the STAT5 signalling pathway in tilapia (Oreochromis niloticus) embryos
Provedor de dados: 74
Autores: Marins,Luis Fernando; Iyengar,Arati; Maclean,Norman; Levy,Jose A.; Sohm,Frédéric.
In this study, we describe the use of a STAT5 responsive element (LHRE) reporter gene to monitor the activity of the growth hormone (GH) transduction pathway following expression of heterologous fish GH and rat STAT5b in tilapia embryos and fish fibroblast cells. Our results indicate that both GH and STAT5b are able to activate the LHRE at high levels when transferred separately, demonstrating the substantial level of conservation of the GH signal transduction pathways between fish and mammals. Unexpectedly, co-expression experiments show a strong inhibition of the GH-dependent activation, suggesting that simultaneous GH and STAT5b overexpression can counteract effects of GH expression in tilapia embryos.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Teleost; Growth hormone; Signal transduction; Cytokine; Trangenesis signal transducers and activators of transcription.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000300007

Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model
Provedor de dados: 74
Autores: Silveira,Luiz Guilherme G.; Furlan,Luiz R.; Curi,Rogério A.; Ferraz,André Luiz J.; Alencar,Maurício M. de; Regitano,Luciana C.A.; Martins,Cyntia L.; Arrigoni,Mário de Beni; Suguisawa,Liliane; Silveira,Antônio C.; Oliveira,Henrique N. de.
The growth hormone 1 gene (GH1) is a candidate gene for body weight and weight gain in cattle since it plays a fundamental role in growth regulation. We investigated the GH1 gene AluI and DdeI restriction enzyme polymorphisms, located 149 bp apart in the cattle genome, as possible markers of the production potential of Canchim crossbreed cattle, a 5/8 Charolais (Bos taurus) and 3/8 Nelore (Bos indicus) breed developed in Brazil, by evaluating the birth weight, weaning weight, yearling weight and plasma insulin-like growth factor-1 (IGF-1) concentration of 7 month to 10 months old Canchim calves (n = 204) of known genealogy and which had been genotyped for the AluI and DdeI markers. Our results showed significant effect (p &lt; 0.05) between the homozygous...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Beef cattle; Polymorphism; Growth hormone; Candidate gene.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500012

Molecular cloning and sequence analysis of growth hormone cDNA of Neotropical freshwater fish Pacu (Piaractus mesopotamicus)
Provedor de dados: 74
Autores: Pinheiro,Janeth Silva; Wolff,José Luiz Caldas; Araújo,Ronaldo de Carvalho; Hilsdorf,Alexandre Wagner Silva.
RT-PCR was used for amplifying Piaractus mesopotamicus growth hormone (GH) cDNA obtained from mRNA extracted from pituitary cells. The amplified fragment was cloned and the complete cDNA sequence was determined. The cloned cDNA encompassed a sequence of 543 nucleotides that encoded a polypeptide of 178 amino acids corresponding to mature P. mesopotamicus GH. Comparison with other GH sequences showed a gap of 10 amino acids localized in the N terminus of the putative polypeptide of P. mesopotamicus. This same gap was also observed in other members of the family. Neighbor-joining tree analysis with GH sequences from fishes belonging to different taxonomic groups placed the P. mesopotamicus GH within the Otophysi group. To our knowledge, this is the first GH...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Piaractus mesopotamicus; Growth hormone; CDNA cloning; Sequencing.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000200037

Association of GH and IGF-1 polymorphisms with growth traits in a synthetic beef cattle breed
Provedor de dados: 74
Autores: Pereira,Andréa Pozzi; Alencar,Maurício Mello de; Oliveira,Henrique Nunes de; Regitano,Luciana Correia de Almeida.
The Canchim beef cattle (5/8 Charolais + 3/8 Zebu) has been selected for meat production in Brazil since late 1950. In the present work the effects of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) polymorphisms were investigated in 688 animals born between 1998 and 2000. These animals belonged to two genetic groups, i.e., traditional and new lineages. Genotype effects on expected breeding values for birth weight (BW), weaning weight (WW) and yearling weight (YW) were investigated by the least square method. Significant effects were found for GH genotype on YW (p &lt; 0.05), with positive effects associated with the LV (leucine/valine) genotype. For IGF-1 genotypes, significant effects were found on BW (p &lt; 0.01) and YW (p &lt; 0.01)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Beef cattle; Genetic association; Genotype; Growth hormone; Insulin-like growth factor 1.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000200009

