Consulta: subjectFacets:"Kaempferol"
Registros recuperados: 4
Data/hora: 10/06/2024 18:00:27

Prospecção química de compostos produzidos por Senna alata com atividade alelopática
Provedor de dados: 87
Autores: Rodrigues,I.M.C.; Souza Filho,A.P.S.; Ferreira,F.A.; Demuner,A.J.
Senna alata é uma espécie daninha frequente em pastagens da região amazônica. Suas folhas apresentam propriedades medicinais capazes de influenciar a germinação e o desenvolvimento de outras plantas. Objetivou-se neste estudo a prospecção química e a avaliação da atividade alelopática dos compostos presentes nas folhas de S. alata. O material vegetal foi seco, triturado e submetido à extração exaustiva, com solução água:metanol (3:7). O extrato obtido foi então fracionado por coluna cromatográfica por via úmida. As frações mais puras foram submetidas à espectroscopia de Ressonância Magnética Nuclear, para determinação das fórmulas estruturais das moléculas. Na avaliação dos efeitos das substâncias químicas isoladas, utilizaram-se as concentrações de 50,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leguminosae; Aleloquímicos; RMN; Flavonoides glicosilados; Kaempferol.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582010000100001

Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis
Provedor de dados: 56
Autores: Zhang,Fan; Ma,Cuimei.
Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as underlying potential mechanisms. Viability, proliferation, and apoptosis of SNU-216 cells after kaempferol treatment were evaluated using cell counting kit-8 assay, 5-btomo-2′-deoxyuridine incorporation assay, and annexin V-FITC/PI staining, respectively. Quantitative reverse transcription PCR was performed to measure the mRNA expressions of cyclin D1 and microRNA-181a (miR-181a) in SNU-216 cells. Cell transfection was used to down-regulate the expression...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gastric cancer; Kaempferol; MicroRNA-181a; Cell proliferation; Cell autophagy.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000200610

Kaempferol inhibited VEGF and PGF expression and in vitro angiogenesis of HRECs under diabetic-like environment
Provedor de dados: 56
Autores: Xu,X.H.; Zhao,C.; Peng,Q.; Xie,P.; Liu,Q.H.
Diabetic retinopathy (DR) is one of the common and specific microvascular complications of diabetes. This study aimed to investigate the anti-angiogenic effect of kaempferol and explore its underlying molecular mechanisms. The mRNA expression level of vascular endothelial growth factor (VEGF) and placenta growth factor (PGF) and the concentrations of secreted VEGF and PGF were measured by qTR-PCR and ELISA assay, respectively. Human retinal endothelial cells (HRECs) proliferation, migration, and sprouting were measured by CCK-8 and transwell, scratching wound, and tube formation assays, respectively. Protein levels were determined by western blot. High glucose (25 mM) increased the mRNA expression levels of VEGF and PGF as well as the concentrations of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diabetic retinopathy; Kaempferol; VEGF; PGF; Anti-angiogenic.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000300605

Binding effect of proline-rich-proteins (PRPs) on in vitro antimicrobial activity of the flavonoids
Provedor de dados: 58
Autores: Ansari,Jawaad Ahmed; Naz,Shahina; Tarar,Omer Mukhtar; Siddiqi,Rahmanullah; Haider,Muhammad Samee; Jamil,Khalid.
The interaction of the cyanidin, pelargonidin, catechin, myrecetin and kaempferol with casein and gelatin, as proline rich proteins (PRPs), was studied. The binding constants calculated for both flavonoid-casein and flavonoid-gelatin were fairly large (105–107 M−1) indicating strong interaction. Due to higher proline content in gelatin, the binding constants of flavonoid-gelatin (2.5 × 105–6.2 × 107M−1) were found to be higher than flavonoid-casein (1.2 × 105–5.0 × 107 M−1). All the flavonoids showed significant antibacterial activity against the tested strains. Significant loss in activity was observed due to the complexation with PRPs confirming that binding effectively reduced the concentration of the free flavonoids to be available for antibacterial...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Proline rich proteins; Flavonoids; Catechin; Myrecetin; Kaempferol; Pelargonidin; Cyanidin; Gelatin; Casein; Binding constants.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100183