Consulta: subjectFacets:"Interleukin-12"
Registros recuperados: 4
Data/hora: 14/06/2024 03:26:22

Interleukin-15 as a potential regulator of the innate immune response
Provedor de dados: 56
Autores: Carson,W.; Caligiuri,M.A.
Interleukin-15 (IL-15) is a newly-discovered cytokine that is produced by activated monocytes early in the course of the innate immune response. IL-15 is able to bind to components of the interleukin-2 receptor (IL-2R) despite the fact that it has no sequence homology with IL-2. IL-15 stimulates human natural killer cell proliferation, cytotoxicity, and cytokine production and can substitute for IL-2 under most conditions. In vitro studies indicate that monocyte-derived IL-15 may be an important determinant of IFN-gamma production by NK cells. In addition, IL-15 is able to promote the survival of natural killer cells under serum-free conditions. The IL-15 receptor is a heterotrimeric complex which is composed of the IL-2Rß and &lt;FONT...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Interleukin-15; Interleukin-12; Gamma interferon; Natural killer cell; Innate immunity.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100001

Interleukin-12 and protective immunity to schistosomes
Provedor de dados: 56
Autores: Mountford,A.P.; Shires,V.L.; Anderson,S.
The attenuated vaccine against Schistosoma mansoni induces Th1-mediated protective immunity and we have sought to identify a role for IL-12 in this model. Elevated levels of IL-12 (p40 mRNA) were detected in the lymph nodes (LN) and the lungs of vaccinated mice, whilst treatment of vaccinated mice with anti-IL-12 antibodies decreased the ratio of IFN&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt;:IL-4 secreted by in vitro-cultured LN cells. However, there was only marginal abrogation of the level of resistance in these mice. Soluble antigens from the lung-stage of the parasite (SLAP) appeared to be efficient stimulators of IFN&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; and IL-12 secretion. These antigens when used to immunise mice in conjunction with IL-12 as an...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Schistosoma; Interleukin-12; Adjuvant; Vaccine; Th1.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100023

Cytokines in innate and acquired immunity to Trypanosoma cruzi infection
Provedor de dados: 56
Autores: Abrahamsohn,I.A.
Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; and TNF-&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt; in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Interferon-gamma; Interleukin-12; TNF-alpha; Interleukin-10; Innate immunity; Knock-out mice.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100015

Correlation between serum levels of interleukins 10 and 12 and thrombocytopenia in hepatitis C cirrhotic (class A) patients
Provedor de dados: 80
Autores: Abdallah,N; Abdel Aziz,HK; Hamed,NA; Gamal,M.
Hepatitis C virus (HCV) patients commonly have low platelet counts; however, the exact role of HCV infection in thrombocytopenia is unknown. This work aimed to study the serum levels of interleukins (IL) 10 and 12 in patients with mild and moderate thrombocytopenia associated with chronic hepatitis C infection. Our study included 15 patients with chronic HCV infection and newly diagnosed isolated autoimmune thrombocytopenia (Group I) and 15 patients with chronic HCV infection and normal platelet count as controls (Group II). All patients were examined for personal history and clinical aspects, complete blood count, bone marrow aspiration, liver function tests, HCV antibody assay by ELISA and polymerase chain reaction (PCR), abdominal ultrasound,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Interleukin-10; Interleukin-12; Thrombocytopenia; Hepatitis C activity.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300012