Regulation of the somatotropic axis by dietary factors in rainbow trout (Oncorhynchus mykiss)
Provedor de dados: 5
Autores: Gomez Requeni, P; Calduch Giner, J; De Celis, S; Medale, Francoise; Kaushik, Sadasivam; Perez Sanchez, J.
The activity of the somatotropic axis was analysed in juvenile rainbow trout (Oncorhynchus mykiss) fed either a fishmeal-based diet (FM) or graded levels of plant proteins to replace 50 % (PP50 diet), 75 % (PP75 diet) or 100 % (PP100 diet) of the fishmeal protein. For this purpose, partial cloning and sequencing of the gene encoding rainbow trout growth hormone receptor (GHR) was first accomplished by RT-PCR, using degenerate primers based on the sequences of non-salmonid fish GHR. Growth rates and energy retention were lowered by the PP75 and PP100 diets and a concurrent and progressive increase in plasma levels of growth hormone (GH) was found. However, no changes in hepatic GH binding and total plasma insulin-like growth factor (IGF)-I levels were...
Tipo: Text
Palavras-chave: Insulin like growth factor; Growth hormone receptor; Growth hormone; Plant proteins; Rainbow trout.
Ano: 2005
URL: http://archimer.ifremer.fr/doc/2005/publication-3620.pdf

Assessing the effects of genotype-by-environment interaction on epigenetic, transcriptomic, and phenotypic response in a Pacific salmon
Provedor de dados: 5
Autores: Christensen, Kris A; Le Luyer, Jeremy; Chan, Michelle T T; Rondeau, Eric B; Koop, Ben F; Bernatchez, Louis; Devlin, Robert H.
Genotype-by-environment (GxE) interactions are non-parallel reaction norms among individuals with different genotypes in response to different environmental conditions. GxE interactions are an extension of phenotypic plasticity and consequently studying such interactions improves our ability to predict effects of different environments on phenotype as well as the fitness of genetically distinct organisms and their capacity to interact with ecosystems. Growth hormone transgenic coho salmon grow much faster than non-transgenics when raised in tank environments, but show little difference in growth when reared in nature-like streams. We used this model system to evaluate potential mechanisms underlying this growth rate GxE interaction, performing RNA-seq to...
Tipo: Text
Palavras-chave: Epigenetics; Transcriptome; GxE; Transgenic; Growth hormone; Salmonid.
Ano: 2021
URL: https://archimer.ifremer.fr/doc/00677/78890/81188.pdf

Immunoreactive human growth hormone like peptides in tropical Penaeids and the effect of dietary hGH on Penaeus vannamei larval development
Provedor de dados: 5
Autores: Toullec, J. Y.; Le Moullac, Gilles; Cuzon, Gerard; Van Wormhoudt, A.
Human growth hormone like peptides were present in Penaeus indicus as two molecular forms: one with a molecular weight about 25 kDa which is similar to that of the vertebrate growth hormone and a smaller form of 2 kDa. Quantitative variations of hGH-like peptides in different larval stages of three species of Penaeids (Penaeus vannamei, P. stylirostris, P. indicus) suggest a possible involvement of hGH-like peptides in the development. Human growth hormone (hGH) supplementation in the diet of Penaeus vannamei larvae seems to have a positive effect on the size and on the quality of the animals estimated by their resistance to salinity stress.
Tipo: Text
Palavras-chave: Growth hormone; Growth; P. indicus; P. stylirostris; P. vannamei; Penaeids; Hormone de croissance; Croissance; P. indicus; P. stylirostris; P. vannamei; Pénéides.
Ano: 1991
URL: http://archimer.ifremer.fr/doc/1991/publication-4429.pdf

