Consulta: subjectFacets:"Liver"
Registros recuperados: 95
Data/hora: 13/06/2024 02:29:20

Diet high in &amp;#945;-linolenic acid up-regulate PPAR-&amp;#945; gene expression in the liver of goats
Provedor de dados: 69
Autores: Ebrahimi,Mahdi; Rajion,Mohamed Ali; Meng,Goh Yong; Farjam,Abdoreza Soleimani; Oskoueian,Ehsan; Jafari,Saeid.
Background There is little information on the effects of diets containing high &amp;#945;-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high &amp;#945;-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-&amp;#945;) and stearoyl-CoA-desaturase (SCD) in the liver. Results An increase in the levels of C18:3n-3 and C20:5n-3, C22:5n-3, C22:6n-3 was observed in the liver of FSO-treated goats. There was a significant (P &lt; 0.05) up-regulation of...
Tipo: Journal article
Palavras-chave: Gene expression; Goat; Liver; Omega-3 fatty acid; PPAR.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000300011

Differential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C
Provedor de dados: 74
Autores: Jiao,Yan; Zhang,Jifei; Yan,Jian; Stuart,John; Gibson,Griffin; Lu,Lu; Willaims,Robert; Wang,Yong Jun; Gu,Weikuan.
The aim of this study was to test the hypothesis that hepatic vitamin C (VC) levels in VC deficient mice rescued with high doses of VC supplements still do not reach the optimal levels present in wild-type mice. For this, we used a mouse scurvy model (sfx) in which the L-gulonolactone oxidase gene (Gulo) is deleted. Six age- (6 weeks old) and gender- (female) matched wild-type (WT) and sfx mice (rescued by administering 500 mg of VC/L) were used as the control (WT) and treatment (MT) groups (n = 3 for each group), respectively. Total hepatic RNA was used in triplicate microarray assays for each group. EDGE software was used to identify differentially expressed genes and transcriptomic analysis was used to assess the potential genetic regulation of Gulo...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gene expression; L-gulonolactone oxidase; Liver; Oxidative stress; Vitamin C.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300004

Histology of the liver of Oligosarcus jenynsii (Ostariophysi, Characidae) from Los Padres Lake, Argentina
Provedor de dados: 76
Autores: Petcoff,Gladys M.; Díaz,Alcira O.; Escalante,Alicia H.; Goldemberg,Adriana L.
The liver is an organ notable for its sensitivity to a great variety of environmental factors. It is composed of a parenchyma divided into irregular lobules by the exocrine pancreas or hepatopancreas; the pancreatic cells are arranged around a branch of the portal vein. The hepatocytes are radially arranged in cords around a central sinusoid. The liver histomorphology and the organization of exocrine pancreatic tissue of O. jenynsii (Günther, 1864) is similar to the acinar morphology of many teleosts, including freshwater and marine species. The aim of the present work was to carry out the histological analysis of the liver of Oligosarcus jenynsii, one of the most common species inhabiting Los Padres Lake (Buenos Aires Province, Argentina).
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Liver; Histology; Characid; Freshwaters.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0073-47212006000200010

Suplementacao mineral para gado de corte no Estado do Tocantins.
Provedor de dados: 14
Autores: LOPES, H. O. da S.; PEREIRA, E. A.; SOARES, W. V.; SANZONOWICZ, C.; PEREIRA, G.; ALMEIDA, A. D.
bitstream/item/99426/1/comtec-71.pdf
Tipo: Comunicado Técnico (INFOTECA-E)
Palavras-chave: Tocantins; Brasil; Supplements; Bone; Bovino de corte; Heavy; Mineral deficiencies; Mineral nutrients; Pasture.; Cerrado; Deficiência Mineral; Corte; Gado de Corte; Gado; Mineral; Metal; Nutriente Mineral; Nutrição Animal; Suplemento Mineral.; Animal nutrition; Beef cattle; Fluorine; Beef; Brazil; Cattle; Liver; Minerals.
Ano: 1997
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/553044

Identification of Hypoxia-Regulated Genes in the Liver of Common Sole (Solea solea ) Fed Different Dietary Lipid Contents
Provedor de dados: 5
Autores: Mazurais, David; Ferraresso, Serena; Gatta, Pier Paolo; Desbruyeres, Elisabeth; Severe, Armelle; Corporeau, Charlotte; Claireaux, Guy; Bargelloni, Luca; Zambonino, Jose-luis.
Coastal systems could be affected by hypoxic events brought about by global change. These areas are essential nursery habitats for several fish species including the common sole (Solea solea L.). Tolerance of fish to hypoxia depends on species and also on their physiological condition and nutritional status. Indeed, high dietary lipid content has been recently shown to negatively impact the resistance of sole to a severe hypoxic challenge. In order to study the molecular mechanisms involved in the early response to hypoxic stress, the present work examined the hepatic transcriptome in common sole fed diets with low and high lipid content, exposed to severe hypoxia. The activity of AMP-activated protein kinase (AMPK) was also investigated through the...
Tipo: Text
Palavras-chave: Fish; Hypoxia; Nutrition; Liver; Transcriptome; AMPK.
Ano: 2014
URL: http://archimer.ifremer.fr/doc/00169/28062/26474.pdf

Total replacement of fish oil by soybean or linseed oil with a return to fish oil in turbot (Psetta maxima) - 1. Growth performance, flesh fatty acid profile, and lipid metabolism
Provedor de dados: 5
Autores: Regost, Christelle; Arzel, Jacqueline; Robin, Jean; Rosenlund, Grethe; Kaushik, Sadasivam.
The aim of the study was to investigate the replacement of fish oil by vegetable oils and the effects of a washout with a return to fish oil on growth performances and lipid metabolism. three experimental fish meal-based isonitrogenous (crude protein content: 57.5%) and isolipidic (crude lipid content: 16.5%) diets were formulated containing either 9% of added fish oil (170), soybean oil (SO), or linseed oil (LO). Each diet was distributed to triplicate groups of 25 marketable size turbot (initial body weight of 579 g) grown in seawater at water temperature of 17 T. Fish were fed once a day to visual satiety. At the end of the growth trial, which lasted 13 weeks, all groups of turbot were fed with FO diet for 8 weeks. The growth of turbot was high, but the...
Tipo: Text
Palavras-chave: Lipogenesis; Fatty acids; Liver; Muscle; Body composition; Growth; Vegetable oil; Fish oil; Psetta maxima.
Ano: 2003
URL: http://archimer.ifremer.fr/doc/2003/publication-375.pdf

Heavy metal contamination and hepatic toxicological responses in brown trout (Salmo trutta) from the Kerguelen Islands
Provedor de dados: 5
Autores: Jaffal, Ali; Betoulle, Stephane; Biagianti-risbourg, Sylvie; Terreau, Alexandre; Sanchez, Wilfried; Paris-palacios, Severine.
The Kerguelen Islands include various species of freshwater fish such as brown trout (Salmo trutta). These trout are among the most isolated from direct anthropogenic impact worldwide. This study was designed to analyse cadmium (Cd) and copper (Cu) concentrations in the liver of Kerguelen brown trout, and to assess the possible impacts of these metals on hepatic histopathology and oxidative stress parameters (superoxide dismutase and catalase activity and glutathione levels). Trout were caught in the Chateau River, the Studer Lakes and the Ferme Pond, close to the scientific station of the Kerguelen Islands, corresponding to three morphotypes (river, lake and station). Kerguelen trouts' hepatic concentrations of Cd and Cur were similar to those reported in...
Tipo: Text
Palavras-chave: Brown trout; Freshwater; Fish; Sub-Antarctic; Liver; Biomarkers.
Ano: 2015
URL: https://archimer.ifremer.fr/doc/00499/61109/64571.pdf

Liaison de l'oestradiol 17 beta dans les hepatocytes de truite Arc-en-ciel et induction de la vitellogenine et de son ARNm specifique
Provedor de dados: 5
Autores: Maitre, J; Mercier, L; Dolo, L; Valotaire, Y.
In the liver of rainbow trout (Salmo gairdnerii ), vitellogenin (Vg) synthesis is influenced by oestradiol (E sub(2)) which is believed to act through the classical mechanism of steroid hormone action. After binding of the hormone to a soluble specific receptor protein, the oestradiol-receptor complex is translocated to the nucleus, where it interacts with DNA and modulates expression of Vg genes, leading to increased synthesis of specific mRNA and Vg. The authors show here: (i) the presence of specific oestrogen receptors in the cytosol of the male trout liver. (ii) The male liver, offering, an ideal experimental control of "zero" background, the authors followed - in the liver of male trouts - the kinetics of induction of Vg mRNA by hybridization with Vg...
Tipo: Text
Palavras-chave: Salmonidae; Pisces; Proteins; Liver; RNA; Steroids; Biosynthesis; Receptors; Sex hormones; Sexual reproduction.
Ano: 1983
URL: http://archimer.ifremer.fr/doc/1983/acte-1230.pdf

Differential gene expression after total replacement of dietary fish meal and fish oil by plant products in rainbow trout (Oncorhynchus mykiss) liver
Provedor de dados: 5
Autores: Panserat, S.; Hortopan, G. A.; Plagnes-juan, E.; Kolditz, C.; Lansard, M.; Skiba-cassy, S.; Esquerre, D.; Geurden, I.; Medale, Francoise; Kaushik, Sadasivam; Corraze, Genevieve.
Our objective was to analyse the hepatic transcriptomes of juvenile rainbow trout fed with a plant-based diet. We focused our analysis on the total replacement of fish meal (FM) and fish oil (FO) by a 100% plant-based diet (0% FM, 0% FO). We analysed the postprandial hepatic transcriptomes of rainbow trout fed the two diets 8 h after feeding. Six total hepatic RNAs from each dietary group were hybridised against a trout cDNA microarray (9K). After treatment of the data respecting the standard MIAME (Minimum Information About a Microarray Experiment) protocol, we found that 176 hepatic genes were differentially expressed between fish fed the two diets: 96 and 80 were over-expressed and under-expressed, respectively, in trout fed the plant-based diet. A...
Tipo: Text
Palavras-chave: Rainbow trout; Transcriptome; Metabolism; Liver; Vegetable products; Marine ingredients.
Ano: 2009
URL: http://archimer.ifremer.fr/doc/2009/publication-6684.pdf

Etude cytologique ultrastructurale des anomalies hepatiques du loup, de la daurade, et de l'anguille, induites par une alimentation artificielle
Provedor de dados: 5
Autores: Bac, N; Biagianti, S; Brusle, J.
In the three species Dicentrarchus labrax, Sparus auratus , and Anguilla anguilla an artificial feeding (dry pellets) disturbs liver cells as revealed at ultrastructural level. In hepatocytes, anomalies consist of lipids storage (liposomes) considered as deviation in fatty acids metabolism. Moreover are observed cellular alterations (mitochondrial vacuolization, nuclear pycnosis) related to degenerative process. It is of great interest to understand wether liver modifications are just a reaction to an unbalanced feeding or a true trophic pathology.
Tipo: Text
Palavras-chave: Dicentrarchus labrax; Serranidae; Pisces; Natural populations; Fish culture; Lipids; Fatty acids; Cytology; Ultrastructure; Cells; Diseases; Pellet feeds; Metabolism; Liver; Artificial feeding; Nutrition disorders.
Ano: 1983
URL: http://archimer.ifremer.fr/doc/1983/acte-1250.pdf

Variation in Metabolic Rate among Individuals Is Related to Tissue-Specific Differences in Mitochondrial Leak Respiration
Provedor de dados: 5
Autores: Salin, Karine; Auer, Sonya K.; Rudolf, Agata M.; Anderson, Graeme J.; Selman, Colin; Metcalfe, Neil B.
Standard metabolic rate (SMR) and maximum metabolic rate (MMR) typically vary two-or threefold among conspecifics, with both traits assumed to significantly impact fitness. However, the underlying mechanisms that determine such intraspecific variation are not well understood. We examined the influence of mitochondrial properties on intraspecific variation in SMR and MMR and hypothesized that if SMR supports the cost of maintaining the metabolic machinery required for MMR, then the mitochondrial properties underlying these traits should be shared. Mitochondrial respiratory capacity (leak and phosphorylating respiration) and mitochondrial content (cytochrome c oxidase activity) were determined in the liver and white muscle of brown trout Salmo trutta of...
Tipo: Text
Palavras-chave: Brown trout; Fish; Liver; Oxygen consumption; White muscle.
Ano: 2016
URL: https://archimer.ifremer.fr/doc/00413/52497/53321.pdf

