Consulta: subjectFacets:"High throughput screening"
Registros recuperados: 2
Data/hora: 07/06/2024 05:13:42

THE CONTINUING VALUE OF NATURALPRODUCTS FOR DRUG DISCOVERY
Provedor de dados: 101
Autores: Harvey,Alan L.
Natural products are the most consistently successful source of drug leads, both historically and currently. Despite this, the use of natural products in industrial drug discovery has fallen out of favour. Natural products are likely to continue to be sources of new commercially viable drug leads because the chemical novelty associated with natural products is higher than that of any other source: this is particularly important when searching for lead molecules against newly discovered targets for which there are no known small molecule leads. Despite the commonly held assumptions, natural products can be a more economical source of chemical diversity compared with synthesis of equivalent numbers of diverse chemicals. Additionally, natural products that...
Tipo: Journal article
Palavras-chave: Drug discovery; Natural products; High throughput screening; Convention on biological diversity.
Ano: 2009
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0253-570X2009000100002

A roadmap to directed enzyme evolution and screening systems for biotechnological applications
Provedor de dados: 48
Autores: Martínez,Ronny; Schwaneberg,Ulrich.
Enzymes have been long used in man-made biochemical processes, from brewing and fermentation to current industrial production of fine chemicals. The ever-growing demand for enzymes in increasingly specific applications requires tailoring naturally occurring enzymes to the non-natural conditions found in industrial processes. Relationships between enzyme sequence, structure and activity are far from understood, thus hindering the capacity to design tailored biocatalysts. In the field of protein engineering, directed enzyme evolution is a powerful algorithm to generate and identify novel and improved enzymes through iterative rounds of mutagenesis and screening applying a specific evolutive pressure. In practice, critical checkpoints in directed evolution...
Tipo: Journal article
Palavras-chave: Directed evolution; Enzyme engineering; High throughput screening; Random mutagenesis.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000400011