Combined replacement of fish meal and oil in practical diets for fast growing juveniles of gilthead sea bream (Sparus aurata L.): Networking of systemic and local components of GH/IGF axis
Provedor de dados: 5
Autores: Benedito Palos, L; Saera Vila, A; Calduch Giner, J; Kaushik, Sadasivam; Perez Sanchez, J.
Growth performance and growth regulatory pathways were examined in juvenile gilthead sea bream fed diets containing largely plant-based ingredients. Four isonitrogenous and isolipidic extruded diets with a low level (20%) of fish meal inclusion were formulated with graded levels of a vegetable oil mixture (17:58:25 of rapeseed: linseed: palm oils) replacing fish oil at 33, 66 and 100% (33VO, 66VO and VO diets). All diets were supplemented with lysine (0.55%) and contained soy lecithin (1%). Daily growth coefficients and feed efficiency over the course of an 11-week trial were almost identical in fish fed the FO, 33VO and 66VO diets. The VO diet reduced feed intake and growth without significant effects in proximate whole body composition, nitrogen or...
Tipo: Text
Palavras-chave: Contaminants; Endocrine disrupters; Insulin like growth factors; Growth hormone receptors; Growth hormone; Plant proteins; Vegetable oil; Fish oil; Sparidae.
Ano: 2007
URL: http://archimer.ifremer.fr/doc/2007/publication-5017.pdf

Candidate gene variation in gilthead sea bream reveals complex spatiotemporal selection patterns between marine and lagoon habitats
Provedor de dados: 5
Autores: Guinand, B.; Chauvel, C.; Lechene, M.; Tournois, J.; Tsigenopoulos, C. S.; Darnaude, A. M.; Mckenzie, David; Gagnaire, P. A.
In marine fishes, the extent to which spatial patterns induced by selection remain stable across generations remains largely unknown. In the gilthead sea bream Sparus aurata, polymorphisms in the growth hormone (GH) and prolactin (Prl) genes can display high levels of differentiation between marine and lagoon habitats. These genotype-environment associations have been attributed to differential selection following larval settlement, but it remains unclear whether selective mortality during later juvenile stages further shapes genetic differences among habitats. We addressed this question by analysing differentiation patterns at GH and Prl markers together with a set of 21 putatively neutral microsatellite loci. We compared genetic variation of spring...
Tipo: Text
Palavras-chave: Candidate gene; Growth hormone; Prolactin; Genetic differentiation; Amplicon sequencing; Local selection.
Ano: 2016
URL: https://archimer.ifremer.fr/doc/00625/73751/74235.pdf

Protein sparing effect of dietary lipids in common dentex (Dentex dentex): a comparative study with sea bream (Sparus aurata) and sea bass (Dicentrarchus labrax)
Provedor de dados: 5
Autores: Company, Rubén; Calduch Giner, Josep; Perez Sanchez, Jaume; Kaushik, Sadasivam.
The common dentex (Dentex dentex) is a sparid fish which is considered a suitable candidate for Mediterranean aquaculture. A seven-weeks feeding trial was conducted over the summer period with common dentex, sea bream (Sparus aurata) and sea bass (Dicentrarchus labrax). All three species were fed to visual satiety with two practical diets with varying crude protein and crude fat levels (55 % protein, 9 % lipids; 46 % protein, 17 % lipids). The initial body weights were 8.2, 11.6 and 17.3 g for common dentex, sea bass and sea bream, respectively. In all cases, specific growth rates were not significantly affected by dietary treatment, but they varied among species (sea bass 1.7-1.8 %; sea bream 2.1-2.3 %; common dentex 3.1-3.2 %). When comparisons between...
Tipo: Text
Palavras-chave: Sparus aurata; Dicentrarchus labrax; Dentex dentex; Growth hormone; Energy availability; Protein retention; Growth performance; Sparus aurata; Dentex dentex I Dicentrarchus labrax; Hormone de croissance; Energie digestible; Rétention protéinique; Croissance.
Ano: 1999
URL: http://archimer.ifremer.fr/doc/1999/publication-863.pdf