A Study on the Anomalies of Liver in the South Indian Cadavers
Provedor de dados: 77
Autores: Nayak B,Satheesha.
Liver is the largest gland in the body and rarely shows variations in its lobes and fissures. We studied 55 Formalin-fixed livers for occurrence of abnormal shape, lobes, fissures and position of gall bladder. In 60% of cases the liver was normal. 40% livers showed one or the other variations. Additional lobes were found in 9.09% of cases. Additional fissure was found in 1.81% of cases. Presence of dumbbell shaped caudate lobe and presence of large papillary process was noted in 1.81% cases each. In 1.81% cases the fissure for ligamentum teres was absent or situated on the anterior surface of the liver. In 1.81% of cases each the liver was either extremely long or extremely flat. In 18.18% of the cases, the gall bladder was short and its fundus did not...
Tipo: Journal article
Palavras-chave: Liver; Gall bladder; Variation; Lobe; Fissure; Abnormal.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200051

Mixture of Kerosene and Xylene: a Contribution to Clearing Agents
Provedor de dados: 77
Autores: Ofusori,David A; Ayoka,Abiodun O; Adeeyo,Olusola A; Adewole,Stephen O.
The aim of this study was to substitute costly and hazardous compound- xylene, used as clearing agent, with less costly compounds (mixture of xylene and kerosene) having less toxicity and without compromising the cellular integrity and staining characteristics of the sections. Tissues (liver and kidney) obtained from a presumable healthy adult Wistar rat, were fixed in 10% formol saline, separated in to five groups (A, B, C, D and E) and processed for light microscopic study adopting H &amp;amp; E staining procedure. During the clearing section, groups A, B, C, D and E were respectively cleared in solvent 1 (xylene only), solvent 2 (70ml xylene : 30ml kerosene), solvent 3 (50ml xylene : 50ml kerosene), solvent 4 (30ml xylene : 70ml kerosene) and solvent 5...
Tipo: Journal article
Palavras-chave: Xylene; Kerosene; Clearing agent; Liver; Kidney.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100036

Gill and Liver Histopathology in Goodea atripinnis Jordan, Related to Oxidative Stress in Yuriria Lake, Mexico
Provedor de dados: 77
Autores: Ruiz-Picos,R; López-López,E.
In aquatic ecosystems, the complex mixture of pollutants may mediate the formation of free radicals and cause oxidative damage to the biota. Yuriria Lake (a Ramsar site in Central Mexico) receives input of wastewater from its tributaries, agricultural runoff, and municipal discharge. We studied the lipid peroxidation (LPO), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and histopathology of gill and liver of the native fish Goodea atripinnis in Yuriria Lake. Results were compared to a control group of fish cultivated in the laboratory. LPO, SOD, and CAT showed no significant differences compared to controls, but GPx showed greater and significant differences in both tissues. Three class sizes were...
Tipo: Journal article
Palavras-chave: Mexican wetlands; Oxidative stress; Histopathology; Fish health condition; Liver; Gill.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300060

Anatomical Description of the Liver, Hepatic Ligaments and Omenta in the Coypu (Myocastor coypus)
Provedor de dados: 77
Autores: Pérez,W; Lima,M.
The objective of this work is to give a complementary description of the hepatic lobulation, the hepatic ligaments and the omenta of the nutria. Thirty nutrias were studied by gross dissection. The liver of the nutria was divided into six lobules as follows: left lateral, left medial, quadrate, right medial, right lateral, and caudate lobes. The caudate lobe was divided into a papillary and a caudate process. A whole falciform ligament, extending as far as the navel, was found in all animals. This one was the only ligament that contained fat in between its sheets, and it was abundant in the umbilical part. The left triangular ligament had two parts. One of them was attached to the left lateral lobe of the liver and the other one to the left medial lobe....
Tipo: Journal article
Palavras-chave: Anatomy; Liver; Hepatic ligaments; Omenta.
Ano: 2007
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000100007

Effects of Biodegradable Detergents in the Accumulation of Lipofuscin (Age Pigment) in Gill and Liver of Two Neotropical Fish Species
Provedor de dados: 77
Autores: Pereira,Bruno Fiorelini; Alves,Anderson Luis; Senhorini,José Algusto; Rocha,Rita de Cássia Gimenes de Alcântara; Pitol,Dimítrius Leonardo; Caetano,Flávio Henrique.
Currently there is a growing concern, in both population and governments, to identify the effects of substances commonly disposed of into rivers and lakes, on aquatic fauna and flora. Thus the objective of the present study was to verify effects of biodegradable detergents and water from an urban lake on gills and liver of two neotropical fish species of great economic importance, Astyanax altiparanae and Prochilodus lineatus. In order to do so, lipofuscin, also called the ageing pigment, was used as bioindicator. After one and five months of experiment both tissues accumulated this pigment. These data are discussed from physiological points of view, related with lipid peroxidation and mitochondrial damage.
Tipo: Journal article
Palavras-chave: Lipofuscin; Liver; Gill; Prochilodus; Astyanax.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300005

Carbohydrates Detection in the Hepatic Egg - Granuloma System Using Lectin Histochemistry
Provedor de dados: 77
Autores: Ribeiro Melo-Júnior,Mario; Bezerra Cavalcanti,Carmelita de Lima; Teles de Pontes-Filho,Nicodemos; Carvalho Jr,Luiz Bezerra de; Carneiro Beltrão,Eduardo Isidoro.
This study aims to evalúate the egg-granuloma system in hepatic tissues using lectin histochemistry in experimental Schistosomiasis. Eight Swiss mice were infected with a local strain of Schistosoma mansoni, being submitted forty days later to a perfusión after which slices of liver (4|J.m) were prepared. The tissue samples were incubated with the following peroxidase conjugated lectins: Peanut agglutinin (PNA), Wheat Germ agglutinin (WGA), and Concanavalin A (Con A). All lectins recognized the glycoconjugates in the adult worm tegument. In the hepatic tissue, WGA presented the highest staining followed by PNA and Con A. The PNA presented the most intense staining of the egg-granuloma system while WGA stained the hepatic sinusoid cells and Con A bound...
Tipo: Journal article
Palavras-chave: Lectins; Egg-granuloma system; Liver; Schistosoma mansoni.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000400030

Ethanol Intake and Toxicity: In Search of New Treatments
Provedor de dados: 77
Autores: Sandoval,Cristian; Vásquez,Bélgica; Mandarim-de-Lacerda,Carlos; del Sol,Mariano.
Prolonged alcohol consumption has consequences on the liver, producing necrotic precipitates and fibrosis, on the pancreas, causing the pancreatic acini to atrophy and destroying insulin-producing cells, and on the central nervous system (CNS), causing the gray and white matter in the frontal lobes of the brain and cerebellum to atrophy. Generally, alcohol is metabolized via oxidative pathways, where the enzymes alcohol dehydrogenase and aldehyde dehydrogenase participate during its metabolization in the liver and CNS, or via non-oxidative pathways during its metabolization in the pancreas. Ethanol metabolism can produce oxidative stress and tissue damage mediated by free radicals, causing morphological and functional alterations in the liver. In the...
Tipo: Journal article
Palavras-chave: Antioxidants; Ethanol; Liver; Pancreas; Central nervous system.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300024

Somatic, Biochemical and Hepatic Alterations in Wild Type Mice Chronically Fed High Fat Diet
Provedor de dados: 77
Autores: Neves,Renata Heisler; Barros Alencar,Alba Cristina Miranda de; Aguila,Marcia Barbosa; Mandarim-de-Lacerda,Carlos Alberto; Machado-Silva,José Roberto; Gomes,Delir Corrêa.
This study evaluated whether a high fat diet (HFC group) induces overweight, hepatic steatosis and plasma lipoproteins level alteration compared to standard chow diet (SC group). Female mice were submitted to each diet over 6 months. Body mass and food intake were evaluated weekly throughout the experiment. Total cholesterol, TG, LDL-c, HDL-c and VLDL-c were analyzed. Mice were sacrificed to remove liver, spleen, heart and intestine. The volume of the organs was determined according to the submersion method. Fixed livers were embedded in paraffin and stained with hematoxylin and eosin and Masson's trichrome. The analysis used a video microscope system and a test-system with 42 test-points. The volume density was estimated for hepatocytes, steatosis and...
Tipo: Journal article
Palavras-chave: Hypercholesterolemia; Experimental model; Mice; Cholesterol; Diet; Liver.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500018

Histopathological Effects of Aloe barbadensis and Soybean Oil on Rat Liver
Provedor de dados: 77
Autores: Kosif,Rengin; Yilmaz,Fahri; Evrendilek,Gülsün Akdemir; Diramali,Murat.
Aloe Barbadensis, which is a species of Aloe vera, is a popular plant used by the common people and in alternative medicine. This study aimed to analyze the effects of Aloe Barbadensis and soybean oil on liver. For this study Wistar Albino female rats were taken and divided into 3 equal groups; the first group was the control group wherein no treatment was applied, second group in which the dissolved form of A. barbadensis in the soybean oil was applied (25 mg/day), and the third group which only soybean oil was applied (500 mg/day). Biopsy materials were taken from the lobus dexter of the livers of the rats and analyzed with light microscope after the necessary standard processing of histologic slides. Group I demonstrated normal structural...
Tipo: Journal article
Palavras-chave: Aloe barbadensis; Soybean; Rat; Liver; Effect.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400019

A Study on the Number and Arrangement of the Structures Passing Through the Porta Hepatis in South Indian Population
Provedor de dados: 77
Autores: Sapna,M; Shetty,Surekha D; Nayak B,Satheesha.
The porta hepatis of the liver is a very important area surgically. The knowledge of the variations in the structures passing through the porta hepatis might be of great help in reducing the risks of surgery in this area. In the current study 59 livers from South Indian cadavers were observed for the number and arrangement of the structures passing through the porta hepatis. In all the livers the portal vein was posteriormost and the hepatic duct was the anteriormost structure. The hepatic artery and its branches were in between the duct and the vein. The mean weight of the liver was 1.025 kg. The mean length of porta hepatis was 4.825 cm and the mean breadth was 2.433 cm. The number varied from one to three for the duct and vein but for the artery it was...
Tipo: Journal article
Palavras-chave: Liver; Porta hepatis; Bile duct; Portal vein; Hepatic artery.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100026

Effects of Aspartame on Maternal-Fetal and Placental Weights, Length of Umbilical Cord and Fetal Liver: A Kariometric Experimental Study
Provedor de dados: 77
Autores: Pórtela,Gabriela Soares; Azoubel,Reinaldo; Batigália,Fernando.
Aspartame is a synthetic sweetener consumed by more than half the adult population in 75 countries. Their metabolites can be toxic, principally to the liver and retina, and there are few studies on the use of aspartame in gestation. Twenty pregnant rats were weighed and allocated randomly (n=5 per group) to receive 14 mg/kg aspartame or water by oral-gastric drip. Treated Tl: aspartame diluted in water at room temperature; Treated T2: aspartame diluted in water heated to 40° C; control Cl: water at room temperature; and control C2: water heated to 40° C. Placentas were weighed, umbilical cords measured and 1000 nuclei of fetal hepatocytes (250 from each group) were analyzed morphometrically utilizing the technique of kariometry, with application of the...
Tipo: Journal article
Palavras-chave: Aspartam; Fetus; Gestation; Liver; Kariometry.
Ano: 2007
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300012

