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The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine
Provedor de dados: 42
Autores: DAMAZIO,LOUYSE S.; SILVEIRA,FLÁVIA R.; CANEVER,LARA; CASTRO,ADALBERTO A. DE; ESTRELA,JADNE M.; BUDNI,JOSIANE; ZUGNO,ALEXANDRA I.
ABSTRACT Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) in an animal model of schizophrenia (SZ). Rats were supplemented with AA (0.1, 1, or 10 mg/kg), or water for 14 days (gavage). Between the 9th and 15th days, the animals received Ketamine (Ket) (25 mg/kg) or saline (i.p). After the last administration (30 min) rats were subjected to the behavioral test. Brain structures were dissected for biochemical analysis. There was a significant increase in the locomotor activity in Ket treated. AA prevented the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Schizophrenia; Ascorbic acid; Ketamine; Hyperlocomotion; Acetylcholinesterase.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301133