Morphometric Study of Muscle Fibers in Rats Submitted to Strength Training and Growth Hormone
Provedor de dados: 77
Autores: Castoldi,Robson Chacon; Ozaki,Guilherme Akio Tamura; Giometti,Ines Cristina; Camargo,Regina Celi Trindade; EmyKoike,Tatiana; Garcia,Thiago Alves; Filho,José Carlos Silva Camargo; Belangero,William Dias.
The aim of the present study was to observe the changes in the muscle tissue of rats after application of growth hormone (GH) and performing a strength training protocol (ST). In total, 40 male Wistar rats, 60 days old, were used, divided into four groups: control (C), control and application of GH (GHC), strength training (T), and strength training with the application of GH (GHT). The physical training protocol (PT) was composed of four series of 10 jumps in water, 3x/week, with an overload of 50 % of body weight for four weeks. GH was administered intraperitoneally at a dose of 0.2 IU/Kg to the GHC and GHT groups and saline (0.9 % sodium chloride) to the C and T groups. After four weeks of PT, the animals were euthanized and samples taken from the...
Tipo: Journal article
Palavras-chave: Growth hormone; Striated Muscle; Orthopedics; Physical Education and Training; Endocrinology.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200015

Rhamdia quelen (Quoy &amp;amp; Gaimard, 1824), submitted to a stressful condition: effect of dietary addition of the essential oil of Lippia alba on metabolism, osmoregulation and endocrinology
Provedor de dados: 83
Autores: Souza,Carine de Freitas; Salbego,Joseânia; Gressler,Luciane T.; Golombieski,Jaqueline I.; Ferst,Juliana G.; Cunha,Mauro A.; Heinzmann,Berta M.; Caron,Braulio O.; Glanzner,Werner G.; Gonçalves,Paulo B. D.; Baldisserotto,Bernardo.
ABSTRACT The aim of this study was to evaluate the effect of the essential oil of Lippia alba (EOLA) as a feed additive on ionoregulatory and metabolic parameters and pituitary hormones expression in silver catfish, Rhamdia quelen , submitted to a stressful condition (stocking density of 10.6 kg m-3 and limited space). Fish were fed with different concentrations of EOLA (0.0 - control, 0.25 and 0.50 mL kg food-1) for 20 days. Metabolic parameters were not affected by the diet, with the exception of alanine aminotransferase, which was higher in the liver of fish fed 0.50 mL EOLA kg food-1. Plasma ions and activity of H+-ATPase did not change, but fish fed 0.25 mL EOLA kg food-1 presented higher Na+/K+-ATPase activity. Somatolactin expression in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cortisol; Enzymatic activity; Growth hormone; Somatolactin.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252015000400707

Reproductive response of Pelibuey sheep to the application of recombinant bovine somatotropin and a metabolic restorative preparation
Provedor de dados: 86
Autores: Fraire-Cordero,Silvia; Rodríguez,Paulino Pérez; Pérez-Hernández,Ponciano; Cortez-Romero,César; Gallegos-Sánchez,Jaime.
Abstract: The objective of this work was to evaluate the effect of recombinant bovine somatotropin (rBST) and of the metabolic restorative preparation Metabolase (MR) on the reestablishment of the post-partum ovarian activity of Pelibuey sheep. Ninety-four ewes, with their respective lambs, were randomly assigned to one of the following treatments: T1, continuous suckling (CS); T2, CS + MR; T3, CS + rBST; and T4, CS + MR + rBST. Ovulating percentages, weight changes in ewes and lambs, incidence of estrus, onset and return to estrus, calving, fecundity, and prolificacy were evaluated. The highest ovulation percentages were recorded for CS in T1 and T2, and the lowest ones for rBST in T3 and T4. The treatments had a significant effect on lamb weight. Ewes in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ovis aries; Anestrus; Body weight; Estrus induction; Growth hormone; Post-partum reproductive activity.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2018001201392