Morphological Study of the Liver in the Teleost Oreochromis niloticus
Provedor de dados: 77
Autores: Vicentini,C. A.; Franceschini-Vicentini,I. B.; Bombonato,M. T. S.; Bertolucci,B.; Lima,S. G.; Santos,A. S.
Liver samples of Oreochromis niloticus cultivated in floating net cages were fixed for histological and ultrastructural studies with the objective of describing the hepatic parenchymal structure and the intrahepatic exocrine pancreatic tissue. Anatomically, the liver showed only two hepatic lobes. Histological analysis demonstrated that the hepatocytes were spread out as anastomotic cords, arranged in two cellular layers and surrounded by sinusoids. The intrahepatic exocrine pancreatic tissue exhibited an acinar arrangement and was diffused in the hepatic parenchyma. Structural analysis showed that the hepatocytes had a rounded nucleus and a rough endoplasmic reticulum with a parallel disposition to the nuclear membrane. The exocrine pancreatic cells...
Tipo: Journal article
Palavras-chave: Liver; Exocrine pancreas; Morphology; Teleost.
Ano: 2005
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000300003

Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study
Provedor de dados: 77
Autores: Battah,Khairat A; Badran,Darwish H; Shraideh,Ziad A.
The liver is one of the major organs that is indirectly affected by cigarette smoke. The aim of this project is to define the histologic and ultrastructural changes in normal liver cells after exposing animals to cigarette smoke. Thirty albino rats were exposed to cigarette smoke for 90 days, followed by morphologic examination of their livers under light microscope and electron microscope. The liver cells of cigarette smoke exposed rats showed mild swelling with increased eosinophilia. Ultrastructural examination of these cells demonstrated cytoplasm with highly proliferated and crowded mitochondria. There were many electron dense mitochondria. These mitochondria were pleomorphic in shape compared to mitochondrias of control rats. Also, loss of...
Tipo: Journal article
Palavras-chave: Liver; Smoking; Mitochondria; Ultrastructure.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400011

Effects of Oral Nicotine on Rat Liver Stereology
Provedor de dados: 77
Autores: Valenca,Samuel Santos; Gouveia,Lucas; Alves Pimenta,Wagner; Porto,Luís Cristóvão.
Nicotine is the more abundant component in cigarette smoke. Because nicotine is first metabolized in the liver, our aim was to investígate the effects of nicotine on this organ by biochemical and stereological methods. Male Wistar rats were treated with oral nicotine (ON) diluted in drinking water during 32 days. The control group was treated with drinking water in the same period. Rats were sacrificed 24 hours after last day, the blood was collected and the liver was removed. Lipidogram was performed by enzymatic method and collagen fibers, fat globules and hepatocytes were count in the liver by stereological methods. We observed in control group preserved hepatocytes, with no presence of inflammatory cells. However in the ON group was possible to observe...
Tipo: Journal article
Palavras-chave: Nicotine; Rat; Liver; Stereology.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000400037

Morphometric Alterations Induced by the Toxicity of Variable Sizes of Silver Nanoparticles
Provedor de dados: 77
Autores: Almansour,Mansour; Jarrar,Qais; Battah,Abdelkader; Jarrar,Bashir.
Silver nanoprticles (SNPs) are invested in medical, industrial and environmental applications. Little if any, is known about the morphometric alterations induced by the toxicity of SNPs. The aim of the present work is to find out the effect of variable size of SNPs on different morphometric parameters. Adult healthy male mice (BAL/C) were subjected to (10 nm, 20 nm, 40 nm 60 nm and 100 nm) SNPs for 35 days. Silver NPs caused non-significant decline on the average weight, significant decline in food consumption, increase in water intake, unilateral blindness, tanning fur color and cholestasis together with a decrease in the relative ratio of the liver, kidney and spleen weight to body weight. Mice subjected to 10 nm and 20 nm were more affected than mice...
Tipo: Journal article
Palavras-chave: Silver nanoparticles; Morphology; Toxicology; Liver; Kidney; Spleen.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200022

Indigofera suffruticosa Mill (Fabaceae): Hepatic Responses in Mice Bearing Sarcoma 180
Provedor de dados: 77
Autores: da Silva,Ivanise Brito; Lima,Izabela Rangel; Santana,Marllon Alex Nascimento; Leite,Roberta Maria Pereira; Leite,Sônia Pereira.
Indigofera suffruticosa is a plant generally used to treat infectious and inflammatory processes. This work aims to evaluate the histopathological changes in the liver tissue of mice with Sarcoma 180 after subchronic treatment with aqueous extract obtained by infusion and maceration of Indigofera suffruticosa leaves. Male mice were divided into four groups of six animals: G1, G2 and G3 patients with Sarcoma 180 and Sarcoma 180 G4 without sarcoma. G1 and G2 were treated with infusion mashing respectively (50 mg/kg ip); G3 and G4 controls received saline (15 ml/kg ip). The histopathological and morphometric analysis of liver tissue after subchronic treatment with aqueous extracts by infusion and maceration of the groups G1, G2 and G4 were similar and showed...
Tipo: Journal article
Palavras-chave: Liver; I. suffruticosa; Histopathology; Histomorphometry; Sarcoma 180.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400017

The Structural Organization of the Liver in the Chinese Fire-bellied Newt (Cynops orientalis)
Provedor de dados: 77
Autores: Xie,Zhao Hui; Zhong,Hong Bo; Li,Hai Jun; Hou,Yu Jie.
The morphology of Chinese fire-bellied newt liver consists of 5 lobes, with exception of a few individual differences present, which are composed by a number of hepatic lobules. Passing through the center of the lobules, a central vein radiates and is arranged in orderly row from one to several layers. The interval of the hepatic cords or masses are irregular and variable sinusoid. The hepatic sinusoidal wall consists of one layer endothelial cells or Macrophagocytus stellatus (Kupffer cells), which have protrusions and elongations. The intervals of the hepatic cells have perisinusoidal space (space of Disse). The hepatic cell is polygonal in shape with uniform, round or oval nucleus, 17.8­12.4µm in diameter, mean 14.2 µm 2-6 nucleoli, nuclear-cytoplasmic...
Tipo: Journal article
Palavras-chave: Cynops orientalis; Liver; Histology; Morphology.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400041

Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Ghafari,Soraya; Farsi,Mir Mehrdad.
Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative morphometric changes in parenchymal cells of the livers in STZ diabetic rats. Thirty male Wistar rats were allocated in 3 groups: normal, diabetic and treatment. Hyperglycemia was induced by 80 mg/kg Streptozotocin intraperitoneally. One week after the injection of STZ, the third group received the hydroalcoholic extract of Urtica dioica at 100 mg/kg/day over four weeks. After five weeks, the animals were sacrificed and whole livers were removed. Liver specimens were used for quantitative morphometric analyze...
Tipo: Journal article
Palavras-chave: Diabetes; Urtica dioica; Liver; Hepatocyte; Morphometry.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400058

Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)
Provedor de dados: 77
Autores: Adisa,J. O; Ajayi,Y; Egbujo,E. C.
Persea americana (avocado) is widely grown in parts of Southeastern Nigeria and used as a medicinal plant in the treatment of several ailments by alternative medical practitioners but very little research has been carried out on its pharmacotoxicity. This study therefore intends to study the histopathologic effect(s) of Persea americana aqueous leaf extract on the liver and kidneys of rabbits. Fresh leaves of Persea americana were processed using the Soxhlet extraction to obtain the aqueous extract. Three (3) groups of weaner rabbits namely the control, the recommended dose and the high dose groups were given water, 75mg/kg/ and 150mg/kg per day of the extract respectively for 28 days. The animals were sacrificed, the liver and kidney were harvested, fixed...
Tipo: Journal article
Palavras-chave: Persea Americana; Liver; Kidney; Histopathology.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400053

Effects of STZ-Induced Diabetes on the Relative Weights of Kidney, Liver and Pancreas in Albino Rats: A Comparative Study
Provedor de dados: 77
Autores: Zafar,Muhammad; Naeem-ul-Hassan Naqvi,Syed.
We studied the effects of streptozotocin (STZ)-induced diabetes on the body weights of animals and the relative weights of kidney, liver and pancreas in albino rats. The aim of the study was to find an association between the reduction in the body weights of diabetic animals and the relative weights of kidney, liver and pancreas in proportion to the body weight of animals in albino rats. This study was performed in the Department of Anatomy and Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi and Pathology department of College of Physicians &amp;amp; Surgeons (CPSP) Pakistan in 2007-08. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty albino rats were...
Tipo: Journal article
Palavras-chave: STZ-diabetes; Body weights; Weight of kidney; Liver; Pancreas; Rats.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100019

Action of Trivalent Chromium on Rat Liver Structure. Histometric and Haematological Studies
Provedor de dados: 77
Autores: Silva,Rogério Ferreira da; Lopes,Ruberval A; Sala,Miguel A; Vinha,Dionísio; Regalo,Simone C. H.; Souza,Ana Maria de; Gregório,Zita Maria de O.
The trace mineral trivalent chromium (Cr3+) is an essential nutrient involved in the regulation of carbohydrate, lipid and protein metabolism via an enhancement of insulin action. The present work had as objective to characterize histopathologically and histometrically the hepatic alterations of female Wistar rats, determined by the chromium III administration in drinking water. Adult rats received ration and drinking water ad libitum containing 300 or 500 mg/l chromium III during 4 months. Control animals received only water and ration. All animals were sacrificed by lethal dose of anesthetic. Samples of liver were fixed in 10% formalin for 24 h. Tissues for microscopical pathology were processed using standard procedures. Paraffin sections prepared at 6...
Tipo: Journal article
Palavras-chave: Liver; Rat; Chromium; Morphometry; Hematology.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300014

The Effect of Rhododendron Honey on Mice Liver Tissue
Provedor de dados: 77
Autores: Kükner,Aysel; Ilter,Gizem; Söyler,Gizem; Rasgele,Pinar Göç; Kekeçoglu,Meral; Kambur,Merve.
Rhododendron honey, made by bees from rhododendron pollen, contains a toxic substance called grayanotoxin. Depending on the dose, the poisonous honey can result in serious effects such as cardiac arrhythmia, fibrillation, and myocardial infarction. The purpose of this study is to investigate the effects of the poisonous RH of the Black Sea Region on the liver. Male mice were divided into five groups of twelve mice each, two being the control groups (distilled water) and the others being the rhododendron honey (RH) groups (25, 50, and 75 mg/kg) and 0.01 mg/kg grayanotoxin (GTx) groups. Liver tissues were collected 24 and 48 h later. The sections were stained with hematoxylin, eosin and PAS, then the histopathological score was performed. Significant...
Tipo: Journal article
Palavras-chave: Rhododendron honey; Mice; Liver.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300004

Micro-ultrastructure Features of Liver in Chinese Taihe Black-bone Silky Fowl (Gallus gallus domesticus Brisson)
Provedor de dados: 77
Autores: Zhang,Hui; Ge,Tingting; Gandahi,Jameel Ahmed; Peng,Shasha; Zhong,Shengwei; Zhou,Zuohong.
In this work, the morphological features of liver in Chinese Taihe black-bone silky Fowl (BSF) were analyzed by light microscope and transmission electron microscopy. The results showed that two kinds of hepatocytes were present in Taihe BSF liver, i.e., the dark and the light hepatocyte. The dark hepatocyte was electron-dense and lager, with many organelles, mitochondria especially. The light hepatocytes were smaller than the dark. They had electron-lucent cytoplasm with a small number of organelles. Furthermore, there were lipolysosomes in the light hepatocyte. The numerous long and serried finger-like microvilli spread into bile canaliculus lumen. The glycogen granules intensely stained, spread in some hepatocytes. Numerous glycogen granules scattered...
Tipo: Journal article
Palavras-chave: Chinese Taihe black-bone silky fowl; Liver; Ultrastructure.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300043

The Liver Micromorphology of the African Palm Squirrel Epixerus ebii
Provedor de dados: 77
Autores: Ikpegbu,E; Nlebedum,U. C; Nnadozie,O; Agbakwuru,I. O.
The normal liver histology of the African palm squirrel Epixerus ebii was investigated to fill the information gap on its micromorphology from available literature. The liver was covered by a capsule of dense connective tissue- the perivascular fibrous capsule. Beneath this capsule is the liver parenchyma were the hepatocyte were supported by reticular fibres. The hepatocytes in the lobules were hexagonal to polygonal in shape. Some hepatocytes were bi-nucleated. Clear spaces in the parenchyma must be storage sites for lipids in the liver. The classic hepatic lobules presented central vein surrounded by several liver cells. At the portal triad, hepatic vein, hepatic arteries and bile ducts were seen. While the hepatic arteries and veins were lined by...
Tipo: Journal article
Palavras-chave: Palm squirrel; Liver; Histology; Portal triad.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100040

