Consulta: subjectFacets:"Histoplasma capsulatum"
Registros recuperados: 4
Data/hora: 11/06/2024 04:25:03

The importance of serological assays in diagnosing acute pulmonary histoplasmosis
Provedor de dados: 80
Autores: Freitas,RS; Carvalho-Vivi,JO; Zamboni,IM; Assis,CM; Costa-Martins,JE; Vicentini-Moreira,AP.
Histoplasmosis is a systemic mycosis caused by inhalation of Histoplasma capsulatum microconidia. The disease does not normally affect immunocompetent individuals after a single, transient inhalation exposure. However, longer exposure may cause chronic or disseminated acute pulmonary infection. Herein, we report the case of a 24-year-old immunocompetent patient, who presented fever, cough and dyspnea for one month. The chest radiography revealed interstitial infiltrate and diffuse micronodules. The patient reported having had close and prolonged contact with bats. Diagnosis was confirmed by positive double immunodifusion and immunoblotting assays. She was treated with ketoconazole (400 mg) and there was complete resolution of the disease.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Histoplasmosis; Histoplasma capsulatum; Immunocompetence; Serodiagnosis; Bats.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200010

Bilateral afrenal nodules due to histoplasmosis in an elderly
Provedor de dados: 55
Autores: Carvalho,Flávio Pedreira de Freitas de; Curiati,José Antônio Esper; Mauad,Thaís; Incerti,Milena Mendes; Jacob Filho,Wilson.
We report a case history of an 84-year-old elderly male patient that presented with a clinical picture suggestive of adrenal failure and bilateral adrenal nodules detected by abdominal computed tomography. A fine needle-guided biopsy was inconclusive for achieving a final diagnosis. The patient died due to septic shock and the autopsy disclosed histoplasmosis with extensive bilateral necrosis of the adrenal glands. Although the adrenal involvement in chronic disseminated histoplasmosis has been described, there have been few reports of the infection being associated with adrenal insufficiency.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Histoplasmosis; Adrenal nodule; Addison disease; Elderly; Histoplasma capsulatum.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100033

Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro
Provedor de dados: 55
Autores: Brilhante,Raimunda Sâmia Nogueira; Caetano,Érica Pacheco; Riello,Giovanna Barbosa; Guedes,Glaucia Morgana de Melo; Castelo-Branco,Débora de Souza Collares Maia; Fechine,Maria Auxiliadora Bezerra; Oliveira,Jonathas Sales de; Camargo,Zoilo Pires de; Mesquita,Jacó Ricarte Lima de; Monteiro,André Jalles; Cordeiro,Rossana de Aguiar; Rocha,Marcos Fábio Gadelha; Sidrim,José Júlio Costa.
Abstract Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1 μg mL−1 for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4 μg mL−1and from 0.0625 to 1 μg mL−1 for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Histoplasma capsulatum; Saquinavir; Ritonavir; Itraconazole.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200155

Interleukin-5 mediates peritoneal eosinophilia induced by the F1 cell wall fraction of Histoplasma capsulatum
Provedor de dados: 56
Autores: Sá-Nunes,A.; Medeiros,A.I.; Faccioli,L.H.
An alkali-insoluble fraction 1 (F1), which contains mainly ß-glucan isolated from the cell wall of Histoplasma capsulatum, induces eosinophil recruitment into the peritoneal cavity of mice. The present study was carried out to determine the participation of interleukin-5 (IL-5) in this process. Inbred C57BL/6 male mice weighing 15-20 g were treated ip with 100 µg of anti-IL-5 monoclonal antibody (TRFK-5, N = 7) or an isotype-matched antibody (N = 7), followed by 300 µg F1 in 1 ml PBS ip 24 h later. Controls (N = 5) received only 1 ml PBS. Two days later, cells from the peritoneal cavity were harvested by injection of 3 ml PBS and total cell counts were determined using diluting fluid in a Neubauer chamber. Differential counts were performed using...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Eosinophils; Histoplasma capsulatum; Inflammation; Interleukin-5; Anti-IL-5 monoclonal antibody.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300009