Growth hormone-insuline-like growth factor-I system in pejerrey Odontesthes bonariensis (Atheriniformes)
Provedor de dados: 96
Autores: Arranz,S.E.; Sciara,A. A.; Botta,P.; Cerutti,P.; Tobin,M.; Somoza,G.M.
Using biotechnology to increase the growth rates of fish is likely to reduce production costs per unit of food. Among vertebrates, fish appear to occupy a unique position, when growth patterns are considered. With few exceptions, fish species tend to grow indeterminately, implying that size is never fixed. Both hyperplasia and hypertrophy contribute to post-larval muscle growth in fish. Growth hormone (GH) - Insulin-like Growth Factor I (IGF-I) is the most important growth axis in fish. Our experimental model, the pejerrey, Odontesthes bonariensis (Ateriniformes) is a South American inland water fish considered to be a promising species for intensive aquaculture. However, one major drawback to achieve this goal is its slow growth in captivity. In order to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Growth; Growth hormone; Muscle hypertrophy; Oral administration; Recombinant protein.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982008001300001

A comparative expression analysis of gene transcripts in brain tissue of non-transgenic and GH-transgenic zebrafish (Danio rerio) using a DDRT-PCR approach
Provedor de dados: 42
Autores: Alves-Costa,Fernanda A.; Figueiredo,Márcio A.; Lanes,Carlos F.C.; Almeida,Daniela V.; Marins,Luis F.; Wasko,Adriane P.
The presence of higher level of exogenous growth hormone (GH) in transgenic animals could lead to several physiological alterations. A GH transgenic zebrafish (Danio rerio) line was compared to nontransgenic (NT) samples of the species through a DDRT-PCR approach, with the goal of identifying candidate differentially expressed transcripts in brain tissues that could be involved in GH overexpression. Densitometric analyses of two selected amplification products, p300 and ADCY2, pointed to a significant lower gene expression in the transgenic zebrafish (104.02 ± 57.71; 224.10 ± 91.73) when compared to NT samples (249.75 ± 30.08; 342.95 ± 65.19). The present data indicate that p300 and ADCY2 are involved in a regulation system for GH when high circulating...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Differential display; GH; Growth hormone; Transgenic; Zebrafish.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000200017

Prepartum administration of recombinant bovine somatotropin (rBST) on adaptation to subclinical ketosis of the ewes and performance of the lambs
Provedor de dados: 45
Autores: Feijó,J.O.; Schneider,A.; Schmitt,E.; Brauner,C.C.; Martins,C.F.; Barbosa-Ferreira,M.; Del Pino,F.A.B.; Faria Junior,S.P.; Rabassa,V.R.; Corrêa,M.N.
The aim of this study was to determine the effect of prepartum rbST injection on the metabolic profile of pregnant ewes induced to subclinical ketosis, as well as the metabolism until seven days of life and weight gain until seven weeks of life of the lambs. Twenty seven pregnant ewes of the pantaneiro genetic group were used, divided into two groups: rbST group (n = 14) and control group (n = 13). The rbST group received two applications of 1 mg/kg of rbST, at 97 and 111 days gestation, while the control group received placebo injections. There were significant differences between groups in levels of GGT in the ketosis post induction period and BHB concentrations in the postpartum period. Concentrations of glucose, urea, phosphorus, albumin, cholesterol,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sheep; Growth hormone; Ketosis; Pregnancy toxemia.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000100103

Effect of porcine somatotropin on metabolism, testicular size and sperm characteristics in young boars
Provedor de dados: 45
Autores: Rabassa,V.R.; Feijó,J.O.; Perazzoli,D.; Pereira,C.M.; Schild,A.L.P.; Lucia Júnior,T.; Corcini,C.D.; Schmitt,E.; Schneider,A.; Pino,F.A.B.D.; Bianchi,I.; Corrêa,M.N.
ABSTRACT The aim of this study was to evaluate the effect of pST injections on metabolism, testicular size, and sperm characteristics in young boars. Sixty 22-day old piglets were divided into two groups: pST (n=30) and Control (n=30). The pST group was submitted to pST injections (90µg/kg body weight) every three days up to 330 days of age. Blood collections were performed weekly. Testicular weight was measures at 22, 82, 142, 202 and 365 days of age. Libido and fresh semen characteristics were evaluated between 150 and 210 days of age. Semen characteristics were also evaluated during a 72h storage period (15ºC). Testosterone, albumin, and phosphorus blood concentrations were higher in the pST group (P&lt;0.05). The pST group had a higher IGF-I...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Swine; Growth hormone; PST; Testicle; Semen.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000100073