Histomorphology of Liver, Testicle and Body Fat in Farm Rabbits Fed with an Obesogenic Diet During the Peripuberal Period
Provedor de dados: 77
Autores: Mejía Huerta,Nancy Guadalupe; Córdova Izquierdo,Alejandro; Aragón Hernández,Jesús; Flores Pérez,Fernando Iván; Pérez-Martínez,Mario.
Two groups were formed in order to evaluate the effect of an obesogenic diet on body and liver weight, body fat accumulation and the histometric characteristics of liver and testicles of New Zealand rabbits during the peripuberal period. One group received a standard farm diet and the other received a standard farm diet with canola oil added. During the study, weight of both groups was recorded. At the end of the study, the rabbits were euthanized and liver, testicles, and visceral, scapular and scrotal fat were weighed. Tissue samples were obtained from liver and testicles to carry out histometric analysis. Body weight, body mass index, liver and visceral fat weight were significantly different (P&lt;0.01) in the obesogenic diet when compared to the...
Tipo: Journal article
Palavras-chave: Histometry; Rabbits; Liver; Testicle; Weight; Peripuberal period.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400030

Predicting the Presence of an Accessory Hepatic Vein Using Abdominal Computed Tomography
Provedor de dados: 77
Autores: Kim,Hyung Soo; Lee,Chang Hee; Kim,Seong Hyun; Kim,Jeong Woo; Park,Cheol Min; Yeom,Suk Keu.
The incidence of detection of accessory hepatic vein (AHV) using MRI or CT has been reported. However, previous studies had a small sample size or only reported on the incidence of hepatic vein variants. To the best of our knowledge, there has been no previous report evaluating the factors predictive of the presence of an AHV. To evaluate the incidence and morphology of the accessory hepatic vein (AHV) using multidetector row computed tomography (MDCT) and to investigate the factors which may be helpful in predicting the presence of an AHV. We enrolled 360 patients who underwent abdominal MDCT. We investigated whether the AHV was present and evaluated the frequency of AHVs greater than 5 mm in diameter. We classified the morphology of the AHV entering the...
Tipo: Journal article
Palavras-chave: Accessory hepatic vein; MDCT; Liver; Hepatic vein.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100004

Conjugated linoleic acid and fatty acid binding protein as antioxidants
Provedor de dados: 78
Autores: Piergiacomi,V.A.; Palacios,A.
Studies were carried out to determine the effect of conjugated linoleic acid (CLA) and rat liver cytosolic protein enriched in fatty acid binding protein (FABP) on the non-enzymatic lipid peroxidation of rat liver microsomes. The inhibition of lipid peroxidation was more evident when the FABP containing fraction obtained from CLA-group was used with either kind of microsomes (CLA and control). The chemiluminescence and polyunsaturated fatty acid composition of rat liver microsomes changed after CLA treatment. When native and peroxidized microsomes obtained from control group were compared, the most affected polyunsaturated fatty acids were: C18:2, C18:3 and C20:4, while in CLA-group C20:4 was mainly peroxidized The simultaneous analysis of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Conjugated Linoleic Acid; Fatty Acid Binding Protein; Lipid peroxidation; Liver; Microsomes.
Ano: 2006
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1668-34982006000100013

Oxidative stress biomarkers and aggressive behavior in fish exposed to aquatic cadmium contamination
Provedor de dados: 83
Autores: Almeida,Jeane A.; Barreto,Rodrigo E.; Novelli,Ethel L. B.; Castro,Fabio J.; Moron,Sandro E.
The objective of this study was to investigate the possible link between cadmium exposure, hepatic markers of oxidative stress and aggressive behavior in Nile tilapia (Oreochromis niloticus). Fish were first exposed to 0.75 mg/L CdCl2 for 15 days (12 isolated fish for each group) and afterward a behavioral test was performed. Fish from the control and cadmium-exposed groups were paired for 1 h (6 pairs of fish per group) for determination of aggressiveness parameters. Immediately after the behavioral test, the animals were sacrificed and the liver was used to determine biochemical parameters. Cadmium decreased aggression in Nile tilapia. Subordinate animals exposed to cadmium showed decreased glutathione peroxidase (GSH-Px) activity compared to dominant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Oreochromis niloticus; Stress response; Antioxidant enzymes; Social stress; Liver; Nile tilapia.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252009000100013

Comparison of Damage to Kidneys and Liver Caused by Lethal Babesia rodhaini Infection and Non-lethal Babesia microti Infection in Mice
Provedor de dados: 19
Autores: Igarashi, Ikuo; Hosomi, Takushi; Kaidoh, Toshiyuki; Omata, Yoshitaka; Saito, Atsushi; Suzuki, Naoyoshi; Aikawa, Masamichi.
Palavras-chave: Babesia rodhaini; Babesia microti; Kidneys; Liver; Mice infection.
Ano: 1993
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/198

Studies of Liver of Mice in the Course of an Experimental Infection with Babesia microti. I : Histopathological Changes and Changes in the Glycogen Content
Provedor de dados: 19
Autores: Kuzna-Grygiel, Wanda; Kolodziejczyk, Lidia.
Palavras-chave: Babesia microti; Liver; Histopathology; Glycogen.
Ano: 2000
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/333

Studies of Liver of Mice in the Course of an Experimental Infection with Babesia microti. Ⅱ : Histopathological Studies on Oxidative and Antioxidative Enzymes
Provedor de dados: 19
Autores: Kuzna-Grygiel, Wanda; Kolodziejczyk, Lidia.
Palavras-chave: Babesia microti; Liver; Histopathology.
Ano: 2000
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/334

Potato Pulps Lowered the Serum Cholesterol and Triglyceride Levels in Rats
Provedor de dados: 19
Autores: HASHIMOTO, Naoto; ITO, Yusaku; HAN, Kyu-Ho; SHIMADA, Ken-ichiro; SEKIKAWA, Mitsuo; TOPPING, David L.; BIRD, Anthony R.; NODA, Takahiro; CHIJI, Hideyuki; FUKUSHIMA, Michihiro; 韓, 圭鎬; 島田, 謙一郎; 関川, 三男; 福島, 道広.
日本ビタミン学会、日本栄養・食糧学会共同編集
Palavras-chave: Cholesterol; Triglyceride; Potato pulps; Liver.
Ano: 2006
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2910

Systematisch-anatomische Untersuchungen über die marsupialen Lebermoose der Sierra Nevada de Santa Marta in Kolumbien.
Provedor de dados: 20
Autores: Winkler, S.
1. En las colecciones de Hepáticas terrestres, de los páramos de la Sierra Nevada de Santa Marta, se encontraron 4 nuevas formas con marsupios: Stephaniellidium sleumeri (K. Muller) n.gen., Gongylanthus innovans n.sp., Lethocolea repens n.sp., y Neoprasathus granatesis n.gen. et n.sp.  2. Con el material presente se hicieron studios anatómicos de los marsupios. Los resultados de éstos están discutidos con los conceptos existentes. Relaciones parentescas se pudieron mostrar, sobre todo en la familiaGymnomitriaceae, que aparentemente tiene ambas posibilidades de formar el masurpio. 3. Como particularidad se descubrió en Lethocolea repens caulos antheridiales de cuatro filas de células, lo que aparentemente es un criterio conservador.
Tipo: Journal Contribution
Palavras-chave: Liver; Liver; Http://aims.fao.org/aos/agrovoc/c_4395.
Ano: 1969
URL: http://hdl.handle.net/1834/3310

The Effect of Thyme Essential Oil (Thymus Vulgaris) Added to Quail Diets on Performance, Some Blood Parameters, and the Antioxidative Metabolism of the Serum and Liver Tissues
Provedor de dados: 89
Autores: Gumus,R; Ercan,N; Imik,H.
ABSTRACT This study was conducted to determine the effect of diets containing different levels of thyme essential oil (TEO) on performance, some serum parameters and the antioxidative metabolism of the serum and liver tissues in quails. A total number of 200 sixteen-days-old Japanese quails (Coturnix coturnix japonica) were used in the study. The animals were divided into 4 groups; the control group was fed only basal diet but groups TEO1, TEO2 and TEO3 had thyme essential oil of 150, 300 and 450 mg/kg, respectively, added to their diets. Body weight and daily weight gain increased with higher levels of thyme essential oil in the feed, yet a statistically significant increase was detected in only group TEO3 (p&lt;0.05). Furthermore, in all of the groups...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antioxidant; Quail; Liver; Performance; Thyme essential oil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000200297

Upregulation of TLR4 mRNA Expression Levels in Broiler Chickens Under Acute Heat Stress
Provedor de dados: 89
Autores: Huang,S.
ABSTRACT Toll-like receptors (TLRs) are well-characterized in mice and rats, but little is known on their role in broiler chickens during acute heat stress (AHS). The aim of the present study was to estimate the change in TLR4 mRNA expression in the liver, kidney's pleen, heart, and small intestine of broiler chickens under AHS. A total of 240 healthy Arbor Acres (AA) broiler chickens were randomly divided into four groups: control group (22±1°C; 0h), HS2, HS5 and HS10 (38±1°C; 2h, 5h and 10h of heat stress, respectively). As AHS duration increased, TLR4 mRNA expression slightly decreased at HS2 and HS5, but was dramatically elevated in HS10 (p&lt;0.001) compared with the control group in the small intestine, as well as in the spleen at HS2 (p=0.001) and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toll-like receptors 4; Liver; Small intestine; Acute heat stress; Broiler chickens.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000100087

Blood parameters and hepatic histopathology of broilers fed rations supplemented with essential oils
Provedor de dados: 96
Autores: Santos,Vanessa Kelly Ferreira do Rosário; Nogueira,Wedson Carlos Lima; Santos,Renato de Lima; Oliveira,Neide Judith Faria de; Martins,Ernane Ronie; Azevedo,Izabela Lorena; Carvalho,Tatiane Furtado de; Almeida,Anna Christina de.
ABSTRACT This study aimed to evaluate the hematological profile, hepatic function, and histopathology of mixed-sex broilers fed rations supplemented with microencapsulated essential oils from Cymbopogon flexuosus (lemon grass) and Lippia rotundifolia (chá-de-pedestre). One hundred and fifty Cobb chicks were housed in cages from 1 to 42 days of age in a completely randomized design, with six replicates with five chickens in each of five treatments (150 total chicks): basal diet without antibiotic growth promoter (negative control), diet with enramicina and salinomycin (positive control), diet with lemon grass essential oil, diet with L. rotundifolia essential oil, and diet with a mixture of lemon grass and L. rotundifolia essential oils. Mean corpuscular...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Animal production; Bird; Bird nutrition; Essential oils; Hematology; Liver.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982019000100518

Ultrasonographic identification of canine tiver portal vessels and hepatic veins
Provedor de dados: 195
Autores: Salgado, Annelise Baldaein; Mariana, Arani Nanei Bomfim.
Objective: To identify the canine hepatic veins and portal hepatic vessels by ultrasonography, evaluating the possibility of hepatic lobe determination based on these vessels in dogs, similar lo human fiver segmentation. Ultrasonography is a good method for evaluation of the liver, giving information on size, shape and parenchymal changes. Although the visualization and differentiation between hepatic veins and portal vessels is possible in dogs, their anatomical identification is difficult and the literature does not describe any methods for hepatic lobe determination. Material and Method: Ultrasound scans were done in 15 five animals - 10 healthy dogs and 5 dogs presenting with right venous congestion. A cadaver was employed for obtainance of a vinyl...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anatomy; Liver; Hepatic veins; Ultrasonography; Dogs Anatomia; Hígado; Venas hepáticas; Ultrasonografia; Perros anatomia; Fígado; Veias hepáticas; Ultrasonografia; Cães.
Ano: 2005
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/3181

Differential growth retardation and Myofibrillar fragmentation in rats submitted to feed restriction and realimentation
Provedor de dados: 63
Autores: Leonardo,Eric Franchi; Delgado,Eduardo Francisquine; Bagaldo,Adriana Regina; Lanna,Dante Pazzanese Duarte; Paz,Claudia Cristina Paro de.
Feed regimens alter muscle growth rate, hence they might impact the proteolytic system involved in tenderization during meat conditioning. The aim of this project was to verify the effects of feed restriction regimens on muscular and animal growth and their impact on postmortem myofibrillar fragmentation. The regimens were: 1) Feeding ad libitum for 11 d (Al/2); 2) Feed restriction (60% of Net Energy for maintenance - NEm) for 11 d (Rt/2); 3) Ad libitum for 22 d (Al); 4) Ad libitum for 4 d and feed restriction (60% NEm) for 18 d (Rt); 5) Ad libitum for 19 d and 3 d of fast (Ft); 6) Feed restriction (60% NEm) for 11 d and ad libitum until 22 d (Ral). The regimens Al/2 and Rt/2 had different intestine weights (19.3 ± 1.1 and 15.8 ± 1.9 g, respectively; P...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Myofibrillar fragmentation index; Muscle; Intestine; Liver.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162008000200003

Liver histopathology of the fish brachydanio rerio hamilton-buchman after acute exposure to sublethal levels of the organophosphate dimethoate 500
Provedor de dados: 104
Autores: Rodrigues,Edson de Lara; Fanta,Edith.
Among the new substances that were synthesised by the chemical industiy during the last decades, with the aim to improve human prosperity, some cause negative effects on non target organisms like fish. Among the pesticides, the organophosphates (OP) are widely used in cattle management, agriculture and aquaculture activities. Brachydanio rerio Hamilton-Buchman, 1822 is used world-wide in fish-tests for the establishment of the lethal levels of pesticides. Nevertheless, these fish show morphological changes in their hepatocytes when exposed experimentally for 24 hours to the sublethal dose of 0.025 µl/l of the OP Dimethoate 500, in acute tests. Right hours after exposure, a high density of cells with cytoplasmic granulation is seen as well as focal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dimethoate; Histopathology; Fish; Liver; Organophosphates; Sublethal contamination.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-81751998000200014

New records of Leptospira spp. in wild marsupials and a rodent in the eastern Brazilian Amazon through PCR detection
Provedor de dados: 36
Autores: SOUZA ROCHA,Katarine de; SCHUPP DE SENA MESQUITA,Gleiciane; SILVA FERREIRA,Maeli Fernanda; LEITE BARROS,Flávia de Nazaré; MACEDO,Renata Cecília Soares de Lima; ARAÚJO SARAIVA,Elane de; MENDES-OLIVEIRA,Ana Cristina; DUARTE CERQUEIRA,Valíria; SCOFIELD,Alessandra; GOES CAVALCANTE,Gustavo; ABEL,Isis; GUIMARÃES DE MORAES,Carla Cristina.
ABSTRACT We analyzed the presence of Leptospira spp. in liver and kidney tissue of wild marsupials and rodents trapped in a periurban forest in the eastern Brazilian Amazon. We examined 25 individuals of four marsupial and seven rodent species for the presence of the 16S rRNA gene of Leptospira in the DNA extracted from 47 liver and kidney tissue samples using PCR. We detected positive samples in 12% (3/25) of the individuals, in kidney fragments of two marsupial species (Didelphis marsupialis and Marmosops pinheiroi) and in a liver fragment of one rodent species (Echimys chrysurus). These are the first records of Leptospira spp. in M. pinheiroi and E. chrysurus and it is the first molecular survey of marsupials and rodents in the Brazilian Amazon.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Didelphimorphia; Rodentia; Live traps; Kidney; Liver; 16S rRNA.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672020000400305

Fish histopathology and catalase activity as biomarkers of the environmental quality of the industrial district on the Amazon estuary, Brazil - doi: 10.4025/actascibiolsci.v35i3.18032
Provedor de dados: 3
Autores: Viana, Andréa Pontes; Universidade Federal Rural de Pernambuco; Frédou, Flávia Lucena; Universidade Federal Rural de Pernambuco; Montes, Caroline da Silva; Universidade Federal do Pará; Rocha, Rossineide Martins; Universidade Federal do Pará.
The environment quality of an industrial district on the river Pará, Amazon estuary, Brazil, based on the assessment of histological alterations and on the determination of catalase activity of the hepatic tissue of two fish species, Plagioscion squamossissimus and Lithodoras dorsalis, is provided. Histopathological changes were evaluated semi-quantitatively and qualitatively. Mean Assessment Values (MAV) and Histological Alteration Index (HAI) of organ lesions were calculated for each zone under analysis, with different impact levels: Zone 1 (industrial district, with high contamination risk); Zone 2 (medium risk) and Zone 3 (minimum risk). Strong positive catalase activity and histopathological changes were reported in Zone 1. None of the specimens of...
Palavras-chave: 2.04.06.01-0; 2.06.03.00-2 biomonitoring; Liver; Industrialization; Northern Brazil 2.06.03.00-2 Biomonitoring  liver  industrialization  North Brazil. 2.06.03.00-2.
Ano: 2013
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/18032

Hepatic steatosis associated with microsporidiosis in teleost fishes from Marajó Island, Brazil
Provedor de dados: 42
Autores: VIDEIRA,MARCELA; VELASCO,MICHELE; MATOS,PATRÍCIA; CLEMENTE,SÉRGIO C. DE SÃO; SANCHES,OSIMAR; SANTOS,PATRÍCIA; MATOS,EDILSON.
A total of 40 specimens of the teleost fish Gobioides grahamae Palmer &amp; Wheeler, 1955 were obtained from the municipality of Salvaterra on Marajó Island in the Brazilian state of Pará. Their livers were removed and processed for light microscopy. Overall, 90% of the specimens presented some degree of steatosis of the liver, which was invariably associated with the presence of Microsporidium sp. The present study confirms the occurrence of steatosis in G. grahamae associated with parasitic infections by Microsporidium. The findings indicate that the condition of otherwise healthy fishes in their natural environment may be affected negatively by parasites.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Marajó Island; Gobioides grahamae; Liver; Steatosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301347

Protective Effect of Vitamin C on Triptolide-induced Acute Hepatotoxicity in Mice through mitigation of oxidative stress
Provedor de dados: 42
Autores: XU,PENGJUAN; LI,YOUYOU; YU,ZHICHAO; YANG,LIN; SHANG,RONG; YAN,ZIHANG.
Abstract: Triptolide, a purified diterpenoid from the herb Tripterygium wilfordii Hook.f., was widely used to treat many diseases. However, the hepatotoxicity of triptolide limited its clinical use. Research showed oxidative stress played an important role in triptolide-induced liver injury. To investigate the effect of vitamin C, which was one of the most effective antioxidants, on triptolide-induced hepatotoxicity and its potential mechanism in mice. In the present study, acute liver injury was induced by intraperitoneal injection of triptolide and vitamin C was orally administered. The results showed treatment with vitamin C prevented the triptolide-induced liver injury by reducing the levels of aspartate transaminase from 286.86 to 192.48 U/mL and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vitamin C; Triptolide; Liver; Oxidative stress; Mice.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300713

Ammonia poisoning causes muscular but not liver damage in cattle
Provedor de dados: 45
Autores: Antonelli,A.C.; Torres,G.A.S.; Soares,P.C.; Mori,C.S.; Sucupira,M.C.A.; Ortolani,E.L.
Twelve steers were intraruminally administered a high dose (0.5g/kg BW) of urea to study the damage effect of ammonia poisoning on liver and/or muscles. Blood samples were collected to determine ammonia and activities of gammaGT, AST and CK. Eleven steers were successfully poisoned and treated properly, but one succumbed. Poisoned cattle showed high concentration of ammonia, and higher activities of AST and CK. The higher the ammonia, the greater were the activities of AST (r=0.59) and CK (r=0.61). The correlation between AST and CK was high and significant (r=0.80), but not between AST and gammaGT (r=0.19). The activities of AST and CK were higher after the beginning of the convulsive episodes due to ammonia poisoning. Those results showed that occurred...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cattle; Ammonia poisoning; Urea; Muscle damage; Liver.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000100002

Qualitative feed restriction on productive performance and lipid metabolism in broiler chickens
Provedor de dados: 45
Autores: Cornejo,S.; Gadelha,A.C.; Pokniak,J.; Villouta,G.
A trial was carried out to evaluate the effect of qualitative restriction at different rearing phases on liver fatness and plasma triglycerides without impairing the productive performance of broiler chickens. One hundred and seventy-six male chicks were randomly assigned to four treatments and reared in battery brooders (16 pens with 11 birds each) from 1 to 49-day-old. In the control group, chicks were fed a starter diet (1 to 28-day-old) with 3,300kcal ME/kg of diet and 22.5% CP; grower diet (29 to 42-day-old) 3,300kcal ME/kg of diet and 18.2% CP; and the finisher diet (43 to 49-day-old) 3,300kcal ME/kg and 18.2% CP. Three restrict groups were fed a low 2,800kcal ME/kg of diet and 24% CP from 7 to 14-day-old (treatment 1); from 7 to 21-day-old...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Broiler chicken; Feed restriction; Productive performance; Liver; Triglyceride.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000600031

Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice
Provedor de dados: 48
Autores: Dkhi,Mohamed A.
BACKGROUND: Schistosomiasis is caused by helminth parasites of the genus Schistosoma. Berberine chloride (BER), an isoquinoline alkaloid, has been used in vivo for its antiparasitic, antioxidant and hepatoprotective properties. In this study, the protective effect of BER and praziquantel has been compared for the extent of schistosomiasis-induced oxidative stress in hepatic tissue of mice. RESULTS: S. mansoni was able to induce inflammation and injury to the liver, evidenced (i) by an increase in inflammatory cellular infiltrations, dilated sinusoids and vacuolated hepatocytes, (ii) by decreased levels of alanine and aspartate aminotransferases and increased levels of alkaline phosphatase, &amp;#947;-glutamyl transferase in the liver homogenate, (iii) by...
Tipo: Journal article
Palavras-chave: Schistosoma mansoni; Berberine; Liver; Mice.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100008

The effects of 4-nonylphenol contamination on livers of Tilapia fish (Oreochromus spilurs) in Jeddah
Provedor de dados: 48
Autores: Abdulla Bin-Dohaish,El-jawaher.
Alkylphenol polyethoxylates is a group of estrogenic compounds. Natural or synthetic types of these compounds react with the endocrine system by binding hormone receptors, resulting in interference with their action, which is why they are called endocrine disrupting chemicals. Among their hydrolytic products are nonylphenols (NP), which are considered pollutants of aquatic environments. The objective of this study was to evaluate the pathological alterations on liver tissue of fish exposed to these compounds for long durations, starting from beginning of life and during the period of sexual maturity. Tilapia fish were obtained from Abhur fish farms, reared in the laboratory in special basins, and divided into two groups. The first maternal group was...
Tipo: Journal article
Palavras-chave: Nonylphenol; Tilapia fish; Liver; Histology.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100002

Hepatic steatosis in six-banded armadillo (Euphractus sexcinctus Linnaeus, 1758)
Provedor de dados: 49
Autores: Silva,Andrezza Braga Soares da; Rizzo,Marcia dos Santos; Viloria-Petit,Alicia; Conde Junior,Airton Mendes.
Abstract The six-banded armadillo (Euphractus sexcinctus) stands out among wild mammals due to the rare occurrence of spontaneous metabolic diseases. When altered, the liver, which is important in metabolism, may trigger a dysfunctional cascade, leading to hepatic steatosis. Here we describe a case of hepatic steatosis in a six-banded armadillo living in captivity. The female specimen was captured and donated to the Federal University of Piaui under SISBIO authorization nº53303. The animal was first referred for a veterinary clinical evaluation, and then euthanized following the ethical standards of the Federal Council of Veterinary Medicine. At the start of the dissection, the abdominal cavity was accessed and sections of all ex situ liver lobes, spleen...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Euphractus sexcinctus; Infectious; Liver; Six-banded armadillo; Steatosis.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032018000100504