Influence of feeding differentiation on the age at onset of puberty in Brazilian Bergamasca dairy ewe lambs
Provedor de dados: 45
Autores: Dantas,A.; Siqueira,E.R.; Fernandes,S.; Oba,E.; Castilho,A.M.; Meirelles,P.R.L.; Sartori,M.M.P.; Santos,P.T.R.
The objective of the study was to evaluate body growth and age at onset of puberty on lambs fed two specific diets for low and high growth rates. A herd of 20 Brazilian Bergamasca lambs was divided in two groups (n= 10) and kept confined throughout the experimental period, two animals of the same treatment/pen. Two phases were established: Phase 1, from 90 days of age until the onset of puberty; and Phase 2, from puberty onset up to 1 year old. For Phase 1, two distinct diets were formulated, being: Treatment A, which was formulated to obtain an average daily gain of approximately 150g; and Treatment B, for an average daily gain of about 250g. In Phase 2, a balanced, equal diet was provided to both groups. Every 14 days, the animals were weighed and given...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nutrition; Performance; Reproduction; Growth hormone; Sheep.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000100022

Growth hormone in the presence of laminin modulates interaction of human thymic epithelial cells and thymocytes in vitro
Provedor de dados: 48
Autores: Lins,Marvin Paulo; Vieira,Larissa Fernanda de Araújo; Rosa,Alfredo Aurélio Marinho; Smaniotto,Salete.
BACKGROUND: Several evidences indicate that hormones and neuropeptides function as immunomodulators. Among these, growth hormone (GH) is known to act on the thymic microenvironment, supporting its role in thymocyte differentiation. The aim of this study was to evaluate the effect of GH on human thymocytes and thymic epithelial cells (TEC) in the presence of laminin. RESULTS: GH increased thymocyte adhesion on BSA-coated and further on laminin-coated surfaces. The number of migrating cells in laminin-coated membrane was higher in GH-treated thymocyte group. In both results, VLA-6 expression on thymocytes was constant. Also, treatment with GH enhanced laminin production by TEC after 24 h in culture. However, VLA-6 integrin expression on TEC remained...
Tipo: Journal article
Palavras-chave: Thymocyte; Growth hormone; Laminin; Thymic epithelial cells.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100037

Beneficial effect of recombinant human growth hormone on the intestinal mucosa barrier of septic rats
Provedor de dados: 56
Autores: Yi,C.; Cao,Y.; Wang,S.R.; Xu,Y.Z.; Huang,H.; Cui,Y.X.; Huang,Y.
The objective of the present study was to investigate the effects of recombinant human growth hormone (rhGH) on the intestinal mucosa barrier of septic rats and explore its possible mechanism. Female Sprague-Dawley rats were randomized into three groups: control, Escherichia coli-induced sepsis (S) and treatment (T) groups. Groups S and T were subdivided into subgroups 1d and 3d, respectively. Expression of liver insulin-like growth factor-1 (IGF-1) mRNA, Bcl-2 and Bax protein levels and the intestinal Bax/Bcl-2 ratio, and plasma GH and IGF-1 levels were determined. Histological examination of the intestine was performed and bacterial translocation was determined. rhGH significantly attenuated intestinal mucosal injuries and bacterial translocation in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Intestinal mucosa barrier; Growth hormone; Sepsis; Insulin-like growth factor-1; Apoptosis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100006

Role of high mobility group box-1 and protection of growth hormone and somatostatin in severe acute pancreatitis
Provedor de dados: 56
Autores: Wang,Y.F.; Wu,M.; Ma,B.J.; Cai,D.A.; Yin,B.B.
In this study, we investigated the potential role of high-mobility group box 1 (HMGB1) in severe acute pancreatitis (SAP) and the effects of growth hormone (G) and somatostatin (S) in SAP rats. The rats were randomly divided into 6 groups of 20 each: sham-operated, SAP, SAP+saline, SAP+G, SAP+S and SAP+G+S. Ileum and pancreas tissues of rats in each group were evaluated histologically. HMGB1 mRNA expression was measured by reverse transcription-PCR. Levels of circulating TNF-α, IL-1, IL-6, and endotoxin were also measured. In the SAP group, interstitial congestion and edema, inflammatory cell infiltration, and interstitial hemorrhage occurred in ileum and pancreas tissues. The levels of HMGB1, TNF-α, IL-1, IL-6 and endotoxin were significantly up-regulated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Severe acute pancreatitis; High-mobility group box 1; Growth hormone; Somatostatin; Inflammatory response.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201075

Response of the growth plate of uremic rats to human growth hormone and corticosteroids
Provedor de dados: 56
Autores: Barbosa,A.P.F.; Silva,J.D.P.; Fonseca,E.C.; Lopez,P.M.; Fernandes,M.B.C.; Balduino,A.; Duarte,M.E.L.
Children with chronic renal failure in general present growth retardation that is aggravated by corticosteroids. We describe here the effects of methylprednisolone (MP) and recombinant human growth hormone (rhGH) on the growth plate (GP) of uremic rats. Uremia was induced by subtotal nephrectomy in 30-day-old rats, followed by 20 IU kg-1 day-1 rhGH (N = 7) or 3 mg kg-1 day-1 MP (N = 7) or 20 IU kg-1 day-1 rhGH + 3 mg kg-1 day-1 MP (N = 7) treatment for 10 days. Control rats with intact renal function were sham-operated and treated with 3 mg kg-1 day-1 MP (N = 7) or vehicle (N = 7). Uremic rats (N = 7) were used as untreated control animals. Structural alterations in the GP and the expression of anti-proliferating cell nuclear antigen (PCNA) and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Corticosteroids; Growth hormone; Renal failure; Growth retardation; Growth plate; Insulin-like growth factor I.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800011

Clinical and molecuar characterization of Brazilian patients with growth hormone gene deletions
Provedor de dados: 56
Autores: Arnhold,I.J.P.; Osorio,M.G.F.; Oliveira,S.B.; Estefan,V.; Kamijo,T.; Krishnamani,M.R.S.; Cogan,J.D.; Phillips III,J.A.; Mendonça,B.B.
Genomic DNA from 23 patients with isolated growth hormone (GH) deficiency (12 males and 11 females: heights -4.9 ± 1.4 SDS) was screened for GH gene deletions by restriction endonuclease analysis of polymerase chain reaction amplification products. Three unrelated patients had typical features of severe GH deficiency and deletions (6.7 kb in two and 7.6 kb in one) of the GH gene. The two patients with 6.7-kb deletions developed growth-attenuating anti-GH antibodies whereas the patient with the 7.6-kb deletion continued to grow with GH replacement therapy. Our finding that 3/23 (~13%) Brazilian subjects had GH gene deletions agrees with previous studies of severe isolated GH deficiency subjects in other populations. Two of three subjects (67%) with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Growth; Growth hormone; Dwarfism; Gene.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400003

Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin
Provedor de dados: 56
Autores: Lengyel,A.-M.J.
Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues. Ghrelin is a novel acylated peptide which is produced mainly by the stomach. It is also synthesized in the hypothalamus and is present in several other tissues. This endogenous growth hormone secretagogue was discovered by reverse pharmacology when a group of synthetic growth hormone-releasing compounds was initially produced, leading to the isolation of an orphan receptor and, finally, to its endogenous ligand. Ghrelin binds to an active receptor to increase growth hormone release and food intake. It is still not known how...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Growth hormone; Growth hormone secretagogues; Ghrelin; Somatostatin; Hypothalamus.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000800002