Investigation of liver tissue and biochemical parameters of adult wistar rats treated with Arctium lappa L.
Provedor de dados: 52
Autores: Predes,Fabrícia Souza; Matta,Sérgio Luis Pinto da; Monteiro,Juliana Castro; Oliveira,Tânia Toledo de.
This study was carried out to evaluate the effects of Arctium lappa L. (burdock) on the liver of adult male Wistar rats as measured by light microscopy and biochemical parameters. The rats received the extract in water bottles at doses of 10 or 20 g/L daily for 40 days. There were no significant changes in the plasma levels of albumin, aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transferase (GGT), total protein, total cholesterol, urea, uric acid, triacylglycerol, calcium, phosphorus, chlorine and direct bilirubin. The morphological analysis did not reveal histopathological alterations in liver tissue. Both biochemical and morphological data did not indicate A. lappa toxicity.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Arctium lappa; Burdock; Plasma components; Liver.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000200010

Effects of Replacement of Fishmeal with other Alternative Plant Sources in the Feed on Proximate Composition of Muscle, Liver and Ovary in Tilapia (Oreochromis nioloticus)
Provedor de dados: 52
Autores: Al-Ghanim,Khalid; Al-Thobaiti,Ahmed; Al-Balawi,Humoud F. Alkahem; Ahmed,Zubair; Mahboob,Shahid.
ABSTRACT The major objective of this experiment was to assess the effect of alternate plant protein sources as a replacement for fish meal in feed on the proximate composition of muscle, liver and tissue in Oreochromis niloticus. O. niloticus of average size (average Weight 45.00±1.25 g, total length 13.28±1.42 cm) were stocked in 100 L glass aquarium. Fish were fed with three experimental feeds (A, B and C) and reference commercial feed (D) for 16 weeks. Feed A, B and C was prepared from four different plant sources and fish meal (40 % crude protein). Fish were fed at the rate 3 % of body weight daily. It has been observed that tilapia fed with feed B in which 20 % fish meal was replaced compared to feed C with other plant sources of protein, had shown...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Feed; Plant sources; Muscle; Liver; Ovary.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100420

The Influence of Ca2+ on Gluconeogenesis Stimulation by Glucagon in the Liver of Arthritic Rats
Provedor de dados: 52
Autores: Kelmer-Bracht,Ana M.; Fedatto-Júnior,Zélio; Ishii-Iwamoto,Emy L.; Caparroz-Assef,Silvana M.; Bracht,Adelar.
Ca2+ participates in the stimulation of hepatic gluconeogenesis by glucagon and there is evidence that Ca2+ fluxes are modified in arthritic rats. These findings raise the question whether hepatic gluconeogenesis in arthritic rats responds differently to glucagon and Ca2+. The experimental system was the isolated perfused rat liver. In the presence of Ca2+, stimulation of hepatic gluconeogenesis by glucagon in arthritic rats was equal to that in normal rats in absolute terms, but higher in relative terms (104.5 and 45.2%, respectively). In the absence of Ca2+, however, stimulation of hepatic gluconeogenesis by glucagon in arthritic rats was smaller in both absolute and relative terms (18.5 and 41.9%, respectively). It can be concluded that the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Arthritis; Liver; Gluconeogenesis; Glucagon.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000300009

Ultra-structural and histochemical analysis of channel catfish (Ictalurus punctatus) liver treated with fumonisin B1
Provedor de dados: 52
Autores: Scaff,Rejane Maria Cirra; Scussel,Vildes Maria.
The histopathological effects of fumonisin B1 (FB1) injected intraperitoneally (IP), was evaluated in catfish (Ictalurus punctatus). Fishes were divided into four Groups. Groups II, III and IV were treated IP with FB1 injections of 1; 5 and 10 mg/kg bw/day, respectively, during 21 days. At the 7th, 14th and 21st day, fishes were sacrificed. The livers were hystologicaly analysed by the light and transmission electronic microscopy. Livers from the 7th day showed organelles alterations, particularly in the granular endoplasmatic reticle, mitochondria, nucleus and nucleolus mediated by FB1 doses. The occurrence of processes involved in the necrosis and apoptosis was detected. At the highest FB1 dose,the livers presented an intense response with an accentuate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Liver; Catfish; Fumonisin B1; Histopathology; Ultra-structural microscopy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000200013

Lake Baikal Endemic Sculpins (Cottoidei): A Promising Model to Study Adaptive Plasticity of Blood Cholesterol Metabolism
Provedor de dados: 52
Autores: Sudakov,Nikolay P.; Klimenkov,Igor V.; Pastukhov,Mikhail V.
We analyzed the blood lipid spectra in four closely related sculpin (Cottoidei) species endemic to Lake Baikal. These data characterize the Baikal sculpins as a set of model organisms for studying the adaptive plasticity of cholesterol metabolism and also mechanisms of resistance to the development of dyslipidemia and atherosclerosis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cholesterol; Lipoproteins; Liver; Cottoidei; Lake Baikal.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400613

Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy
Provedor de dados: 52
Autores: Pereira,Kércia Regina Santos Gomes; Açucena,Maria Kadja Meneses Torres; Villarim Neto,Arthur; Rêgo,Amália Cínthia Meneses; Bernardo-Filho,Mário; Azevedo,Ítalo Medeiros; Araújo Filho,Irami; Medeiros,Aldo Cunha.
Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Splenectomy; Sodium phytate; Biodistribution; Liver.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033

Hepatoprotective effects of Iranian Hypericum scabrum essential oils against oxidative stress induced by acetaminophen in rats
Provedor de dados: 52
Autores: Dadkhah,Abolfazl; Fatemi,Faezeh; Farsani,Mohsen Eslami; Roshanaei,Kambiz; Alipour,Mahdi; Aligolzadeh,Hadi.
This studied examined the protective role of Hypericum scabrum oils (100 and 200 mg/kg b.w, i.p) on acetaminophen-induced liver damages in the rat. The hepatic oxidative/antioxidant parameters such as lipid peroxidation (LP), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and ferric reducing ability of plasma (FRAP) were measured 2, 4, 8, 16 and 24h after the treatments confirmed by histopathological consideration. The results indicated that increased levels of hepatic LP and FRAP and SOD activity were reversed in the rats treated with oils. In addition, the depleted GSH were compensated with the oil treatments. The protective effect of the oils was further confirmed by the histophatological examination carried out on liver biopsies. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hypericum scabrum; Essential oils; Acetaminophen; Rat; Oxidative stress; Liver.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000300005

Acute intraperitoneal mercury chloride contamination and distribution in liver, muscle and gill of a neotropical fish Hoplias malabaricus (BLOCK, 1794)
Provedor de dados: 52
Autores: Jesus,Taise Bomfim de; Almeida,Priscila Gontijo Aguiar de; Vergílio,Cristiane dos Santos; Machado,André Luiz dos Santos; Carvalho,Carlos Eduardo Veiga de.
The present study investigated with the distribution of mercury chloride in muscle, liver and gills of Hoplias malabaricus contaminated through intraperitoneal injection (6 µg in 0.1mL of PBS) for a period of 24, 48, 72 and 96h. The liver, gill and muscle were analyzed for mercury content in an ICP/AES (Varian Liberty II) with vapor generating accessory (VGA 77). The muscle and liver tissues presented the same contamination pattern increasing concentrations in 24 h of exposure with a decrease in Hg concentration with 72 h and a new increase in Hg concentrations with 96 h of exposure. The Hg concentrations in contaminated organisms were always higher than the control although only for liver samples the difference was statistically significant. Liver samples...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inorganic mercury; Liver; Acute effects; Intraperitoneal contamination.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200021

Nephroprotective and anti-inflammatory effects of aqueous extract of Melissa officinalis L. on acetaminophen-induced and pleurisy-induced lesions in rats
Provedor de dados: 52
Autores: Müzell,Denise Pereira; Lunardelli,Adroaldo; Leite,Carlos Eduardo; Fagundes,Rodrigo Medeiros; Saciura,Vasyl Custódio; Reichel,Carlos Luiz; Oliveira,Jarbas Rodrigues de; Astarita,Leandro Vieira.
This study assessed the bioactive properties of an aqueous extract of M. officinalis for its anti-inflammatory activity and its protection against hepatic and renal lesions induced by acetaminophen (APAP). Animals pre-treated with the crude extract in pleurisy induced by carrageenan showed a reduction in the amounts of exudate, in the numbers of leukocytes and polymorphonuclear cells. Intragastric administration of the extract for seven days prior to the APAP-induced lesion showed no protective effect on the liver. The treatment with the extract induced an increase of serum aspartate aminotransferase, indicating a rise of toxicity. Contrarily, the same treatment reduced the APAP induced lesion in kidney, with respect to ν-glutamyltransferase. The results...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acetaminophen; Melissa officinalis; Pleurisy; Anti-inflammatory; Kidney; Liver.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300006

Incorporation of n-3 fatty acids by the liver of mice fed linseed oil as a function of feeding duration
Provedor de dados: 52
Autores: Perini,João Angelo Lima; Stevanato,Flávia Braidotti; Visentainer,Jeane Eliete Laguila; Sargi,Sheisa Cyléia; Oliveira,Marcia Machado; Souza,Nilson Evelázio; Matsushita,Makoto; Visentainer,Jesuí Vergílio.
The objective of this study was to evaluate the incorporation of omega-3 fatty acids (n-3 FA) on male Swiss mice livers receiving diets based on linseed oil (LO) for up to 56 days. The mice were sacrificed at 7, 14, 28, 42, 56 days and FA concentration was analyzed by gas chromatography. A total of 13 FA were identified on LO feeds presenting alpha-linolenic acid (LNA) contents of 26.97 %. A total 22 FA were identified in the livers of the mice. Part of the LNA was converted into n-3 FA (20:3n-3, eicosapentaenoic acid-EPA, 22:5n-3, and docosahexaenoic acid-DHA), and some of the LNA was stored in the liver. LNA, EPA and DHA concentrations (mg/g total lipids ) from 0 days for up 56 days increased from 1.29 to 18.90 (LNA), 0.20 to 18.90 (EPA) and 41.26 to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Polyunsaturated fatty acids; Mice; Liver; Linseed oil.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200012

Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride
Provedor de dados: 52
Autores: Fernandes,Mileni da Silva; Iano,Flávia Godoy; Rocia,Vivian; Yanai,Marcela Mitsuko; Leite,Aline de Lima; Furlani,Tatiana Almeida; Buzalaf,Marília Afonso Rabelo; Oliveira,Rodrigo Cardoso de.
The aim of this study was to compare the effect of fluoride (F) on alkaline phosphatase activity in the liver and plasma of the rats. Four groups of male Wistar rats (n=6), which received drinking water containing 5, 15 or 50 ppm F or deionized water (control) throughout the experiment were included in the study. The animals were euthanized and had their tissues and blood plasma collected for the analysis of fluoride and alkaline phosphatase. There was an increase in F concentration in most tissues in the animals treated with higher F concentrations, except for the heart. The alkaline phosphatase assay showed an increase in the activity in the liver and blood plasma of the animals treated with fluoride concentrations of 15 and 50 ppm (p&lt;0.05). This...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alkaline phosphatase; Fluoride; Liver; Kidney.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600014

Blood glucose regulation during fasting in rats under food restriction since birth
Provedor de dados: 52
Autores: Vitoriano,Adriana de Souza; Malta,Ananda; Barrena,Helenton Christian; Furlan,Maria Montserrat Diaz Pedrosa; Bazotte,Roberto Barbosa; Gazola,Vilma Godoi.
The effect of severe food restriction since birth on regulation of fasting glycemia in male Wistar rats was investigated. The control group (CG) had free supply of chow, while the restriction group (RG) received 50% of the amount ingested by the CG. The experiments were done in adult (60 days) overnight fasted rats in which glycemia, liver free glucose levels and hepatic glycogen concentration were measured. In part of the experiments in situ liver perfusion was done. The results showed that livers from the RG had higher glycogenolysis rates but lower gluconeogenesis rates from L-alanine (10 mM). Since RG showed maintained glycemia during fasting, it could be concluded that livers from RG produced glucose preferentially from glycogenolysis in detriment of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Food restriction; Rats; Liver; Gluconeogenesis; Glycogenolysis.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000100009

Effect of (-)-∆9-tetrahydrocannabinoid on the hepatic redox state of mice
Provedor de dados: 56
Autores: Pinto,C.E.; Moura,E.; Serrão,M.P.; Martins,M.J.; Vieira-Coelho,M.A.
(-)-∆9-Tetrahydrocannabinol (∆9-THC), a psychoactive component of marijuana, has been reported to induce oxidative damage in vivo and in vitro. In this study, we administered ∆9-THC to healthy C57BL/6J mice aged 15 weeks in order to determine its effect on hepatic redox state. Mice were divided into 3 groups: ∆9-THC (N = 10), treated with 10 mg/kg body weight ∆9-THC daily; VCtrl (N = 10), treated with vehicle [1:1:18, cremophor EL® (polyoxyl 35 castor oil)/ethanol/saline]; Ctrl (N = 10), treated with saline. Animals were injected ip twice a day with 5 mg/kg body weight for 10 days. Lipid peroxidation, protein carbonylation and DNA oxidation were used as biomarkers of oxidative stress. The endogenous antioxidant defenses analyzed were glutathione (GSH)...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: (-)-∆9-Tetrahydrocannabinol; Oxidative stress; Liver; Cannabinoid receptors; Cremophor EL®.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400001

Endothelium-dependent and -independent hepatic artery vasodilatation is not impaired in a canine model of liver ischemia-reperfusion injury
Provedor de dados: 56
Autores: Miranda,L.C.; Viaro,F.; Ceneviva,R.; Evora,P.R.B.
We investigated whether hepatic artery endothelium may be the earliest site of injury consequent to liver ischemia and reperfusion. Twenty-four heartworm-free mongrel dogs of either sex exposed to liver ischemia/reperfusion in vivo were randomized into four experimental groups (N = 6): a) control, sham-operated dogs, b) dogs subjected to 60 min of ischemia, c) dogs subjected to 30 min of ischemia and 60 min of reperfusion, and d) animals subjected to 45 min of ischemia and 120 min of reperfusion. The nitric oxide endothelium-dependent relaxation of hepatic artery rings contracted with prostaglandin F2a and exposed to increasing concentrations of acetylcholine, calcium ionophore A23187, sodium fluoride, phospholipase-C, poly-L-arginine, isoproterenol, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Endothelium; Hepatic artery; Nitric oxide; Liver; Ischemia/reperfusion injury.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600016

Advancement in liver laparoscopic resection – development of a new surgical device
Provedor de dados: 56
Autores: Vavra,P.; Karnik,L.; Skrobankova,M.; Jurcikova,J.; Ihnat,P.; Zonca,P.; Peteja,M.; El-Gendi,A.; Czudek,S.
Liver resection is the standard treatment for any liver lesion. Laparoscopic liver resection is associated with lower intra-operative blood loss and fewer complications than open resection. Access to the posterior part of the right liver lobe is very uncomfortable and difficult for surgeons due the anatomic position, especially when employing laparoscopic surgery. Based on these experiences, a new laparoscopic device was developed that is capable of bending its long axis and allowing the application of radiofrequency energy in areas that were not technically accessible. The device is equipped with four telescopic needle electrodes that cause tissue coagulation after the delivery of radiofrequency energy. Ex vivo testing was performed in 2012 and 2014 at...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Laparoscopic surgery; Liver; Radiofrequency energy; Posterior liver segments.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400617

The use of light-emitting diodes to stimulate mitochondrial function and liver regeneration of partially hepatectomized rats
Provedor de dados: 56
Autores: Castro-e-Silva,T.; Castro-e-Silva,O.; Kurachi,C.; Ferreira,J.; Zucoloto,S.; Bagnato,V.S.
The biostimulating effect of laser radiation has been observed in many areas of Medicine. However, there are still several questions to be answered, among them the importance of light coherence in the stimulatory process. In the present study, we used light-emitting diodes (LED) to promote the stimulation of liver regeneration after partial hepatectomy in rats. Fourteen male Wistar rats weighing 200-250 g were submitted to partial hepatectomy (70%) followed by LED light irradiation (630 nm) of the remaining part of the liver at two doses, i.e., 10 (N = 7) and 140 (N = 7) J/cm². A group irradiated with laser, 590 nm (N = 7, 15 J/cm²) was performed for the study of proliferating cell nuclear antigen-labeling index. Data are reported as mean ± SEM....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Liver; Mitochondria; Laser; Light-emitting diode; Liver regeneration; Proliferating cell nuclear antigen.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800006

Hepatic changes in mice chronically infected with Helicobacter trogontum
Provedor de dados: 56
Autores: Moura,S.B.; Queiroz,D.M.M.; Rocha,G.A.; Comunian,L.B.; Cara,D.C.
We infected NIH germ-free female mice with Helicobacter trogontum, a recently described intestinal bacterium of rats, in order to study the lesions it induced in the liver of this host. Fifteen mice were challenged with a single dose of H. trogontum (test group) and killed 6, 12 and 18 months after inoculation (5 animals/group). Nine animals were challenged with 0.85% saline alone (control group) and killed at the same times. Fragments from the liver, cecum and colon were obtained for microbiologic and histologic examination. Stool samples were also collected. H. trogontum was detected in the cecum, colon and/or stool samples of all test mice. As expected, the bacterium was not isolated from any specimen obtained from the control animals. On the other...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Helicobacter; Helicobacter trogontum; Animal model; Liver; Mice.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900010

Treatment with Ilex paraguariensis (yerba mate) aqueous solution prevents hepatic redox imbalance, elevated triglycerides, and microsteatosis in overweight adult rats that were precociously weaned
Provedor de dados: 56
Autores: de Oliveira,E.; Lima,N.S.; Conceição,E.P.S.; Peixoto-Silva,N.; Moura,E.G.; Lisboa,P.C.
Early weaning (EW) leads to overweight, visceral obesity, hyperleptinemia, and insulin resistance in adulthood. Treatment with Ilex paraguariensis (yerba mate) improves obesity and insulin resistance in these animals. Here, we evaluated the effects of chronic treatment with yerba mate on the redox balance and liver morphology of overweight early-weaned rats. To induce EW, we wrapped the dams with bandages to interrupt milk access during the last 3 days of lactation. Control pups (C) had free access to maternal milk for the full 21 days of lactation. On postnatal day (PN) 150, EW offspring were subdivided into the EW+YM group, which received the aqueous extract of yerba mate (1 g/kg bw by gavage once a day for 30 days) and the EW group, which received water...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Early weaning; Programming; Oxidative stress; Steatosis; Liver.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600619

Effects of endurance training on reduction of plasma glucose during high intensity constant and incremental speed tests in Wistar rats
Provedor de dados: 56
Autores: Abreu,P.; Vitzel,K.F.; Monteiro,I.C.C.R.; Lima,T.I.; Queiroz,A.N.; Leal-Cardoso,J.H.; Hirabara,S.M.; Ceccatto,V.M.
The aim of this research was to investigate the effects of endurance training on reduction of plasma glucose during high intensity constant and incremental speed tests in Wistar rats. We hypothesized that plasma glucose might be decreased in the exercised group during heavy (more intense) exercise. Twenty-four 10-week-old male Wistar rats were randomly assigned to sedentary and exercised groups. The prescription of endurance exercise training intensity was determined as 60% of the maximum intensity reached at the incremental speed test. The animals were trained by running on a motorized treadmill, five days/week for a total period of 67 weeks. Plasma glucose during the constant speed test in the exercised group at 20 m/min was reduced at the 14th, 21st and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Exercise; Skeletal muscle; Liver; Blood glucose; Training.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001100602

Hepatic inducible nitric oxide synthase expression increases upon exposure to hypergravity
Provedor de dados: 56
Autores: Kim,H.S.; Jung,Y.Y.; Do,S.I.
Stimulation by a number of conditions, including infection, cytokines, mechanical injury, and hypoxia, can upregulate inducible nitric oxide synthase (iNOS) in hepatocytes. We observed that exposure to hypergravity significantly upregulated the transcription of the hepatic iNOS gene. The aim of this study was to confirm our preliminary data, and to further investigate the distribution of the iNOS protein in the livers of mice exposed to hypergravity. ICR mice were exposed to +3 Gz for 1 h. We investigated the time course of change in the iNOS expression. Hepatic iNOS mRNA expression progressively increased in centrifuged mice from 0 to 12 h, and then decreased rapidly by 18 h. iNOS mRNA levels in the livers of centrifuged mice was significantly higher at...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inducible nitric oxide synthase; Mouse; Liver; Hypergravity.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100940

Meal-feeding scheme: twenty years of research in Brazil
Provedor de dados: 56
Autores: Bazotte,R.B.; Batista,M.R.; Curi,R.
Naomi Shinomiya Hell was the first researcher to investigate the physiological adaptations to a meal-feeding scheme (MFS) in Brazil. Over a period of 20 years, from 1979 to 1999, Naomi's group determined the physiological and metabolic adaptations induced by this feeding scheme in rats. The group showed the persistence of such adaptations even when MFS is associated with moderate exercise training and the performance to a session of intense physical effort. The metabolic changes induced by the feeding training were discriminated from those caused by the effective fasting period. Naomi made an important contribution to the understanding of the MFS but a lot still has to be done. One crucial question still remains to be satisfactorily answered: what is the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Meal-feeding scheme; Metabolism; Exercise; Fasting; Liver.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900001

Detection of immunoglobulin G in the lung and liver of hamsters with visceral leishmaniasis
Provedor de dados: 56
Autores: Mathias,R.; Costa,F.A.L.; Goto,H.
Several organs are affected in visceral leishmaniasis, not only those rich in mononuclear phagocytes. Hypergammaglobulinemia occurs during visceral leishmaniasis; anti-Leishmania antibodies are not primarily important for protection but might be involved in the pathogenesis of tissue lesions. The glomerulonephritis occurring in visceral leishmaniasis has been attributed to immune complex deposition but in other organs the mechanism has not been studied. In the current study we demonstrated the presence of IgG in the lung and liver of hamsters with visceral leishmaniasis. Hamsters were injected intraperitoneally with 2 x 10(7) amastigotes of Leishmania (Leishmania) chagasi and the presence of IgG in the liver and lung was evaluated at 7, 15, 30, 45, 80 and...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Leishmania (Leishmania) chagasi; Visceral leishmaniasis; Immunopathology; Immunoglobulin G; Liver; Lung.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400015

Gender differences in the activities of aspirin-esterases in rat tissues
Provedor de dados: 56
Autores: Benedito,M.A.C.
The activities of aspirin (acetylsalicylic acid)-esterases were measured in several tissues (liver, kidney, adrenal glands, brain and serum) from adult male and female Wistar rats. In males, both aspirin-esterase I (assayed at pH 5.5) and II (assayed at pH 7.4) activities were higher in liver homogenates when compared to females (aspirin-esterase I: males 48.9 ± 4.8 (N = 8) and females 29.3 ± 4.2 (N = 8) nmol of salicylic acid formed min-1 mg protein-1; aspirin-esterase II: males 41.4 ± 4.1 (N = 8) and females 26.1 ± 4.5 (N = 8) nmol of salicylic acid formed min-1 mg protein-1, P&amp;lt;0.001). In serum, enzyme activity was higher in females than in males (aspirin-esterase I: males 0.85 ± 0.06 (N = 6) and females 1.18 ± 0.11 (N = 6) nmol of salicylic acid...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aspirin-esterases; Sex differences; Rats; Liver; Serum.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900002

Sex-dependent differences in the activities of acetylsalicylic acid-esterases in mouse kidneys
Provedor de dados: 56
Autores: Benedito,M.A.C.
Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans. Sex differences in drug metabolism by rodent liver are documented in the literature. In this paper we report a difference in the activities of the esterases (ASA-esterase I and II) in the kidneys of male and female mice. In this species there is no difference between males and females in liver ASA-esterases (ASA-esterase I: males 38.5 ± 7.9 (N = 5) and females 31.6 ± 7.6 (N = 5) nmol of salicylic acid formed min-1 mg protein-1, P&amp;gt;0.05; ASA-esterase II: males 77.3 ± 17.4 (N = 5) and females 61.4 ± 15.1 (N = 5) nmol of salicylic acid formed min-1 mg protein-1, P&amp;gt;0.05)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acetylsalicylic acid; Esterases; Mice; Sex differences; Kidneys; Liver.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300004

Pros and cons of insulin administration on liver glucose metabolism in strength-trained healthy mice
Provedor de dados: 56
Autores: Pereira,V.A.R.; Vedovelli,K.S.; Muller,G.Y.; Depieri,Y.F.; Avelar,D.H.C.G.; de Amo,A.H.E.; Jimenes,D.R.; Martins,J.N.L.; Silvério,A.C.; Gomes,C.R.G.; Godoi,V.A.F.; Pedrosa,M.M.D.
Non-diabetic individuals use hormones like insulin to improve muscle strength and performance. However, as insulin also leads the liver and the adipose tissue to an anabolic state, the purpose of this study was to investigate the effects of insulin on liver metabolism in trained non-diabetic Swiss mice. The mice were divided into four groups: sedentary treated with saline (SS) or insulin (SI) and trained treated with saline (TS) or insulin (TI). Training was made in a vertical stair, at 90% of the maximum load, three times per week. Insulin (0.3 U/kg body weight) or saline were given intraperitoneally five times per week. After eight weeks, tissue and blood were collected and in situ liver perfusion with glycerol+lactate or alanine+glutamine (4 mM each)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Muscle strength; Gluconeogenesis; Liver; Adiposity; Training.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000200605

Effects of nanoparticles of hydroxy-aluminum phthalocyanine on markers of liver injury and glucose metabolism in diabetic mice
Provedor de dados: 56
Autores: Melo,M.A.B.; Caetano,W.; Oliveira,E.L.; Barbosa,P.M.; Rando,A.L.B.; Pedrosa,M.M.D.; Godoi,V.A.F.
Photodynamic therapy, by reducing pain and inflammation and promoting the proliferation of healthy cells, can be used to treat recurrent lesions, such as diabetic foot ulcers. Studies using the photosensitizer phthalocyanine, together with the nanostructured copolymeric matrix of Pluronic® and Carbopol® for the treatment of diabetic foot ulcers and leishmaniosis lesions, are showing promising outcomes. Despite their topical or subcutaneous administration, these molecules are absorbed and their systemic effects are unknown. Therefore, we investigated the effect of the subcutaneous administration of the hydroxy-aluminum phthalocyanine hydrogel without illumination on systemic parameters, markers of liver injury, and liver energy metabolism in type 1 diabetic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hydroxy-aluminum phthalocyanine; Hydrogel; Liver; Type 1 diabetes; Mice.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100609

Streptozotocin-induced diabetes mellitus affects lysosomal enzymes in rat liver
Provedor de dados: 56
Autores: Peres,G.B.; Juliano,M.A.; Aguiar,J.A.K.; Michelacci,Y.M.
It has been previously shown that dextran sulfate administered to diabetic rats accumulates in the liver and kidney, and this could be due to a malfunction of the lysosomal digestive pathway. The aim of the present study was to evaluate the expression and activities of lysosomal enzymes that act upon proteins and sulfated polysaccharides in the livers of diabetic rats. Diabetes mellitus was induced by streptozotocin in 26 male Wistar rats (12 weeks old), while 26 age-matched controls received only vehicle. The livers were removed on either the 10th or the 30th day of the disease, weighed, and used to evaluate the activity, expression, and localization of lysosomal enzymes. A 50-60% decrease in the specific activities of cysteine proteases, especially...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Liver; Diabetes mellitus; Lysosomal enzymes; Cathepsin; Glycosidase; Sulfatase.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600452

Effect of bullfrog (Rana catesbeiana) oil administered by gavage on the fatty acid composition and oxidative stress of mouse liver
Provedor de dados: 56
Autores: Silva,L.P.; Miyasaka,C.K.; Martins,E.F.; Leite,J.R.S.A.; Lacava,Z.G.M.; Curi,R.; Azevedo,R.B.
The aim of the present study was to investigate the effects of daily intragastric administration of bullfrog oil (oleic, linoleic and palmitoleic acid-rich oil), corresponding to 0.4% of body weight for four weeks, on fatty acid composition and oxidative stress (lipid peroxidation and catalase activity) in mouse liver. The activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT), biomarkers of tissue injury, were determined in liver homogenates and serum. The proportions of 18:2n-6, 20:4n-6, 20:5n-3, and 22:6n-3 (polyunsaturated fatty acids, from 37 to 60%) in the total fatty acid content were increased in the liver of the bullfrog oil-treated group (P &lt; 0.05)...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Bullfrog oil; Liver; TBARS; Catalase activity; Lipid peroxidation; Monounsaturated fatty acid.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000007

Costus root aqueous extract modulates rat liver toxicity, DNA damage, injury, proliferation alterations induced by plant growth regulator Ethephon
Provedor de dados: 60
Autores: Tousson,Ehab; El-Atrsh,Afaf; Mansour,Merfaat; Assem,Abdallah.
Ethephon (Ethrel®) is an ethylene-based plant growth regulator that used in agriculture and it has direct and indirect effects on human health, direct effect via its inhalation during usage in agriculture and indirect effect through the diet (Fruits and vegetables) that is sprayed with it. The current study aimed to examine the possible modifying effects of costus (Saussurea lappa) root aqueous extract against Ethephon induced liver toxicity, injury, DNA fragmentation and PCNA alterations in male rats. Fifty adult male rats were divided into 5 groups (1st, control; 2nd, Costus; 3rd, Ethephon; 4th, Post treated Ethephon with costus; 5th, self-healing Ethephon). Current results revealed that; a significant increase in aspartate transaminase (AST), alanine...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Plant growth regulator; Ethephon; Costus; Liver; DNA damage; PCNA expression; Rat.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100600

Hepatic protective effect of grape seed proanthocyanidin extract against Gleevec-induced apoptosis, liver Injury and Ki67 alterations in rats
Provedor de dados: 60
Autores: Al-Rasheed,Nawal Mohammed; El-Masry,Thanaa Ahmed; Tousson,Ehab; Hassan,Hanan Mohammad; Al-Ghadeer,Areej.
ABSTRACT Gleevec (imatinib) is an antineoplastic chemotherapeutic agent used in the treatment of many types of cancer. The current study was conducted to examine the possible modifying effects of grape seeds proanthocyandins extract (GSPE) against apoptosis, liver injury and Ki67 alterations induced by Gleevec in male rats. 40 male albino rats were equally divided into four groups (First and second groups were control and GSPE groups; third group was Gleevec group and fourth group was treated with Gleevec and GSPE). Gleevec induced elevations in P53 and depletion of Bcl2 levels in liver tissues were compared with the control group. Liver sections in rats treated with Gleevec exhibited marked cellular infiltrations, vacuolar degeneration hepatocytes,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chemotherapy; Gleevec/effects; Gleevec/Imatinib; Proanthocyandins; Liver; Apoptosis; Proliferation.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200612

Canine hypertrophic osteopathy associated with extra-thoracic lesions
Provedor de dados: 65
Autores: Headley,Selwyn Arlington; Ribeiro,Eduardo Alcântara; Santos,Gustavo José Von G. dos; Bettini,Carlos Maia; Mattos Júnior,Ewaldo.
Canine hypertrophic osteopathy is described in a dog that presented extra-thoracic lesions, mainly in the liver. Hepatic lesions were characterized by necrosis, hemorrhage, severe hydropic degeneration of centrolobular hepatocytes, proliferation of epithelial cells of bile ducts, and mild biliary stasis. The disease syndrome was diagnosed based on clinical signs, radiological evaluation, and inspection of macerated bones.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hypertrophic osteopathy; Dog; Pathology; Radiology; Liver.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782005000400033

Protein concentrates obtained from pig by-products using pH-shifting technique: a preliminary study
Provedor de dados: 65
Autores: Costa,Claudine Garcia Chaves da; Paula,Marielle Maria de Oliveira; Massingue,Armando Abel; Torres Filho,Robledo de Almeida; Ramos,Eduardo Mendes; Carneiro,João de Deus de Souza.
ABSTRACT:  This study aimed to investigate the extraction and characterization of protein concentrates from pig by-products (heart, liver and kidneys) using the pH-shifting technique. From the solubility profiles (pH 2 to 12), the protein extraction was performed at alkaline pH (10.0 to 11.5), obtaining two fractions: soluble (SC) and insoluble (IC). Higher protein content (71 to 77%) and extractability (214 to 459 mg/g) were observed in heart and liver concentrates; whereas, for water holding capacity (WHC) the highest values (4.20 to 4.54 g water/g protein) were for the heart (SC) and kidney (SC and IC) concentrates. All concentrates had high emulsion stability and higher WHC than commercial protein extenders (whey and soybean). The concentrates obtained...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heart; Kidney; Liver; Protein extensor; PH-shifting.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000600751

Cholelithiasis with atrophy of the right lateral hepatic lobe in a horse
Provedor de dados: 65
Autores: Santos,Renato de Lima; Oliveira,Tatiane de Fátima Brandão de; Oliveira,Taismara Simas de; Galvão,João Felipe Brito; Paixão,Tatiane Alves da; Goloubeff,Barbara.
A 22 year-old horse developed cholelithiasis with marked atrophy of the right lateral hepatic lobe. The horse had a history of intermittent colic since three years of age, and one of the first episodes of colic was associated with icterus. The size of the right lateral hepatic lobe was extremely reduced. There was a large choledocholith in the common hepatic duct, and several hepatoliths and choleliths in the intra- and extra-hepatic billiary ducts. Microscopically, there was severe atrophy of the right lobe with diffuse proliferation of connective tissue and billiary ducts. The left lateral lobe had peri-portal fibrosis with proliferation of billiary ducts, and billiary stasis. Chemical analysis of the calculi detected amorphous and triple phosphate,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Horse; Cholelithiasis; Biliary calculi; Biliary obstruction; Liver; Hepatic atrophy.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000200049

Visceral metabolism and efficiency of energy use by ruminants
Provedor de dados: 65
Autores: Kozloski,Gilberto Vilmar; Rocha,João Batista Teixeira da; Ciocca,Maria de Lourdes Santorio.
The visceral system (liver and portal-drained viscera) represents an interface between diet and the animal, and it acts as the main site of regulation of nutrients that are used for maintenance, growth, lactation, reproduction, and physical activities of animals. However the functions carried out by visceral organs have, however, a significant energetic cost and are influenced by a variety of factors, such as the level of feed intake and diet composition, among others. As a result, variable quantities of substances are metabolized by them and, thus, the pattern and the quantity of nutrients available to the peripheral tissues can be quite different from those absorbed at the intestinal lumen. Probably, the major source of variation in the efficiency of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Portal- drained viscera; Liver; Metabolism; Energy; Efficiency.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782001000500030

Morphometry of megakaryocytes in the liver of New Zealand White rabbits during intrauterine and postnatal development
Provedor de dados: 65
Autores: Pacheco,Maria Rita; Ferreira,Nilson; Melo,Válder Rodrigues; Baraldi-Artoni,Silvana Martinez; Orsi,Antonio Marcos; Machado,Márcia Rita Fernandes; Oliveira,Fabrício Singaretti de.
The hepatic megakaryocytic cells of New Zealand White rabbit in the intrauterine phase and in the immediate postnatal period were studied. Statistical analysis of the data concerning the cytoplasm and nucleus of those cells, i.e., area, perimeter, maximum diameter, minimum diameter, volume and shape factor, presented significant differences (p&lt;0.01) for F values concerning the life phases studied on15th, 22nd and 29th day of intrauterine life and 10th day of postnatal life, and for F values for animal within each phase. The Tukey’s test showed that most of the parameters studied in the cytoplasm and nucleus of these megakaryocytic cells presented the lowest values on the 15th day of intrauterine life and the highest on the 22nd day of the same phase.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Liver; Megakaryocytes; Morphometry; Rabbits.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782002000600015

LICURY CAKE IN LAMB FEED: CHARACTERISTICS OF CARCASS AND NON-CARCASS COMPONENTS
Provedor de dados: 64
Autores: Santos,Fernanda Maria dos; Santos,Juliana Dantas Rodrigues; Carvalho,Francisco Allan Leandro de; Queiroz,Mário Adriano Ávila; Yamamoto,Sandra Mari; Guimarães,Omair Dantas.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Centesimal composition; Byproduct; Liver.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542015000300260